UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ZK1067.3	ZK1067.3	0	chrII 9,224,144	contains similarity to Mus musculus Serine/threonine-protein kinase Nek9 (EC 2.7.1.37) (NimA-relatedsprotein kinase 9).; SW:NEK9_MOUSE
2	D1043.1	D1043.1	n/a	chrII 11,585,601	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
3	C48B4.10	C48B4.10	n/a	chrIII 9,563,945	contains similarity to Homo sapiens Transmembrane 9 superfamily protein member 2 precursor; ENSEMBL:ENSP00000245361
4	K06H7.7	K06H7.7	n/a	chrIII 8,084,529
5	W02D9.3	W02D9.3	n/a	chrI 12,536,484	contains similarity to Pfam domain PF00505 HMG (high mobility group) box contains similarity to Interpro domains IPR000910 (High mobility group box, HMG1/HMG2), IPR009071 (High mobility group box, HMG)
6	mrp-4	F21G4.2	n/a	chrX 9,886,947	mrp-4 encodes a putative member of subfamily C of the ATP-binding cassette transporters; MRP-4 is required, redundantly with its paralog WHT-2, for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; hermaphrodites subjected to double wht-2(RNAi) mrp-4(RNAi) are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them; in mammalian eicosanoid signalling, subfamily C ABC transporters are required for PUFA and eicosanoid transport.
7	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
8	T01B7.6	T01B7.6	n/a	chrII 8,723,943	contains similarity to Interpro domain IPR000694 (Proline-rich region)
9	sna-2	T13F2.7	n/a	chrIV 9,776,092	sna-2 encodes an snRNP-binding protein (SNA-2/SL75p) homologous to Ascaris SL95p (SL 175kd); SNA-2 is found in at least two Sm snRNPs, SL1 and Y, but not in SL2; in snRNP SL1, SNA-2 associates with the SNA-1/SL21p protein, while associating with SUT-1/SL26p (a paralog of SNA-1) in snRNP Y; sna-2(RNAi) is lethal; SNA-2 can bind either SNA-1 or SUT-1 even in the absence of RNA.
10	C01G10.7	C01G10.7	n/a	chrV 15,086,381	contains similarity to Pfam domain PF03328 HpcH/HpaI aldolase/citrate lyase family contains similarity to Interpro domains IPR011206 (Citrate lyase, beta subunit), IPR005000 (HpcH/HpaI aldolase), IPR015813 (Pyruvate/Phosphoenolpyruvate kinase, catalytic core)
11	K02B12.5	K02B12.5	n/a	chrI 8,522,044	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domains IPR002110 (Ankyrin), IPR013026 (Tetratricopeptide region)
12	apc-2	K06H7.6	n/a	chrIII 8,082,080	apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC, a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae's Apc2p have 32% identity in their cullin domains (considered crucial for function), but otherwise share no obvious similarity; inactivating apc-2 with RNAi causes embryos to arrest at the meiotic one-cell stage, implying that APC-2 is required for the metaphase-to-anaphase transition of meiosis I; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16, cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphic alleles, APC-2 is likely to be required for asymmetrical segregation of cell fate determinants in two-cell embryos.
13	cutc-1	ZK353.7	n/a	chrIII 8,402,774	C. elegans CUTC-1 protein; contains similarity to Pfam domain PF03932 CutC family contains similarity to Interpro domain IPR005627 (CutC)
14	ZK1058.3	ZK1058.3	n/a	chrIII 3,919,762	ZK1058.3 is orthologous to the human gene UNNAMED PROTEIN PRODUCT (GALT; OMIM:606999), which when mutated leads to disease.
15	xpg-1	F57B10.6	n/a	chrI 6,560,500	F57B10.6 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 5 (XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G (COCKAYNE SYNDROME)) (ERCC5; OMIM:133530), which when mutated leads to disease.
16	stl-1	F30A10.5	n/a	chrI 9,487,412	C. elegans STL-1 protein; contains similarity to Pfam domain PF01145 SPFH domain / Band 7 family contains similarity to Interpro domains IPR001107 (Band 7 protein), IPR001972 (Stomatin)
17	htp-1	F41H10.10	n/a	chrIV 5,390,947	C. elegans HTP-1 protein; contains similarity to Pfam domain PF02301 HORMA domain contains similarity to Interpro domain IPR003511 (DNA-binding HORMA)
18	F31C3.4	F31C3.4	n/a	chrI 15,051,595	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
19	rpa-1	F18A1.5	n/a	chrII 7,665,772	rpa-1 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, RPA-1 is predicted to function as a DNA-binding and oligonucleotide oligosaccharide-binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that rpa-1 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that rpa-1 transcripts are expressed in germ cells.
20	C48E7.2	C48E7.2	n/a	chrI 6,256,337	contains similarity to Pfam domains PF08221 (RNA polymerase III subunit RPC82 helix-turn-helix domain) , PF05645 (RNA polymerase III subunit RPC82) contains similarity to Interpro domains IPR013197 (RNA polymerase III subunit RPC82-related, helix-turn-helix), IPR008806 (RNA polymerase III Rpc82, C -terminal)
21	R07E5.1	R07E5.1	n/a	chrIII 4,410,321	contains similarity to Pfam domains PF07713 (Protein of unknown function (DUF1604)) , PF01585 (G-patch domain) contains similarity to Interpro domains IPR011666 (Protein of unknown function DUF1604), IPR000467 (D111/G-patch), IPR005398 (Tubby, N-terminal)
22	cyn-7	Y75B12B.2	n/a	chrV 15,186,997	cyn-7 encodes a cyclophilin A isoform; while not tested for peptidyl-prolyl isomerase activity in vitro, it is very similar to CYN-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYN-7 was required for embryonic viability in one set of mass RNAi assays.
23	F11A10.5	F11A10.5	n/a	chrIV 12,095,498	contains similarity to Pfam domain PF04184 ST7 protein contains similarity to Interpro domain IPR007311 (ST7)
24	ehbp-1	F25B3.1	n/a	chrV 9,553,309	C. elegans EHBP-1 protein; contains similarity to Pfam domain PF00307 Calponin homology (CH) domain contains similarity to Interpro domains IPR016146 (Calponin-homology), IPR001715 (Calponin-like actin-binding)
25	C34B7.2	C34B7.2	n/a	chrI 8,339,396	contains similarity to Pfam domain PF02383 SacI homology domain contains similarity to Interpro domain IPR002013 (Synaptojanin, N-terminal)
26	sid-1	C04F5.1	n/a	chrV 5,123,427	The sid-1 gene encodes a predicted transmembrane protein with conserved human (OMIM:606816) and mouse homologs of unknown function and is required cell autonomously for systemic RNA interference (RNAi); a SID-1::GFP fusion is enriched at the cell periphery of most nonneuronal cells from late embryogenesis through adulthood with highest levels detected in cells exposed to the environment.
27	C27A2.1	C27A2.1	n/a	chrII 5,064,604	contains similarity to Pfam domain PF02463 RecF/RecN/SMC N terminal domain contains similarity to Interpro domain IPR003395 (RecF/RecN/SMC protein, N-terminal)
28	C35D10.10	C35D10.10	n/a	chrIII 4,861,200	contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR013766 (Thioredoxin domain)
29	cdd-2	F49E8.4	n/a	chrIV 7,547,502	A functional cytidine deaminase that affects morphology of embryos; it is expressed at all life cycle stages.
30	K02B2.1	K02B2.1	n/a	chrIV 5,942,943	contains similarity to Pfam domains PF01591 (6-phosphofructo-2-kinase) , PF00300 (Phosphoglycerate mutase family) contains similarity to Interpro domains IPR016260 (Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase), IPR001345 (Phosphoglycerate/bisphosphoglycerate mutase), IPR003094 (Fructose-2,6-bisphosphatase), IPR013079 (6-phosphofructo-2-kinase), IPR013078 (Phosphoglycerate mutase)
31	msh-2	H26D21.2	n/a	chrI 3,695,931	The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).
32	B0024.4	B0024.4	n/a	chrV 10,298,103	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
33	bath-4	F52C6.8	n/a	chrII 1,917,377	C. elegans BATH-4 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
34	R02D3.7	R02D3.7	n/a	chrIV 254,500	contains similarity to Interpro domains IPR009060 (UBA-like), IPR015880 (Zinc finger, C2H2-like)
35	C27A12.9	C27A12.9	n/a	chrI 6,064,908	contains similarity to Pfam domain PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase contains similarity to Interpro domains IPR017849 (Alkaline phosphatase-like, alpha/beta/alpha), IPR002591 (Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase), IPR017850 (Alkaline-phosphatase-like, core domain)
36	H14A12.3	H14A12.3	n/a	chrIII 7,464,450	H14A12.3 encodes an ortholog of S. cerevisiae RAV2; like RAV2, H14A12.3 may be required for the reassociation of vacuolar proton-translocating ATPase (V-ATPase) after temporary glucose starvation.
37	brc-1	C36A4.8	n/a	chrIII 3,858,030	brc-1 encodes an ortholog of human BRCA1 (OMIM:113705, mutated in early onset breast and ovarian cancer) required for double-strand break repair via inter-sister recombination during meiosis; BRC-1 forms a heterodimer with BRD-1, which constitutes an E3 ubiquitin ligase; after irradiation, the DNA checkpoint proteins ATL-1 and MRE-11 are required for BRC-1/BRD-1 heterodimers to associate with RAD-51 and LET-70/Ubc5, and to ubiquitylate damaged chromatin; brc-1(RNAi) animals have excess chromosomal nondisjunction, abnormally high levels of CEP-1-dependent germ cell apoptosis (both with and without gamma-irradiation) and hypersensitivity to gamma-irradiation (e.g., abnormal sterility after irradiation); BRC-1 and BRD-1 bind one another, probably through their N-terminal RING domains, in yeast two-hybrid experiments and pull-down assays; BRC-1/BRD-1 heterodimers may interact with RAD-51 and other proteins via mutual binding to UBC-9; brc-1 is genetically dispensable for the induction of nuclear ATL-1 foci by gamma-irradiation or hydroxyurea.
38	zfp-2	F35H8.3	n/a	chrII 9,558,501	zfp-2 encodes a zinc-finger transcription factor; loss of zfp-2 and lin-35/Rb results in almost complete sterility accompanied by defects in somatic gonad development and vulval morphology, as well as polyploidization of somatic cell nuclei; loss of zfp-2 activity by itself reveals that zfp-2 is also required for cosuppression, inhibition of RNAi of some genes, and wild-type levels of expression of a rol-6 extrachromosomal array; a zfp-2::GFP promoter fusion construct is expressed in vulval cells and all somatic gonad structures, such as the spermatheca, sheath cells, uterine cells and distal tip cells (DTCs).
39	C27A12.2	C27A12.2	n/a	chrI 6,043,841	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
40	cdc-25.1	K06A5.7	n/a	chrI 6,470,859	cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3.
41	Y102A5C.4	Y102A5C.4	n/a	chrV 16,923,224	contains similarity to Pfam domain PF05075 Protein of unknown function (DUF684) contains similarity to Interpro domain IPR007767 (Protein of unknown function DUF684)
42	bath-3	F59H6.10	n/a	chrII 2,029,895	C. elegans BATH-3 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
43	F43G9.10	F43G9.10	n/a	chrI 8,639,367	contains similarity to Pfam domain PF06991 Micro-fibrillar-associated protein 1 C-terminus contains similarity to Interpro domains IPR009730 (Micro-fibrillar-associated 1, C-terminal), IPR000533 (Tropomyosin)
44	F58G11.6	F58G11.6	n/a	chrV 13,680,190	F58G11.6 (also known as ccz-1 or hps-4) encodes an ortholog of human C7orf28A and C7orf28B, with more distant similarity to human HPS4 (OMIM:606682) and S. cerevisiae Ccz1p in its N-terminal CHiPS domain; the CHiPS domain of F58G11.6 is predicted to have a longin-like fold; by analogy with Ccz1p and C. elegans SAND-1, F58G11.6 might be required for normal (RAB-7-mediated) traffic between early and late endosomes, or for autophagy; F58G11.6 is bound by SAND-1.
45	M01G5.1	M01G5.1	n/a	chrIII 1,503,267	contains similarity to Homo sapiens hypothetical protein; VG:OTTHUMP00000024537
46	F19F10.10	F19F10.10	n/a	chrV 7,579,007	F19F10.10 encodes a protein with a THAP or THAP-like domain; other proteins with such domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1.
47	tbg-1	F58A4.8	n/a	chrIII 9,627,816	tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes.
48	F29G9.7	F29G9.7	n/a	chrV 6,036,359	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
49	K04G2.6	K04G2.6	n/a	chrI 8,041,954	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR000357 (HEAT), IPR016024 (Armadillo-type fold)
50	npp-14	C03D6.4	n/a	chrI 9,662,535	npp-14 is orthologous to the human gene NUCLEOPORIN, 214-KD (NUP214; OMIM:114350), which encodes part of the nucleopore complex mediating nucleocytoplasmic transport; NUP214, as a fusion gene with DEK (OMIM:125264), is found in a subset of acute myeloid leukemia.