UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ZK836.2	ZK836.2	0	chrV 12,199,854	contains similarity to Pfam domains PF02779 (Transketolase, pyrimidine binding domain) , PF00676 (Dehydrogenase E1 component) contains similarity to Interpro domains IPR011603 (2-oxoglutarate dehydrogenase, E1 component), IPR005475 (Transketolase, central region), IPR001017 (Dehydrogenase, E1 component)
2	C35D10.6	C35D10.6	n/a	chrIII 4,859,975	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
3	klc-1	M7.2	n/a	chrIV 11,085,048	klc-1 encodes one of two C. elegans kinesin light chains; by homology, KLC-1 is predicted to function, along with kinesin-like heavy chains, as part of a multimeric kinesin complex involved in intracellular transport; consistent with this, KLC-1 has been shown to interact with UNC-116/kinesin, KCA-1/kinesin cargo adaptor, and the ARX-2/Arp2/3 complex component in yeast two-hybrid assays; RNAi experiments indicate that klc-1 activity is required for normal embryonic development.
4	B0001.2	B0001.2	n/a	chrIV 12,148,704	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
5	bath-5	F59H6.11	n/a	chrII 2,031,389	C. elegans BATH-5 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
6	ZK418.8	ZK418.8	n/a	chrIII 7,084,302	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR009019 (K Homology, prokaryotic type), IPR004087 (K Homology), IPR004088 (K Homology, type 1)
7	lsl-1	F52F12.4	n/a	chrI 9,902,069	C. elegans LSL-1 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
8	C05C8.5	C05C8.5	n/a	chrV 7,233,733	contains similarity to Pfam domain PF00929 Exonuclease contains similarity to Interpro domains IPR013520 (Exonuclease, RNase T and DNA polymerase III), IPR006055 (Exonuclease), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
9	bath-4	F52C6.8	n/a	chrII 1,917,377	C. elegans BATH-4 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
10	bath-2	F52C6.11	n/a	chrII 1,922,182	C. elegans BATH-2 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
11	F49E8.2	F49E8.2	n/a	chrIV 7,549,959	contains similarity to Interpro domains IPR011767 (Glutaredoxin active site), IPR007087 (Zinc finger, C2H2-type)
12	msh-2	H26D21.2	n/a	chrI 3,695,931	The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).
13	zim-2	T07G12.10	n/a	chrIV 10,556,907	zim-2 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-1, ZIM-3, and C02F5.12; ZIM-2 is specifically required for homolog pairing, synapsis, and segregation of chromosome V during meiosis; zim-2(tm574) oocytes ending prophase have ~5 bivalents and ~2 univalents, the latter of which are consistently chromosome V; zim-2 oocytes fail to begin chromosome V pairing at the start of meiosis; ZIM-2 associates with the right end of chromosome V, which may indicate an association with its pairing center; while the C-terminal region of ZIM-2 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-2 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-2 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
14	rnh-1.3	C04F12.9	n/a	chrI 9,710,453	C. elegans RNH-1.3 protein; contains similarity to Pfam domain PF00075 RNase H contains similarity to Interpro domains IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
15	ugt-58	F35H8.6	n/a	chrII 9,585,502	C. elegans UGT-58 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
16	C16C8.14	C16C8.14	n/a	chrII 3,450,118	C16C8.14 encodes a Caenorhabditis-specific protein, with a central predicted coiled-coil and a C-terminal ubiqutin-like domain; C16C8.14 inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51; C16C8.14 is paralogous to C16C8.4, C16C8.11, C16C8.12, C16C8.13, C16C8.15, C16C8.16, and F54D10.7.
17	C55B7.11	C55B7.11	n/a	chrI 6,512,726
18	klp-18	C06G3.2	n/a	chrIV 7,041,936	klp-18 encodes a kinesin motor protein whose motor domain is most similar to that of the Xenopus and human klp2 proteins; loss of klp-18 activity via RNAi indicates that KLP-18 is required for the assembly of a disordered array of acentrosomal (female meiotic) microtubules into an organized, functional, bipolar spindle; in addition, KLP-18 may also play a role in cortex dynamics during post-meiotic development; antibody staining indicates that during meiosis and mitosis (early embryonic) KLP-18 localizes to: 1) spindles, and especially spindle poles, during prometaphase, metaphase, and early anaphase, and 2) the interzone during late anaphase and telophase; in early embryos, KLP-18 is also seen around the nucleus and cell cortex at sites of cell-cell contact; KLP-18 expression in later embryos and larvae is confined to the germ line which, in adults, stains brightly in both distal and proximal regions.
19	R52.2	R52.2	n/a	chrII 2,127,157	contains similarity to Pfam domains PF03564 (Protein of unknown function (DUF1759)) , PF05585 (Protein of unknown function (DUF1758)) contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR008737 (Protein of unknown function DUF1758), IPR005312 (Protein of unknown function DUF1759), IPR001878 (Zinc finger, CCHC-type)
20	T09A5.9	T09A5.9	n/a	chrII 7,858,979	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype), IPR003603 (U2A'/phosphoprotein 32 family A, C-terminal)
21	R05D3.1	R05D3.1	n/a	chrIII 8,384,526	contains similarity to Pfam domains PF00521 (DNA gyrase/topoisomerase IV, subunit A) , PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) , PF00204 (DNA gyrase B) contains similarity to Interpro domains IPR002205 (DNA topoisomerase, type IIA, subunit A or C-terminal), IPR013506 (DNA topoisomerase, type IIA, subunit B, region 2), IPR001241 (DNA topoisomerase, type IIA, subunit B or N-terminal), IPR011558 (DNA topoisomerase, type IIA, subunit B, conserved region), IPR013758 (DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta), IPR013757 (DNA topoisomerase, type IIA, subunit A, alpha-helical), IPR003594 (ATP-binding region, ATPase-like), IPR013759 (DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta), IPR001154 (DNA topoisomerase II, eukaryotic-type), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR013760 (DNA topoisomerase, type IIA, central)
22	ptr-2	C32E8.8	n/a	chrI 3,791,060	ptr-2 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-2 is required for cytokinesis in somatic cells, but not in the germline (the converse of PTC-1's function); PTR-2 is partially required for normal molting from L4 to adult stages; PTR-2 is also required for normal male tail development, growth to full size, locomotion, and viability.
23	pgl-2	B0523.3	n/a	chrIII 8,672,707	pgl-2 encodes a novel protein of 532 amino acids that, in C. elegans, is one of three PGL protein family members; PGL-2 associates with P granules during postembryonic development; PGL-2 interacts with PGL-1, an additional P granule component, in yeast two-hybrid assays, but neither protein is required for proper localization of the other.
24	puf-12	ZK945.3	n/a	chrII 10,101,606	C. elegans PUF-12 protein; contains similarity to Pfam domain PF08144 CPL (NUC119) domain contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR001313 (Pumilio RNA-binding region), IPR012959 (CPL), IPR016024 (Armadillo-type fold)
25	fbxa-114	Y113G7B.7	n/a	chrV 20,197,592	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
26	zim-3	T07G12.11	n/a	chrIV 10,559,796	zmp-3 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-1/-2, and C02F5.12; ZIM-3 is specifically required for homolog pairing, synapsis, and segregation of chromosomes I and IV during meiosis; zim-3(tm2303) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes I and IV; ZIM-3 associates with the right end of chromosome I and the left end of chromosome IV, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-3 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-3 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-3 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
27	F55G1.6	F55G1.6	n/a	chrIV 7,474,219	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR011016 (Zinc finger, variant RING-type)
28	his-15	ZK131.9	n/a	chrII 13,818,464	his-15 encodes an H2B histone.
29	F57B10.4	F57B10.4	n/a	chrI 6,567,540	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2E8Z5
30	ZK1248.15	ZK1248.15	n/a	chrII 5,837,633	contains similarity to Pfam domain PF00397 WW domain contains similarity to Interpro domains IPR006596 (Nucleotide binding protein, PINc), IPR001202 (WW/Rsp5/WWP)
31	glh-2	C55B7.1	n/a	chrI 6,515,665	glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males.
32	set-14	R06F6.4	n/a	chrII 10,794,856	set-14 encodes a divergent ortholog of human SMYD1 (OMIM:606846), SMYD2 (OMIM:610663), and SYMD3 (OMIM:608783); SET-14 is paralogous to SET-10, SET-18, and SET-30; SET-14 has no obvious function in individual RNAi assays of vulval development, or in mass RNAi assays.
33	F21F3.4	F21F3.4	n/a	chrI 4,896,773	contains similarity to Homo sapiens Uncharacterized protein ENSP00000372122; ENSEMBL:ENSP00000372122
34	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
35	F07H5.10	F07H5.10	n/a	chrII 8,807,812	contains similarity to Arabidopsis thaliana Myosin heavy chain-like protein.; TR:Q9FJ35
36	F25G6.9	F25G6.9	n/a	chrV 8,567,613	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
37	fbxa-108	F59A1.7	n/a	chrV 17,657,524	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
38	bath-1	F59H6.9	n/a	chrII 2,028,219	C. elegans BATH-1 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
39	T24A6.1	T24A6.1	n/a	chrV 3,559,431
40	cul-4	F45E12.3	n/a	chrII 7,303,864	cul-4 encodes one of six C. elegans cullin proteins; CUL-4 activity is essential for negative regulation of DNA-replication licensing and thus, for maintenance of genome stability; in regulating DNA replication, CUL-4 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that degrades the replication licensing factor CDT-1 and indirectly promotes nuclear export of the replication licensing factor CDC-6 by negatively regulating the levels of the CKI-1 CDK inhibitor; cul-4 mRNA is expressed throughout development with highest levels seen in embryos and lower levels seen in larvae and adults; maternal cul-4 mRNA is present in early embryos and larval and adult mRNA is most notably present in the intestine and germ line.
41	3R5.1	3R5.1	n/a	chrIII 13,780,560	contains similarity to Mus musculus Paired amphipathic helix protein Sin3a.; SW:SN3A_MOUSE
42	C25D7.8	C25D7.8	n/a	chrV 15,066,857	contains similarity to Interpro domains IPR003323 (Ovarian tumour, otubain), IPR016615 (Ubiquitin thioesterase Otubain)
43	M01E11.2	M01E11.2	n/a	chrI 5,580,733	contains similarity to Pfam domain PF08216 Eukaryotic domain of unknown function (DUF1716) contains similarity to Interpro domains IPR013180 (Protein of unknown function DUF1716, eukaryotic), IPR011989 (Armadillo-like helical), IPR000225 (Armadillo), IPR016024 (Armadillo-type fold)
44	R11A8.1	R11A8.1	n/a	chrIV 10,356,114	contains similarity to Homo sapiens Hypothetical protein; ENSEMBL:ENSP00000299601
45	K08C7.6	K08C7.6	n/a	chrIV 10,685,135	contains similarity to Arabidopsis thaliana Tetratricoredoxin.; TR:Q8VWG7
46	ulp-5	K02F2.4	n/a	chrI 6,813,375	C. elegans ULP-5 protein; contains similarity to Pfam domain PF02902 Ulp1 protease family, C-terminal catalytic domain contains similarity to Interpro domain IPR003653 (Peptidase C48, SUMO/Sentrin/Ubl1)
47	K02C4.3	K02C4.3	n/a	chrII 8,083,916	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domain IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
48	K06B9.2	K06B9.2	n/a	chrIV 4,192,443	K06B9.2 encodes a putative UDP-N-acetylglucosamine pyrophosphorylase, paralogous to C36A4.4 and orthologous to human UAP1 (OMIM:602862) and UAP1L1; K06B9.2 is thought to catalyse the fourth step of the hexosamine pathway to UDP-N-acetylglucosamine or UDP-N-acetylgalactosamine; K06B9.2 transcripts are enriched during oogenesis; K06B9.2(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, presumably because of defects in chitin and eggshell synthesis.
49	T10B11.8	T10B11.8	n/a	chrI 6,953,068
50	ZK792.5	ZK792.5	n/a	chrIV 11,686,516	contains similarity to Pfam domain PF00806 Pumilio-family RNA binding repeat contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR002952 (Eggshell protein), IPR001313 (Pumilio RNA-binding region), IPR016024 (Armadillo-type fold)