UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ZK669.4	ZK669.4	0	chrII 7,943,957	ZK669.4 is orthologous to the human gene DIHYDROLIPOAMIDE BRANCHED CHAIN TRANSACYLASE (E2 COMPONENT OF BRANCHED CHAIN KETO ACID DEHYDROGENASE COMPLEX; (DBT), which when mutated leads to maple syrup urine disease, type II (OMIM:248610); the ZK669.4 protein is predicted to be mitochondrial with 68% accuracy.
2	nhr-232	Y22F5A.1	n/a	chrV 10,257,478	C. elegans NHR-232 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	W07G4.4	W07G4.4	n/a	chrV 13,045,013	contains similarity to Pfam domain PF00883 Cytosol aminopeptidase family, catalytic domain contains similarity to Interpro domain IPR000819 (Peptidase M17, leucyl aminopeptidase, C-terminal)
4	R07B7.2	R07B7.2	n/a	chrV 12,058,156	contains similarity to Saccharomyces cerevisiae Protein required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; protects centromeric Spo69p; SGD:YOR073W
5	ers-1	Y41E3.4	n/a	chrIV 15,010,805	ers-1 encodes a glutaminyl (Q) tRNA synthetase that affects growth and embryonic and larval viability in large-scale RNAi screens; it is predicted to be mitochondrial.
6	rpt-5	F56H1.4	n/a	chrI 5,742,805	rpt-5 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-5 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome.
7	asp-4	R12H7.2	n/a	chrX 13,220,146	asp-4 encodes an aspartyl protease homolog that is required, in parallel with ASP-3 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).
8	ptr-2	C32E8.8	n/a	chrI 3,791,060	ptr-2 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-2 is required for cytokinesis in somatic cells, but not in the germline (the converse of PTC-1's function); PTR-2 is partially required for normal molting from L4 to adult stages; PTR-2 is also required for normal male tail development, growth to full size, locomotion, and viability.
9	F16A11.1	F16A11.1	n/a	chrI 9,398,979	contains similarity to Pfam domain PF00622 SPRY domain contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR001870 (B302, (SPRY)-like), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR003877 (SPla/RYanodine receptor SPRY)
10	R13H4.6	R13H4.6	n/a	chrV 11,864,309	contains similarity to Archaeoglobus fulgidus Putative protease La homolog type (EC 3.4.21.-).; SW:O29883
11	C05C8.5	C05C8.5	n/a	chrV 7,233,733	contains similarity to Pfam domain PF00929 Exonuclease contains similarity to Interpro domains IPR013520 (Exonuclease, RNase T and DNA polymerase III), IPR006055 (Exonuclease), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
12	C50F7.4	C50F7.4	n/a	chrIV 7,729,765	contains similarity to Pfam domains PF08442 (ATP-grasp domain) , PF00549 (CoA-ligase) contains similarity to Interpro domains IPR013650 (ATP-grasp fold, succinyl-CoA synthetase-type), IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR005809 (Succinyl-CoA synthetase, beta subunit), IPR013815 (ATP-grasp fold, subdomain 1), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR013816 (ATP-grasp fold, subdomain 2), IPR016102 (Succinyl-CoA synthetase-like)
13	C36A4.5	C36A4.5	n/a	chrIII 3,846,247	contains similarity to Interpro domains IPR003993 (Treacher Collins syndrome, treacle), IPR000694 (Proline-rich region), IPR005819 (Histone H5)
14	C32D5.3	C32D5.3	n/a	chrII 6,319,574	C32D5.3 encodes an ortholog of ROLLING BLACKOUT (RBO; also called CMP44E or STAMPHA), a eukaryotic protein required for sustained phospholipase C activity during Drosophila phototransduction; RBO homologs have two predicted transmembrane helices, are significantly similar to several acylglycerol lipases, and share motifs characteristic of carboxyesterases and lipases.
15	mrp-2	F57C12.4	n/a	chrX 568,214	mrp-2 encodes a predicted multidomain transmembrane protein that is a member of the ATP-binding cassette (ABC) superfamily of transport proteins and is homologous to the human multidrug resistance-associated protein 1 (MRP1, OMIM:158343); by homology, MRP-2 is predicted to function as a membrane pump that couples the energy of ATP hydrolysis to membrane transport; as loss of MRP-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of MRP-2 in C. elegans development and/or behavior is not yet known; mrp-2 expression is, however, upregulated early in the exit from the alternative dauer stage and then remains induced, suggesting that MRP-2 activity is required for the transition to, and maintenance of, a more active metabolic state.
16	C25D7.8	C25D7.8	n/a	chrV 15,066,857	contains similarity to Interpro domains IPR003323 (Ovarian tumour, otubain), IPR016615 (Ubiquitin thioesterase Otubain)
17	W09D10.1	W09D10.1	n/a	chrIII 10,738,396	contains similarity to Pfam domain PF01412 Putative GTPase activating protein for Arf contains similarity to Interpro domain IPR001164 (Arf GTPase activating protein)
18	F46F11.6	F46F11.6	n/a	chrI 5,617,576	contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
19	ZC373.3	ZC373.3	n/a	chrX 10,061,060	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
20	lgc-14	T01H10.2	n/a	chrX 12,112,417	C. elegans LGC-14 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
21	srd-11	F53F4.9	n/a	chrV 13,618,750	C. elegans SRD-11 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR003002 (7TM chemoreceptor, subfamily 1)
22	F28D1.9	F28D1.9	n/a	chrIV 12,395,382	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
23	emb-5	T04A8.14	n/a	chrIII 4,717,943	emb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is required for the correct timing of the second E (endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb-5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a positive downstream effector in Notch-like signaling pathways during C. elegans development; emb-5 mRNA is most abundant during embryonic stages, with lower levels apparent during the L1-L3 larval stages, and even lower levels observed during L4.
24	C29F4.2	C29F4.2	n/a	chrIV 11,228,390	contains similarity to Pfam domain PF01062 Bestrophin contains similarity to Interpro domain IPR000615 (Bestrophin)
25	B0495.2	B0495.2	n/a	chrII 7,700,550	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR008351 (JNK MAP kinase), IPR002290 (Serine/threonine protein kinase), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core)
26	ZC410.3	ZC410.3	n/a	chrIV 9,077,529	contains similarity to Pfam domain PF01532 Glycosyl hydrolase family 47 contains similarity to Interpro domain IPR001382 (Glycoside hydrolase, family 47)
27	C30G12.2	C30G12.2	n/a	chrII 7,290,986	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
28	F35H12.4	F35H12.4	n/a	chrX 922,380	contains similarity to Pfam domain PF00454 Phosphatidylinositol 3- and 4-kinase contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR000403 (Phosphatidylinositol 3- and 4-kinase, catalytic), IPR015433 (Phosphatidylinositol Kinase)
29	nhr-106	T01G6.4	n/a	chrV 490,539	nhr-106 encodes a nuclear receptor that is most highly conserved amongst nematode species.
30	ugt-58	F35H8.6	n/a	chrII 9,585,502	C. elegans UGT-58 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
31	ZK1248.15	ZK1248.15	n/a	chrII 5,837,633	contains similarity to Pfam domain PF00397 WW domain contains similarity to Interpro domains IPR006596 (Nucleotide binding protein, PINc), IPR001202 (WW/Rsp5/WWP)
32	F55A11.7	F55A11.7	n/a	chrV 11,785,988	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
33	F20A1.9	F20A1.9	n/a	chrV 7,050,345	contains similarity to Pfam domains PF04326 (Divergent AAA domain) , PF00622 (SPRY domain) contains similarity to Interpro domains IPR001870 (B302, (SPRY)-like), IPR003877 (SPla/RYanodine receptor SPRY), IPR007421 (ATPase associated with various cellular activities, AAA-4)
34	T10E9.2	T10E9.2	n/a	chrI 6,543,527
35	F55A12.5	F55A12.5	n/a	chrI 5,347,791	contains similarity to Gallus gallus Nucleolin (Protein C23).; SW:P15771
36	nhr-9	ZK418.1	n/a	chrIII 7,096,245	C. elegans NHR-9 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
37	F25G6.9	F25G6.9	n/a	chrV 8,567,613	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
38	W01A11.1	W01A11.1	n/a	chrV 6,500,809	contains similarity to Pfam domains PF06441 (Epoxide hydrolase N terminus) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR016292 (Epoxide hydrolase), IPR000073 (Alpha/beta hydrolase fold-1), IPR000639 (Epoxide hydrolase-like), IPR010497 (Epoxide hydrolase, N-terminal)
39	rrt-2	C29H12.1	n/a	chrII 6,126,706	C. elegans RRT-2 protein; contains similarity to Pfam domains PF05746 (DALR anticodon binding domain) , PF00750 (tRNA synthetases class I (R)) contains similarity to Interpro domains IPR015945 (Arginyl-tRNA synthetase, class Ic, core), IPR008909 (DALR anticodon binding), IPR001412 (Aminoacyl-tRNA synthetase, class I, conserved site), IPR009080 (Aminoacyl-tRNA synthetase, class 1a, anticodon-binding), IPR001278 (Arginyl-tRNA synthetase, class Ic), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold)
40	ZK1193.3	ZK1193.3	n/a	chrX 418,922	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR013032 (EGF-like region, conserved site)
41	F47B8.5	F47B8.5	n/a	chrV 14,326,311	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domains IPR002485 (Protein of unknown function DUF13), IPR000694 (Proline-rich region), IPR000976 (Wilm's tumour protein), IPR003071 (Orphan nuclear receptor, HMR type)
42	nol-1	W07E6.1	n/a	chrII 473,591	C. elegans NOL-1 protein; contains similarity to Pfam domain PF01189 NOL1/NOP2/sun family contains similarity to Interpro domains IPR011023 (Nop2p), IPR006174 (rRNA subunit methyltransferase), IPR001678 (Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p)
43	C32D5.11	C32D5.11	n/a	chrII 6,354,177	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
44	F52B5.3	F52B5.3	n/a	chrI 8,321,160	The F52B5.3 gene encodes a DEAH helicase orthologous to the Drosophila SpindleE protein.
45	T07F10.3	T07F10.3	n/a	chrV 12,869,009	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
46	T02B5.3	T02B5.3	n/a	chrV 14,159,248	contains similarity to Pfam domain PF00135 (Carboxylesterases)
47	K02C4.3	K02C4.3	n/a	chrII 8,083,916	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domain IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
48	T24D1.2	T24D1.2	n/a	chrI 9,954,687	contains similarity to Interpro domain IPR001841 (Zinc finger, RING-type)
49	glh-2	C55B7.1	n/a	chrI 6,515,665	glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males.
50	C35D10.6	C35D10.6	n/a	chrIII 4,859,975	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)