UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	FAS1	YKL182W	475	n/a	chrXI 103,748	Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
2	URA2	YJL130C	475	n/a	chrX 169,045	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines both activities are subject to feedback inhibition by UTP
3	STE6	YKL209C	475	n/a	chrXI 44,359	Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells
4	STE12	YHR084W	475	n/a	chrVIII 275,207	Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways cooperates with Tec1p transcription factor to regulate genes specific for invasive growth
5	PUF4	YGL014W	475	n/a	chrVII 467,474	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
6	BUD3	YCL014W	475	n/a	chrIII 98,736	Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
7	NAM7	YMR080C	475	n/a	chrXIII 428,169	ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies involved in telomere maintenance
8	MSB2	YGR014W	475	n/a	chrVII 518,903	Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway also functions as an osmosensor in parallel to the Sho1p-mediated pathway potential Cdc28p substrate
9	YBT1	YLL048C	475	n/a	chrXII 43,772	Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport similar to mammalian bile transporters
10	NUP2	YLR335W	475	n/a	chrXII 798,511	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels also has a role in chromatin organization
11	KAP122	YGL016W	475	n/a	chrVII 463,288	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus binds to nucleoporins Nup1p and Nup2p may play a role in regulation of pleiotropic drug resistance
12	SMY2	YBR172C	475	n/a	chrII 580,261	Protein of unknown function involved in COPII vesicle formation interacts with the Sec23p/Sec24p subcomplex overexpression suppresses the temperature sensitivity of a myo2 mutant has similarity to S. pombe Mpd2
13	PMT1	YDL095W	475	n/a	chrIV 288,285	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein Ser/Thr residues 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity involved in ER quality control
14	GCN1	YGL195W	475	n/a	chrVII 135,534	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p proposed to stimulate Gcn2p activation by an uncharged tRNA
15	SAS3	YBL052C	475	n/a	chrII 120,626	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing homolog of the mammalian MOZ proto-oncogene mutant has aneuploidy tolerance sas3gcn5 double mutation is lethal
16	MCD4	YKL165C	475	n/a	chrXI 139,311	Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis multimembrane-spanning protein that localizes to the endoplasmic reticulum highly conserved among eukaryotes
17	NUP133	YKR082W	475	0	chrXI 594,561	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p required also for transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
18	SHM1	YBR263W	475	n/a	chrII 737,000	Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis reverse reaction generates serine
19	RDH54	YBR073W	475	n/a	chrII 384,550	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis proposed to be involved in crossover interference
20	KAP104	YBR017C	475	n/a	chrII 272,325	Transportin or cytosolic karyopherin beta 2 functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p regulates asymmetric protein synthesis in daughter cells during mitosis
21	YBR074W	YBR074W	475	n/a	chrII 387,751	Putative metalloprotease
22	FKS1	YLR342W	475	n/a	chrXII 812,812	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p binds to regulatory subunit Rho1p involved in cell wall synthesis and maintenance localizes to sites of cell wall remodeling
23	FPR3	YML074C	475	n/a	chrXIII 120,706	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) FK506 binding protein phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
24	POM152	YMR129W	475	n/a	chrXIII 529,810	Nuclear pore membrane glycoprotein may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase
25	SIM1	YIL123W	475	n/a	chrIX 128,866	Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
26	NUP159	YIL115C	475	n/a	chrIX 146,518	Nucleoporin, subunit of the Nup82 subcomplex of the nuclear pore part of the nuclear pore that is found exclusively on the cytoplasmic side required for mRNA export regulates ADP release from the ATP-dependent RNA helicase Dbp5p
27	IRC5	YFR038W	475	n/a	chrVI 230,660	Putative ATPase containing the DEAD/H helicase-related sequence motif null mutant displays increased levels of spontaneous Rad52p foci
28	NET1	YJL076W	475	n/a	chrX 297,029	Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit stimulates transcription by RNA polymerase I and regulates nucleolar structure
29	NUP188	YML103C	475	n/a	chrXIII 65,065	Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
30	YGR054W	YGR054W	475	n/a	chrVII 597,657	Eukaryotic initiation factor (eIF) 2A associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E homologous to mammalian eIF2A
31	YNR021W	YNR021W	475	n/a	chrXIV 668,984	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum YNR021W is not an essential gene
32	BRE5	YNR051C	475	n/a	chrXIV 717,553	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments null is sensitive to brefeldin A
33	ORC3	YLL004W	475	n/a	chrXII 141,998	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
34	BCK1	YJL095W	475	n/a	chrX 249,473	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
35	CLU1	YMR012W	475	n/a	chrXIII 293,050	eIF3 component of unknown function deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
36	PDS5	YMR076C	475	n/a	chrXIII 418,112	Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold also required during meiosis
37	VBA4	YDR119W	475	n/a	chrIV 689,380	Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny GFP-fusion protein localizes to vacuolar membrane physical interaction with Atg27p suggests a possible role in autophagy non-essential gene
38	RKR1	YMR247C	475	n/a	chrXIII 765,695	RING domain E3 ubiquitin ligase involved in the ubiquitin-mediated degradation of non-stop proteins functional connections to chromatin modification nuclear protein that also co-localizes with ribosomes homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice
39	YSP2	YDR326C	475	n/a	chrIV 1,122,767	Protein involved in programmed cell death mutant shows resistance to cell death induced by amiodarone or intracellular acidification
40	DIS3	YOL021C	475	n/a	chrXV 283,923	Exosome core complex catalytic subunit possesses both endonuclease and 3'-5' exonuclease activity involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm has similarity to E. coli RNase R and to human DIS3
41	MDM20	YOL076W	475	n/a	chrXV 188,219	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences involved in mitochondrial inheritance and actin assembly
42	YOR345C	YOR345C	475	n/a	chrXV 981,987	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data overlaps the verified gene REV1 null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
43	YGR115C	YGR115C	475	n/a	chrVII 720,761	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data partially overlaps the verified and essential ORF SPT6/YGR115C
44	APQ13	YJL075C	475	n/a	chrX 298,668	Dubious open reading frame, unlikely to encode a protein not conserved in closely related Saccharomyces species 85% of ORF overlaps the verified gene NET1 null mutant is sensitive to sorbate
45	YCL046W	YCL046W	475	n/a	chrIII 46,801	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data partially overlaps the uncharacterized ORF YCL045C