UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	unc-27	ZK721.2	3e-76	chrX 8,789,978	unc-27 encodes a troponin I isoform; unc-27 is required for coordinated motility and normal muscle morphology; structural analyses indicate that unc-27 is required for proper sarcomeric organization; unc-27/troponin I interacts with the body wall and pharynx types of troponin C; expression studies show that unc-27 is expressed in body wall, vulval and anal muscles.
2	K04F1.1	K04F1.1	n/a	chrV 1,658,856	contains similarity to Pfam domain PF02807 ATP:guanido phosphotransferase, N-terminal domain contains similarity to Interpro domain IPR000749 (ATP:guanido phosphotransferase)
3	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
4	VC5.1	VC5.1	n/a	chrV 7,102,942
5	rpl-4	B0041.4	n/a	chrI 4,646,348	rpl-4 encodes a large ribosomal subunit L4 protein.
6	F58B4.5	F58B4.5	n/a	chrV 10,933,422	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
7	act-2	T04C12.5	n/a	chrV 11,077,425	act-2 encodes an invertebrate actin that may function specifically in the pharynx.
8	lec-10	W01A11.4	n/a	chrV 6,488,658	lec-10 encodes a galectin, a soluble galactose-binding lectin; recombinant lec-10 can bind to sugar in an in vitro assay.
9	F32B5.1	F32B5.1	n/a	chrI 2,701,252	contains similarity to Pfam domains PF02807 (ATP:guanido phosphotransferase, N-terminal domain) , PF00217 (ATP:guanido phosphotransferase, C-terminal catalytic domain) contains similarity to Interpro domains IPR000749 (ATP:guanido phosphotransferase), IPR014746 (Glutamine synthetase/guanido kinase, catalytic region)
10	F54E2.1	F54E2.1	n/a	chrV 2,811,213	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
11	C05D2.8	C05D2.8	n/a	chrIII 5,608,885	contains similarity to Aedes aegypti Putative uncharacterized protein (Fragment).; TR:Q16Z88
12	dhs-28	M03A8.1	n/a	chrX 6,819,210	dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type.
13	pgk-1	T03F1.3	n/a	chrI 3,868,329	T03F1.3 is orthologous to the human gene PHOSPHOGLYCERETE KINASE 1 (PGK1; OMIM:311800), which when mutated leads to hemolytic anemia and neurologic disturbances.
14	clec-48	C14A6.1	n/a	chrV 18,158,762	C. elegans CLEC-48 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002353 (Type II antifreeze protein)
15	T28F3.8	T28F3.8	n/a	chrIV 17,306,594	contains similarity to Interpro domain IPR013032 (EGF-like region, conserved site)
16	hsp-1	F26D10.3	n/a	chrIV 17,280,029	hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity.
17	C26B9.5	C26B9.5	n/a	chrX 5,330,863	contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domain IPR008758 (Peptidase S28)
18	clec-49	W04E12.6	n/a	chrV 19,745,488	C. elegans CLEC-49 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002353 (Type II antifreeze protein)
19	F55G11.2	F55G11.2	n/a	chrIV 12,968,338	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
20	R13F6.10	R13F6.10	n/a	chrIII 6,867,259	contains similarity to Interpro domain IPR011990 (Tetratricopeptide-like helical)
21	ZK1321.4	ZK1321.4	n/a	chrII 9,772,248	contains similarity to Pfam domain PF00595 PDZ domain (Also known as DHR or GLGF) contains similarity to Interpro domains IPR006643 (ZASP), IPR001478 (PDZ/DHR/GLGF)
22	ZK829.4	ZK829.4	n/a	chrIV 11,954,203	ZK829.4 is orthologous to the human gene GLYCINE DECARBOXYLASE PRECURSOR (GLUD1; OMIM:238300), which when mutated leads to disease.
23	egl-45	C27D11.1	n/a	chrIII 7,826,432	egl-45 encodes a homolog of eukaryotic translation initiation factor 3, subunit 10, that affects development of the HSNs that affect egg laying.
24	T25C12.3	T25C12.3	n/a	chrX 11,495,472	contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00059 (Lectin C-type domain) contains similarity to Interpro domains IPR011162 (MHC classes I and II-like antigen recognition), IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR013032 (EGF-like region, conserved site), IPR001304 (C-type lectin), IPR006582 (Region of unknown fuction MD, Caenorhabditis elegans), IPR002035 (von Willebrand factor, type A)
25	C08H9.2	C08H9.2	n/a	chrII 9,888,735	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR004087 (K Homology), IPR004088 (K Homology, type 1)
26	dod-17	K10D11.1	n/a	chrIV 12,977,287	C. elegans DOD-17 protein; contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
27	itx-1	W03D8.6	n/a	chrI 2,809,305	itx-1 encodes one of two Caspr orthologues found in the C. elegans genome; Caspr proteins belong to the Neurexin superfamily and are involved in mediating cell-cell contacts and in the formation of specialized membrane-domains in polarized epithelial and nerve cells; RNA interference of itx-1 suggests that itx-1 is involved in the correct positioning and maintenance of apical junctions and in maintaining epithelial integrity in the gut; gfp-reporter studies indicate that ITX-1 is expressed in intestinal cell epithelia and in the socket cells of the inner and outer labial sensilla; immunofluorescence studies indicate that ITX-1 localizes to the baso-lateral membranes of intestinal epithelia.
28	F28A10.6	F28A10.6	n/a	chrII 847,752	contains similarity to Pfam domains PF08028 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02770 (Acyl-CoA dehydrogenase, middle domain) , PF00441 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02771 (Acyl-CoA dehydrogenase, N-terminal domain) contains similarity to Interpro domains IPR013107 (Acyl-CoA dehydrogenase, type 2, C-terminal), IPR006090 (Acyl-CoA oxidase/dehydrogenase, type 1), IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR006089 (Acyl-CoA dehydrogenase, conserved site), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR009075 (Acyl-CoA dehydrogenase/oxidase C-terminal), IPR006092 (Acyl-CoA dehydrogenase, N-terminal)
29	ile-1	K07A1.8	n/a	chrI 9,610,665	ile-1 is orthologous to the human gene human ERGIC-53, which when mutated leads to deficiency of coagulation factors V/VIII (OMIM:227300).
30	Y76A2B.3	Y76A2B.3	n/a	chrIII 13,541,717	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
31	ZC416.6	ZC416.6	n/a	chrIV 3,611,139	n/a
32	F35E12.5	F35E12.5	n/a	chrV 13,737,761	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003366 (CUB-like region)
33	gstk-1	ZK1320.1	n/a	chrII 9,657,127	C. elegans GSTK-1 protein; contains similarity to Pfam domain PF01323 DSBA-like thioredoxin domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR001853 (DSBA oxidoreductase), IPR014440 (HCCA isomerase/glutathione S-transferase kappa)
34	tag-18	T14G12.3	n/a	chrX 3,732,674	C. elegans TAG-18 protein ;
35	F01D5.5	F01D5.5	n/a	chrII 14,001,897	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
36	ugt-8	H23N18.3	n/a	chrV 4,904,931	C. elegans UGT-8 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
37	C16C10.11	C16C10.11	n/a	chrIII 4,152,344	contains similarity to Pfam domain PF06747 CHCH domain contains similarity to Interpro domains IPR010625 (CHCH), IPR000104 (Antifreeze protein, type I), IPR000694 (Proline-rich region)
38	F54D5.4	F54D5.4	n/a	chrII 11,570,295	contains similarity to Haemonchus contortus NIM-2 protein.; TR:Q4QYX5
39	T04A8.5	T04A8.5	n/a	chrIII 4,690,700	contains similarity to Pfam domains PF00310 (Glutamine amidotransferases class-II) , PF00156 (Phosphoribosyl transferase domain) contains similarity to Interpro domains IPR000583 (Glutamine amidotransferase, class-II), IPR005854 (Amidophosphoribosyl transferase), IPR000836 (Phosphoribosyltransferase), IPR002375 (Purine/pyrimidine phosphoribosyl transferase, conserved site)
40	T16G1.6	T16G1.6	n/a	chrV 12,936,341	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
41	tba-4	F44F4.11	n/a	chrII 10,919,367	tba-4 encodes a member of the alpha tubulin family that also includes tba-1, tba-2, and tba-3, and affects embryonic viability.
42	F55G11.8	F55G11.8	n/a	chrIV 12,963,684	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
43	R10H10.3	R10H10.3	n/a	chrIV 10,390,865	contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00431 (CUB domain) contains similarity to Interpro domains IPR000859 (CUB), IPR016857 (Uncharacterised conserved protein UCP027682, CUB, vWA), IPR002035 (von Willebrand factor, type A)
44	C01B10.3	C01B10.3	n/a	chrIV 6,620,429	C01B10.3 encodes a paralog of IPP-5, and thus may functionally overlap with ipp-5 in vivo.
45	alh-9	F01F1.6	n/a	chrIII 5,858,031	C. elegans ALH-9 protein; contains similarity to Pfam domain PF00171 Aldehyde dehydrogenase family contains similarity to Interpro domains IPR016163 (Aldehyde dehydrogenase, C-terminal), IPR016162 (Aldehyde dehydrogenase, N-terminal), IPR016161 (Aldehyde/histidinol dehydrogenase), IPR015590 (Aldehyde dehydrogenase), IPR016160 (Aldehyde dehydrogenase, conserved site)
46	mup-2	T22E5.5	n/a	chrX 6,409,410	mup-2 encodes the muscle contractile protein troponin T ( TnT ) homologous to vertebrate and invertebrate TnT and contains an invertebrate- specific COOH -terminal tail; mup-2 affects embryonic body wall muscle cell contraction, sarcomere organization, cell positioning, regulated muscle contraction in larval and adult body wall muscle, epidermal morphogenesis, and is required for proper function of the hermaphrodite nonstriated oviduct myoepithelial sheath, proper growth, and fertility.
47	F54F11.2	F54F11.2	n/a	chrII 13,512,057	F54F11.2 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F54F11.2 has no clear orthologs in other organisms.
48	spl-1	Y66H1B.4	n/a	chrIV 381,542	C. elegans SPL-1 protein; contains similarity to Pfam domains PF00282 (Pyridoxal-dependent decarboxylase conserved domain) , PF00266 (Aminotransferase class-V) contains similarity to Interpro domains IPR002129 (Pyridoxal phosphate-dependent decarboxylase), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR000192 (Aminotransferase, class V/Cysteine desulphurase), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
49	R03D7.1	R03D7.1	n/a	chrII 10,928,740	R03D7.1 is orthologous to the human gene METHIONINE SYNTHASE (MTR; OMIM:156570), which when mutated leads to disease.
50	atp-2	C34E10.6	n/a	chrIII 5,229,290	atp-2 encodes the beta subunit of the soluble, catalytic F1 portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); atp-2 activity is required for embryonic and larval development past the L3 stage, as well as for normal mobility, pharyngeal pumping, defecation, growth rate, and larval lifespan; in males, atp-2 activity is also required cell autonomously in male-specific sensory neurons for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; in vitro, the N-terminus of ATP-2 interacts directly with the conserved PLAT domains of human polycystin (PC)-1 and C. elegans LOV-1, which is expressed exclusively in adult male sensory neurons and is also required for the response to hermaphrodite contact; atp-2 is widely expressed throughout development in both sexes; ATP-2 localizes to mitochondria and to cilia of male-specific neurons; in the male-specific CEM neurons ATP-2 colocalizes with PKD-2, the C. elegans homolog of human polycystin (PC)-2.