UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	inx-12	ZK770.3	0	chrI 3,757,299	inx-12 (innexin=invertebrate connexin analogue) encodes a protein of the innexin family; innexins are gap junction proteins similar in function, though dissimilar in sequence to the vertebrate connexins; innexins are the only known gap junction proteins in invertebrates; inx-12 and inx-13 appear to be a tandom duplication; RNA interference of inx-12 results in an arrest at the L1 larval stage with fluid filled dead rods; this phenotype and sequence homology to Drosophila innexins suggest that INX-12 may be required to form gap junctions between the excretory canal and hypodermis, thus playing an essential role in osmoregulation; an INX-12::GFP fusion protein is expressed in the excretory canal.
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	T05H10.3	T05H10.3	n/a	chrII 8,049,736
4	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
5	mec-5	E03G2.3	n/a	chrX 15,946,401	mec-5 encodes a collagen unique in the number of Gly-X-Y repeats and in the composition of amino acids surrounding these repeats; MEC-5 is required for normal mechanosensory response to gentle touch and for the proper functioning of the touch receptor neurons; mec-5 interacts genetically with mec-4 and mec-10 which encode degenerins (ion channels) expressed in the touch neurons, mec-9, which encodes a protein containing EGF-like and Kunitz/protease inhibitor domains secreted by the touch neurons, and mec-12, which encodes an alpha-tubulin expressed in the touch neurons; these genetic interactions suggest that MEC-5 may play a role in anchoring the degenerin complex to the extracellular matrix; MEC-5 is produced and secreted by hypodermal cells.
6	his-16	ZK131.10	n/a	chrII 13,817,860	his-16 encodes an H2A histone; his-16 is contained within the histone gene cluster HIS3.
7	R07B1.5	R07B1.5	n/a	chrX 9,865,660	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
8	C52E4.5	C52E4.5	n/a	chrV 11,984,169	contains similarity to Pfam domain PF01532 Glycosyl hydrolase family 47 contains similarity to Interpro domain IPR001382 (Glycoside hydrolase, family 47)
9	Y38H6C.20	Y38H6C.20	n/a	chrV 20,544,616	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR005427 (Salmonella/Shigella invasin protein C)
10	F16G10.7	F16G10.7	n/a	chrII 2,379,927	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domain IPR003326 (Protein of unknown function DUF130)
11	T13F2.4	T13F2.4	n/a	chrIV 9,790,151	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8IIE7
12	ugt-38	F10D2.7	n/a	chrV 7,146,544	C. elegans UGT-38 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR003567 (Cytochrome c-type biogenesis protein), IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
13	abts-1	F52B5.1	n/a	chrI 8,302,240	abts-1 encodes an anion transporter; when expressed in Xenopus oocytes, ABTS-1 exhibits robust chloride transport, as well as chloride/bicarbonate exchange activity; abts-1 promoter gfp fusions are expressed primarily in neurons and hypodermis, with weak fluorescence also seen in the pharynx and body wall muscle cells.
14	F38H4.3	F38H4.3	n/a	chrIV 11,845,293	contains similarity to Interpro domain IPR000694 (Proline-rich region)
15	ceh-26	K12H4.1	n/a	chrIII 8,069,282	ceh-26 encodes a protein that contains a prospero-related homeodomain; expressed in nuclei of the adult head, tail neurons, and one cell in the postdeirids.
16	F13A2.4	F13A2.4	n/a	chrV 4,399,097
17	ZC190.5	ZC190.5	n/a	chrV 8,672,433
18	F36F2.1	F36F2.1	n/a	chrI 9,019,505	contains similarity to Homo sapiens Actin-binding Rho-activating protein; ENSEMBL:ENSP00000311436
19	F53B3.3	F53B3.3	n/a	chrX 2,868,560
20	C52B9.4	C52B9.4	n/a	chrX 4,262,578	contains similarity to Pfam domain PF06814 Lung seven transmembrane receptor contains similarity to Interpro domains IPR009637 (Transmembrane receptor, eukaryota), IPR008983 (Tumour necrosis factor-like)
21	sgn-1	F07H5.2	n/a	chrII 8,782,783	C. elegans SGN-1 protein; contains similarity to Pfam domain PF04790 Sarcoglycan complex subunit protein contains similarity to Interpro domain IPR006875 (Sarcoglycan complex subunit protein)
22	B0238.13	B0238.13	n/a	chrV 5,245,859	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
23	F25D1.3	F25D1.3	n/a	chrV 10,529,632	contains similarity to Pfam domain PF06083 Interleukin-17 contains similarity to Interpro domain IPR010345 (Interleukin-17)
24	mec-18	C52B9.9	n/a	chrX 4,272,688	mec-18 encodes a protein similar to firefly luciferase and plant protein 4-coumarate coA ligase; mec-18 is involved in sensory mechanotransduction; genetic interactions with other mec genes suggest that mec-18 may be involved in negative regulation of the degenerin channel in the touch receptor neurons; mec-18 is expressed exclusively in the touch cells.
25	tag-241	C34E11.3	n/a	chrX 11,831,339	C. elegans TAG-241 protein; contains similarity to Interpro domains IPR010978 (tRNA-binding arm), IPR009061 (Putative DNA binding), IPR004827 (Basic-leucine zipper (bZIP) transcription factor)
26	AC8.4	AC8.4	n/a	chrX 227,022
27	C07B5.2	C07B5.2	n/a	chrX 9,516,733	contains similarity to Listeria monocytogenes Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferases(EC 2.1.1.61).; SW:TRMU_LISMO
28	trpa-1	C29E6.2	n/a	chrIV 11,870,347	trpa-1 encodes a transient receptor potential (TRP) ion channel orthologous to the vertebrate and Drosophila TRPA1 channels; in C. elegans, trpa-1 activity is required for specific mechanosensory behaviors such as nose-touch avoidance and touch-mediated foraging; when expressed in mammalian cells, TRPA-1 exhibits channel activity in response to mechanical stimulation; TRPA-1::GFP reporters are expressed in a number of different cell types including sensory neurons, muscle, and epithelial cells.
29	F08D12.1	F08D12.1	n/a	chrII 2,790,710	contains similarity to Pfam domains PF08492 (SRP72 RNA-binding domain) , PF00515 (Tetratricopeptide repeat) (2), PF07720 (Tetratricopeptide repeat) contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR001440 (Tetratricopeptide TPR-1), IPR013699 (Signal recognition particle, SRP72 subunit, RNA-binding), IPR013026 (Tetratricopeptide region)
30	daf-14	F01G10.8	n/a	chrIV 10,254,701	daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development.
31	H22K11.2	H22K11.2	n/a	chrX 6,785,820	contains similarity to Pfam domain PF01301 Glycosyl hydrolases family 35 contains similarity to Interpro domains IPR000583 (Glutamine amidotransferase, class-II), IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR001944 (Glycoside hydrolase, family 35)
32	K07G5.4	K07G5.4	n/a	chrI 7,167,846	contains similarity to Interpro domain IPR002048 (Calcium-binding EF-hand)
33	ztf-2	F13G3.1	n/a	chrI 7,292,255	C. elegans ZTF-2 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR013993 (Zinc finger, N-recognin, metazoa), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
34	ctl-1	Y54G11A.6	n/a	chrII 14,304,828	ctl-1 encodes one of three C. elegans catalases; CTL-1 exhibits catalase activity in vitro, and thus likely functions in vivo as an antioxidant enzyme that protects cells from reactive oxygen species; ctl-1 activity contributes to the extended lifespan seen in daf-2 mutant animals; in addition, ctl-1 expression is negatively regulated by DAF-2-mediated insulin signaling; as CTL-1 does not possess a C-terminal peroxisomal targeting signal (PTS), it is predicted to be a cytosolic catalase.
35	glb-13	F19H6.2	n/a	chrX 12,374,995	glb-13 encodes a globin with no obvious function in mass RNAi assays.
36	ZK228.3	ZK228.3	n/a	chrV 18,459,731	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
37	T01D3.1	T01D3.1	n/a	chrV 13,691,269	contains similarity to Pfam domain PF00008 (EGF-like domain)
38	ZC416.1	ZC416.1	n/a	chrIV 3,637,332	n/a
39	K04C1.4	K04C1.4	n/a	chrX 14,246,093	contains similarity to Pfam domain PF00036 EF hand contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand)
40	ZK742.3	ZK742.3	n/a	chrV 7,809,120	contains similarity to Pfam domain PF00724 NADH:flavin oxidoreductase / NADH oxidase family contains similarity to Interpro domains IPR013785 (Aldolase-type TIM barrel), IPR001155 (NADH:flavin oxidoreductase/NADH oxidase, N-terminal)
41	C18B2.3	C18B2.3	n/a	chrX 3,603,031
42	K11G9.1	K11G9.1	n/a	chrV 6,677,918	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
43	T28D9.7	T28D9.7	n/a	chrII 6,478,174	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
44	lin-33	H32C10.2	n/a	chrIV 5,931,939	C. elegans LIN-33 protein; contains similarity to Interpro domain IPR002873 (Non-structural protein NSP3, Rotavirus)
45	F09G8.3	F09G8.3	n/a	chrIII 8,266,869	contains similarity to Pfam domain PF00380 Ribosomal protein S9/S16 contains similarity to Interpro domains IPR000754 (Ribosomal protein S9), IPR014721 (Ribosomal protein S5 domain 2-type fold)
46	tag-278	C02F12.7	n/a	chrX 3,686,384	C. elegans TAG-278 protein; contains similarity to Interpro domain IPR000533 (Tropomyosin)
47	nhr-248	ZK218.6	n/a	chrV 17,103,987	C. elegans NHR-248 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
48	F45B8.3	F45B8.3	n/a	chrX 14,960,981	contains similarity to Interpro domains IPR003267 (Small proline-rich), IPR000694 (Proline-rich region)
49	tba-9	F40F4.5	n/a	chrX 3,254,559	tba-9 encodes one of nine C. elegans alpha tubulins; by homology, TBA-9 is predicted to be a component of microtubules; as loss of tba-9 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, TBA-9 likely functions redundantly with other alpha tubulins as a basic component of cellular architecture that may play additional roles in processes such as cell division, cell movement, and intracellular transport.
50	cpt-6	W01A11.5	n/a	chrV 6,491,977	C. elegans CPT-6 protein; contains similarity to Pfam domain PF00755 Choline/Carnitine o-acyltransferase contains similarity to Interpro domain IPR000542 (Acyltransferase ChoActase/COT/CPT)