UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ZK856.6	ZK856.6	9e-101	chrV 10,199,178	contains similarity to Ralstonia solanacearum Composite TWO-component regulatory (Sensor kinase and responsesregulator hybrid) transcription regulator protein.; TR:Q8XWL8
2	srh-229	C04F2.4	n/a	chrV 7,503,586	C. elegans SRH-229 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
3	kqt-3	Y54G9A.3	n/a	chrII 13,704,530	kqt-3 encodes one of three C. elegans KCNQ-like potassium channel subunits and, with respect to humans, is most similar to the KCNQ1 channel protein which when mutated leads to inherited long QT syndrome (OMIM:607542); although loss of KQT-3 activity via large-scale RNAi screens results in no obvious abnormalities, KQT-3 likely functions to regulate cellular excitability as expression of KQT-3 in Xenopus oocytes can produce K+ channel currents that functionally resemble vertebrate M-currents; activity of these KQT-3 channels can be suppressed by coexpression with the human M1 muscarinic receptor and treatment with diacylglycerol analogs, although KQT-3 is less sensitive to each of these treatments than KQT-1; a KQT-3::GFP fusion protein is expressed in the anterior- and posterior-most intestinal cells, the anterior and posterior mechanosensory neurons ALM and PLM, amphid and phasmid neurons, and in some additional head neurons.
4	nhr-136	C13C4.3	n/a	chrV 12,108,116	C. elegans NHR-136 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
5	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
6	C46F2.1	C46F2.1	n/a	chrX 8,078,758
7	F09D1.1	F09D1.1	n/a	chrII 2,570,590	contains similarity to Pfam domains PF00443 (Ubiquitin carboxyl-terminal hydrolase) , PF02148 (Zn-finger in ubiquitin-hydrolases and other protein) contains similarity to Interpro domains IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR001607 (Zinc finger, UBP-type)
8	fbxa-168	C31C9.4	n/a	chrII 13,647,223	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
9	C01C4.2	C01C4.2	n/a	chrX 3,717,428
10	srt-65	C03A7.10	n/a	chrV 5,171,907	C. elegans SRT-65 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
11	T03F7.6	T03F7.6	n/a	chrV 11,295,604	contains similarity to Interpro domain IPR001036 (Acriflavin resistance protein)
12	C49A9.7	C49A9.7	n/a	chrIV 6,203,875	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR001681 (Neurokinin receptor), IPR005395 (Neuropeptide FF receptor), IPR005384 (Duffy antigen/chemokine receptor), IPR000611 (Neuropeptide Y receptor), IPR000276 (GPCR, rhodopsin-like)
13	hda-4	C10E2.3	n/a	chrX 16,737,045	hda-4 encodes a class II histone deacetylase that contains a putative MEF-2 DNA binding domain, a nuclear localization signal domain, and a single catalytic domain and may affect locomotion, body morphology, and growth; interacts with MEF-2 in in vitro assays and is expressed in body-wall muscle, neurons, and hypodermal seam cells
14	R05H10.5	R05H10.5	n/a	chrII 14,868,296	contains similarity to Pfam domain PF00255 Glutathione peroxidase contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR000889 (Glutathione peroxidase)
15	F02H6.7	F02H6.7	n/a	chrIV 14,227,256	contains similarity to Interpro domain IPR000884 (Thrombospondin, type I)
16	ckr-1	T23B3.4	n/a	chrI 6,688,888	T23B3.4 encodes a seven transmembrane receptor that is most closely related to the mammalian cholecystokinin receptors; loss of T23B3.4 activity via RNAi, either singly or in combination with another cholecystokinin receptor-encoding gene, Y39A3B.5, has no effect on fat metabolism, however large-scale RNAi screens have reported that T23B3.4(RNAi) results in embryonic lethality and reduced brood sizes; a T23B3.4::GFP reporter is expressed in a subset of nerve ring neurons.
17	F47G4.8	F47G4.8	n/a	chrI 14,053,124
18	F29A7.5	F29A7.5	n/a	chrII 2,747,560
19	srh-118	K03D7.6	n/a	chrV 17,495,205	C. elegans SRH-118 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
20	F59B2.13	F59B2.13	n/a	chrIII 9,025,413	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
21	T20D4.6	T20D4.6	n/a	chrV 3,411,676	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
22	sri-7	T06E6.4	n/a	chrV 15,401,049	C. elegans SRI-7 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
23	fbxa-10	T12B5.3	n/a	chrIII 953,160	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
24	C30G4.5	C30G4.5	n/a	chrX 17,071,948
25	K04A8.2	K04A8.2	n/a	chrV 6,563,097	contains similarity to Pfam domain PF03269 Caenorhabditis protein of unknown function, DUF268 contains similarity to Interpro domain IPR004951 (Protein of unknown function DUF268, Caenorhabditis species)
26	srw-65	Y38H6C.2	n/a	chrV 20,497,408	C. elegans SRW-65 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
27	C30E1.4	C30E1.4	n/a	chrX 16,924,785	contains similarity to Homo sapiens SID1 transmembrane family member 1 precursor; ENSEMBL:ENSP00000264852
28	F25G6.1	F25G6.1	n/a	chrV 8,577,457
29	fip-4	F41E6.10	n/a	chrV 8,611,069	C. elegans FIP-4 protein
30	F56H6.2	F56H6.2	n/a	chrI 12,288,243	contains similarity to Pfam domain PF03269 Caenorhabditis protein of unknown function, DUF268 contains similarity to Interpro domain IPR004951 (Protein of unknown function DUF268, Caenorhabditis species)
31	T05G5.5	T05G5.5	n/a	chrIII 9,750,414	contains similarity to Pfam domain PF01121 Dephospho-CoA kinase contains similarity to Interpro domains IPR000764 (Uridine kinase), IPR001977 (Dephospho-CoA kinase)
32	F38A1.13	F38A1.13	n/a	chrIV 1,265,538
33	F19C6.5	F19C6.5	n/a	chrX 9,983,681	contains similarity to Homo sapiens Isoform 2 of Zinc transporter 8; HI:HIT000389038
34	ceh-24	F55B12.1	n/a	chrV 13,814,273	ceh-24 is orthologous to the human gene SIMILAR TO THYROID TRANSCRIPTION FACTOR 1 (TITF1; OMIM:600635), which when mutated leads to disease.
35	Y59C2A.1	Y59C2A.1	n/a	chrII 2,210,488	contains similarity to Pfam domain PF00246 Zinc carboxypeptidase contains similarity to Interpro domains IPR000834 (Peptidase M14, carboxypeptidase A), IPR009020 (Proteinase inhibitor, propeptide), IPR000276 (GPCR, rhodopsin-like)
36	ces-1	F43G9.11	n/a	chrI 8,634,989	ces-1 encodes a C2H2-type zinc finger transcription factor that is a member of the Snail family of proteins that includes Drosophila Scratch, Snail, and Slug, and human SNAIL and SLUG; although the normal function of CES-1 is not fully understood, gain-of-function mutations indicate that CES-1 can function as a transcriptional repressor that blocks programmed cell death in specific neurons by inhibiting expression of the cell-death activator EGL-1; in regulating EGL-1 expression, CES-1 appears to antagonize the transcriptional activity of the bHLH proteins, HLH-2 and HLH-3; despite its cell-type specific role in apoptosis, CES-1 expression is reportedly detected in many embryonic nuclei from the 100-cell stage of embryogenesis through the beginning of morphogenesis, with some CES-1 expression remaining at later embryonic stages; genetic studies indicate that CES-1 is negatively regulated by the bZIP transcription factor CES-2, which can bind CES-1 upstream sequences in vitro and thus may directly regulate CES-1 transcription in vivo
37	F42G8.5	F42G8.5	n/a	chrIV 8,137,753
38	srj-40	F38H12.2	n/a	chrV 4,102,865	C. elegans SRJ-40 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
39	W04G3.7	W04G3.7	n/a	chrX 11,084,822	contains similarity to Interpro domain IPR001211 (Phospholipase A2)
40	Y43F8B.13	Y43F8B.13	n/a	chrV 19,459,852	contains similarity to Puumala virus Nucleocapsid protein (Fragment).; TR:Q8B3A4
41	D1053.3	D1053.3	n/a	chrX 11,731,700	contains similarity to Interpro domain IPR001208 (MCM)
42	srbc-58	R09E12.2	n/a	chrV 776,135	C. elegans SRBC-58 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
43	egl-36	R07A4.1	n/a	chrX 10,739,267	egl-36 encodes a Shaw-type voltage-gated potassium channel that regulates egg laying and defecation; expression of egl-36::gfp reporters is observed in several different cell types including muscle cells such as the uterine and vulval egg-laying muscles, sensory, motor and interneurons, and the distal tip cells of the gonad; when expressed in a heterologous system, EGL-36 exhibits channel activity.
44	str-198	ZK285.1	n/a	chrV 16,048,450	C. elegans STR-198 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
45	srh-82	W03F9.6	n/a	chrV 146,062	C. elegans SRH-82 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
46	brc-2	T07E3.5	n/a	chrIII 6,901,783	brc-2 encodes a BRC domain-containing protein that is homologous to human BRCA2 which when mutated leads to early-onset breast cancer 2 or hereditary male breast cancer (OMIM:600185); in C. elegans, BRC-2 activity is essential for RAD-51-mediated repair of meiotic and radiation-induced double-strand breaks (DSBs); BRC-2 physically interacts with RAD-51 and single-stranded DNA and is required for proper localization of RAD-51 to sites of DNA damage and stabilization of RAD-51-DNA filaments; BRC-2 can also promote RAD-51-independent DSB repair via single-strand annealing (SSA) when the homologous recombination (HR) and nonhomologous end joining pathways (NHEJ) are compromised; in nonirradiated animals, BRC-2 is seen at diffuse, low levels in germline nuclei, but upon radiation treatment BRC-2 localizes to discrete foci that coincide with presumptive sites of DNA damage.
47	srt-37	F47D2.8	n/a	chrV 4,280,809	C. elegans SRT-37 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR002651 (Protein of unknown function DUF32), IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
48	nspb-2	F38A5.12	n/a	chrIV 6,591,852	C. elegans NSPB-2 protein; contains similarity to Pfam domain PF07312 Protein of unknown function (DUF1459) contains similarity to Interpro domain IPR009924 (Protein of unknown function DUF1459)
49	ZC482.7	ZC482.7	n/a	chrIII 12,752,251	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
50	dgk-5	K06A1.6	n/a	chrII 6,462,041	dgk-5 encodes a putative diacylglycerol kinase, orthologous to Drosophila RDGA, and to human DGKI (OMIM:604072) and DGKZ (OMIM:601441); DGK-5 has no obvious function in mass RNAi assays.