IEDB Prediction IEDB Pred Macaque I Track Settings
Assembly: Ebola virus Sierra Leone 2014 (G3683/KM034562.1/eboVir3)
Description
This track shows peptides that are predicted to be displayed by
macaque class I MHCs.
Display Conventions and Configuration
Peptides are shaded by IC50 values and split into subtracks by HLA-alleles.
Methods
For human epitope prediction, binding affinity for all possible 9-mer peptides
from each protein sequence to a set of 27 HLA alleles that are most frequent in
the global population, using the SMM method available in the IEDB MHC class
I binding prediction tool. All peptides with predicted binding affinity (expressed
as IC50 nM) below previously optimized allele-specific thresholds were
selected as predicted binders. In the case of rhesus macaque class I T cell
epitope prediction, the binding affinity of all 9-mer peptides was predicted
for a total of 19 alleles (7 Indian and 12 Chinese rhesus macaques) that are
most frequent in these species. The binding affinity predictions utilized the
"IEDB recommended" method from the IEDB MHC class I binding prediction tool.
Peptides with the IEDB consensus percentile rank <= 1.0 were selected. Lower
values for either IC50 or percentile rank indicate stronger binding.