UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	pgp-3	ZK455.7	0	chrX 11,354,551	pgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells; loss of pgp-3 activity via large-scale RNAi screens does not result in any obvious abnormalities.
2	twk-42	W06D12.2	n/a	chrV 17,728,557	C. elegans TWK-42 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2)
3	prp-8	C50C3.6	n/a	chrIII 8,168,465	prp-8 is orthologous to the human gene SIMILAR TO U5 SNRNP-SPECIFIC PROTEIN (220 KD), ORTHOLOG OF S.
4	Y54G9A.4	Y54G9A.4	n/a	chrII 13,714,353	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
5	K02C4.2	K02C4.2	n/a	chrII 8,076,226	contains similarity to Brugia pahangi Alt-1 protein.; TR:O96781
6	csp-3	Y47H9C.6	n/a	chrI 11,888,911	csp-3 encodes a protein that is homologous to the C-terminal domain of caspase-like cysteine proteases; unlike other caspases, CSP-3 does not contain a middle or N-terminal domain, and thus may either function in concert with the middle domains of other caspases or may play a regulatory (dominant negative) role in caspase activation; as loss of csp-3 activity via large-scale RNAi does not result in any obvious abnormalities, the precise role of CSP-3 in C. elegans development and/or behavior is not yet known.
7	prx-13	F32A5.6	n/a	chrII 7,251,051	prx-13 is orthologous to the human gene PEX13 (OMIM:601789), which when mutated leads to Zellweger syndrome or neonatal adrenoleukodystrophy.
8	F58A6.1	F58A6.1	n/a	chrII 5,143,154	contains similarity to Pfam domain PF00378 Enoyl-CoA hydratase/isomerase family contains similarity to Interpro domains IPR014748 (Crontonase, C-terminal), IPR001753 (Crotonase, core)
9	col-69	K01A2.7	n/a	chrII 304,726	C. elegans COL-69 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
10	gst-14	F37B1.3	n/a	chrII 13,615,382	C. elegans GST-14 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
11	wrt-3	F38E11.7	n/a	chrIV 9,476,571	wrt-3 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a region of low-complexity sequence; WRT-3 is expressed in the trinucleate pharyngeal gland cell g1 beginning at the three-fold stage of embryogenesis, in seam cells and hypodermis, and in single muscle cells and the distal tip cells of late stage larvae and adults; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-3 is required for normal growth to full size and locomotion; both of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
12	C53B4.3	C53B4.3	n/a	chrIV 8,972,115	C53B4.3 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:23098) (SLC22A1L; OMIM:602631), which when mutated leads to disease.
13	M02F4.3	M02F4.3	n/a	chrX 3,038,574	M02F4.3 encodes a predicted transmembrane protein orthologous to human ACDP1-ACDP4 and S. cerevisiae MAM3, and paralogous to C01H6.6, C33D12.2, C52D10.12, R04E5.2, and R13G10.4; by orthology with MAM3, M02F4.3 may participate in metal homoeostasis; M02F4.3, MAM3, and ACDP1-ACDP4 belong to a family of proteins (sharing an ACD domain) from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein; bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; M02F4.3 has no obvious function in RNAi assays.
14	fbxa-31	ZC47.5	n/a	chrIII 1,270,493	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
15	T08D10.3	T08D10.3	n/a	chrX 11,956,831	contains similarity to Homo sapiens Hypothetical protein KIAA1681; ENSEMBL:ENSP00000316543
16	C10C5.1	C10C5.1	n/a	chrIV 9,362,924	contains similarity to Drosophila melanogaster Flybase gene name is CG8486-PA;; FLYBASE:CG8486
17	K08D10.10	K08D10.10	n/a	chrIV 4,155,758
18	gex-2	F56A11.1	n/a	chrIV 578,227	The gex-2 gene encodes a homolog of p140/Sra-1, a mammalian protein ligand of the small GTPase Rac1; gex-2 is required for tissue morphogenesis and cell migrations.
19	pgp-1	K08E7.9	0	chrIV 12,595,402	pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities.
20	R10E8.3	R10E8.3	n/a	chrV 18,235,608	contains similarity to Pfam domains PF01827 (FTH domain) , PF00646 (F-box domain) contains similarity to Interpro domains IPR002900 (Protein of unknown function DUF38, Caenorhabditis species), IPR001810 (Cyclin-like F-box)
21	M01G12.9	M01G12.9	n/a	chrI 12,111,806	contains similarity to Lactococcus lactis ORF (Fragment).; TR:Q48730
22	pgp-4	F42E11.1	0	chrX 11,361,531	pgp-4 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-4 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-4 activity via deletion mutations or RNAi results in no obvious defects, the precise role of PGP-4 in C. elegans development and/or behavior is not yet known; pgp-4 promoter-gfp fusion proteins are expressed in the larval excretory cell.
23	R08C7.5	R08C7.5	n/a	chrIV 4,431,281	contains similarity to Pfam domain PF03941 Inner centromere protein, ARK binding region contains similarity to Interpro domains IPR005819 (Histone H5), IPR005635 (Inner centromere protein, ARK binding region)
24	H03A11.1	H03A11.1	n/a	chrX 15,211,201	H03A11.1 encodes an FAM20 ortholog; murine FAM20A is a secreted protein expressed in hematopoietic cells.
25	C25E10.5	C25E10.5	n/a	chrV 9,031,538	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
26	F27E5.3	F27E5.3	n/a	chrII 10,142,746	contains similarity to Homo sapiens Isoform 1 of Cell division cycle 2-related protein kinase 7; ENSEMBL:ENSP00000300647
27	C25D7.5	C25D7.5	n/a	chrV 15,054,998	contains similarity to Pfam domain PF00753 (Metallo-beta-lactamase superfamily)
28	fbxa-90	Y102A5C.19	n/a	chrV 16,967,704	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
29	F28F5.4	F28F5.4	n/a	chrIII 6,816,698
30	grd-14	T01B10.2	n/a	chrX 8,500,290	grd-14 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-14 is required for normal growth to full size, locomotion, and vulval morphogenesis; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
31	F01D5.2	F01D5.2	n/a	chrII 13,998,627	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR001368 (TNFR/CD27/30/40/95 cysteine-rich region), IPR000480 (Glutelin), IPR003582 (Metridin-like ShK toxin)
32	F40A3.6	F40A3.6	n/a	chrV 7,893,039
33	Y39A1A.14	Y39A1A.14	n/a	chrIII 10,649,949	contains similarity to Pfam domain PF03587 Nep1 ribosome biogenesis protein contains similarity to Interpro domain IPR005304 (Suppressor Mra1)
34	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
35	Y54G11A.4	Y54G11A.4	n/a	chrII 14,294,300	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR003006 (Immunoglobulin/major histocompatibility complex, conserved site), IPR000023 (Phosphofructokinase)
36	tag-335	C42C1.5	n/a	chrIV 12,277,039	C. elegans TAG-335 protein; contains similarity to Pfam domains PF00132 (Bacterial transferase hexapeptide (three repeats)) (4), PF00483 (Nucleotidyl transferase) contains similarity to Interpro domains IPR001451 (Bacterial transferase hexapeptide repeat), IPR005835 (Nucleotidyl transferase), IPR011004 (Trimeric LpxA-like)
37	F54D10.3	F54D10.3	n/a	chrII 3,812,819	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domains IPR000976 (Wilm's tumour protein), IPR005020 (Protein of unknown function DUF278)
38	W03G11.3	W03G11.3	n/a	chrX 12,101,925	contains similarity to Pfam domain PF01120 Alpha-L-fucosidase contains similarity to Interpro domains IPR016286 (Alpha-L-fucosidase), IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR000933 (Glycoside hydrolase, family 29 (alpha-L-fucosidase))
39	VT23B5.1	VT23B5.1	n/a	chrIV 12,665,034	contains similarity to Homo sapiens Isoform 2 of WD repeat and FYVE domain-containing protein 3; ENSEMBL:ENSP00000318466
40	T26E3.7	T26E3.7	n/a	chrI 12,655,698	contains similarity to Pfam domain PF00006 ATP synthase alpha/beta family, nucleotide-binding domain contains similarity to Interpro domain IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
41	H02F09.3	H02F09.3	n/a	chrX 1,570,762	contains similarity to Interpro domain IPR001757 (ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)
42	glb-13	F19H6.2	n/a	chrX 12,374,995	glb-13 encodes a globin with no obvious function in mass RNAi assays.
43	pad-1	Y18D10A.13	n/a	chrI 12,890,677	The pad-1 gene encodes a highly conserved, but unfamiliar, protein that is required for embryonic development.
44	pmp-2	C44B7.9	0.0000000001	chrII 6,885,843	C. elegans PMP-2 protein; contains similarity to Pfam domains PF06472 (ABC transporter transmembrane region 2) , PF00005 (ABC transporter) contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR011527 (ABC transporter, transmembrane region, type 1), IPR010509 (ABC transporter, N-terminal), IPR003593 (AAA+ ATPase, core), IPR005283 (Peroxysomal long chain fatty acyl transporter)
45	Y32F6B.1	Y32F6B.1	n/a	chrV 10,482,818	contains similarity to Pfam domain PF03137 Organic Anion Transporter Polypeptide (OATP) family contains similarity to Interpro domains IPR004156 (Organic anion transporter polypeptide OATP), IPR016196 (MFS general substrate transporter)
46	F39E9.1	F39E9.1	n/a	chrII 3,318,116	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
47	W10G11.19	W10G11.19	n/a	chrII 3,552,038	contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR000886 (Endoplasmic reticulum, targeting sequence)
48	C06H2.2	C06H2.2	n/a	chrV 11,126,240	contains similarity to Pfam domain PF01852 START domain contains similarity to Interpro domain IPR002913 (Lipid-binding START)
49	tre-4	F15A2.2	n/a	chrX 13,473,950	C. elegans TRE-4 protein; contains similarity to Pfam domain PF01204 Trehalase contains similarity to Interpro domains IPR001661 (Glycoside hydrolase, family 37), IPR000886 (Endoplasmic reticulum, targeting sequence), IPR008928 (Six-hairpin glycosidase-like)
50	W09C5.8	W09C5.8	n/a	chrI 13,658,783	contains similarity to Pfam domain PF02936 Cytochrome c oxidase subunit IV contains similarity to Interpro domains IPR013288 (Cytochrome c oxidase subunit 4), IPR004203 (Cytochrome c oxidase subunit IV)