UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	tfg-1	Y63D3A.5	1e-141	chrI 14,103,115	C. elegans TFG-1 protein; contains similarity to Pfam domain PF00564 PB1 domain contains similarity to Interpro domains IPR006030 (Molluscan rhodopsin C-terminal tail), IPR000694 (Proline-rich region), IPR000270 (Octicosapeptide/Phox/Bem1p)
2	dpy-18	Y47D3B.10	n/a	chrIII 11,375,393	An alpha subunit of prolyl-4-hydroxylase which is a procollagen modifying enzyme required for exoskeleton formation, morphogenesis and maintenance of body shape; it is expressed throughout the hypodermis and certain head and posterior neurons.
3	mup-2	T22E5.5	n/a	chrX 6,409,410	mup-2 encodes the muscle contractile protein troponin T ( TnT ) homologous to vertebrate and invertebrate TnT and contains an invertebrate- specific COOH -terminal tail; mup-2 affects embryonic body wall muscle cell contraction, sarcomere organization, cell positioning, regulated muscle contraction in larval and adult body wall muscle, epidermal morphogenesis, and is required for proper function of the hermaphrodite nonstriated oviduct myoepithelial sheath, proper growth, and fertility.
4	hsp-4	F43E2.8	n/a	chrII 7,351,305	hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress.
5	Y57A10C.6	Y57A10C.6	n/a	chrII 12,424,519	contains similarity to Pfam domain PF00108 Thiolase, N-terminal domain contains similarity to Interpro domains IPR016038 (Thiolase-like, subgroup), IPR002155 (Thiolase), IPR016039 (Thiolase-like)
6	F48E3.3	F48E3.3	n/a	chrX 7,498,278	contains similarity to Pfam domain PF06427 UDP-glucose:Glycoprotein Glucosyltransferase contains similarity to Interpro domain IPR009448 (UDP-glucose:Glycoprotein Glucosyltransferase)
7	act-2	T04C12.5	n/a	chrV 11,077,425	act-2 encodes an invertebrate actin that may function specifically in the pharynx.
8	C05G5.4	C05G5.4	n/a	chrX 14,755,163	contains similarity to Pfam domains PF00549 (CoA-ligase) , PF02629 (CoA binding domain) contains similarity to Interpro domains IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR005810 (Succinyl-CoA ligase, alpha subunit), IPR016040 (NAD(P)-binding), IPR017440 (ATP-citrate lyase/succinyl-CoA ligase, active site), IPR003781 (CoA-binding), IPR016102 (Succinyl-CoA synthetase-like)
9	F38E11.5	F38E11.5	n/a	chrIV 9,461,841	F38E11.5 encodes a beta' (beta-prime) subunit of the coatomer (COPI) complex; in mass RNAi assays, F38E11.5 is required for fertility and general health.
10	ZK662.2	ZK662.2	n/a	chrX 15,697,316	contains similarity to Homo sapiens Metallothionein-IL; ENSEMBL:ENSP00000290704
11	W04G3.5	W04G3.5	n/a	chrX 11,074,823	contains similarity to Pfam domain PF00156 Phosphoribosyl transferase domain contains similarity to Interpro domains IPR005946 (Phosphoribosyl pyrophosphokinase), IPR000836 (Phosphoribosyltransferase)
12	hke-4.2	H13N06.5	n/a	chrX 15,506,879	C. elegans HKE-4.2 protein; contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domains IPR002395 (HMW kininogen), IPR003689 (Zinc/iron permease)
13	dod-17	K10D11.1	n/a	chrIV 12,977,287	C. elegans DOD-17 protein; contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
14	tbb-1	K01G5.7	n/a	chrIII 10,741,585	This gene encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-1 is redundant for embryonic viability, due to its paralog TBB-2.
15	ZK1025.8	ZK1025.8	n/a	chrI 11,470,513	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
16	F53F1.4	F53F1.4	n/a	chrV 13,411,377	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR013286 (Annexin, type VII)
17	F55G11.2	F55G11.2	n/a	chrIV 12,968,338	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
18	ZK686.3	ZK686.3	n/a	chrIII 7,768,245	ZK686.3 is orthologous to the putative tumor suppressor N33 (OMIM:601385, associated with homozygous deletion in metastatic prostate cancer and with loss of function in other tumors); ZK686.3 is also homologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3.
19	sec-23	Y113G7A.3	n/a	chrV 20,093,804	C. elegans SEC-23 protein; contains similarity to Pfam domains PF04811 (Sec23/Sec24 trunk domain) , PF04815 (Sec23/Sec24 helical domain) , PF04810 (Sec23/Sec24 zinc finger) , PF00626 (Gelsolin repeat) , PF08033 (Sec23/Sec24 beta-sandwich domain) contains similarity to Interpro domains IPR006900 (Sec23/Sec24 helical region), IPR012990 (Sec23/Sec24 beta-sandwich), IPR006896 (Sec23/Sec24 trunk region), IPR006895 (Zinc finger, Sec23/Sec24-type), IPR007123 (Gelsolin region)
20	C16C10.11	C16C10.11	n/a	chrIII 4,152,344	contains similarity to Pfam domain PF06747 CHCH domain contains similarity to Interpro domains IPR010625 (CHCH), IPR000104 (Antifreeze protein, type I), IPR000694 (Proline-rich region)
21	myo-3	K12F2.1	n/a	chrV 12,230,556	myo-3 encodes MHC A, the minor isoform of MHC (myosin heavy chain) that is essential for thick filament formation, and for viability, movement, and embryonic elongation; expressed in body muscle, the somatic sheath cell covering the hermaphrodite gonad, and also expressed in enteric muscle, vulval muscles of the hermaphrodite and the diagonal muscles of the male tail.
22	F54F11.2	F54F11.2	n/a	chrII 13,512,057	F54F11.2 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F54F11.2 has no clear orthologs in other organisms.
23	egl-45	C27D11.1	n/a	chrIII 7,826,432	egl-45 encodes a homolog of eukaryotic translation initiation factor 3, subunit 10, that affects development of the HSNs that affect egg laying.
24	dhs-28	M03A8.1	n/a	chrX 6,819,210	dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type.
25	dpy-13	F30B5.1	n/a	chrIV 4,236,154	dpy-13 encodes a member of the collagen superfamily containing 20 copies of the collagen triple helix repeat; transcipt levels oscillate, peaking once during each larval stage.
26	F13E6.1	F13E6.1	n/a	chrX 10,676,336	contains similarity to Pfam domain PF04201 Tumour protein D52 family contains similarity to Interpro domain IPR007327 (Tumor protein D52)
27	Y76A2B.3	Y76A2B.3	n/a	chrIII 13,541,717	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
28	alh-9	F01F1.6	n/a	chrIII 5,858,031	C. elegans ALH-9 protein; contains similarity to Pfam domain PF00171 Aldehyde dehydrogenase family contains similarity to Interpro domains IPR016163 (Aldehyde dehydrogenase, C-terminal), IPR016162 (Aldehyde dehydrogenase, N-terminal), IPR016161 (Aldehyde/histidinol dehydrogenase), IPR015590 (Aldehyde dehydrogenase), IPR016160 (Aldehyde dehydrogenase, conserved site)
29	ZK899.2	ZK899.2	n/a	chrX 9,451,048	contains similarity to Aedes aegypti Putative uncharacterized protein.; TR:Q16QQ2
30	K12C11.1	K12C11.1	n/a	chrI 1,343,024	The K12C11.1 gene encodes an ortholog of the human gene PEPTIDASE D (PEPD), which when mutated leads to prolidase deficiency (OMIM:170100).
31	Y47D3B.6	Y47D3B.6	n/a	chrIII 11,427,622	contains similarity to Pfam domain PF01683 EB module contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR000480 (Glutelin), IPR006149 (Nematode-specific EB region)
32	F40E10.5	F40E10.5	n/a	chrX 14,702,656	contains similarity to Onchocerca volvulus OV39 antigen (Fragment).; SW:P31730
33	erv-46	K09E9.2	n/a	chrX 15,615,388	C. elegans ERV-46 protein; contains similarity to Pfam domain PF07970 Protein of unknown function (DUF1692) contains similarity to Interpro domain IPR012936 (Protein of unknown function DUF1692)
34	atp-2	C34E10.6	n/a	chrIII 5,229,290	atp-2 encodes the beta subunit of the soluble, catalytic F1 portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); atp-2 activity is required for embryonic and larval development past the L3 stage, as well as for normal mobility, pharyngeal pumping, defecation, growth rate, and larval lifespan; in males, atp-2 activity is also required cell autonomously in male-specific sensory neurons for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; in vitro, the N-terminus of ATP-2 interacts directly with the conserved PLAT domains of human polycystin (PC)-1 and C. elegans LOV-1, which is expressed exclusively in adult male sensory neurons and is also required for the response to hermaphrodite contact; atp-2 is widely expressed throughout development in both sexes; ATP-2 localizes to mitochondria and to cilia of male-specific neurons; in the male-specific CEM neurons ATP-2 colocalizes with PKD-2, the C. elegans homolog of human polycystin (PC)-2.
35	ZC123.1	ZC123.1	n/a	chrI 839,873	contains similarity to Interpro domains IPR000381 (Inhibin, beta B subunit), IPR003267 (Small proline-rich), IPR000694 (Proline-rich region), IPR000480 (Glutelin)
36	T06E4.7	T06E4.7	n/a	chrV 9,627,246	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
37	itx-1	W03D8.6	n/a	chrI 2,809,305	itx-1 encodes one of two Caspr orthologues found in the C. elegans genome; Caspr proteins belong to the Neurexin superfamily and are involved in mediating cell-cell contacts and in the formation of specialized membrane-domains in polarized epithelial and nerve cells; RNA interference of itx-1 suggests that itx-1 is involved in the correct positioning and maintenance of apical junctions and in maintaining epithelial integrity in the gut; gfp-reporter studies indicate that ITX-1 is expressed in intestinal cell epithelia and in the socket cells of the inner and outer labial sensilla; immunofluorescence studies indicate that ITX-1 localizes to the baso-lateral membranes of intestinal epithelia.
38	srh-274	C32B5.2	n/a	chrII 983,859	C. elegans SRH-274 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
39	K10C2.1	K10C2.1	n/a	chrX 6,425,780	contains similarity to Pfam domain PF00450 Serine carboxypeptidase contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001563 (Peptidase S10, serine carboxypeptidase)
40	col-182	R09A8.4	n/a	chrX 12,636,305	C. elegans COL-182 protein; contains similarity to Pfam domain PF01391 Collagen triple helix repeat (20 copies) contains similarity to Interpro domain IPR008160 (Collagen triple helix repeat)
41	F32B5.1	F32B5.1	n/a	chrI 2,701,252	contains similarity to Pfam domains PF02807 (ATP:guanido phosphotransferase, N-terminal domain) , PF00217 (ATP:guanido phosphotransferase, C-terminal catalytic domain) contains similarity to Interpro domains IPR000749 (ATP:guanido phosphotransferase), IPR014746 (Glutamine synthetase/guanido kinase, catalytic region)
42	tni-1	F42E11.4	n/a	chrX 11,376,606	tni-1 encodes a member of the troponin family that affects body morphology, locomotion, egg laying, and epithelial morphogenesis in a large-scale RNAi analysis.
43	F19H8.4	F19H8.4	n/a	chrII 14,619,275	contains similarity to Pfam domain PF04870 Protein of unknown function, DUF644 contains similarity to Interpro domain IPR006954 (Protein of unknown function DUF644)
44	ile-2	T04G9.3	n/a	chrX 769,684	C. elegans ILE-2 protein; contains similarity to Pfam domains PF03388 (Legume-like lectin family) , PF00139 (Legume lectin domain) contains similarity to Interpro domains IPR013320 (Concanavalin A-like lectin/glucanase, subgroup), IPR001220 (Legume lectin, beta domain), IPR005052 (Legume-like lectin), IPR008985 (Concanavalin A-like lectin/glucanase)
45	ZK1025.2	ZK1025.2	n/a	chrI 11,450,904	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
46	sec-24.1	F12F6.6	n/a	chrIV 11,564,055	sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis.
47	C08H9.2	C08H9.2	n/a	chrII 9,888,735	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR004087 (K Homology), IPR004088 (K Homology, type 1)
48	C15C7.5	C15C7.5	n/a	chrX 3,151,795	contains similarity to Oryctolagus cuniculus Trichohyalin.; SW:P37709
49	F01F1.9	F01F1.9	n/a	chrIII 5,862,653	contains similarity to Pfam domain PF02127 Aminopeptidase I zinc metalloprotease (M18) contains similarity to Interpro domain IPR001948 (Peptidase M18, aminopeptidase I)
50	gstk-1	ZK1320.1	n/a	chrII 9,657,127	C. elegans GSTK-1 protein; contains similarity to Pfam domain PF01323 DSBA-like thioredoxin domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR001853 (DSBA oxidoreductase), IPR014440 (HCCA isomerase/glutathione S-transferase kappa)