UCSC C. elegans Gene Sorter

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

UCSC C. elegans Gene Sorter

genome assembly search

sort by display output

#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	fzy-1	ZK177.6	0	chrII 5,502,742	fzy-1 encodes an ortholog of S. cerevisiae Cdc20p that is required for the metaphase-to-anaphase transition, the deposition of extra meiotic chromosomes to polar bodies, and postembryonic vulval development; on the basis of orthology, FZY-1 is predicted to regulate anaphase-promoting complex (APC); FZY-1 protein is found in early embryonic cells at prometaphase and metaphase of mitosis and meiosis I, being localized to condensed chromosomes in prometaphase, and chromosomes on the metaphase plate during metaphase; FZY-1 binds IFY-1 and MDF-2 in yeast two-hybrid experiments; the missense fzy-1(h1983) mutation suppresses the lethal phenotype of mdf-1; fzy-1(RNAi) animals have vulval defects reflecting those seen in homozygotes for mat-3(ku233), whereas mat-3(ku233) is partly suppressed by RNAi of the fzy-1 paralog fzr-1.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	hil-6	F59A7.4	n/a	chrV 2,031,066	C. elegans HIL-6 protein; contains similarity to Pfam domain PF00538 linker histone H1 and H5 family contains similarity to Interpro domains IPR003993 (Treacher Collins syndrome, treacle), IPR011991 (Winged helix repressor DNA-binding), IPR005819 (Histone H5), IPR003882 (Pistil-specific extensin-like protein), IPR005818 (Histone H1/H5), IPR003216 (Linker histone, N-terminal)
4	F10G2.2	F10G2.2	n/a	chrV 7,331,479
5	F59E12.11	F59E12.11	n/a	chrII 5,648,707	contains similarity to Homo sapiens Isoform 1 of Loss of heterozygosity 12 chromosomal region 1 protein; ENSEMBL:ENSP00000321546
6	F52D10.2	F52D10.2	n/a	chrX 11,590,643	contains similarity to Interpro domains IPR011993 (Pleckstrin homology-type), IPR006020 (Phosphotyrosine interaction region)
7	smo-1	K12C11.2	n/a	chrI 1,340,894	C. elegans SMO-1 protein; contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
8	F21D5.2	F21D5.2	n/a	chrIV 8,729,166	contains similarity to Pfam domain PF02338 OTU-like cysteine protease contains similarity to Interpro domain IPR003323 (Ovarian tumour, otubain)
9	K07F5.12	K07F5.12	n/a	chrIV 9,856,975	contains similarity to Pfam domain PF07857 CEO family (DUF1632) contains similarity to Interpro domain IPR012435 (Protein of unknown function DUF1632)
10	tag-246	ZK1128.5	n/a	chrIII 10,121,745	ZK1128.5/tag-246 encodes an ortholog of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D (SMARCD) proteins; ZK1128.5/TAG-246 is required for full levels of LIN-3/EGF signalling during vulval development, though this effect is only visible in genetically sensitized backgrounds.
11	mcm-5	R10E4.4	n/a	chrIII 4,289,788	C. elegans MCM-5 protein; contains similarity to Pfam domain PF00493 MCM2/3/5 family contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold), IPR008048 (MCM protein 5), IPR003593 (AAA+ ATPase, core), IPR001208 (MCM)
12	sdz-30	T04D3.2	n/a	chrI 13,307,433	C. elegans SDZ-30 protein; contains similarity to Interpro domain IPR002048 (Calcium-binding EF-hand)
13	ubc-18	R01H2.6	n/a	chrIII 7,068,071	ubc-18 encodes an E2 ubiquitin-conjugating enzyme related to human UBCH7 (OMIM:603731); UBC-18 activity is required for normal growth and reproduction, and UBC-18 functions redundantly with LIN-35/Rb and other class B synthetic multivulval (SynMuv) gene products to regulate pharyngeal morphogenesis during embryonic development; ubc-18 transcripts are detected in the germline, embryos, late larval stages, and adults, suggesting that UBC-18 may function maternally to regulate several aspects of C. elegans development; the substrates of UBC-18 are not yet known.
14	nfya-1	T08D10.1	n/a	chrX 11,945,554	C. elegans NFYA-1 protein; contains similarity to Pfam domain PF02045 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B contains similarity to Interpro domain IPR001289 (CCAAT-binding transcription factor, subunit B)
15	srh-128	Y47G7B.1	n/a	chrII 2,704,344	C. elegans SRH-128 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
16	ceh-49	F17A9.6	n/a	chrV 6,119,282	ceh-49 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; CEH-49 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, CEH-49 is (somewhat distantly) affiliated with CEH-48, Drosophila ONECUT, and mammalian HNF6 proteins; CEH-49 has no obvious function in mass RNAi assays.
17	daf-8	R05D11.1	n/a	chrI 8,586,024	daf-8 encodes a Smad protein that represses dauer development, perhaps by antagonizing DAF-3 activity, and promotes a commitment to reproductive growth; genetic interactions suggest partial functional redundancy with daf-14 with respect to the TGF-beta signaling pathway that regulates dauer formation.
18	F09E5.11	F09E5.11	n/a	chrII 5,357,780	F09E5.11 encodes a divergent ortholog of S. cerevisiae VPH2/VMA12; like VPH2, F09E5.11 may be required for vacuolar proton-translocating ATPase (V-ATPase) assembly in the endoplasmic reticulum.
19	unc-71	Y37D8A.13	n/a	chrIII 12,886,268	unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva.
20	xbx-5	T24A11.2	n/a	chrIII 3,803,450	C. elegans XBX-5 protein ;
21	R05D11.5	R05D11.5	n/a	chrI 8,592,502	contains similarity to Pfam domain PF05620 Protein of unknown function (DUF788) contains similarity to Interpro domain IPR008506 (Protein of unknown function DUF788)
22	hda-3	R06C1.1	n/a	chrI 11,915,408	hda-3 encodes a member of the histone deacetylase family most similar to human histone deacetylase 1 (HD1) that affects radiation sensitivity.
23	T11B7.1	T11B7.1	n/a	chrIV 8,841,747	contains similarity to Mus musculus Girdin (Girders of actin filament) (Coiled-coil domain-containingsprotein 88A) (Akt phosphorylation enhancer) (APE) (Hook-relatedsprotein 1) (HkRP1) (G alpha-interacting vesicle-associated protein)s(GIV).; SW:Q5SNZ0
24	C18E3.2	C18E3.2	n/a	chrI 4,211,756	The C18E3.2 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; C18E3.2 is probably required during mitosis of the T cells for asymmetric cell division.
25	Y106G6H.9	Y106G6H.9	n/a	chrI 10,455,014	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
26	asna-1	ZK637.5	n/a	chrIII 8,895,772	asna-1 encodes a putative membrane transporter that is required, non-cell-autonomously, for L1 larvae to proceed through development when fed, and is also required for normal insulin (DAF-28) secretion; the human ASNA1 ortholog stimulates insulin secretion in pancreatic beta cells, and can transgenically rescue asna-1 mutant C. elegans, suggesting that ASNA-1's function is conserved among metazoa; asna-1 mutants only progress to adulthood when rescued by maternal ASNA-1; without maternal rescue, asna-1 mutants eat food and endocytose nutrients normally, but nevertheless arrest growth as L1 larvae and localize DAF-16 to the nucleus as if food were absent; asna-1 is expressed in some sensory neurons, in insulin-producing intestinal cells, and in hypodermis; ASNA-1 positively regulates dauer exit in the same way that overexpression of the insulins DAF-28 or INS-4 does, and requires DAF-28 to do this efficiently; ASNA-1 has ATPase activity in vitro, and this activity is required for transgenic rescue of asna-1 mutations.
27	B0304.2	B0304.2	n/a	chrII 4,524,073
28	pri-2	W02D9.1	n/a	chrI 12,530,247	pri-2 encodes a homolog of the DNA polymerase alpha-primase subunit C that is required in embryos for the normal timing of embryonic cell divisions (much as DIV-1 is) and for normal mitosis in the germline.
29	C27A12.6	C27A12.6	n/a	chrI 6,054,583	contains similarity to Pfam domain PF01485 IBR domain contains similarity to Interpro domains IPR009060 (UBA-like), IPR002867 (Zinc finger, C6HC-type)
30	F29G9.7	F29G9.7	n/a	chrV 6,036,359	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
31	lsm-4	F32A5.7	n/a	chrII 7,252,636	C. elegans LSM-4 protein; contains similarity to Pfam domain PF01423 LSM domain contains similarity to Interpro domains IPR001163 (Like-Sm ribonucleoprotein, core), IPR006649 (Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core), IPR010920 (Like-Sm ribonucleoprotein-related, core)
32	T21C9.1	T21C9.1	n/a	chrV 10,577,614	contains similarity to Pfam domain PF00595 PDZ domain (Also known as DHR or GLGF) contains similarity to Interpro domain IPR001478 (PDZ/DHR/GLGF)
33	his-38	K03A1.6	n/a	chrX 7,309,668	his-38 encodes an H4 histone; by homology, HIS-38 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-38 is a replication-dependent histone locus that does not reside in a cluster, but exists as a single histone locus on the X chromosome.
34	arl-5	ZK632.8	n/a	chrIII 9,823,591	arl-5 encodes a paralog of the ADP-ribosylation factor-like protein EVL-20; ARL-5 is an ortholog of mammalian ARL5.
35	glr-7	C43H6.9	n/a	chrX 2,415,895	glr-7 encodes a protein containing a ligand-gated ion channel domain and is a predicted non-NMDA type ionotropic glutamate receptor; expressed in the pharyngeal nervous system.
36	div-1	R01H10.1	n/a	chrIII 10,246,876	div-1 encodes a homolog of the B subunit of the DNA polymerase alpha-primase complex; DIV-1 is required in embryos for the normal timing of interphase in cell divisions, and for the asymmetric distribution of PIE-1 and P granules.
37	R07E5.3	R07E5.3	n/a	chrIII 4,405,506	The R07E5.3 gene encodes a homolog of SNF5/Ini1, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; R07E5.3 may be involved in asymmetric cell division of the T cells.
38	T14B4.3	T14B4.3	n/a	chrII 6,735,442	contains similarity to Interpro domain IPR012493 (Renin receptor-like)
39	F01G10.10	F01G10.10	n/a	chrIV 10,247,944	contains similarity to Pfam domains PF02886 (LBP / BPI / CETP family, C-terminal domain) , PF01273 (LBP / BPI / CETP family, N-terminal domain) contains similarity to Interpro domain IPR001124 (Lipid-binding serum glycoprotein)
40	F08B4.5	F08B4.5	n/a	chrIV 8,684,532	contains similarity to Pfam domain PF04042 DNA polymerase alpha/epsilon subunit B contains similarity to Interpro domains IPR016266 (DNA polymerase epsilon, subunit B), IPR007185 (DNA polymerase alpha/epsilon, subunit B)
41	hcp-3	F58A4.3	n/a	chrIII 9,615,787	The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
42	F42G8.6	F42G8.6	n/a	chrIV 8,131,368	contains similarity to Pfam domains PF05237 (MoeZ/MoeB domain) , PF00581 (Rhodanese-like domain) , PF00899 (ThiF family) contains similarity to Interpro domains IPR001763 (Rhodanese-like), IPR003016 (2-oxo acid dehydrogenase, lipoyl-binding site), IPR009036 (Molybdenum cofactor biosynthesis), IPR000594 (UBA/THIF-type NAD/FAD binding fold), IPR007901 (MoeZ/MoeB), IPR016040 (NAD(P)-binding)
43	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
44	adbp-1	VW02B12L.4	n/a	chrII 11,444,624	C. elegans ADBP-1 protein ;
45	cht-1	C04F6.3	n/a	chrX 3,398,895	cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency); CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates; in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism.
46	ZK1010.3	ZK1010.3	n/a	chrIII 12,979,542	contains similarity to Pfam domain PF06229 FRG1-like family contains similarity to Interpro domains IPR010414 (FRG1-like), IPR008999 (Actin-crosslinking proteins)
47	T24G10.2	T24G10.2	n/a	chrIII 5,441,718	contains similarity to Pfam domain PF02201 SWIB/MDM2 domain contains similarity to Interpro domain IPR003121 (SWIB/MDM2)
48	dsh-2	C27A2.6	n/a	chrII 5,079,682	dsh-2 encodes a protein containing a DIX domain, a DEP domain, and a PDZ domain that is required for embryonic viability and functions in Wnt pathway signaling between the embryonic blastomeres P2 and EMS with respect to endoderm specification and to orient the division axis of the EMS cell; expressed from the four-cell embryo stage, and is primarily associated with membranes.
49	cpf-2	F56A8.6	n/a	chrIII 13,267,824	C. elegans CPF-2 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR003954 (RNA recognition, region 1), IPR000504 (RNA recognition motif, RNP-1)
50	srs-1	W03B1.4	n/a	chrIV 4,358,749	srs-1 encodes a predicted mitochondrial seryl-tRNA synthetase (SerRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of serine to its cognate tRNA and is thus required for protein biosynthesis; in C. elegans, SRS-1 activity is required for normal postembryonic morphology and rates of growth.