UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	srh-181	ZK228.6	0	chrV 18,475,360	C. elegans SRH-181 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	nspb-5	F38A5.9	n/a	chrIV 6,599,329	C. elegans NSPB-5 protein; contains similarity to Pfam domain PF07312 Protein of unknown function (DUF1459) contains similarity to Interpro domain IPR009924 (Protein of unknown function DUF1459)
4	B0205.9	B0205.9	n/a	chrI 10,722,143	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
5	coq-5	ZK652.9	n/a	chrIII 7,857,812	coq-5 encodes a putative 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, homologous to COQ5 in S. cerevisiae and to a family of methyltransferases involved in ubiquinone, menaquinone, biotin and sterol biosynthesis and in phosphatidylethanolamine methylation; COQ-5 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; coq-5 can transgenically rescue a coq-5 deletion in S. cerevisiae; coq-5(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans.
6	fbxa-60	T12B5.10	n/a	chrIII 945,562	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
7	fbxb-39	M01D1.7	n/a	chrII 1,040,136	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
8	sri-42	T10D4.9	n/a	chrII 3,141,931	C. elegans SRI-42 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
9	str-260	T24A6.6	0.001	chrV 3,528,795	C. elegans STR-260 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
10	B0244.7	B0244.7	n/a	chrIII 5,732,127	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
11	F30A10.6	F30A10.6	n/a	chrI 9,490,547	contains similarity to Pfam domain PF02383 SacI homology domain contains similarity to Interpro domain IPR002013 (Synaptojanin, N-terminal)
12	clec-242	Y68A4B.2	n/a	chrV 17,244,604	C. elegans CLEC-242 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
13	srw-88	T06G6.7	n/a	chrI 12,721,084	C. elegans SRW-88 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
14	F15A4.9	F15A4.9	n/a	chrII 12,480,165	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
15	R105.1	R105.1	n/a	chrIV 4,635,811	contains similarity to Pfam domain PF03762 Vitelline membrane outer layer protein I (VOMI) contains similarity to Interpro domain IPR005515 (Vitelline membrane outer layer protein I (VOMI))
16	wht-4	F02E11.1	n/a	chrII 3,280,577	C. elegans WHT-4 protein; contains similarity to Pfam domains PF01061 (ABC-2 type transporter) , PF00005 (ABC transporter) contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR003593 (AAA+ ATPase, core), IPR005284 (Pigment precursor permease), IPR013525 (ABC-2 type transporter)
17	C54E10.1	C54E10.1	n/a	chrV 18,816,778	contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
18	ZK550.2	ZK550.2	n/a	chrIV 17,247,626	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
19	wts-1	T20F10.1	n/a	chrI 10,294,898	C. elegans WTS-1 protein; contains similarity to Pfam domains PF00069 (Protein kinase domain) , PF00433 (Protein kinase C terminal domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR000694 (Proline-rich region), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000961 (Protein kinase, C-terminal)
20	srw-134	T05B4.7	n/a	chrV 4,111,591	C. elegans SRW-134 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
21	gtl-2	F54D1.5	n/a	chrIV 11,277,712	gtl-2 encodes a predicted receptor-activated calcium channel and represents a family of calcium channels, the other two family members being gtl-1 and gon-2.
22	F23F12.8	F23F12.8	n/a	chrIII 6,485,986	F23F12.8 encodes a large (980-residue) protein, predicted to be secreted, with two chitin-binding peritrophin-A domains, separated by a low-complexity region; F23F12.8 is synthesized in larval and adult pharynx, a known site of chitin deposition; like CEJ-1 and CPG-2 in embryos, F23F12.8 might participate in chitin synthesis, and its peritrophin-A domains might enable mechanical cross-linking of chitin.
23	T11F9.1	T11F9.1	n/a	chrV 11,460,688	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
24	cka-1	C28D4.2	n/a	chrIV 9,734,654	cka-1 encodes an isoform of choline kinase whose activity has been verified in vitro, and that has a strong preference for choline over ethanolamine; CKA-1 and CKA-2 comprise a related group ('A') of choline kinases.
25	R05D3.8	R05D3.8	n/a	chrIII 8,357,800	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
26	clec-212	F19F10.7	n/a	chrV 7,566,626	C. elegans CLEC-212 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR001304 (C-type lectin)
27	pqn-53	R07B7.3	n/a	chrV 12,064,393	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
28	ZK829.7	ZK829.7	n/a	chrIV 11,960,692	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR016040 (NAD(P)-binding)
29	F47G9.6	F47G9.6	n/a	chrV 11,330,067	contains similarity to Methanosarcina acetivorans Predicted protein.; TR:Q8TS27
30	gcy-8	C49H3.1	n/a	chrIV 7,930,918	gcy-8 encodes a receptor-type guanylyl cyclase that, along with gcy-18 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-8 functions redundantly with gcy-18 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; GCY-8 is expressed exclusively in the AFD thermosensory neurons where it localizes to sensory endings; GCY-8 expression in the AFD neurons requires activity of the TAX-2/4 cyclic nucleotide gated channel and the CMK-1 Ca2+/calmodulin-dependent protein kinase I, while maintenance of GCY-8 expression requires the OTD/OTX homeodomain protein TTX-1.
31	scrm-3	C04E12.7	n/a	chrV 3,356,584	scrm-3 encodes a putative phospholipid scramblase homologous to human PLSCR1-5, and paralogous to other C. elegans SCRMs (e.g., SCRM-1); SCRM-3 is expressed in neurons, anal depressor muscle, and occasionally in body wall muscle cells; however, in apoptotic germline cells, SCRM-3 is fully dispensable for normally rapid engulfment and largely dispensable for phosphatidylserine exposure; SCRM-3 does not bind WAH-1 in vitro, and scrm-3(tm631) mutants have no obvious phenotype.
32	F13H8.3	F13H8.3	n/a	chrII 6,264,731	contains similarity to Pfam domain PF01156 Inosine-uridine preferring nucleoside hydrolase contains similarity to Interpro domain IPR001910 (Inosine/uridine-preferring nucleoside hydrolase)
33	uev-1	F39B2.2	n/a	chrI 14,790,521	uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-1 in C. elegans development and/or behavior is not yet known; UEV-1 does, however, interact with a number of proteins, such as UBC-13, that are likely involved in the response to DNA damage; thus, UEV-1 may play a role in ubiquitination and protein turnover in conjunction with DNA repair or the DNA damage checkpoint pathway.
34	fpn-1.2	R09B5.4	n/a	chrV 1,463,421	R09B5.4 is orthologous to the human gene HYPOTHETICAL PROTEIN (SLC11A3; OMIM:604653), which when mutated leads to disease.
35	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
36	nlp-16	T13A10.5	n/a	chrIV 6,257,461	nlp-16 encodes a predicted neuropeptide that does not belong to a multigene family in C. elegans and is not clearly related to well-characterized neuropeptides; the peptide encoded by nlp-16 has been isolated from Ascaris suum.
37	str-28	F25E5.12	n/a	chrV 7,472,264	C. elegans STR-28 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
38	his-65	H02I12.7	n/a	chrIV 11,401,254	his-65 encodes an H2A histone.
39	end-1	F58E10.2	n/a	chrV 13,986,046	end-1 encodes a GATA-like transcription factor sufficient to initiate endoderm differentiation and binds to the canonical target DNA sequence WGATAR with specificity similar to GATA-1 and D4 transcription factors; its expression bypasses requirement for maternal SKN-1 and the maternal Wnt signaling pathway in endoderm formation and it activates endoderm differentiation in isolated Xenopus ectoderm.
40	K08C7.7	K08C7.7	n/a	chrIV 10,665,006	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
41	pme-2	E02H1.4	n/a	chrII 9,594,003	pme-2 encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP2 (OMIM:607725); PME-2 has a predicted C-terminal catalytic domain; PME-2 has PARP activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PME-1 is likely to be required in vivo for repairing broken DNA.
42	grsp-3	C34D4.11	n/a	chrIV 7,131,263	C. elegans GRSP-3 protein; contains similarity to Interpro domains IPR005405 (Potassium channel, voltage dependent, Kv3.4), IPR002952 (Eggshell protein), IPR003991 (Pertactin virulence factor, C-terminal), IPR000817 (Prion protein), IPR001951 (Histone H4)
43	C34F6.5	C34F6.5	n/a	chrX 11,208,547	contains similarity to Homo sapiens Histone acetyltransferase MORF beta; ENSEMBL:ENSP00000287239
44	spd-3	H34C03.1	n/a	chrIV 6,763,933	C. elegans SPD-3 protein ;
45	T27E9.6	T27E9.6	n/a	chrIII 13,475,636	contains similarity to Bradyrhizobium japonicum Bsl1006 protein.; TR:Q89VN9
46	math-23	C46F9.2	n/a	chrII 1,903,365	The C46F9.2 gene encodes a protein closely similar to C46F9.3, which has a meprin-associated Traf homology (MATH) domain and may be involved in apoptosis.
47	F41B5.6	F41B5.6	n/a	chrV 2,240,376	contains similarity to Pfam domain PF03564 Protein of unknown function (DUF1759) contains similarity to Interpro domain IPR005312 (Protein of unknown function DUF1759)
48	clec-21	T07H3.4	n/a	chrII 1,583,563	C. elegans CLEC-21 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00059 (Lectin C-type domain) (2)contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
49	F54B11.7	F54B11.7	n/a	chrX 13,600,836	contains similarity to Neurospora crassa GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).; SW:GCH1_NEUCR
50	srh-27	W05H5.4	n/a	chrII 12,449,129	C. elegans SRH-27 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)