UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	btb-13	ZC204.11	4e-128	chrII 1,654,256	C. elegans BTB-13 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000209 (Peptidase S8 and S53, subtilisin, kexin, sedolisin), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
2	mau-2	C09H6.3	n/a	chrI 8,127,936	mau-2 encodes an ortholog of budding yeast Scc4p, Drosophila CG4203, and human KIAA0892; MAU-2 is required (with PQN-85 and SCC-3) for normal mitotic chromosome segregation, and for cellular (e.g., neuronal) or axonal migration; MAU-2 is required for migration both embryonically and postembryonically, along both dorsoventral and longitudinal body axes; MAU-2 guides the axonal projection of AVM (and probably other neurons) by some cell-autonomous mechanism independent of SLT-1; MAU-2 is also required for normal larval development, locomotion, excretory canals and osmoregulation, phasmid morphology, and egg-laying; the primary sequences of MAU-2 and its Scc4-like orthologs are composed of tetratricopeptide repeats, and are highly divergent between yeast and metazoa; MAU-2 is expressed ubiquitously in embryos during late gastrulation, subsequently becoming restricted to neurons; mau-2 transcripts are abundant in oocytes, and maternal transcripts alone can support normal MAU-2 protein synthesis through the L3 larval stage (but not in L4 larvae or adults); MAU-2's N-terminal 371 residues of MAU-2 are its most conserved domain, and are sufficient to transgenically rescue mau-2 mutants; despite its behavioral phenotype, MAU-2 is thought to act early in development, since the uncoordinated phenotype of mau-2 mutants is maternal; while the uncoordinated phenotype of mau-2 mutants can be rescued either maternally or zygotically, the egg-laying phenotype of mau-2 mutants is purely zygotic; partially penetrant mau-2 dye-filling phenotypes occur on one side of the body, suggesting that MAU-2 acts on a whole side of an embryo at a time; while mau-2(RNAi) has no obvious early embryonic phenotype, joint mau-2/scc-3(RNAi) grossly deranges chromosomal segregation in early embryos, and mau-2(RNAi) enhances the lagging of anaphase chromosomes induced by pqn-85(RNAi).
3	end-3	F58E10.5	n/a	chrV 14,015,253	end-3 encodes a GATA zinc finger protein, paralogous to end-1, that helps specify mesoendodermal (as opposed to mesectodermal) lineages derived from the E blastomere.
4	E04F6.10	E04F6.10	n/a	chrII 7,215,446
5	K10C2.2	K10C2.2	n/a	chrX 6,433,006	contains similarity to Interpro domain IPR000832 (GPCR, family 2, secretin-like)
6	srh-45	T03F7.2	n/a	chrV 11,304,292	C. elegans SRH-45 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR002259 (Delayed-early response protein/equilibrative nucleoside transporter), IPR008075 (Lipocalin-1 receptor)
7	str-1	C42D4.5	n/a	chrIV 7,174,381	C. elegans STR-1 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
8	T05G5.4	T05G5.4	n/a	chrIII 9,749,322	contains similarity to Homo sapiens Trichohyalin; ENSEMBL:ENSP00000290632
9	ZK856.4	ZK856.4	n/a	chrV 10,183,835	contains similarity to Interpro domain IPR011001 (Saposin-like)
10	exos-1	Y48A6B.5	n/a	chrIII 11,009,701	C. elegans EXOS-1 protein ; contains similarity to Drosophila melanogaster Flybase gene name is Csl4-PA;; FLYBASE:CG6249
11	K07D4.2	K07D4.2	n/a	chrII 4,045,127
12	srx-121	C04E12.8	n/a	chrV 3,371,855	C. elegans SRX-121 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
13	phat-1	C46H11.8	n/a	chrI 5,045,010	C. elegans PHAT-1 protein; contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
14	fbxb-78	E04A4.1	n/a	chrIV 4,738,137	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
15	Y54G11A.11	Y54G11A.11	n/a	chrII 14,350,230	contains similarity to Pfam domain PF05129 Transcription elongation factor Elf1 like contains similarity to Interpro domain IPR007808 (Protein of unknown function DUF701, zinc-binding putative)
16	abce-1	Y39E4B.1	n/a	chrIII 13,156,917	C. elegans ABCE-1 protein; contains similarity to Pfam domains PF04068 (Possible metal-binding domain in RNase L inhibitor, RLI) , PF00037 (4Fe-4S binding domain) , PF00005 (ABC transporter) (2)contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR001450 (4Fe-4S ferredoxin, iron-sulphur binding), IPR013283 (ABC transporter, ABCE), IPR007209 (Possible metal-binding region in RNase L inhibitor, RLI), IPR003593 (AAA+ ATPase, core)
17	adr-2	T20H4.4	n/a	chrIII 7,231,956	adr-2 encodes an adenosine deaminase that acts on RNA (ADAR); ADARs are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA); adr-2 is expressed ubiquitously in early embryos, as well as in the germline of early adults; ADR-2 is required for ADAR activity in vivo, and for normal chemotaxis.
18	T02G6.6	T02G6.6	n/a	chrI 11,821,054	contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
19	R08F11.1	R08F11.1	n/a	chrV 3,781,014	contains similarity to Pfam domain PF04685 Protein of unknown function, DUF608 contains similarity to Interpro domains IPR006775 (Protein of unknown function DUF608), IPR014551 (Beta-glucosidase, GBA2 type), IPR008928 (Six-hairpin glycosidase-like)
20	F29B9.1	F29B9.1	n/a	chrIV 4,666,256	contains similarity to Pfam domain PF08242 Methyltransferase domain contains similarity to Interpro domain IPR013217 (Methyltransferase type 12)
21	str-134	C05E4.6	n/a	chrV 744,563	C. elegans STR-134 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
22	F37B4.10	F37B4.10	n/a	chrV 2,876,718	contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
23	T21C9.4	T21C9.4	n/a	chrV 10,578,742	contains similarity to Pfam domain PF01133 Enhancer of rudimentary contains similarity to Interpro domain IPR000781 (Enhancer of rudimentary)
24	evl-20	F22B5.1	n/a	chrII 8,444,637	evl-20 encodes a functional ortholog of human ADP-ribosylation factor-like protein 2 (ARL2; OMIM:601175), with evl-20(ar103) mutants being rescued by transgenic human ARL2 but not ARL1 or ARL3-7; EVL-20 is required for cortical microtubule formation during cytokinesis and morphogenesis; EVL-20 is required for vulval, gonadal, and male tail development, as well as for embryonic mitosis, hypodermal enclosure, and elongation; EVL-20 is expressed in migrating hypodermal embryonic cells, larval vulval and somatic gonad cells, larval and adult neurons, and adult male proctodeal cells, being subcellularly associated with both the cell cortex and astral microtubules.
25	C14F11.2	C14F11.2	n/a	chrX 6,211,298	contains similarity to Pfam domains PF00560 (Leucine Rich Repeat) (6), PF00307 (Calponin homology (CH) domain) contains similarity to Interpro domains IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype), IPR016146 (Calponin-homology), IPR001715 (Calponin-like actin-binding), IPR003590 (Leucine-rich repeat, ribonuclease inhibitor subtype)
26	rfc-2	F58F6.4	n/a	chrIV 1,350,136	rfc-2 encodes a member of the AAA family that are ATPases associated with DNA replication and has highest similarity to the mouse Replication factor C 40 kDa subunit, and affects embryonic viability, fertility, and locomotion in a large-scale RNAi screen.
27	T17A3.9	T17A3.9	n/a	chrIII 152,890
28	pfd-5	R151.9	n/a	chrIII 7,198,447	pfd-5 encodes a putative prefoldin 5 subunit, orthologous to human PFDN5 (OMIM:604899), that is required for normal microtubule growth, embryonic and larval viability, fertility, vulval development, and locomotion; PFD-5 is expressed in most, if not all, tissues; pfd-5(RNAi) animals show sterile progeny, larval arrest or lethality, uncoordination, and abnormal body shapes, and pfd-5(RNAi) embryos show a reduced microtubule growth rate.
29	F58B3.7	F58B3.7	n/a	chrIV 11,639,167	contains similarity to Pfam domains PF01585 (G-patch domain) , PF00076 (RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR016967 (Splicing factor, SPF45), IPR003954 (RNA recognition, region 1), IPR000467 (D111/G-patch), IPR000504 (RNA recognition motif, RNP-1), IPR009145 (U2 auxiliary factor small subunit)
30	srab-2	C04F5.5	n/a	chrV 5,104,023	C. elegans SRAB-2 protein; contains similarity to Pfam domain PF02175 C.elegans integral membrane protein Srb contains similarity to Interpro domains IPR001005 (SANT, DNA-binding), IPR002184 (Serpentine beta receptor), IPR007087 (Zinc finger, C2H2-type)
31	uba-2	W02A11.4	n/a	chrI 12,745,085	uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation.
32	T22H2.4	T22H2.4	n/a	chrI 11,694,849	contains similarity to Pfam domain PF03860 Domain of Unknown Function (DUF326) contains similarity to Interpro domain IPR005560 (Protein of unknown function DUF326)
33	srd-3	K10B4.5	n/a	chrII 127,822	C. elegans SRD-3 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR003002 (7TM chemoreceptor, subfamily 1)
34	C26E6.3	C26E6.3	n/a	chrIII 4,945,871	contains similarity to Pfam domain PF04078 Cell differentiation family, Rcd1-like contains similarity to Interpro domain IPR007216 (Cell differentiation proteins, Rcd1-like)
35	W04A8.1	W04A8.1	n/a	chrI 13,837,656	W04A8.1 encodes a protein weakly similar to human microcephalin (MCPH1; OMIM:607117, mutated in primary microcephaly); while their primary sequence similarity is very subtle (only being detectable with psi-BLAST on NCBI-nr, using C. briggsae CBG13622 as a query sequence), both W04A8.1 and microcephalin has similar ordering of BRCT domains (one N-terminal, two C-terminal); W04A8.1 has no obvious function in mass RNAi screens.
36	nhr-258	C26B2.4	n/a	chrIV 8,045,986	C. elegans NHR-258 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
37	R01B10.2	R01B10.2	n/a	chrV 6,042,173
38	C27D8.4	C27D8.4	n/a	chrIV 12,705,410	contains similarity to Interpro domains IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
39	R05F9.9	R05F9.9	n/a	chrII 4,900,966
40	F56B3.9	F56B3.9	n/a	chrIV 772,200
41	srh-308	F58E10.6	n/a	chrV 14,016,755	C. elegans SRH-308 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
42	F01G12.1	F01G12.1	n/a	chrX 16,395,930	contains similarity to Pfam domain PF04145 Ctr copper transporter family contains similarity to Interpro domain IPR007274 (Ctr copper transporter)
43	F31D5.1	F31D5.1	n/a	chrII 4,220,835	contains similarity to Pfam domain PF05978 Eukaryotic protein of unknown function (DUF895) contains similarity to Interpro domains IPR010291 (Protein of unknown function DUF895, eukaryotic), IPR003976 (Potassium channel, two pore-domain, TREK), IPR016196 (MFS general substrate transporter)
44	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
45	W02D7.6	W02D7.6	n/a	chrV 8,300,526	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
46	ZK1248.11	ZK1248.11	n/a	chrII 5,828,127	contains similarity to Xenopus laevis E3 SUMO-protein ligase NSE2 (EC 6.-.-.-) (Non-structural maintenancesof chromosomes element 2 homolog) (Non-SMC element 2 homolog).; SW:Q7ZXH2
47	M01G12.5	M01G12.5	n/a	chrI 12,130,715	contains similarity to Interpro domain IPR000215 (Protease inhibitor I4, serpin)
48	rpb-6	C06A1.5	n/a	chrII 10,579,552	C. elegans RPB-6 protein; contains similarity to Pfam domain PF01192 RNA polymerase Rpb6 contains similarity to Interpro domains IPR006110 (RNA polymerase Rpb6), IPR002048 (Calcium-binding EF-hand), IPR006111 (DNA-directed RNA polymerase, 14 to 18 kDa subunit), IPR012293 (RNA polymerase subunit, RPB6/omega)
49	C44C10.5	C44C10.5	n/a	chrX 11,691,705	contains similarity to Homo sapiens Structural maintenance of chromosomes protein 1A; ENSEMBL:ENSP00000323421
50	rap-1	C27B7.8	n/a	chrIV 8,917,869	rap-1 encodes a member of the Ras superfamily of small GTPases; the activated protein interacts with W05B10.4 and T14G10.2 in yeast two-hybrid assays and rap-1 is expressed in some neurons in the head and tail, the rectal epithelial cells, body muscle, hypodermis, and in the somatic cells of the gonad.