UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	cul-5	ZK856.1	0	chrV 10,181,305	cul-5 encodes a cullin, orthologous to vasopressin-activated calcium-mobilizing receptor-1 in mammals, that is thought to regulate the cell cycle by virtue of its paralogy to cul-1 and cul-2; however, CUL-5 is dispensable for viability and gross morphology in mass RNAi screens, and does not appear to interact with any of 17 Skp1-related proteins (SKR-1 through SKR-21).
2	F22F7.2	F22F7.2	n/a	chrV 2,125,082	contains similarity to Pfam domain PF03435 Saccharopine dehydrogenase contains similarity to Interpro domains IPR005097 (Saccharopine dehydrogenase), IPR016040 (NAD(P)-binding)
3	math-21	C40D2.3	n/a	chrII 1,994,852	C. elegans MATH-21 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
4	F53B1.2	F53B1.2	n/a	chrX 2,110,346	contains similarity to Pfam domains PF07647 (SAM domain (Sterile alpha motif)) , PF00536 (SAM domain (Sterile alpha motif)) contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR000326 (Phosphatidic acid phosphatase type 2/haloperoxidase), IPR013761 (Sterile alpha motif-type), IPR001660 (Sterile alpha motif SAM), IPR011510 (Sterile alpha motif homology 2)
5	C36B1.9	C36B1.9	n/a	chrI 8,745,380	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR003604 (Zinc finger, U1-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000568 (ATPase, F0 complex, subunit A)
6	cacn-1	W03H9.4	n/a	chrII 14,137,700	cacn-1 encodes an ortholog of Drosophila CACTIN and human C19orf29 that is required for normal distal tip cell migration, embryonic viability, fertility, locomotion, vulval morphogenesis, and normally rapid growth; like CACTIN, CACN-1 contains predicted coiled-coil domains, but otherwise lacks recognizable similarity to known proteins.
7	K09B11.3	K09B11.3	n/a	chrIV 13,430,380	contains similarity to Homo sapiens DJ614O4.3; ENSEMBL:ENSP00000305301
8	Y52B11A.10	Y52B11A.10	n/a	chrI 11,045,757	contains similarity to Pfam domains PF02854 (MIF4G domain) , PF02847 (MA3 domain) contains similarity to Interpro domains IPR003890 (MIF4G-like, type 3), IPR016021 (MIF4-like, type 1/2/3), IPR003891 (Initiation factor eIF-4 gamma, MA3), IPR016024 (Armadillo-type fold)
9	T15D6.4	T15D6.4	n/a	chrI 12,375,417	contains similarity to Aedes aegypti N-acetyllactosaminide beta-1,3-n-acetylglucosaminyltransferase.; TR:Q175J5
10	Y45G12C.6	Y45G12C.6	n/a	chrV 2,541,544	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
11	nfyc-1	F23F1.1	n/a	chrII 44,432	C. elegans NFYC-1 protein; contains similarity to Pfam domains PF00808 (Histone-like transcription factor (CBF/NF-Y) and archaeal histone) , PF00125 (Core histone H2A/H2B/H3/H4) contains similarity to Interpro domains IPR009072 (Histone-fold), IPR007125 (Histone core), IPR003958 (Transcription factor CBF/NF-Y/archaeal histone)
12	tgt-1	ZK829.6	n/a	chrIV 11,958,629	tgt-1 encodes a tRNA-guanine transglycosylase predicted to be mitochondrial.
13	F34H10.2	F34H10.2	n/a	chrX 9,630,584	contains similarity to Anabaena sp Hypothetical protein Alr0331.; TR:Q8YZX4
14	ddl-2	Y48E1B.1	n/a	chrII 13,545,140	C. elegans DDL-2 protein; contains similarity to Interpro domains IPR006077 (Vinculin/alpha-catenin), IPR000381 (Inhibin, beta B subunit), IPR000694 (Proline-rich region), IPR003882 (Pistil-specific extensin-like protein)
15	ZK596.3	ZK596.3	n/a	chrIV 10,903,190	contains similarity to Mus musculus DNA-dependent protein kinase catalytic subunit (EC 2.7.1.37) (DNA-sPKcs) (P460).; SW:PRKD_MOUSE
16	F56E10.1	F56E10.1	n/a	chrV 105,397	contains similarity to Neurospora crassa Protein bfr-2.; SW:Q7S6P8
17	Y44E3A.4	Y44E3A.4	n/a	chrI 3,325,798	contains similarity to Pfam domains PF07653 (Variant SH3 domain) (2), PF00018 (SH3 domain) (2)contains similarity to Interpro domains IPR000104 (Antifreeze protein, type I), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR000694 (Proline-rich region), IPR011511 (Variant SH3), IPR003071 (Orphan nuclear receptor, HMR type)
18	F40G9.1	F40G9.1	n/a	chrIII 196,177	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
19	W08D2.5	W08D2.5	n/a	chrIV 9,821,001	contains similarity to Pfam domains PF00122 (E1-E2 ATPase) , PF00702 (haloacid dehalogenase-like hydrolase) contains similarity to Interpro domains IPR008250 (E1-E2 ATPase-associated region), IPR006544 (P-type ATPase of unknown pump specificity (type V)), IPR001757 (ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter), IPR000150 (Cof protein), IPR005834 (Haloacid dehalogenase-like hydrolase)
20	F15D4.6	F15D4.6	n/a	chrII 13,249,439	contains similarity to Bacillus halodurans Acetolactate synthase large subunit.; TR:Q9K8E5
21	F28C1.1	F28C1.1	n/a	chrV 12,452,041	contains similarity to Drosophila melanogaster Flybase gene name is CG6695-PA;; FLYBASE:CG6695
22	F44E2.3	F44E2.3	n/a	chrIII 8,828,256	contains similarity to Interpro domain IPR000694 (Proline-rich region)
23	tra-3	LLC1.1	n/a	chrIV 14,440,241	tra-3 encodes an atypical calpain regulatory protease that lacks calcium-binding EF hand domains; during development, TRA-3 likely promotes female development in XX hermaphrodites by cleaving the membrane-associated TRA-2A protein to generate a TRA-2 peptide likely to have feminizing activity; in addition, TRA-3 is one of several proteases that mediate necrotic cell death during neurodegeneration.
24	glr-8	F22A3.3	n/a	chrX 6,508,340	glr-8 encodes a highly divergent putative ionotropic glutamate receptor subunit, unclassifiable as NMDA or non-NMDA (though possibly of the Delta subfamily), and without any clear close homologs in metazoa or plants; glr-8 is expressed in the pharyngeal nervous system, the body wall mechanoreceptors ALM and PLM, and two other neurons (BDU and URB); glr-8 is expressed from embryogenesis to adulthood.
25	T07F10.5	T07F10.5	n/a	chrV 12,866,209	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domains IPR002168 (Lipase, GDXG, active site), IPR002018 (Carboxylesterase, type B)
26	atp-4	T05H4.12	n/a	chrV 6,426,736	C. elegans ATP-4 protein; contains similarity to Pfam domain PF05511 Mitochondrial ATP synthase coupling factor 6 contains similarity to Interpro domain IPR008387 (ATPase, F0 complex, subunit F6, mitochondrial)
27	figl-1	F32D1.1	n/a	chrV 4,343,730	F32D1.1 encodes an homolog of human SPASTIN (OMIM:604277, mutated in spastic paraplegia), FIDGETIN (OMIM:605295, mutated in fidget mice), and FIDGETIN-LIKE-1, and of Drosophila SPASTIN; recombinant F32D1.1 protein has N-ethylmaleimide-sensitive ATPase activity in vitro, which is strongly dependent on the C368 residue immediately C-terminal to its Walker A motif; F32D1.1 is required for persistence of the germline in RNAi assays.
28	C34F6.5	C34F6.5	n/a	chrX 11,208,547	contains similarity to Homo sapiens Histone acetyltransferase MORF beta; ENSEMBL:ENSP00000287239
29	Y26D4A.3	Y26D4A.3	n/a	chrI 13,072,492	contains similarity to Pfam domain PF00059 (Lectin C-type domain short and long forms)
30	tag-324	C27C12.5	n/a	chrX 14,850,888	C. elegans TAG-324 protein; contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
31	nhr-264	F14A5.1	n/a	chrIV 9,293,087	C. elegans NHR-264 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
32	sdz-15	F23F12.4	n/a	chrIII 6,499,273	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
33	R105.1	R105.1	n/a	chrIV 4,635,811	contains similarity to Pfam domain PF03762 Vitelline membrane outer layer protein I (VOMI) contains similarity to Interpro domain IPR005515 (Vitelline membrane outer layer protein I (VOMI))
34	Y43F4B.7	Y43F4B.7	n/a	chrIII 13,310,326	contains similarity to Pfam domain PF01490 Transmembrane amino acid transporter protein contains similarity to Interpro domains IPR013057 (Amino acid transporter, transmembrane), IPR003568 (Cytochrome c-type biogenesis protein CcmF)
35	F09G8.5	F09G8.5	n/a	chrIII 8,256,200	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR003603 (U2A'/phosphoprotein 32 family A, C-terminal), IPR010916 (TonB box, conserved site)
36	Y48E1C.2	Y48E1C.2	n/a	chrII 13,426,646	contains similarity to Pfam domain PF07942 N2227-like protein contains similarity to Interpro domain IPR012901 (N2227-like)
37	K09C4.5	K09C4.5	n/a	chrX 3,284,155	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
38	T25G12.1	T25G12.1	n/a	chrX 17,249,457
39	B0334.6	B0334.6	n/a	chrII 11,512,193	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
40	F53G12.3	F53G12.3	n/a	chrI 141,205	F53G12.3 encodes a large partial homolog of dual oxidase ('Ce-Duox2'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; F53G12.3 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; F53G12.3 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; F53G12.3 has no visible expression pattern detectable by antibodies, implying very low or rare expression.
41	C30E1.4	C30E1.4	n/a	chrX 16,924,785	contains similarity to Homo sapiens SID1 transmembrane family member 1 precursor; ENSEMBL:ENSP00000264852
42	cah-5	R173.1	n/a	chrX 7,021,932	cah-5 encodes a member of the carbonic anhydrase family.
43	drh-3	D2005.5	n/a	chrI 7,823,605	drh-3 encodes a DExH-box helicase.
44	str-78	Y40H7A.1	n/a	chrIV 15,145,449	C. elegans STR-78 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
45	end-1	F58E10.2	n/a	chrV 13,986,046	end-1 encodes a GATA-like transcription factor sufficient to initiate endoderm differentiation and binds to the canonical target DNA sequence WGATAR with specificity similar to GATA-1 and D4 transcription factors; its expression bypasses requirement for maternal SKN-1 and the maternal Wnt signaling pathway in endoderm formation and it activates endoderm differentiation in isolated Xenopus ectoderm.
46	lips-1	F45E6.4	n/a	chrX 12,494,285	C. elegans LIPS-1 protein; contains similarity to Pfam domain PF01674 Lipase (class 2) contains similarity to Interpro domain IPR002918 (Lipase, class 2)
47	R09A8.1	R09A8.1	n/a	chrX 12,615,226	contains similarity to Homo sapiens FLASH; ENSEMBL:ENSP00000237177
48	Y54E5A.6	Y54E5A.6	n/a	chrI 14,709,596	contains similarity to Pfam domains PF01207 (Dihydrouridine synthase (Dus)) , PF00035 (Double-stranded RNA binding motif) contains similarity to Interpro domains IPR013785 (Aldolase-type TIM barrel), IPR001159 (Double-stranded RNA binding), IPR014720 (Double-stranded RNA-binding-like), IPR000632 (Yeast Mrs6p protein), IPR001269 (Dihydrouridine synthase, DuS)
49	sra-31	C56C10.5	n/a	chrII 6,577,792	C. elegans SRA-31 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domain IPR000344 (Nematode chemoreceptor, Sra)
50	EEED8.6	EEED8.6	n/a	chrII 5,385,733	EEED8.6 encodes an ATP/ADP-activated metallocarboxypeptidase, orthologous to mammalian AGBL4 proteins, that may function in vivo as an alpha-tubulin C-terminal tyrosine carboxypeptidase; recombinant EEED8.6 is active in vitro on several different C-terminal amino acids of synthetic peptide substrates (with carboxypeptidase A- and B-like, but not O-like specificity); unlike most carboxypeptidases, but like tubulin carboxypeptidase, EEED8.6 is inhibited by high salt or by Z-Glu-Tyr dipeptide; EEED8.6 and its mammalian AGBL4 orthologs, along with other proteins such as mammalian AGBL5, comprise a M14D2 peptidase subfamily; by homolog-based structural modelling, EEED8.6 is predicted to have an unusually open active site.