UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	Y76A2B.3	Y76A2B.3	0	chrIII 13,541,717	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
2	F01F1.9	F01F1.9	n/a	chrIII 5,862,653	contains similarity to Pfam domain PF02127 Aminopeptidase I zinc metalloprotease (M18) contains similarity to Interpro domain IPR001948 (Peptidase M18, aminopeptidase I)
3	R03D7.1	R03D7.1	n/a	chrII 10,928,740	R03D7.1 is orthologous to the human gene METHIONINE SYNTHASE (MTR; OMIM:156570), which when mutated leads to disease.
4	F38E11.5	F38E11.5	n/a	chrIV 9,461,841	F38E11.5 encodes a beta' (beta-prime) subunit of the coatomer (COPI) complex; in mass RNAi assays, F38E11.5 is required for fertility and general health.
5	hsp-1	F26D10.3	n/a	chrIV 17,280,029	hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity.
6	rpl-4	B0041.4	n/a	chrI 4,646,348	rpl-4 encodes a large ribosomal subunit L4 protein.
7	gas-1	K09A9.5	n/a	chrX 15,588,527	The gas-1 gene encodes a 49 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, fecundity, and normal lifespan; gas-1 is expressed in the nematode neuromuscular system; its subcellular distribution appears to be mitochondrial; drug effects on mutants versus wild-type indicate that gas-1 functions at least partially through presynaptic effects; gas-1 mutants have strongly reduced Complex I-dependent metabolism in mitochondria, while Complex II-dependent metabolism is conversely increased in mutants; gas-1 mitochondria look structurally normal.
8	atp-2	C34E10.6	n/a	chrIII 5,229,290	atp-2 encodes the beta subunit of the soluble, catalytic F1 portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); atp-2 activity is required for embryonic and larval development past the L3 stage, as well as for normal mobility, pharyngeal pumping, defecation, growth rate, and larval lifespan; in males, atp-2 activity is also required cell autonomously in male-specific sensory neurons for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; in vitro, the N-terminus of ATP-2 interacts directly with the conserved PLAT domains of human polycystin (PC)-1 and C. elegans LOV-1, which is expressed exclusively in adult male sensory neurons and is also required for the response to hermaphrodite contact; atp-2 is widely expressed throughout development in both sexes; ATP-2 localizes to mitochondria and to cilia of male-specific neurons; in the male-specific CEM neurons ATP-2 colocalizes with PKD-2, the C. elegans homolog of human polycystin (PC)-2.
9	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
10	gst-13	T26C5.1	n/a	chrII 9,231,840	C. elegans GST-13 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
11	K10C2.1	K10C2.1	n/a	chrX 6,425,780	contains similarity to Pfam domain PF00450 Serine carboxypeptidase contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001563 (Peptidase S10, serine carboxypeptidase)
12	ugt-12	T19H12.9	n/a	chrV 4,888,389	C. elegans UGT-12 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
13	Y49A3A.1	Y49A3A.1	n/a	chrV 14,349,107	Y49A3A.1 encodes a homolog of choline/ethanolaminephosphotransferase choline phosphotransferase 1; Y49A3A.1 shares an operon with vha-13, and thus might be a previously undescribed V-ATPase component or ancillary protein.
14	gstk-1	ZK1320.1	n/a	chrII 9,657,127	C. elegans GSTK-1 protein; contains similarity to Pfam domain PF01323 DSBA-like thioredoxin domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR001853 (DSBA oxidoreductase), IPR014440 (HCCA isomerase/glutathione S-transferase kappa)
15	egl-45	C27D11.1	n/a	chrIII 7,826,432	egl-45 encodes a homolog of eukaryotic translation initiation factor 3, subunit 10, that affects development of the HSNs that affect egg laying.
16	eif-3.D	R08D7.3	n/a	chrIII 8,970,522	eif-3.D encodes the C. elegans ortholog of the translation initiation factor 3 subunit d (eIF3d/Moe1); by homology, EIF-3.D is predicted to function as part of the eIF3 translation initiation complex but also as part of a Ras-mediated pathway that regulates mitotic spindle formation; in C. elegans, large-scale RNAi screens indicate that eif-3.D is required for embryonic and germline development, locomotion, and normal rates of post-embryonic growth; in the early embryo, eif-3.D is specifically required for the fidelity of meiotic divisions and normal pseudocleavage; eif-3.D function is likely conserved, as expression of eif-3.D in Schizosaccharomyces pombe can rescue the mitotic spindle and growth defects associated with moe1 mutant cells; to date, eif-3.D expression has been reported in anterior neurons and the pharynx, beginning at late stages of embryogenesis.
17	C08H9.2	C08H9.2	n/a	chrII 9,888,735	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR004087 (K Homology), IPR004088 (K Homology, type 1)
18	dhs-28	M03A8.1	n/a	chrX 6,819,210	dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type.
19	C26B9.5	C26B9.5	n/a	chrX 5,330,863	contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domain IPR008758 (Peptidase S28)
20	srt-55	T16H12.8	n/a	chrIII 10,105,558	C. elegans SRT-55 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
21	daf-36	C12D8.5	n/a	chrV 10,224,591	daf-36 encodes a protein homologous to the catalytic subunit of Rieske-like oxygenases; DAF-36 functions in a hormone biosynthetic pathway producing a ligand for the DAF-12 nuclear receptor that regulates the developmental decision between reproductive growth and dauer formation; a daf-36::gfp reporter fusion is expressed in the intestine, the head mesodermal cell, two unidentified head neurons (not XXXR/L) and, in dauers, the lateral seam cells; DAF-36 localizes to the cytoplasm in the intestine and to a cytosolic meshwork in dauer seam cells.
22	K12C11.1	K12C11.1	n/a	chrI 1,343,024	The K12C11.1 gene encodes an ortholog of the human gene PEPTIDASE D (PEPD), which when mutated leads to prolidase deficiency (OMIM:170100).
23	T16G1.6	T16G1.6	n/a	chrV 12,936,341	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
24	lec-10	W01A11.4	n/a	chrV 6,488,658	lec-10 encodes a galectin, a soluble galactose-binding lectin; recombinant lec-10 can bind to sugar in an in vitro assay.
25	T04A8.5	T04A8.5	n/a	chrIII 4,690,700	contains similarity to Pfam domains PF00310 (Glutamine amidotransferases class-II) , PF00156 (Phosphoribosyl transferase domain) contains similarity to Interpro domains IPR000583 (Glutamine amidotransferase, class-II), IPR005854 (Amidophosphoribosyl transferase), IPR000836 (Phosphoribosyltransferase), IPR002375 (Purine/pyrimidine phosphoribosyl transferase, conserved site)
26	R07H5.8	R07H5.8	n/a	chrIV 11,210,138	contains similarity to Pfam domain PF00294 pfkB family carbohydrate kinase contains similarity to Interpro domains IPR011611 (Carbohydrate/purine kinase), IPR002139 (Ribokinase), IPR001805 (Adenosine kinase), IPR002173 (Carbohydrate/puine kinase, PfkB, conserved site)
27	pqn-47	F59B10.1	n/a	chrII 10,499,684	pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays; pqn-47(cxP5915) homozygotes are sluggish.
28	dod-17	K10D11.1	n/a	chrIV 12,977,287	C. elegans DOD-17 protein; contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
29	pqn-57	R09F10.7	n/a	chrX 8,320,224	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
30	F44B9.2	F44B9.2	n/a	chrIII 8,023,742	contains similarity to Interpro domain IPR000694 (Proline-rich region)
31	ucr-1	F56D2.1	n/a	chrIII 5,593,099	C. elegans UCR-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR000209 (Peptidase S8 and S53, subtilisin, kexin, sedolisin), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
32	T08B1.1	T08B1.1	n/a	chrV 1,984,861	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR000817 (Prion protein), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
33	ile-1	K07A1.8	n/a	chrI 9,610,665	ile-1 is orthologous to the human gene human ERGIC-53, which when mutated leads to deficiency of coagulation factors V/VIII (OMIM:227300).
34	F29C12.4	F29C12.4	n/a	chrII 13,119,692	contains similarity to Pfam domains PF03764 (Elongation factor G, domain IV) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) , PF00679 (Elongation factor G C-terminus) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR005517 (Translation elongation factor EFG/EF2, domain IV), IPR005225 (Small GTP-binding protein), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009000 (Translation elongation and initiation factors/Ribosomal, beta-barrel), IPR000640 (Translation elongation factor EFG/EF2, C-terminal), IPR004540 (Translation elongation factor EFG/EF2), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR009022 (Elongation factor G, III and V)
35	R13F6.10	R13F6.10	n/a	chrIII 6,867,259	contains similarity to Interpro domain IPR011990 (Tetratricopeptide-like helical)
36	F01D5.5	F01D5.5	n/a	chrII 14,001,897	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
37	Y45G12C.3	Y45G12C.3	n/a	chrV 2,556,848	contains similarity to Pfam domain PF02798 Glutathione S-transferase, N-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
38	ZK686.3	ZK686.3	n/a	chrIII 7,768,245	ZK686.3 is orthologous to the putative tumor suppressor N33 (OMIM:601385, associated with homozygous deletion in metastatic prostate cancer and with loss of function in other tumors); ZK686.3 is also homologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3.
39	R10H10.3	R10H10.3	n/a	chrIV 10,390,865	contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00431 (CUB domain) contains similarity to Interpro domains IPR000859 (CUB), IPR016857 (Uncharacterised conserved protein UCP027682, CUB, vWA), IPR002035 (von Willebrand factor, type A)
40	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
41	rpl-9	R13A5.8	n/a	chrIII 7,572,403	rpl-9 encodes a large ribosomal subunit L9 protein that affects fertility and embryonic viability.
42	pgk-1	T03F1.3	n/a	chrI 3,868,329	T03F1.3 is orthologous to the human gene PHOSPHOGLYCERETE KINASE 1 (PGK1; OMIM:311800), which when mutated leads to hemolytic anemia and neurologic disturbances.
43	F57B9.3	F57B9.3	n/a	chrIII 6,940,892	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014014 (RNA helicase, DEAD-box type, Q motif), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
44	K08D8.6	K08D8.6	n/a	chrIV 12,888,793	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003492 (Batten's disease protein Cln3), IPR003366 (CUB-like region)
45	act-2	T04C12.5	n/a	chrV 11,077,425	act-2 encodes an invertebrate actin that may function specifically in the pharynx.
46	F35D11.4	F35D11.4	n/a	chrII 4,603,738	contains similarity to Pfam domain PF01928 CYTH domain contains similarity to Interpro domains IPR008172 (Adenylate cyclase), IPR008173 (Adenylyl cyclase CyaB)
47	Y57A10C.6	Y57A10C.6	n/a	chrII 12,424,519	contains similarity to Pfam domain PF00108 Thiolase, N-terminal domain contains similarity to Interpro domains IPR016038 (Thiolase-like, subgroup), IPR002155 (Thiolase), IPR016039 (Thiolase-like)
48	F54E2.1	F54E2.1	n/a	chrV 2,811,213	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
49	F01D5.1	F01D5.1	n/a	chrII 13,997,179	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
50	F55G11.2	F55G11.2	n/a	chrIV 12,968,338	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)