Variant Annotation Integrator

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Your search resulted in multiple matches. Please select a position:
Gencode Genes

BIRC5 (ENST00000592734.5_1) at chr17:76210398-76219073 - Multitasking protein that has dual roles in promoting cell  proliferation and preventing apoptosis (PubMed:9859993,  PubMed:21364656, PubMed:20627126, PubMed:25778398, PubMed:28218735).  Component of a chromosome passage protein complex (CPC) which is  essential for chromosome alignment and segregation during mitosis and  cytokinesis (PubMed:16322459). Acts as an important regulator of the  localization of this complex; directs CPC movement to different  locations from the inner centromere during prometaphase to midbody  during cytokinesis and participates in the organization of the center  spindle by associating with polymerized microtubules (PubMed:20826784).  Involved in the recruitment of CPC to centromeres during early mitosis  via association with histone H3 phosphorylated at 'Thr-3' (H3pT3)  during mitosis (PubMed:20929775). The complex with RAN plays a role in  mitotic spindle formation by serving as a physical scaffold to help  deliver the RAN effector molecule TPX2 to microtubules  (PubMed:18591255). May counteract a default induction of apoptosis in  G2/M phase (PubMed:9859993). The acetylated form represses STAT3  transactivation of target gene promoters (PubMed:20826784). May play a  role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7  (PubMed:21536684). Essential for the maintenance of mitochondrial  integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do  not appear to play vital roles in mitosis (PubMed:12773388,  PubMed:16291752). Isoform 3 shows a marked reduction in its anti-  apoptotic effects when compared with the displayed wild-type isoform  (PubMed:10626797). (from UniProt O15392)
BIRC5 (ENST00000590925.6_1) at chr17:76210344-76219635 - Multitasking protein that has dual roles in promoting cell  proliferation and preventing apoptosis (PubMed:9859993,  PubMed:21364656, PubMed:20627126, PubMed:25778398, PubMed:28218735).  Component of a chromosome passage protein complex (CPC) which is  essential for chromosome alignment and segregation during mitosis and  cytokinesis (PubMed:16322459). Acts as an important regulator of the  localization of this complex; directs CPC movement to different  locations from the inner centromere during prometaphase to midbody  during cytokinesis and participates in the organization of the center  spindle by associating with polymerized microtubules (PubMed:20826784).  Involved in the recruitment of CPC to centromeres during early mitosis  via association with histone H3 phosphorylated at 'Thr-3' (H3pT3)  during mitosis (PubMed:20929775). The complex with RAN plays a role in  mitotic spindle formation by serving as a physical scaffold to help  deliver the RAN effector molecule TPX2 to microtubules  (PubMed:18591255). May counteract a default induction of apoptosis in  G2/M phase (PubMed:9859993). The acetylated form represses STAT3  transactivation of target gene promoters (PubMed:20826784). May play a  role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7  (PubMed:21536684). Essential for the maintenance of mitochondrial  integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do  not appear to play vital roles in mitosis (PubMed:12773388,  PubMed:16291752). Isoform 3 shows a marked reduction in its anti-  apoptotic effects when compared with the displayed wild-type isoform  (PubMed:10626797). (from UniProt O15392)
BIRC5 (ENST00000590449.1_2) at chr17:76210361-76211180 - Multitasking protein that has dual roles in promoting cell  proliferation and preventing apoptosis (PubMed:9859993,  PubMed:21364656, PubMed:20627126, PubMed:25778398, PubMed:28218735).  Component of a chromosome passage protein complex (CPC) which is  essential for chromosome alignment and segregation during mitosis and  cytokinesis (PubMed:16322459). Acts as an important regulator of the  localization of this complex; directs CPC movement to different  locations from the inner centromere during prometaphase to midbody  during cytokinesis and participates in the organization of the center  spindle by associating with polymerized microtubules (PubMed:20826784).  Involved in the recruitment of CPC to centromeres during early mitosis  via association with histone H3 phosphorylated at 'Thr-3' (H3pT3)  during mitosis (PubMed:20929775). The complex with RAN plays a role in  mitotic spindle formation by serving as a physical scaffold to help  deliver the RAN effector molecule TPX2 to microtubules  (PubMed:18591255). May counteract a default induction of apoptosis in  G2/M phase (PubMed:9859993). The acetylated form represses STAT3  transactivation of target gene promoters (PubMed:20826784). May play a  role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7  (PubMed:21536684). Essential for the maintenance of mitochondrial  integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do  not appear to play vital roles in mitosis (PubMed:12773388,  PubMed:16291752). Isoform 3 shows a marked reduction in its anti-  apoptotic effects when compared with the displayed wild-type isoform  (PubMed:10626797). (from UniProt O15392)
BIRC5 (ENST00000374948.6_2) at chr17:76210345-76221717 - baculoviral IAP repeat containing 5, transcript variant 2 (from RefSeq NM_001012270.2)