UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	rev-1	ZK675.2	0	chrII 7,902,571	C. elegans REV-1 protein; contains similarity to Pfam domains PF00817 (impB/mucB/samB family) , PF00533 (BRCA1 C Terminus (BRCT) domain) contains similarity to Interpro domains IPR001126 (UMUC-like DNA-repair protein), IPR012112 (DNA repair protein, Rev1), IPR001357 (BRCT)
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	C16C8.12	C16C8.12	n/a	chrII 3,453,161
4	B0035.3	B0035.3	n/a	chrIV 11,314,534	contains similarity to Pfam domain PF01661 Macro domain contains similarity to Interpro domain IPR002589 (Appr-1-p processing)
5	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
6	C07D8.5	C07D8.5	n/a	chrX 7,344,247	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
7	C17E4.4	C17E4.4	n/a	chrI 9,419,701	contains similarity to Thermoplasma acidophilum Hypothetical membrane protein.; TR:Q9HLF7
8	F57C9.3	F57C9.3	n/a	chrI 4,838,180
9	F57A10.4	F57A10.4	n/a	chrV 15,769,845	contains similarity to Oceanobacillus iheyensis Alkaliphily related protein.; TR:Q8EQ12
10	B0304.2	B0304.2	n/a	chrII 4,524,073
11	F27C8.6	F27C8.6	n/a	chrIV 9,587,998	F27C8.6 encodes a putative arylacetamide deacetylase and microsomal lipase; F27C8.6 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; F27C8.6(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them.
12	M116.1	M116.1	n/a	chrIV 8,411,585
13	hus-1	H26D21.1	n/a	chrI 3,698,705	hus-1 encodes the C. elegans ortholog of the Schizosaccharomyces pombe Hus1 DNA damage checkpoint protein; in C. elegans, hus-1 activity is required for DNA damage-induced cell cycle arrest and apoptosis, telomere maintenance, and hence, genome stability and development; specifically, hus-1 is required for the CEP-1/p53-dependent increase in germline egl-1 expression following irradiation; a HUS-1::GFP fusion protein is detected in the nuclei of mitotic and meiotic germ cells, mature oocytes, embryos, and somatic larval cells, particularly those that are proliferating; while HUS-1 localization is generally diffuse throughout these nuclei, following irradiation, HUS-1 localizes to discrete foci that overlap with chromatin; HUS-1 nuclear localization is dependent upon the Rad9 homologue HPR-9 and upon the checkpoint protein MRT-2, with which it interacts in yeast two-hybrid and in vitro assays.
14	rab-21	T01B7.3	n/a	chrII 8,714,514	rab-21 encodes a Rab GTPase most closely related to the Drosophila and vertebrate Rab21 GTPases and Saccharomyces cerevisiae VPS21; by homology, RAB-21 is predicted to be involved in membrane trafficking/vesicle transport; loss of rab-21 activity via RNAi results in 7-8% embryonic lethality.
15	C34G6.5	C34G6.5	n/a	chrI 5,873,231	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
16	rnh-1.2	ZK938.7	n/a	chrII 9,840,817	C. elegans RNH-1.2 protein; contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF00075 (RNase H) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011021 (Arrestin-like, N-terminal), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
17	EEED8.13	EEED8.13	n/a	chrII 5,411,874	contains similarity to Interpro domain IPR011038 (Calycin-like)
18	W02D9.4	W02D9.4	n/a	chrI 12,538,320	contains similarity to Oryza sativa Hypothetical protein.; TR:Q8H7L3
19	C49C8.3	C49C8.3	n/a	chrIV 8,644,987
20	F14D2.11	F14D2.11	n/a	chrII 3,341,568	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
21	F35C11.5	F35C11.5	n/a	chrII 8,254,199	contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR013090 (Phospholipase A2, active site)
22	C42C1.2	C42C1.2	n/a	chrIV 12,266,886	contains similarity to Pfam domain PF00481 Protein phosphatase 2C contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR000222 (), IPR014045 (Protein phosphatase 2C, N-terminal), IPR015655 (Protein phosphatase 2C)
23	ttr-30	T08A9.2	n/a	chrX 7,331,455	C. elegans TTR-30 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
24	bra-2	F23H11.1	n/a	chrIII 911,744	The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway
25	mxl-1	T19B10.11	n/a	chrV 11,245,345	mxl-1 encodes a basic helix-loop-helix protein similar to the vertebrate MAX transcriptional regulators; in vitro, MXL-1 can heterodimerize, and bind an E-box DNA sequence, with MDL-1, a C. elegans MAD-like bHLH protein; mxl-1::gfp reporter fusions are expressed in the posterior intestine and in head and tail neurons.
26	C16A3.2	C16A3.2	n/a	chrIII 6,390,183	contains similarity to Pfam domain PF00782 Dual specificity phosphatase, catalytic domain contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
27	F32D1.6	F32D1.6	n/a	chrV 4,374,245
28	gln-6	C28D4.3	n/a	chrIV 9,740,184	C. elegans GLN-6 protein; contains similarity to Pfam domains PF03951 (Glutamine synthetase, beta-Grasp domain) , PF00120 (Glutamine synthetase, catalytic domain) contains similarity to Interpro domains IPR008147 (Glutamine synthetase, beta-Grasp), IPR014746 (Glutamine synthetase/guanido kinase, catalytic region), IPR008146 (Glutamine synthetase, catalytic region)
29	bath-15	C08C3.2	n/a	chrIII 7,775,331	C. elegans BATH-15 protein; contains similarity to Pfam domains PF00917 (MATH domain) , PF00651 (BTB/POZ domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
30	grl-23	E02A10.2	n/a	chrV 12,576,078	grl-23 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a glycine-rich low-complexity region, a Ground-like (Grl) domain, and an acid-rich low-complexity region; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
31	cpar-1	F54C8.2	n/a	chrIII 9,434,486	cpar-1 encodes one of two C. elegans proteins homologous to the inner kinetochore histone H3 variant CENP-A (the other is encoded by hcp-3); loss of cpar-1 and hcp-3 activity via RNAi results in mitotic chromosome segregation defects, but no significant defects in meiotic chromosome segregation; when expressed in the germline using the pie-1 promoter, a CPAR-1::GFP fusion protein localizes to meiotic chromosomes during late prophase/prometaphase of meiosis I, but is not seen on chromosomes during meiosis II.
32	C16C8.5	C16C8.5	n/a	chrII 3,445,041	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
33	ZK930.2	ZK930.2	n/a	chrII 11,892,790	contains similarity to Interpro domain IPR010989 (t-SNARE)
34	C48B4.9	C48B4.9	n/a	chrIII 9,562,829	contains similarity to Arabidopsis thaliana Hypothetical protein (At1g32400/F5D14_22) (Tobamovirus multiplications2A).; TR:Q9C5W7
35	T13F2.6	T13F2.6	n/a	chrIV 9,779,719
36	W07E6.5	W07E6.5	n/a	chrII 477,174
37	M02B7.1	M02B7.1	n/a	chrIV 3,806,054
38	W03G11.2	W03G11.2	n/a	chrX 12,107,432	contains similarity to Pfam domain PF03381 LEM3 (ligand-effect modulator 3) family / CDC50 family contains similarity to Interpro domain IPR005045 (Protein of unknown function DUF284, transmembrane eukaryotic)
39	ric-3	T14A8.1	n/a	chrIV 7,819,689	The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.
40	acl-1	F59F4.4	n/a	chrX 15,850,758	acl-1 encodes a 1-acyl-sn-glycerol-3-phosphate acyltransferase; ACL-1 is predicted to be a membrane protein that plays a role in phospholipid biosynthesis, but as loss of acl-1 activity via large-scale RNAi experiments results in no obvious defects, the precise role of ACL-1 in C. elegans development and/or behavior is not yet known.
41	C18A3.1	C18A3.1	n/a	chrII 5,720,938	contains similarity to Pfam domain PF05063 MT-A70 contains similarity to Interpro domains IPR007757 (MT-A70), IPR002052 (N-6 adenine-specific DNA methylase, conserved site)
42	ZK1320.7	ZK1320.7	n/a	chrII 9,672,350	contains similarity to Pfam domains PF00023 (Ankyrin repeat) , PF01585 (G-patch domain) contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR002110 (Ankyrin), IPR000467 (D111/G-patch)
43	spp-6	T08A9.10	n/a	chrX 7,317,449	spp-6 encodes a predicted transmembrane protein containing a saposin (B) domain that is a member of a saposin-like protein superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapores; SPP-6 is predicted to function as a lipid-binding protein that may possess pore-forming, cytotoxic activity; as loss of SPP-6 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of SPP-6 in C. elegans development and/or behavior is not yet known.
44	taf-11.2	K10D3.3	n/a	chrI 7,133,402	C. elegans TAF-11.2 protein; contains similarity to Pfam domain PF04719 hTAFII28-like protein conserved region contains similarity to Interpro domains IPR006809 (TAFII28-like protein), IPR009072 (Histone-fold)
45	T01E8.4	T01E8.4	n/a	chrII 10,238,236	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains WD repeats.
46	C04E6.11	C04E6.11	n/a	chrV 5,915,960	contains similarity to Homo sapiens Leucine-rich PPR motif-containing protein, mitochondrial precursor; ENSEMBL:ENSP00000260665
47	F31E3.6	F31E3.6	n/a	chrIII 6,982,722
48	F48C1.5	F48C1.5	n/a	chrI 5,317,876
49	mat-2	W10C6.1	n/a	chrII 11,116,985	mat-2 encodes a subunit of the anaphase-promoting complex or cyclosome (APCC) which is a multi-subunit E3 ubiquitin ligase that targets proteins for degradation during the metaphase-to-anaphase transition of the cell cycle; mat-2 is required for chromosome segregation during meiosis I and is involved in polarity specification of the anterior/posterior axis in the developing embryo.
50	lgg-3	B0336.8	n/a	chrIII 5,697,730	lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities.