UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	mppb-1	ZC410.2	0	chrIV 9,075,567	C. elegans MPPB-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
2	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
3	K08E4.6	K08E4.6	n/a	chrIV 12,077,637	contains similarity to Pfam domain PF01105 emp24/gp25L/p24 family/GOLD contains similarity to Interpro domains IPR009038 (GOLD), IPR000348 (emp24/gp25L/p24)
4	cyp-25A1	C36A4.1	n/a	chrIII 3,833,539	C. elegans CYP-25A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
5	srv-29	T13A10.6	n/a	chrIV 6,265,730	C. elegans SRV-29 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
6	F48C1.6	F48C1.6	n/a	chrI 5,318,763
7	ZK328.6	ZK328.6	n/a	chrIII 6,029,645	contains similarity to Pfam domains PF02818 (PPAK motif) , PF00646 (F-box domain) contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
8	mdh-1	F20H11.3	n/a	chrIII 6,607,404	mdh-1 encodes a homolog of malate dehydrogenase that is predicted to be mitochondrial.
9	spon-1	F10E7.4	n/a	chrII 7,118,495	C. elegans SPON-1 protein; contains similarity to Pfam domains PF06468 (Spondin_N) , PF00090 (Thrombospondin type 1 domain) (5), PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) , PF02014 (Reeler domain) contains similarity to Interpro domains IPR000884 (Thrombospondin, type I), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR003067 (Plasmodium circumsporozoite protein), IPR009465 (Spondin, N-terminal), IPR002861 (Reeler region)
10	sel-1	F45D3.5	n/a	chrV 12,562,037	sel-1 encodes two isoforms of a highly conserved transmembrane protein orthologous to human SEL1 (OMIM:602329) and Saccharomyces cerevisiae HRD3, a member of the HMG-CoA Reductase Degradation (HRD) complex that degrades malfolded endoplasmic reticulum (ER)-resident proteins; SEL-1 functions as a negative regulator of the LIN-12/GLP-1 Notch-like signaling pathway in C. elegans where it appears to function cell autonomously to regulate LIN-12 turnover; along with ABU-1, an ER-associated Type I transmembrane protein, SEL-1 may be a component of a cell survival pathway induced when unfolded proteins accumulate in the ER; SEL-1 is expressed throughout larval and adult stages of development, and detected in all tissues except the pharynx; within cells, SEL-1 appears to localize to intracellular vesicles, consistent with its proposed role in protein turnover.
11	H34C03.2	H34C03.2	n/a	chrIV 6,759,933	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domains IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR006615 (Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)
12	ZK370.8	ZK370.8	n/a	chrIII 8,753,333	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013026 (Tetratricopeptide region)
13	sgt-1	R05F9.10	n/a	chrII 4,903,031	C. elegans SGT-1 protein; contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (2), PF00515 (Tetratricopeptide repeat) (3)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR008940 (Protein prenyltransferase), IPR001440 (Tetratricopeptide TPR-1), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region)
14	tli-1	F25H2.1	n/a	chrI 10,536,634	C. elegans TLI-1 protein; contains similarity to Pfam domains PF00168 (C2 domain) , PF02845 (CUE domain) contains similarity to Interpro domains IPR003892 (Ubiquitin system component Cue), IPR009060 (UBA-like), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR000008 (C2 calcium-dependent membrane targeting)
15	C13C4.5	C13C4.5	n/a	chrV 12,116,190	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
16	ptr-24	F46G10.5	n/a	chrX 13,345,071	ptr-24 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-24 has no known function in vivo.
17	fshr-1	C50H2.1	n/a	chrV 9,892,316	fshr-1 encodes a putative neuropeptide receptor required for normal acetylcholine secretion by synapses; FSHR-1 is orthologous to human follicle-stimulating hormone receptor (OMIM:136435; mutated in ovarian dysgenesis), thyrotropin receptor (OMIM:603372; mutated in hyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutated in precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1 puncta at synapses, suggesting exocytotic defects; the requirement for FSHR-1 and ten other predicted neuropeptide signalling proteins in cholinergic neurotransmission indicates that such signalling is important for regulating acetylcholine release at neuromuscular junctions; possible ligands of FSHR-1 are FLP-1 and NLP-12.
18	ZK1058.9	ZK1058.9	n/a	chrIII 3,924,612	contains similarity to Borrelia burgdorferi Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57)s(Glycoprotease).; SW:GCP_BORBU
19	clec-166	F38A1.5	n/a	chrIV 1,250,233	C. elegans CLEC-166 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
20	T08D10.3	T08D10.3	n/a	chrX 11,956,831	contains similarity to Homo sapiens Hypothetical protein KIAA1681; ENSEMBL:ENSP00000316543
21	T11G6.3	T11G6.3	n/a	chrIV 10,853,967	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
22	fbf-2	F21H12.5	n/a	chrII 6,090,134	fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
23	M116.5	M116.5	n/a	chrIV 8,417,632	contains similarity to Pfam domains PF00307 (Calponin homology (CH) domain) (4), PF02187 (Growth-Arrest-Specific Protein 2 Domain) contains similarity to Interpro domains IPR003108 (Growth-arrest-specific protein 2), IPR002017 (Spectrin repeat), IPR016146 (Calponin-homology), IPR001715 (Calponin-like actin-binding), IPR001589 (Actinin-type, actin-binding, conserved site)
24	nduf-2.2	T26A5.3	n/a	chrIII 6,466,129	T26A5.3 encodes a predicted mitochondrial protein whose mature sequence has near-identity (95%) to GAS-1; T26A5.3 transcription is detectable by RT-PCR, but not visible by promoter-GFP fusion; however, a transgene containing a fusion of the gas-1 promoter to the T26A5.3 protein-coding sequence is able to fully rescue gas-1 mutants, indicating that T26A5.3 encodes a fully functional mitochondrial 49 kDa subunit that may rescue gas-1(fc21) mutants from lethality; mutants homozygous for a T26A5.3 deletion have normal anesthetic sensitivity and normal sensitivity to oxygen (unlike gas-1 mutants) but a shortened lifespan at normal laboratory oxygen levels (20%); animals doubly mutant for gas-1 and T26A5.3 have maternal-effect lethality, but sterile surviving parents are abnormally long-lived (2.7 times longer than wild-type and 4.2 times longer than gas-1 mutants); double mutants remain hypersensitive to oxygen.
25	F57B10.1	F57B10.1	n/a	chrI 6,582,350	contains similarity to Pfam domains PF07716 (Basic region leucine zipper) , PF00170 (bZIP transcription factor) contains similarity to Interpro domains IPR002112 (Transcription factor Jun), IPR011700 (Basic leucine zipper), IPR004827 (Basic-leucine zipper (bZIP) transcription factor), IPR002227 (Tyrosinase), IPR008917 (Eukaryotic transcription factor, Skn-1-like, DNA-binding), IPR011616 (bZIP transcription factor, bZIP-1)
26	F55A12.6	F55A12.6	n/a	chrI 5,340,452	contains similarity to Interpro domain IPR002952 (Eggshell protein)
27	lbp-8	T22G5.6	n/a	chrV 13,891,011	lpb-8 belongs to a family of small intracellular fatty acid binding proteins (FABPs) that includes As-p18, found in the parasitic nematode Ascaris suum; lpb-8 shares 55% identity with bovine heart FABP but only 25% identity with As-p18 and lacks a secretory signal
28	spd-5	F56A3.4	n/a	chrI 5,173,414	C. elegans SPD-5 protein; contains similarity to Interpro domains IPR002017 (Spectrin repeat), IPR000533 (Tropomyosin), IPR009053 (Prefoldin)
29	F20B6.5	F20B6.5	n/a	chrX 4,199,245	contains similarity to Homo sapiens Conserved hypothetical protein; VG:OTTHUMP00000076919
30	F52G2.3	F52G2.3	n/a	chrIV 13,545,784	contains similarity to Pfam domain PF07547 RSD-2 N-terminal domain contains similarity to Interpro domain IPR011508 (RSD-2, N-terminal)
31	E01G4.6	E01G4.6	n/a	chrII 13,483,996	contains similarity to Caenorhabditis remanei P17 (Fragment).; TR:A0MIX2
32	fce-1	C04F12.10	n/a	chrI 9,711,884	fce-1 encodes an ortholog of 'farnesylated-proteins converting enzyme 1' (FACE-1), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-1 protein probably accounts for the EDTA-sensitive, tosylphenylalanylchloromethane-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans, and FCE-1 can cleave a farnesylated peptide in vitro; the S. cerevisiae homolog of FCE-1 (Ste24p) cleaves the precursor of yeast a-factor mating pheromone after its farnesylated cysteine residue, and transgenic FCE-1 rescues a mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases.
33	K02B12.3	K02B12.3	n/a	chrI 8,510,282	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
34	C01G6.5	C01G6.5	n/a	chrII 9,277,455	contains similarity to Pfam domain PF00498 FHA domain contains similarity to Interpro domains IPR005819 (Histone H5), IPR008984 (SMAD/FHA domain), IPR001965 (Zinc finger, PHD-type), IPR000253 (Forkhead-associated), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011011 (Zinc finger, FYVE/PHD-type)
35	maoc-1	E04F6.3	n/a	chrII 7,196,834	maoc-1 encodes an ortholog of human HSD17B4 (OMIM:601860, mutated in D-bifunctional protein deficiency); MAOC-1 contains a MaoC-like domain found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit) and by homology, is predicted to function in peroxisomal fatty acid beta-oxidation; loss of maoc-1 activity via RNAi results in lifespan extension, increased fat content, and an increased susceptibility to pathogens.
36	pbs-7	F39H11.5	n/a	chrI 8,695,820	pbs-7 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-7 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-7 activity via large-scale RNAi screens indicates that, in C. elegans, PBS-7 is required for normal movement and for embryonic, germline, and larval development.
37	F18H3.4	F18H3.4	n/a	chrX 13,530,481	contains similarity to Mus musculus GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).; SW:Q8VD04
38	F42E8.1	F42E8.1	n/a	chrV 13,063,254	contains similarity to Campylobacter jejuni DNA polymerase III alpha subunit (EC 2.7.7.7).; SW:DP3A_CAMJE
39	cyp-36A1	C34B7.3	n/a	chrI 8,343,858	C. elegans CYP-36A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I)
40	fbxa-58	C29F9.11	n/a	chrIII 110,182	C. elegans FBXA-58 protein; contains similarity to Pfam domains PF01827 (FTH domain) , PF00646 (F-box domain) contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
41	C01B10.10	C01B10.10	n/a	chrIV 6,626,165	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domains IPR002410 (Peptidase S33, prolyl aminopeptidase), IPR002018 (Carboxylesterase, type B)
42	C56C10.11	C56C10.11	n/a	chrII 6,599,683
43	clec-67	F56D6.2	n/a	chrIV 3,923,599	C. elegans CLEC-67 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
44	dhp-2	C47E12.8	n/a	chrIV 9,979,451	The dhp-2 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINASE (DPYS), which when mutated leads to dihydropyrimidinuria (OMIM:222748).
45	rps-30	C26F1.4	n/a	chrV 7,776,842	rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
46	Y49G5A.1	Y49G5A.1	n/a	chrV 5,286,867	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domain IPR002223 (Proteinase inhibitor I2, Kunitz metazoa)
47	T18D3.3	T18D3.3	n/a	chrX 12,465,679	contains similarity to Pfam domain PF01545 Cation efflux family contains similarity to Interpro domains IPR002524 (Cation efflux protein), IPR000425 (Major intrinsic protein)
48	F59E12.9	F59E12.9	n/a	chrII 5,643,532	contains similarity to Interpro domains IPR003618 (Transcription elongation factor S-II, central region), IPR000694 (Proline-rich region), IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
49	pat-3	ZK1058.2	n/a	chrIII 3,911,515	C. elegans PAT-3 protein; contains similarity to Pfam domains PF00008 (EGF-like domain) , PF00362 (Integrin, beta chain) , PF07965 (Integrin beta tail domain) , PF07974 (EGF-like domain) (2), PF08725 (Integrin beta cytoplasmic domain) contains similarity to Interpro domains IPR002369 (Integrin beta subunit, N-terminal), IPR012896 (Integrin beta subunit, tail), IPR001169 (Integrin beta subunit, C-terminal), IPR006209 (EGF-like), IPR002049 (EGF-like, laminin), IPR015812 (Integrin beta subunit), IPR014836 (Integrin beta subunit, cytoplasmic), IPR003659 (Plexin/semaphorin/integrin), IPR013032 (EGF-like region, conserved site), IPR013111 (EGF, extracellular), IPR012012 (Integrin beta subunit, subgroup), IPR002035 (von Willebrand factor, type A)
50	vpr-1	F33D11.11	n/a	chrI 5,869,119	C. elegans VPR-1 protein; contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein), IPR016763 (Vesicle-associated membrane protein)