UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ZK1010.3	ZK1010.3	6e-124	chrIII 12,979,542	contains similarity to Pfam domain PF06229 FRG1-like family contains similarity to Interpro domains IPR010414 (FRG1-like), IPR008999 (Actin-crosslinking proteins)
2	sup-17	DY3.7	n/a	chrI 8,795,117	sup-17 encodes an ADAM protein, an integral membrane disintegrin and zinc-activated metalloproteinase, orthologous to Drosophila and mouse KUZBANIAN and the vertebrate ADAM10 proteins; SUP-17 is required maternally for embryonic development and plays a role in LIN-12/Notch-mediated cell signaling required for several cell fate decisions during vulval development; SUP-17 is also required for normal body morphology and male tail development; SUP-17 functions cell autonomously to facilitate LIN-12 signaling and requires the LIN-12 extracellular domain to do so.
3	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
4	B0035.11	B0035.11	n/a	chrIV 11,328,468	contains similarity to Pfam domain PF04004 Leo1-like protein contains similarity to Interpro domain IPR007149 (Leo1-like protein)
5	ZK1098.2	ZK1098.2	n/a	chrIII 9,530,428	contains similarity to Klebsiella aerogenes Siroheme synthetase.; TR:Q9EYX8
6	F29B9.5	F29B9.5	n/a	chrIV 4,652,758	contains similarity to Pfam domains PF00085 (Thioredoxin) , PF00578 (AhpC/TSA family) contains similarity to Interpro domains IPR011594 (Thioredoxin-like), IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR000866 (Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen), IPR013766 (Thioredoxin domain), IPR006662 (Thioredoxin-related)
7	K08F11.2	K08F11.2	n/a	chrIV 4,718,190	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
8	ergo-1	R09A1.1	n/a	chrV 1,013,580	C. elegans ERGO-1 protein; contains similarity to Pfam domains PF02170 (PAZ domain) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
9	sna-1	W02F12.6	n/a	chrV 6,710,071	sna-1 encodes an snRNP-binding protein (SNA-1/SL21p) orthologous to Ascaris SL30p (SL 30kd) and Brugia 13258.m00169, and paralogous to Brugia 14704.m00455; SNA-1 is found in the Sm snRNP SL1, but not in SL2; in snRNP SL1, SNA-1 associates with the SNA-2/SL75p protein, while being replaced by SUT-1/SL26p (a paralog of SNA-1) in snRNP Y; sna-1(RNAi) animals, like sut-1(bk79) mutants, have cold-sensitive sterility, whereas sna-1(RNAi) combined with sut-1(bk79) is synthetically lethal; double sna-1(RNAi) sut-1(RNAi) is lethal; these RNAi data indicate that SNA-1 and SUT-1 are partially redundant, and suggest that snRNP Y (like snRNP SL1) may participate in trans-splicing; SNA-1 can bind SNA-2 even in the absence of RNA.
10	C14A4.3	C14A4.3	n/a	chrII 10,586,058	contains similarity to Pfam domain PF03901 Alg9-like mannosyltransferase family contains similarity to Interpro domain IPR005599 (Alg9-like mannosyltransferase)
11	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
12	ceh-49	F17A9.6	n/a	chrV 6,119,282	ceh-49 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; CEH-49 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, CEH-49 is (somewhat distantly) affiliated with CEH-48, Drosophila ONECUT, and mammalian HNF6 proteins; CEH-49 has no obvious function in mass RNAi assays.
13	T07F8.4	T07F8.4	n/a	chrII 7,131,218	contains similarity to Pfam domain PF01448 ELM2 domain contains similarity to Interpro domains IPR001005 (SANT, DNA-binding), IPR000949 (ELM2)
14	C06H2.3	C06H2.3	n/a	chrV 11,128,767	contains similarity to Pfam domains PF02373 (JmjC domain) , PF00583 (Acetyltransferase (GNAT) family) contains similarity to Interpro domains IPR013129 (Transcription factor jumonji), IPR003347 (Transcription factor jumonji/aspartyl beta-hydroxylase), IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
15	F44E7.9	F44E7.9	n/a	chrV 5,791,637	contains similarity to Pfam domain PF07019 Rab5-interacting protein (Rab5ip) contains similarity to Interpro domain IPR010742 (Rab5-interacting)
16	sec-3	F52E4.7	n/a	chrX 3,097,634	C. elegans SEC-3 protein ; contains similarity to Danio rerio Exocyst complex component 1.; TR:Q7T2A6
17	K07C5.3	K07C5.3	n/a	chrV 10,344,230	contains similarity to Pfam domain PF00645 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region contains similarity to Interpro domain IPR001510 (Zinc finger, PARP-type)
18	C25A11.2	C25A11.2	n/a	chrX 9,115,559	contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
19	ekl-6	T16G12.5	n/a	chrIII 10,066,125	C. elegans EKL-6 protein; contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
20	npp-5	F07A11.3	n/a	chrII 11,598,202	C. elegans NPP-5 protein; contains similarity to Interpro domain IPR007252 (Nuclear pore protein 84/107)
21	apm-3	F53H8.1	n/a	chrX 956,347	apm-3 encodes an adaptin, orthologous to the mu3 subunit of adaptor protein complex 3 (AP-3); APM-3 is also orthologous to human HPS, which when mutated leads to Hermansky-Pudlak syndrome (OMIM:203300); based on structural similarity, APM-3 is predicted to be involved in the formation of intracellular transport vesicles, and genetic analyses indicate that apm-3 activity is required for biogenesis of lysosome-related gut granules.
22	R07E5.1	R07E5.1	n/a	chrIII 4,410,321	contains similarity to Pfam domains PF07713 (Protein of unknown function (DUF1604)) , PF01585 (G-patch domain) contains similarity to Interpro domains IPR011666 (Protein of unknown function DUF1604), IPR000467 (D111/G-patch), IPR005398 (Tubby, N-terminal)
23	F17A9.2	F17A9.2	n/a	chrV 6,111,285	contains similarity to Pfam domains PF04676 (Protein similar to CwfJ C-terminus 2) , PF04677 (Protein similar to CwfJ C-terminus 1) contains similarity to Interpro domains IPR006768 (Protein similar to CwfJ, C-terminal 1), IPR006767 (Protein similar to CwfJ, C-terminal 2), IPR011146 (Histidine triad-like motif)
24	ZK1236.5	ZK1236.5	n/a	chrIII 8,431,825	ZK1236.5 encodes a protein with no obvious non-nematode homologs; either ZK1236.9, or ZK1236.5, or both proteins weakly inhibit DHC-1 in vivo; likewise, either ZK1236.5, or ZK1236.9, or both proteins are required in mass RNAi assays for normal osmoregulation and normally rapid growth.
25	K10E9.1	K10E9.1	n/a	chrI 196,071
26	F32B6.3	F32B6.3	n/a	chrIV 9,883,182	contains similarity to Pfam domains PF02840 (Prp18 domain) , PF08799 (pre-mRNA processing factor 4 (PRP4) like) contains similarity to Interpro domains IPR014906 (Pre-mRNA processing factor 4 (PRP4) like), IPR003648 (Splicing factor motif), IPR004098 (Prp18)
27	C24G6.3	C24G6.3	n/a	chrV 5,517,383	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
28	F59E12.11	F59E12.11	n/a	chrII 5,648,707	contains similarity to Homo sapiens Isoform 1 of Loss of heterozygosity 12 chromosomal region 1 protein; ENSEMBL:ENSP00000321546
29	C18E3.2	C18E3.2	n/a	chrI 4,211,756	The C18E3.2 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; C18E3.2 is probably required during mitosis of the T cells for asymmetric cell division.
30	W03F8.4	W03F8.4	n/a	chrIV 5,184,667	contains similarity to Pfam domain PF08617 Kinase binding protein CGI-121 contains similarity to Interpro domain IPR013926 (Kinase binding protein CGI-121)
31	T03G11.6	T03G11.6	n/a	chrX 5,178,330	contains similarity to Pfam domains PF05219 (DREV methyltransferase) , PF08242 (Methyltransferase domain) contains similarity to Interpro domains IPR013217 (Methyltransferase type 12), IPR007884 (DREV methyltransferase)
32	hse-5	B0285.5	n/a	chrIII 4,347,680	hse-5 encodes the C. elegans ortholog of the heparan sulfate modifying enzyme glucuronyl C5-epimerase; by homology, HSE-5 is predicted to function in heparan sulfate biosynthesis by catalyzing the chain-modifying epimerization of glucuronic acid to iduronic acid; during development, hse-5 activity is required for normal body size, locomotion, and nervous system development; an hse-5::gfp transcriptional reporter fusion is expressed beginning at early embryonic stages and continuing through adulthood; expression in embryos is nearly ubiquitous with later expression primarily restricted to the hypodermis and intestine.
33	K08D10.1	K08D10.1	n/a	chrIV 4,182,875	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
34	Y47H9C.8	Y47H9C.8	n/a	chrI 11,895,073	contains similarity to Streptococcus pneumoniae Magnesium transporter, CorA family.; TR:Q97SX8
35	Y106G6D.7	Y106G6D.7	n/a	chrI 10,126,327	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR000694 (Proline-rich region), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
36	snr-6	Y49E10.15	n/a	chrIII 12,429,334	snr-6 encodes the C. elegans ortholog of the small nuclear ribonucleoprotein E, one of seven subunits of the heptameric Sm complex required for the biogenesis and function of snRNPs that catalyze mRNA splicing; in addition to its predicted role in pre-mRNA processing, SNR-6 activity is essential for embryogenesis and is required for several aspects of germ cell specification including cell division patterns, localization and subcellular distribution of P granules, maintenance of transcriptional quiescence, and expression of the germ lineage-specific proteins PIE-1, GLD-1, and NOS-2; snr-6 is also required for wild-type levels of fertility; immunostaining of adults and embryos using antibodies raised against mammalian Sm proteins suggests that SNR-6 localizes to the nucleus and cytoplasm in many cell types, as well as to P granules in germ cells and their embryonic precursors.
37	T08A11.1	T08A11.1	n/a	chrIII 4,255,571	contains similarity to Interpro domains IPR015425 (Actin-binding FH2), IPR000694 (Proline-rich region), IPR000591 (Pleckstrin/ G-protein, interacting region)
38	C45G9.5	C45G9.5	n/a	chrIII 5,049,097
39	xpg-1	F57B10.6	n/a	chrI 6,560,500	F57B10.6 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 5 (XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G (COCKAYNE SYNDROME)) (ERCC5; OMIM:133530), which when mutated leads to disease.
40	arx-7	M01B12.3	n/a	chrI 3,069,767	arx-7 encodes the C. elegans ortholog of the p16Arc subunit of the actin-related protein (Arp)2/3 complex.
41	div-1	R01H10.1	n/a	chrIII 10,246,876	div-1 encodes a homolog of the B subunit of the DNA polymerase alpha-primase complex; DIV-1 is required in embryos for the normal timing of interphase in cell divisions, and for the asymmetric distribution of PIE-1 and P granules.
42	exoc-7	C43E11.8	n/a	chrI 4,245,201	C. elegans EXOC-7 protein; contains similarity to Pfam domain PF03081 Exo70 exocyst complex subunit contains similarity to Interpro domain IPR004140 (Exo70 exocyst complex subunit)
43	cir-1	F55F8.4	n/a	chrI 5,654,871	C. elegans CIR-1 protein ; contains similarity to Homo sapiens Isoform 1 of CBF1-interacting corepressor; ENSEMBL:ENSP00000339723
44	T24C4.7	T24C4.7	n/a	chrIII 893,471	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR007087 (Zinc finger, C2H2-type)
45	bub-3	Y54G9A.6	n/a	chrII 13,727,744	C. elegans BUB-3 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
46	his-6	F45F2.13	n/a	chrV 8,534,749	his-6 encodes an H3 histone.
47	T24G10.2	T24G10.2	n/a	chrIII 5,441,718	contains similarity to Pfam domain PF02201 SWIB/MDM2 domain contains similarity to Interpro domain IPR003121 (SWIB/MDM2)
48	W02D3.4	W02D3.4	n/a	chrI 6,720,208	contains similarity to Pfam domain PF07857 CEO family (DUF1632) contains similarity to Interpro domain IPR012435 (Protein of unknown function DUF1632)
49	F29A7.6	F29A7.6	n/a	chrII 2,752,187	contains similarity to Mus musculus M-phase phosphoprotein 6.; SW:Q9D1Q1
50	F54B8.1	F54B8.1	n/a	chrV 15,811,031	contains similarity to Pfam domain PF03380 Caenorhabditis protein of unknown function, DUF282 contains similarity to Interpro domain IPR005044 (Protein of unknown function DUF282, Caenorhabditis species)