UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	nit-1	ZK1058.6	2e-178	chrIII 3,923,096	C. elegans NIT-1 protein; contains similarity to Pfam domain PF00795 Carbon-nitrogen hydrolase contains similarity to Interpro domains IPR003010 (Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase), IPR000132 (Nitrilase/cyanide hydratase, conserved site)
2	C54G6.2	C54G6.2	n/a	chrI 1,007,329	The C54G6.2 gene encodes a homolog of human RP2, which when mutated leads to X-linked retinitis pigmentosa 2 (OMIM:312600).
3	Y43E12A.2	Y43E12A.2	n/a	chrIV 10,983,505	contains similarity to Interpro domain IPR001878 (Zinc finger, CCHC-type)
4	ZK1067.4	ZK1067.4	n/a	chrII 9,211,645	ZK1067.4 is orthologous to the human gene PROTEOLIPID PROTEIN 1 (PLP1; OMIM:300401), encoding the primary constituent of myelin, which when mutated leads to Pelizaeus-Merzbacher disease (OMIM:312080).
5	F55A4.2	F55A4.2	n/a	chrX 1,015,147
6	sru-24	F31F4.13	n/a	chrV 669,671	C. elegans SRU-24 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domains IPR003839 (Protein of unknown function DUF215), IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
7	nep-2	T05A8.4	n/a	chrII 2,721,578	T05A8.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; while T05A8.4 is an ortholog of mammalian neutral endopeptidase (NEP), expressed on the brush-border membranes of kidney; more generally, T05A8.4 falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes).
8	F40F4.7	F40F4.7	n/a	chrX 3,244,931	contains similarity to Pfam domain PF00583 Acetyltransferase (GNAT) family contains similarity to Interpro domains IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
9	C52B9.8	C52B9.8	n/a	chrX 4,300,505	contains similarity to Pfam domains PF00271 (Helicase conserved C-terminal domain) , PF07529 (HSA) , PF04851 (Type III restriction enzyme, res subunit) , PF00176 (SNF2 family N-terminal domain) contains similarity to Interpro domains IPR006935 (Restriction endonuclease, type I, R subunit/Type III, Res subunit), IPR013999 (HAS subgroup), IPR014012 (Helicase/SANT-associated, DNA binding), IPR000330 (SNF2-related), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR006562 (HSA), IPR005448 (Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
10	ZK262.3	ZK262.3	n/a	chrV 18,415,571	contains similarity to Pfam domain PF01764 Lipase (class 3) contains similarity to Interpro domains IPR002921 (Lipase, class 3), IPR008262 (Lipase, active site)
11	R05D7.4	R05D7.4	n/a	chrI 12,182,156	contains similarity to Pfam domains PF07819 (PGAP1-like protein) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR012908 (PGAP1-like), IPR000639 (Epoxide hydrolase-like), IPR008262 (Lipase, active site), IPR003089 (Alpha/beta hydrolase)
12	cav-2	C56A3.7	n/a	chrV 13,558,462	cav-2 encodes one of two C. elegans proteins related to caveolins, integral transmembrane proteins that are believed to function in regulation of signal transduction and that are the major component of caveolae, specialized lipid rafts found in the plasma membrane of most cell types; as loss of cav-2 function via large-scale RNA-mediated interference (RNAi) screens does not result in any obvious abnormalities, the role of cav-2 in C. elegans development and/or behavior is not yet known; cav-2 mRNA is expressed in eggs and mixed stage populations.
13	K03H6.1	K03H6.1	n/a	chrIV 1,525,035	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
14	lgc-4	F18G5.4	n/a	chrX 9,238,639	C. elegans LGC-4 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002394 (Nicotinic acetylcholine receptor, N-terminal), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
15	R10E4.3	R10E4.3	n/a	chrIII 4,286,638	contains similarity to Saccharomyces cerevisiae Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; also involved in the translocation of macromolecules between the nucleoplasm and the NPC; SGD:YIL149C
16	tag-96	M01D7.4	n/a	chrI 1,847,837	tag-96 encodes a galactokinase that is a member of the GHMP family of kinases and closely related to the vertebrate galactokinase 2 (GALK2) carbohydrate kinases.
17	D2023.3	D2023.3	n/a	chrV 11,804,015	contains similarity to Pfam domain PF00168 C2 domain contains similarity to Interpro domains IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR000008 (C2 calcium-dependent membrane targeting)
18	F42G9.4	F42G9.4	n/a	chrIII 761,894
19	H14E04.3	H14E04.3	n/a	chrIII 2,385,751
20	T07D3.4	T07D3.4	n/a	chrII 889,513	T07D3.4 is orthologous to the human gene FUKUTIN (FCMD; OMIM:253800), which when mutated leads to disease.
21	abf-4	Y38H6C.22	n/a	chrV 20,553,545	abf-4 encodes a homolog of the antibacterial factor ASABF from Ascaris suum; ABF-4 may play a role in innate immunity, though at present the only evidence for its having an antimicrobial humoral function is its sequence similarity.
22	sid-2	ZK520.2	n/a	chrIII 13,680,827	sid-2 encodes a novel, single-pass transmembrane protein; SID-2 is required for environmental-mediated (i.e. ingestion or soaking) RNA interference (RNAi); SID-2::GFP is expressed strongly in the intestine where it localizes to the apical (lumenal) membrane; SID-2::GFP is also expressed at much lower levels in the excretory duct cells; when expressed in Caenorhabditis briggsae, a related nematode species deficient for environmental RNAi, SID-2 is able to confer environmental RNAi.
23	E03A3.5	E03A3.5	n/a	chrIII 4,061,679	contains similarity to Pfam domain PF00431 CUB domain contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold)
24	fozi-1	K01B6.1	n/a	chrIII 9,291,244	fozi-1 encodes an unusual zinc-finger protein that has two C2H2 zinc-finger motifs that probably mediate transcriptional regulation along with a glutamine-rich region and a vestigial formin homology 2 (FH2) domain that has lost its ability to polymerize actin but retained its ability to dimerize; during postembryonic development, FOZI-1 acts with MAB-5 and redundantly with HLH-1/CeMyoD to autonomously specify coelomocyte and striated body wall muscle fates; in addition, fozi-1 is required for the fully asymmetrical phenotypic distinction of ASER cells from ASEL cells; fozi-1 mutant animals variably express flp-4, gcy-6, gcy-7 and lim-6, genes normally restricted to ASEL, in ASER as well, while maintaining expression of ASER-specific genes; ectopic FOZI-1 expression in ASEL can suppress lim-6 expression; fozi-1 genetically interacts with several regulatory proteins and miRNAs; FOZI-1 is a nuclear protein that is expressed in neuronal lineages beginning at the 2-fold stage of embryogenesis, and then in neurons and cells derived from the M mesoblast during larval development; expression in the M lineage corresponds to cells that will generate coelomocytes and body wall muscles and is not seen in the sex myoblasts (SMs); FOZI-1 expression in the M lineage requires the Hox co-factor CEH-20.
25	K08F9.3	K08F9.3	n/a	chrV 15,143,291	contains similarity to Pfam domains PF00168 (C2 domain) (3), PF08165 (FerA (NUC095) domain) , PF08150 (FerB (NUC096) domain) contains similarity to Interpro domains IPR012561 (FerB), IPR006614 (Dysferlin, C-terminal), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR012560 (FerA), IPR006613 (Dysferlin, N-terminal), IPR000008 (C2 calcium-dependent membrane targeting)
26	F13D2.4	F13D2.4	n/a	chrX 11,188,488	contains similarity to Homo sapiens Isoform 3 of CD109 antigen precursor; HI:HIT000020743
27	rgs-6	C41G11.3	n/a	chrX 5,724,513	rgs-6 encodes a regulator of G protein signaling; by homology, RGS-6 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-6 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-6 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; the rgs-6 expression pattern has not yet been reported.
28	hsp-16.48	T27E4.3	n/a	chrV 9,088,350	hsp-16.48 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.48 reporter fusion, expressed broadly but most strongly in body muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.48 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating.
29	B0238.13	B0238.13	n/a	chrV 5,245,859	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
30	F38C2.4	F38C2.4	n/a	chrIV 16,270,980	contains similarity to Pfam domain PF05050 Protein of unknown function (DUF672) contains similarity to Interpro domain IPR007744 (Protein of unknown function DUF672)
31	F48G7.12	F48G7.12	n/a	chrV 644,981	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
32	sri-10	C54E10.4	n/a	chrV 18,805,260	C. elegans SRI-10 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR016040 (NAD(P)-binding)
33	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
34	C37C3.7	C37C3.7	n/a	chrV 7,836,124	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site)
35	Y37H9A.3	Y37H9A.3	n/a	chrI 13,785,519	contains similarity to Interpro domains IPR003072 (Orphan nuclear receptor, NOR1 type), IPR000694 (Proline-rich region), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR006608 (Protein of unknown function DM14), IPR000008 (C2 calcium-dependent membrane targeting)
36	maa-1	C18D11.2	n/a	chrIII 11,821,012	maa-1 encodes a novel, transmembrane acyl-CoA-binding protein; maa-1 activity, together with that of rme-1, is required for normal rates of endosomal recycling and for proper endosomal shape and morphology; a rescuing MAA-1::GFP fusion protein is expressed in the hypodermis (excluding the seam cells) and the intestine, as well as in an area near the dorsal and ventral nerve cords; within the hypodermis and intestine, MAA-1::GFP localizes to endosomal and Golgi vesicle membranes.
37	gst-12	F37B1.2	n/a	chrII 13,617,244	C. elegans GST-12 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
38	W05B5.2	W05B5.2	n/a	chrI 13,052,842	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002286 (P2 purinoceptor), IPR000611 (Neuropeptide Y receptor), IPR000276 (GPCR, rhodopsin-like)
39	nhr-84	T06C12.7	n/a	chrV 15,878,178	C. elegans NHR-84 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
40	W09H1.3	W09H1.3	n/a	chrII 13,184,626	contains similarity to Homo sapiens cDNA FLJ31139 fis, clone IMR322001185; ENSEMBL:ENSP00000380962
41	W04G5.8	W04G5.8	n/a	chrI 11,650,893	contains similarity to Pfam domain PF05075 Protein of unknown function (DUF684) contains similarity to Interpro domain IPR007767 (Protein of unknown function DUF684)
42	T28C12.2	T28C12.2	n/a	chrV 6,330,074	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
43	srsx-35	F53F8.2	n/a	chrV 20,677,605	C. elegans SRSX-35 protein; contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR013305 (ABC transporter, ABCB2), IPR000276 (GPCR, rhodopsin-like)
44	W09G3.2	W09G3.2	n/a	chrI 13,809,580	contains similarity to Interpro domains IPR006594 (LisH dimerisation motif), IPR013144 (CT11-RanBPM), IPR006595 (CTLH, C-terminal to LisH motif)
45	F47G9.4	F47G9.4	n/a	chrV 11,319,469	contains similarity to Pfam domain PF00643 B-box zinc finger contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000315 (Zinc finger, B-box)
46	F07E5.9	F07E5.9	n/a	chrII 2,077,849	contains similarity to Interpro domain IPR016160 (Aldehyde dehydrogenase, conserved site)
47	K07G5.4	K07G5.4	n/a	chrI 7,167,846	contains similarity to Interpro domain IPR002048 (Calcium-binding EF-hand)
48	lact-3	M28.6	n/a	chrII 10,654,998	lact-3 encodes a beta-lactamase domain-containing protein that contains a predicted signal sequence; loss of lact-3 activity via RNAi has been reported to result in reduced fat content.
49	Y39A1A.17	Y39A1A.17	n/a	chrIII 10,688,996	contains similarity to Interpro domain IPR001611 (Leucine-rich repeat)
50	C24A3.4	C24A3.4	n/a	chrX 8,993,472	contains similarity to Pfam domain PF02515 CoA-transferase family III contains similarity to Interpro domains IPR016160 (Aldehyde dehydrogenase, conserved site), IPR003673 (CoA-transferase family III)