UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ZK1098.7	ZK1098.7	3e-73	chrIII 9,523,311	contains similarity to Drosophila melanogaster Flybase gene name is mRpS23-PA;; FLYBASE:CG31842
2	mel-46	T06A10.1	n/a	chrIV 16,859,204	C. elegans MEL-46 protein; contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
3	B0464.2	B0464.2	n/a	chrIII 9,494,244	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (3), PF00515 (Tetratricopeptide repeat) (8)contains similarity to Interpro domains IPR001440 (Tetratricopeptide TPR-1), IPR011990 (Tetratricopeptide-like helical), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region), IPR008940 (Protein prenyltransferase)
4	lbp-5	W02D3.7	n/a	chrI 6,731,777	lbp-5 encodes a predicted intracellular fatty acid binding protein (iFABP) that is most similar to the vertebrate muscle and heart FABPs; by homology, LBP-5 is predicted to function as an intracellular transporter for small hydrophobic molecules such as lipids and steroid hormones; loss of lbp-5 activity via large-scale RNAi screens indicates that, in C. elegans, LBP-5 is required for movement.
5	K11B4.1	K11B4.1	n/a	chrI 14,796,015	contains similarity to Interpro domain IPR007110 (Immunoglobulin-like)
6	ers-3	T07A9.2	n/a	chrIV 389,575	ers-3 encodes a a glutamine (E)/glutaminyl (Q) tRNA synthetase.
7	C45B2.6	C45B2.6	n/a	chrX 6,055,182	contains similarity to Pfam domains PF01734 (Patatin-like phospholipase) , PF00023 (Ankyrin repeat) (3)contains similarity to Interpro domains IPR016035 (Acyl transferase/acyl hydrolase/lysophospholipase), IPR002641 (Patatin), IPR002110 (Ankyrin)
8	Y48A6C.4	Y48A6C.4	n/a	chrIII 11,121,345	Y48A6C.4 encodes an ortholog of S. cerevisiae IPI1 that may suppress tumorous growth in the germline; like PRO-1, -2, and -3, Y48A6C.4 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline.
9	nol-10	F32E10.1	n/a	chrIV 7,582,143	C. elegans NOL-10 protein; contains similarity to Pfam domain PF08159 NUC153 domain contains similarity to Interpro domains IPR012580 (NUC153), IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
10	K08F11.5	K08F11.5	n/a	chrIV 4,714,405	contains similarity to Pfam domains PF08356 (EF hand associated) , PF08355 (EF hand associated) , PF00071 (Ras family) , PF00036 (EF hand) (2), PF08477 (Miro-like protein) (2)contains similarity to Interpro domains IPR013566 (EF hand associated, type-1), IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras), IPR006689 (ARF/SAR superfamily), IPR013567 (EF hand associated, type-2)
11	H19N07.1	H19N07.1	n/a	chrV 11,111,736	contains similarity to Pfam domains PF03143 (Elongation factor Tu C-terminal domain) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR004160 (Translation elongation factor EFTu/EF1A, C-terminal), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009001 (Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)
12	pfd-3	T06G6.9	n/a	chrI 12,729,010	pfd-3 encodes a putative prefoldin, orthologous to human VBP1 (OMIM:300133), that is required for normal alpha-tubulin synthesis, microtubule growth, mitotic spindle formation and positioning, early embryonic cell division, and embryonic and larval viability; PFD-3 is expressed cytoplasmically in most, if not all, tissues.
13	Y32B12B.2	Y32B12B.2	n/a	chrV 16,544,097	contains similarity to Vitis vinifera Putative uncharacterized protein.; TR:A5AD22
14	K05C4.5	K05C4.5	n/a	chrI 14,745,264	contains similarity to Interpro domains IPR015943 (WD40/YVTN repeat-like), IPR011044 (Quinoprotein amine dehydrogenase, beta chain-like)
15	vha-2	R10E11.2	n/a	chrIII 9,782,355	vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus.
16	C23G10.8	C23G10.8	n/a	chrIII 6,204,357	contains similarity to Homo sapiens Conserved hypothetical protein; VG:OTTHUMP00000076919
17	scpl-4	T21C9.12	n/a	chrV 10,600,600	scpl-4 encodes an ortholog of budding yeast TIM50 and human TIMM50 (OMIM:607381); by orthology, SCPL-4 is expected to be part of the mitochondrial inner membrane protein translocase; SCPL-4 is required for embryonic development and fertility in mass RNAi assays; SCPL-4 is distantly similar to FCP-1 and SCPL-1, -2, and -3.
18	abcf-1	F18E2.2	n/a	chrV 12,762,189	C. elegans ABCF-1 protein; contains similarity to Pfam domain PF00005 ABC transporter contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR003593 (AAA+ ATPase, core)
19	B0334.5	B0334.5	n/a	chrII 11,498,118	contains similarity to Interpro domain IPR008949 (Terpenoid synthase)
20	F49C12.9	F49C12.9	n/a	chrIV 9,315,482	contains similarity to Pfam domain PF00627 UBA/TS-N domain contains similarity to Interpro domains IPR009060 (UBA-like), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)
21	tag-345	F55F8.5	n/a	chrI 5,656,990	C. elegans TAG-345 protein; contains similarity to Pfam domains PF08154 (NLE (NUC135) domain) , PF00400 (WD domain, G-beta repeat) (4)contains similarity to Interpro domains IPR012972 (NLE), IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
22	srx-105	F40H7.8	n/a	chrII 3,700,613	C. elegans SRX-105 protein ;
23	C18D11.3	C18D11.3	n/a	chrIII 11,823,825	contains similarity to Homo sapiens Transcription factor MLL UPN95022; TR:Q86YN8
24	D2013.6	D2013.6	n/a	chrII 9,330,348	contains similarity to Pfam domain PF02893 GRAM domain contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR004182 (GRAM)
25	tag-231	ZK430.2	n/a	chrII 4,421,285	C. elegans TAG-231 protein; contains similarity to Pfam domain PF00459 Inositol monophosphatase family contains similarity to Interpro domains IPR000760 (Inositol monophosphatase), IPR000146 (Inositol phosphatase/fructose-1,6-bisphosphatase)
26	prx-19	F54F2.8	n/a	chrIII 8,808,467	prx-19 is orthologous to the human gene PEROXISOMAL FARNESYLATED PROTEIN (PXF; OMIM:600279), which when mutated leads to peroxisome biogenesis (Zellweger) syndrome of complementation group J.
27	F36G3.2	F36G3.2	n/a	chrX 9,793,271	contains similarity to Pfam domain PF00583 Acetyltransferase (GNAT) family contains similarity to Interpro domains IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
28	oxi-1	Y39A1C.2	n/a	chrIII 10,862,495	C. elegans OXI-1 protein; contains similarity to Pfam domain PF00632 HECT-domain (ubiquitin-transferase) contains similarity to Interpro domain IPR000569 (HECT)
29	ppk-3	VF11C1L.1	n/a	chrX 12,972,222	C. elegans PPK-3 protein; contains similarity to Pfam domains PF01504 (Phosphatidylinositol-4-phosphate 5-Kinase) , PF01363 (FYVE zinc finger) contains similarity to Interpro domains IPR000306 (Zinc finger, FYVE-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002498 (Phosphatidylinositol-4-phosphate 5-kinase, core), IPR016034 (Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup), IPR002423 (Chaperonin Cpn60/TCP-1), IPR017455 (Zinc finger, FYVE-related), IPR011011 (Zinc finger, FYVE/PHD-type)
30	R02D3.1	R02D3.1	n/a	chrIV 248,522	The R02D3.1 gene encodes an ortholog of the human gene ALPHA-AMINOADIPATE SEMIALDEHYDE SYNTHASE (AASS; OMIM:605113), which when mutated leads to hyperlysinemia (OMIM:238700).
31	C44B7.11	C44B7.11	n/a	chrII 6,895,805	contains similarity to Pfam domain PF04389 Peptidase family M28 contains similarity to Interpro domain IPR007484 (Peptidase M28)
32	E04A4.5	E04A4.5	n/a	chrIV 4,744,928	contains similarity to Pfam domain PF02466 Tim17/Tim22/Tim23 family contains similarity to Interpro domains IPR005678 (Mitochondrial import inner membrane translocase, subunit Tim17), IPR003397 (Mitochondrial import inner membrane translocase, subunit Tim17/22)
33	F59A3.3	F59A3.3	n/a	chrI 5,506,231	contains similarity to Pfam domain PF00467 KOW motif contains similarity to Interpro domains IPR005825 (Ribosomal protein L24/L26, conserved site), IPR008991 (Translation protein SH3-like), IPR005824 (KOW), IPR003256 (Ribosomal protein L24)
34	K10D11.6	K10D11.6	n/a	chrIV 12,988,061	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
35	ruvb-1	C27H6.2	n/a	chrV 9,979,753	C. elegans RUVB-1 protein; contains similarity to Pfam domain PF06068 TIP49 C-terminus contains similarity to Interpro domains IPR010339 (TIP49, C-terminal), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal)
36	abu-11	T01D1.6	n/a	chrII 193,544	abu-11 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-11 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-11 may help protect the organism from damage by improperly folded nascent protein.
37	T01E8.6	T01E8.6	n/a	chrII 10,241,373	contains similarity to Pfam domain PF00253 Ribosomal protein S14p/S29e contains similarity to Interpro domain IPR001209 (Ribosomal protein S14)
38	nst-1	K01C8.9	n/a	chrII 8,281,963	nst-1 encodes a homolog of human GNL3 (OMIM:608011, nucleostemin) and GNL3L, and of S. cerevisiae NUG1; NST-1 may suppress tumorous growth in the germline; like PRO-1, -2, and -3, NST-1 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline; nucleostemin is a nucleolar protein found in stem cells that is required in quantitatively correct amounts (neither too little nor too much) for continued cell division and survival by stem cells or transformed cells; NST-1 is required in mass RNAi assays for normally rapid growth, larval viability, and normal body morphology and pigmentation.
39	spt-5	K08E4.1	n/a	chrIV 12,053,606	C. elegans SPT-5 protein; contains similarity to Pfam domains PF03439 (Supt5 repeat) (2), PF00467 (KOW motif) contains similarity to Interpro domains IPR005100 (Supt5 repeat), IPR008991 (Translation protein SH3-like), IPR003257 (Transcription antitermination protein, NusG, archaea), IPR005824 (KOW), IPR017071 (Transcription elongation factor Spt5), IPR006645 (Transcription antitermination protein, NusG, N-terminal)
40	dog-1	F33H2.1	n/a	chrI 15,020,116	dog-1 encodes a predicted DEAH helicase, orthologous to the human BRCA1-binding protein BACH1 (OMIM:605882, mutated in early-onset breast cancer); DOG-1 is required for maintenance of polyguanine tracts of germline and somatic DNA, and is proposed to resolve the secondary structure that can occur in guanine-rich DNA during lagging-strand DNA synthesis.
41	F20G2.1	F20G2.1	n/a	chrV 13,752,929	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
42	rpb-2	C26E6.4	n/a	chrIII 4,941,947	C. elegans RPB-2 protein; contains similarity to Pfam domains PF04566 (RNA polymerase Rpb2, domain 4) , PF04561 (RNA polymerase Rpb2, domain 2) , PF04567 (RNA polymerase Rpb2, domain 5) , PF04565 (RNA polymerase Rpb2, domain 3) , PF00562 (RNA polymerase Rpb2, domain 6) , PF04560 (RNA polymerase Rpb2, domain 7) , PF04563 (RNA polymerase beta subunit) contains similarity to Interpro domains IPR007120 (DNA-directed RNA polymerase, subunit 2, domain 6), IPR007641 (RNA polymerase Rpb2, domain 7), IPR007644 (RNA polymerase, beta subunit, protrusion), IPR015712 (DNA-directed RNA polymerase, subunit 2), IPR007645 (RNA polymerase Rpb2, domain 3), IPR007642 (RNA polymerase Rpb2, domain 2), IPR014724 (RNA polymerase Rpb2, OB-fold), IPR007646 (RNA polymerase Rpb2, domain 4), IPR007647 (RNA polymerase Rpb2, domain 5), IPR007121 (RNA polymerase, beta subunit, conserved site)
43	gly-13	B0416.6	n/a	chrX 9,295,081	gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates; gly-13 is expressed throughout development in many cell types; gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14.
44	acl-8	T05H4.1	n/a	chrV 6,451,547	C. elegans ACL-8 protein; contains similarity to Pfam domain PF01553 Acyltransferase contains similarity to Interpro domain IPR002123 (Phospholipid/glycerol acyltransferase)
45	cyp-13A11	F14F7.2	n/a	chrIII 13,022,359	C. elegans CYP-13A11 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
46	T20B12.3	T20B12.3	n/a	chrIII 7,382,935	contains similarity to Pfam domain PF03914 CBF/Mak21 family contains similarity to Interpro domain IPR005612 (CBF)
47	dnj-11	F38A5.13	n/a	chrIV 6,587,011	This gene encodes a protein containing a DnaJ ('J') domain.
48	W03F9.10	W03F9.10	n/a	chrV 129,988	contains similarity to Pfam domains PF04046 (PSP) , PF04037 (Domain of unknown function (DUF382)) contains similarity to Interpro domains IPR006568 (PSP, proline-rich), IPR007180 (Protein of unknown function DUF382)
49	M03C11.8	M03C11.8	n/a	chrIII 10,432,042	contains similarity to Pfam domains PF00271 (Helicase conserved C-terminal domain) , PF00176 (SNF2 family N-terminal domain) contains similarity to Interpro domains IPR002048 (Calcium-binding EF-hand), IPR000330 (SNF2-related), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
50	T08A11.2	T08A11.2	n/a	chrIII 4,266,506	T08A11.2 encodes the C. elegans ortholog of splicing factor 3b subunit 1, also known as SAP155; by homology, the product of T08A11.2 is predicted to be a component of the U2 snRNP that is required for pre-mRNA splicing; large-scale RNAi assays indicate that T08A11.2 activity is essential for a number of processes including embryonic development, normal adult lifespan, vulval morphogenesis, locomotion, and transgene expression and localization.