UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	srg-67	ZC317.4	1e-173	chrV 5,462,245	C. elegans SRG-67 protein; contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	R06A10.1	R06A10.1	n/a	chrI 1,087,211	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
4	Y57G11C.21	Y57G11C.21	n/a	chrIV 14,846,701	contains similarity to Interpro domain IPR000358 (Ribonucleotide reductase)
5	set-30	ZC8.3	n/a	chrX 5,001,358	set-30 encodes a divergent ortholog of human SMYD1 (OMIM:606846), SMYD2 (OMIM:610663), and SYMD3 (OMIM:608783); SET-30 is paralogous to SET-10, SET-14, and SET-18; neither set-30(gk314) nor set-30(RNAi) have any obvious phenotypes.
6	clec-263	F26F2.6	n/a	chrV 20,571,518	C. elegans CLEC-263 protein; contains similarity to Pfam domains PF08277 (PAN-like domain) (2), PF00024 (PAN domain) contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
7	C33D9.8	C33D9.8	n/a	chrIV 8,784,995	contains similarity to Interpro domains IPR000533 (Tropomyosin), IPR009053 (Prefoldin)
8	srg-37	K04C1.1	n/a	chrX 14,234,536	C. elegans SRG-37 protein; contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
9	T03D8.7	T03D8.7	n/a	chrV 20,811,735	contains similarity to Homo sapiens Uncharacterized protein ENSP00000381489; ENSEMBL:ENSP00000335483
10	nhr-213	T06C12.13	n/a	chrV 15,895,604	C. elegans NHR-213 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
11	aat-1	F27C8.1	n/a	chrIV 9,600,317	aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly.
12	R08B4.3	R08B4.3	n/a	chrX 11,119,911	contains similarity to Homo sapiens 23 kDa protein; VG:OTTHUMP00000170038
13	fbxb-85	R17.1	n/a	chrIII 10,848,088	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
14	rsr-1	F28D9.1	n/a	chrI 11,179,945	C. elegans RSR-1 protein; contains similarity to Pfam domain PF01480 PWI domain contains similarity to Interpro domains IPR002483 (Splicing factor PWI), IPR000694 (Proline-rich region), IPR005819 (Histone H5), IPR002185 (Dopamine D4 receptor)
15	col-75	K03H9.2	n/a	chrII 6,426,809	C. elegans COL-75 protein; contains similarity to Pfam domain PF01391 Collagen triple helix repeat (20 copies) contains similarity to Interpro domains IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
16	T20F7.5	T20F7.5	n/a	chrX 16,850,352	contains similarity to Interpro domain IPR000694 (Proline-rich region)
17	ift-74	C18H9.8	n/a	chrII 6,681,205	C. elegans IFT-74 protein; contains similarity to Interpro domains IPR010989 (t-SNARE), IPR000694 (Proline-rich region)
18	str-148	M01D1.1	n/a	chrII 1,047,396	C. elegans STR-148 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR002091 (Aromatic amino acid permease)
19	K06H7.2	K06H7.2	n/a	chrIII 8,094,871	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
20	srt-72	C36C5.9	n/a	chrV 3,148,851	C. elegans SRT-72 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR002651 (Protein of unknown function DUF32), IPR000215 (Protease inhibitor I4, serpin)
21	Y41C4A.13	Y41C4A.13	n/a	chrIII 11,735,378	contains similarity to Homo sapiens Rabconnectin; ENSEMBL:ENSP00000251076
22	F14H8.5	F14H8.5	n/a	chrV 15,021,516	contains similarity to Bacillus cereus Hypothetical membrane spanning protein.; TR:Q812W2
23	ceh-10	W03A3.1	n/a	chrIII 5,800,012	ceh-10 encodes a member of the Paired-like class of homeodomain proteins; the CEH-10 homeodomain is closely related to the homeodomains of two vertebrate retina proteins (Chx10 from mice and Vsx-1 from goldfish); ceh-10 is required for CAN cell fate specification and migration, complete loss of ceh-10 function results in failure of CAN cell migration and loss of expression of CEH-23 and CEH-10 itself in the CAN and AIY interneurons; CEH-10, along with TTX-3 and CEH-23, constitutes a regulatory cascade of transcription factors that controls all sub-type specific features of the AIY interneurons.
24	lim-7	C04F1.3	n/a	chrI 5,721,019	lim-7 encodes a LIM homeodomain protein; a lim-7 mutation can result in lethality or sterility; lim-7 reporter fusion are specifically expressed in the somatic gonadal sheath cells during the L4 larval stage and continuing through adulthood.
25	chd-3	T14G8.1	n/a	chrX 12,849,438	chd-3 encodes a PHD-finger SNF2 family member containing a chromo domain and a C-terminal helicase domain that affects Notch-dependent vulval development; expressed in virtually all embryonic cells and in many larval nuclei.
26	srw-138	C44C3.3	n/a	chrV 2,962,370	C. elegans SRW-138 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
27	dpy-22	F47A4.2	n/a	chrX 9,816,134	dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression.
28	che-13	F59C6.7	n/a	chrI 10,511,288	che-13 encodes a novel protein homologous to mammalian IFT57/Hippi (OMIM:606621, protein interactor of Huntingtin-interacting protein 1 that is implicated in neuronal apoptosis in the Huntington disease state); CHE-13 is a proposed component of the intraflagellar transport (IFT) complex B, and is required for the construction and maintenance of cilia on a subset of sensory neurons; in addition, CHE-13 is required for proper localization of OSM-5, a murine polaris homolog, to IFT complex B; CHE-13 is expressed in ciliated sensory neurons including the amphids, phasmids, inner and outer labial neurons, and sensory rays of the male tail, localizing to the cilia base (transition zone) as well as to the axoneme; che-13 expression, like that of ciliogenic genes osm-1, osm-5, osm-6, and che-2, is positively regulated by the DAF-19 RFX-type transcription factor.
29	srh-223	F47C12.3	n/a	chrIV 3,982,749	C. elegans SRH-223 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
30	tbb-4	B0272.1	n/a	chrX 9,435,612	C. elegans TBB-4 protein; contains similarity to Pfam domains PF00091 (Tubulin/FtsZ family, GTPase domain) , PF03953 (Tubulin/FtsZ family, C-terminal domain) contains similarity to Interpro domains IPR002454 (Gamma tubulin), IPR002452 (Alpha tubulin), IPR002453 (Beta tubulin), IPR000158 (Cell division protein FtsZ, N-terminal), IPR000217 (Tubulin), IPR003008 (Tubulin/FtsZ, GTPase), IPR008280 (Tubulin/FtsZ, C-terminal), IPR013838 (Beta tubulin, autoregulation binding site), IPR004057 (Epsilon tubulin), IPR002967 (Delta tubulin)
31	clpp-1	ZK970.2	n/a	chrII 10,301,745	clpp-1 encodes a mitochondrial protein, homologous to bacterial ClpP, required to initiate the stress response to unfolded mitochondrial proteins; as with its bacterial ortholog, CLPP-1 is predicted to be a proteolytic subunit of a Clp-like protease, with an N-terminal region required for mitochondrial localization, and a C-terminal region of ClpP similarity; in response to a mutation stressing mitochondria, clpp-1(RNAi) animals show reduced HSP-60 levels, inhibited nuclear translocation and hsp-60 activation by DVE-1, and aberrant mitochondrial morphology; CLPP-1 is biochemically inhibited by the ClpP inhibitor Z-LY-CMK and the peptide aldehyde MG132, and may also be blocked by them when injected in vivo; CLPP-1 is expressed in the intestine.
32	dpy-28	Y39A1B.3	n/a	chrIII 10,770,127	dpy-28 encodes a non-SMC condensin subunit homolog, similar to XCAP-D2 in Xenopus, Cnd1 in S. pombe, and Ycs4p in S. cerevisiae, that is required for negative, chromosome-wide regulation of X-chromosomal genes in XX but not XO animals (dosage compensation), and for some undetermined aspect of body morphogenesis; DPY-28 is part of a multiprotein 'dosage compensation' complex with DPY-26, DPY-27 and MIX-1.
33	M03F8.6	M03F8.6	n/a	chrV 5,954,355	contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
34	col-123	W08D2.6	n/a	chrIV 9,822,477	col-123 is homologous to the human gene A TYPE IV COLLAGEN (COL6A1; OMIM:303631), which when mutated is sometimes associated with diffuse leiomyomatosis.
35	F22E5.1	F22E5.1	n/a	chrII 2,676,663	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domain IPR012444 (Protein of unknown function DUF1647)
36	vab-7	M142.4	n/a	chrIII 10,923,070	The vab-7 gene encodes an even-skipped-like homeodomain protein that is required for DB motoneuron identity and posterior DB axonal polarity.
37	C01H6.3	C01H6.3	n/a	chrI 7,208,985	contains similarity to Pfam domain PF00096 (Zinc finger, C2H2 type)
38	C36A4.10	C36A4.10	n/a	chrIII 3,830,011
39	agr-1	F41G3.12	n/a	chrII 6,767,868	agr-1 encodes a large (1396-residue) putative agrin, orthologous to human AGRIN (OMIM:103320), EGFLAM, and Q9NQ15; AGR-1 is expressed in buccal epithelium and deposited in pharyngeal basal epithelium; AGR-1 is also expressed in IL1 neurons, distal tip cells, and intestine; an AGR-1 fragment can cluster vertebrate dystroglycan in cell culture; agr-1(eg1770) mutations show no obvious phenotype, including levimasole resistance, and do not enhance other mutations perturbing acetylcholine signalling, the dystrophin-glycoprotein-complex, muscle cell differentiation, or the extracellular matrix.
40	R10E12.2	R10E12.2	n/a	chrIII 9,968,408	contains similarity to Homo sapiens Splice isoform 1 of Q96PV0 Ras GTPase-activating protein SynGAP; ENSEMBL:ENSP00000293748
41	F15D3.4	F15D3.4	n/a	chrI 11,568,010	contains similarity to Interpro domain IPR000215 (Protease inhibitor I4, serpin)
42	C27F2.8	C27F2.8	n/a	chrIII 4,994,766	contains similarity to Interpro domain IPR000694 (Proline-rich region)
43	F14H12.2	F14H12.2	n/a	chrX 4,351,596
44	srw-20	T05E12.4	n/a	chrV 17,079,045	C. elegans SRW-20 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
45	gpa-7	R10H10.5	n/a	chrIV 10,406,114	gpa-7 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects egg laying and response to water- soluble odorants; it is expressed in excitable cells.
46	F01G10.7	F01G10.7	n/a	chrIV 10,240,539	contains similarity to Pfam domains PF04083 (ab-hydrolase associated lipase region) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR006693 (AB-hydrolase associated lipase region), IPR000073 (Alpha/beta hydrolase fold-1), IPR008262 (Lipase, active site)
47	srh-148	K08G2.5	n/a	chrV 15,857,580	C. elegans SRH-148 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
48	srh-15	C50B6.6	n/a	chrV 13,321,651	C. elegans SRH-15 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
49	fbxa-141	D1025.3	n/a	chrX 14,512,622	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
50	srh-50	C10G11.2	n/a	chrI 6,303,370	C. elegans SRH-50 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)