UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ZC317.7	ZC317.7	0	chrV 5,469,825	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003980 (Histamine H3 receptor)
2	bath-1	F59H6.9	n/a	chrII 2,028,219	C. elegans BATH-1 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
3	C45B2.1	C45B2.1	n/a	chrX 6,086,305
4	C44E4.3	C44E4.3	n/a	chrI 4,639,174	contains similarity to Pfam domain PF00155 Aminotransferase class I and II contains similarity to Interpro domains IPR004838 (Aminotransferases, class-I, pyridoxal-phosphate-binding site), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR004839 (Aminotransferase, class I and II), IPR000796 (Aspartate/other aminotransferase), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
5	rec-8	W02A2.6	n/a	chrIV 13,351,138	rec-8 encodes a meiosis-specific cohesin complex subunit orthologous to Saccharomyces cerevisiae and Schizosaccharomyces pombe Rec8p; REC-8 is essential for pairing of homologoues and sister chromatids during meiosis and thus for proper chromosome disjunction; in the germline, REC-8 associates with chromatin of transition zone nuclei, and co-localizes with SMC-1 along the longitudinal axes of synapsed chromosomes at pachytene and in a cruciform pattern at diakinesis; REC-8 localization to chromatin is dependent upon TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS, and additionally, REC-8 and SCC-3 are mutually required for chromatin localization; REC-8 cleavage and degradation during meiosis I is dependent on the AIR-2 aurora-like kinase and during meiosis II on AIR-2 and the PLK-1 polo-like kinase.
6	F55G1.5	F55G1.5	n/a	chrIV 7,475,614	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
7	K11H3.4	K11H3.4	n/a	chrIII 9,835,521	contains similarity to Pfam domain PF02213 (GYF domain)
8	cas-2	C18E3.6	n/a	chrI 4,191,639	C. elegans CAS-2 protein; contains similarity to Pfam domains PF01213 (Adenylate cyclase associated (CAP) N terminal) , PF08603 (DE Adenylate cyclase associated (CAP) C terminal) contains similarity to Interpro domains IPR001837 (Adenylate cyclase-associated CAP), IPR000694 (Proline-rich region), IPR013992 (Adenylate cyclase-associated CAP, N-terminal), IPR003073 (Orphan nuclear receptor, NURR type), IPR016098 (Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal), IPR006599 (CARP motif), IPR013912 (Adenylate cyclase-associated CAP, C-terminal)
9	M01A10.1	M01A10.1	n/a	chrI 5,565,037	M01A10.1 encodes a protein, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that is predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; it is most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing.
10	F54D5.2	F54D5.2	n/a	chrII 11,573,977	contains similarity to Interpro domain IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
11	F35G12.5	F35G12.5	n/a	chrIII 4,585,670	contains similarity to Wigglesworthia glossinidia brevipalpis RpoD protein.; TR:Q8D286
12	mut-14	C14C11.6	n/a	chrV 5,659,724	mut-14 mutants exhibit germline transposon activation, a deficient response to RNAi, resistance to co-suppression, and transgene desilencing.
13	K12D12.5	K12D12.5	n/a	chrII 11,862,086	contains similarity to Interpro domains IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
14	C30G12.2	C30G12.2	n/a	chrII 7,290,986	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
15	T08D2.5	T08D2.5	n/a	chrX 178,809
16	F07H5.10	F07H5.10	n/a	chrII 8,807,812	contains similarity to Arabidopsis thaliana Myosin heavy chain-like protein.; TR:Q9FJ35
17	F56A3.1	F56A3.1	n/a	chrI 5,192,666
18	C35D10.5	C35D10.5	n/a	chrIII 4,862,879	contains similarity to Pfam domain PF03981 Ubiquinol-cytochrome C chaperone contains similarity to Interpro domain IPR007129 (Ubiquinol-cytochrome C chaperone)
19	glh-2	C55B7.1	n/a	chrI 6,515,665	glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males.
20	hlh-15	C43H6.8	n/a	chrX 2,413,123	C. elegans HLH-15 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
21	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
22	B0001.2	B0001.2	n/a	chrIV 12,148,704	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
23	T19B10.8	T19B10.8	n/a	chrV 11,243,290	contains similarity to Pfam domain PF07819 PGAP1-like protein contains similarity to Interpro domain IPR012908 (PGAP1-like)
24	hke-4.1	T28F3.3	n/a	chrIV 17,286,682	C. elegans HKE-4.1 protein; contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
25	W05F2.6	W05F2.6	n/a	chrI 3,370,130	contains similarity to Interpro domains IPR000504 (RNA recognition motif, RNP-1), IPR001620 (Dopamine D3 receptor)
26	htp-1	F41H10.10	n/a	chrIV 5,390,947	C. elegans HTP-1 protein; contains similarity to Pfam domain PF02301 HORMA domain contains similarity to Interpro domain IPR003511 (DNA-binding HORMA)
27	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
28	vps-33.2	C56C10.1	n/a	chrII 6,602,269	C. elegans VPS-33.2 protein; contains similarity to Pfam domain PF00995 Sec1 family contains similarity to Interpro domain IPR001619 (Sec1-like protein)
29	C36A4.4	C36A4.4	n/a	chrIII 3,842,530	C36A4.4 encodes a putative UDP-N-acetylglucosamine pyrophosphorylase, paralogous to K06B9.2 and orthologous to human UAP1 (OMIM:602862) and UAP1L1; C36A4.4 is thought to catalyse the fourth step of the hexosamine pathway to UDP-N-acetylglucosamine or UDP-N-acetylgalactosamine; C36A4.4 transcripts are enriched during oogenesis; C36A4.4(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, presumably because of defects in chitin and eggshell synthesis.
30	apc-2	K06H7.6	n/a	chrIII 8,082,080	apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC, a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae's Apc2p have 32% identity in their cullin domains (considered crucial for function), but otherwise share no obvious similarity; inactivating apc-2 with RNAi causes embryos to arrest at the meiotic one-cell stage, implying that APC-2 is required for the metaphase-to-anaphase transition of meiosis I; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16, cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphic alleles, APC-2 is likely to be required for asymmetrical segregation of cell fate determinants in two-cell embryos.
31	bath-5	F59H6.11	n/a	chrII 2,031,389	C. elegans BATH-5 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
32	T01C3.9	T01C3.9	n/a	chrV 15,005,731	contains similarity to Foot-and-mouth disease virus O Polyprotein.; TR:Q80B22
33	ego-1	F26A3.3	n/a	chrI 7,653,372	The ego-1 gene encodes a homolog of RNA-directed RNA polymerase that is essential for germ-line development.
34	zim-2	T07G12.10	n/a	chrIV 10,556,907	zim-2 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-1, ZIM-3, and C02F5.12; ZIM-2 is specifically required for homolog pairing, synapsis, and segregation of chromosome V during meiosis; zim-2(tm574) oocytes ending prophase have ~5 bivalents and ~2 univalents, the latter of which are consistently chromosome V; zim-2 oocytes fail to begin chromosome V pairing at the start of meiosis; ZIM-2 associates with the right end of chromosome V, which may indicate an association with its pairing center; while the C-terminal region of ZIM-2 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-2 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-2 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
35	F56D2.2	F56D2.2	n/a	chrIII 5,588,134	contains similarity to Pfam domains PF05773 (RWD domain) , PF01485 (IBR domain) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR006575 (RWD), IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR002867 (Zinc finger, C6HC-type)
36	F46F11.6	F46F11.6	n/a	chrI 5,617,576	contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
37	C16C8.14	C16C8.14	n/a	chrII 3,450,118	C16C8.14 encodes a Caenorhabditis-specific protein, with a central predicted coiled-coil and a C-terminal ubiqutin-like domain; C16C8.14 inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51; C16C8.14 is paralogous to C16C8.4, C16C8.11, C16C8.12, C16C8.13, C16C8.15, C16C8.16, and F54D10.7.
38	F59A2.6	F59A2.6	n/a	chrIII 3,420,133	contains similarity to Pfam domains PF02524 (KID repeat) , PF01465 (GRIP domain) contains similarity to Interpro domains IPR004089 (Chemotaxis methyl-accepting receptor, signalling), IPR000533 (Tropomyosin), IPR009053 (Prefoldin), IPR000237 (GRIP)
39	puf-12	ZK945.3	n/a	chrII 10,101,606	C. elegans PUF-12 protein; contains similarity to Pfam domain PF08144 CPL (NUC119) domain contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR001313 (Pumilio RNA-binding region), IPR012959 (CPL), IPR016024 (Armadillo-type fold)
40	C25D7.8	C25D7.8	n/a	chrV 15,066,857	contains similarity to Interpro domains IPR003323 (Ovarian tumour, otubain), IPR016615 (Ubiquitin thioesterase Otubain)
41	klp-18	C06G3.2	n/a	chrIV 7,041,936	klp-18 encodes a kinesin motor protein whose motor domain is most similar to that of the Xenopus and human klp2 proteins; loss of klp-18 activity via RNAi indicates that KLP-18 is required for the assembly of a disordered array of acentrosomal (female meiotic) microtubules into an organized, functional, bipolar spindle; in addition, KLP-18 may also play a role in cortex dynamics during post-meiotic development; antibody staining indicates that during meiosis and mitosis (early embryonic) KLP-18 localizes to: 1) spindles, and especially spindle poles, during prometaphase, metaphase, and early anaphase, and 2) the interzone during late anaphase and telophase; in early embryos, KLP-18 is also seen around the nucleus and cell cortex at sites of cell-cell contact; KLP-18 expression in later embryos and larvae is confined to the germ line which, in adults, stains brightly in both distal and proximal regions.
42	ZC410.3	ZC410.3	n/a	chrIV 9,077,529	contains similarity to Pfam domain PF01532 Glycosyl hydrolase family 47 contains similarity to Interpro domain IPR001382 (Glycoside hydrolase, family 47)
43	K02B7.2	K02B7.2	n/a	chrII 14,692,031	contains similarity to Pfam domains PF07735 (F-box associated) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR012885 (F-box associated type 2)
44	msh-5	F09E8.3	n/a	chrIV 13,159,611	msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone.
45	bch-1	F25H2.13	n/a	chrI 10,574,565	C. elegans BCH-1 protein; contains similarity to Pfam domain PF06733 DEAD_2 contains similarity to Interpro domains IPR014013 (Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type), IPR010614 (DEAD2), IPR002464 (DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site), IPR006554 (Helicase-like, DEXD box c2 type), IPR006555 (Helicase, ATP-dependent, c2 type), IPR014001 (DEAD-like helicase, N-terminal), IPR013020 (DNA helicase (DNA repair), Rad3 type)
46	C29H12.5	C29H12.5	n/a	chrII 6,111,947	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR000953 (Chromo domain), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR016197 (Chromo domain-like)
47	rrt-2	C29H12.1	n/a	chrII 6,126,706	C. elegans RRT-2 protein; contains similarity to Pfam domains PF05746 (DALR anticodon binding domain) , PF00750 (tRNA synthetases class I (R)) contains similarity to Interpro domains IPR015945 (Arginyl-tRNA synthetase, class Ic, core), IPR008909 (DALR anticodon binding), IPR001412 (Aminoacyl-tRNA synthetase, class I, conserved site), IPR009080 (Aminoacyl-tRNA synthetase, class 1a, anticodon-binding), IPR001278 (Arginyl-tRNA synthetase, class Ic), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold)
48	W01A11.1	W01A11.1	n/a	chrV 6,500,809	contains similarity to Pfam domains PF06441 (Epoxide hydrolase N terminus) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR016292 (Epoxide hydrolase), IPR000073 (Alpha/beta hydrolase fold-1), IPR000639 (Epoxide hydrolase-like), IPR010497 (Epoxide hydrolase, N-terminal)
49	srp-5	C03G6.18	n/a	chrV 7,382,647	srp-5 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-5 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases; however, as loss of srp-5 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-5 in C. elegans development and/or behavior is not yet known.
50	asb-1	F35G12.10	n/a	chrIII 4,595,209	asb-1 encodes the B subunit of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V) that is closely similar to its paralog ASB-2; asb-1 activity is required for embryonic viability and for normal proliferation of germline cells, specifically their progression to meiosis; in addition, asb-1 is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; expression of asb-1 mRNA is enriched in the germline and an ASB-1::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons.