UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	rpt-6	Y49E10.1	0	chrIII 12,371,416	rpt-6 encodes a triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle (RP) base subcomplex; RPT-6 is required for embryonic and larval development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome.
2	chc-1	T20G5.1	n/a	chrIII 10,206,656	chc-1 encodes the C. elegans clathrin heavy chain ortholog; loss of chc-1 activity via RNAi results in defects in receptor-mediated yolk endocytosis and thus, embryonic lethality.
3	let-721	C05D11.12	n/a	chrIII 6,445,833	The let-721 gene encodes an ortholog of the human gene SIMILAR TO ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE (ETFDH), which when mutated leads to glutaricaciduria type IIC (OMIM:231675).
4	wrt-6	ZK377.1	n/a	chrX 3,481,938	wrt-6 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Wart domain, an short region of low-complexity sequence, and a Hint/Hog domain; WRT-6 is expressed in sheath and socket cells of anterior sensilla, seam cells, and hypodermis; the Hint/Hog domain is predicted to cut WRT-6 into two halves and then covalently link cholesterol to the C-terminus of the Wart domain; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-6 is weakly required for normal molting; WRT-6 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
5	imp-2	T05E11.5	n/a	chrIV 11,117,784	C. elegans IMP-2 protein; contains similarity to Pfam domain PF04258 Signal peptide peptidase contains similarity to Interpro domains IPR006639 (Peptidase A22, presenilin signal peptide), IPR007369 (Peptidase A22B, signal peptide peptidase)
6	pbs-7	F39H11.5	n/a	chrI 8,695,820	pbs-7 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-7 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-7 activity via large-scale RNAi screens indicates that, in C. elegans, PBS-7 is required for normal movement and for embryonic, germline, and larval development.
7	T08D10.3	T08D10.3	n/a	chrX 11,956,831	contains similarity to Homo sapiens Hypothetical protein KIAA1681; ENSEMBL:ENSP00000316543
8	C56G2.7	C56G2.7	n/a	chrIII 6,340,161	contains similarity to Pfam domain PF04683 Adhesion regulating molecule conserved region contains similarity to Interpro domain IPR006773 (Adhesion regulating molecule)
9	rpn-3	C30C11.2	n/a	chrIII 8,448,263	C. elegans RPN-3 protein; contains similarity to Pfam domains PF01399 (PCI domain) , PF08375 (Proteasome regulatory subunit C-terminal) contains similarity to Interpro domains IPR013586 (26S proteasome regulatory subunit, C-terminal), IPR013143 (PCI/PINT associated module), IPR000717 (Proteasome component region PCI), IPR015350 (Beta-trefoil)
10	Y49G5A.1	Y49G5A.1	n/a	chrV 5,286,867	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domain IPR002223 (Proteinase inhibitor I2, Kunitz metazoa)
11	sec-24.1	F12F6.6	n/a	chrIV 11,564,055	sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis.
12	rpt-2	F29G9.5	2.0000000000000002e-96	chrV 6,016,841	C. elegans RPT-2 protein; contains similarity to Pfam domain PF00004 ATPase family associated with various cellular activities (AAA) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR003960 (AAA ATPase, conserved site), IPR005937 (26S proteasome subunit P45), IPR003593 (AAA+ ATPase, core)
13	F42A10.3	F42A10.3	n/a	chrIII 6,156,244	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)
14	K02B12.3	K02B12.3	n/a	chrI 8,510,282	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
15	col-68	C50D2.4	n/a	chrII 105,181	C. elegans COL-68 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
16	C55B7.3	C55B7.3	n/a	chrI 6,500,602	contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
17	M03B6.2	M03B6.2	n/a	chrX 13,855,038	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR002455 (GPCR, family 3, gamma-aminobutyric acid receptor, type B), IPR016196 (MFS general substrate transporter)
18	sec-23	Y113G7A.3	n/a	chrV 20,093,804	C. elegans SEC-23 protein; contains similarity to Pfam domains PF04811 (Sec23/Sec24 trunk domain) , PF04815 (Sec23/Sec24 helical domain) , PF04810 (Sec23/Sec24 zinc finger) , PF00626 (Gelsolin repeat) , PF08033 (Sec23/Sec24 beta-sandwich domain) contains similarity to Interpro domains IPR006900 (Sec23/Sec24 helical region), IPR012990 (Sec23/Sec24 beta-sandwich), IPR006896 (Sec23/Sec24 trunk region), IPR006895 (Zinc finger, Sec23/Sec24-type), IPR007123 (Gelsolin region)
19	C34C6.4	C34C6.4	n/a	chrII 8,697,694	contains similarity to Pfam domains PF00732 (GMC oxidoreductase) , PF05199 (GMC oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR012132 (Glucose-methanol-choline oxidoreductase), IPR007867 (Glucose-methanol-choline oxidoreductase, C-terminal), IPR000172 (Glucose-methanol-choline oxidoreductase, N-terminal), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
20	srt-55	T16H12.8	n/a	chrIII 10,105,558	C. elegans SRT-55 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
21	T26E3.7	T26E3.7	n/a	chrI 12,655,698	contains similarity to Pfam domain PF00006 ATP synthase alpha/beta family, nucleotide-binding domain contains similarity to Interpro domain IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
22	T04A8.5	T04A8.5	n/a	chrIII 4,690,700	contains similarity to Pfam domains PF00310 (Glutamine amidotransferases class-II) , PF00156 (Phosphoribosyl transferase domain) contains similarity to Interpro domains IPR000583 (Glutamine amidotransferase, class-II), IPR005854 (Amidophosphoribosyl transferase), IPR000836 (Phosphoribosyltransferase), IPR002375 (Purine/pyrimidine phosphoribosyl transferase, conserved site)
23	kcc-1	R13A1.2	n/a	chrIV 7,215,841	C. elegans KCC-1 protein; contains similarity to Pfam domain PF00324 Amino acid permease contains similarity to Interpro domains IPR000076 (K-Cl co-transporter), IPR004841 (Amino acid permease-associated region), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
24	M04F3.3	M04F3.3	n/a	chrI 4,764,191	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
25	F49E11.2	F49E11.2	n/a	chrIV 13,037,470	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
26	ldh-1	F13D12.2	n/a	chrII 11,725,839	ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency.
27	ZK180.6	ZK180.6	n/a	chrIV 4,522,552	contains similarity to Interpro domain IPR000694 (Proline-rich region)
28	clec-67	F56D6.2	n/a	chrIV 3,923,599	C. elegans CLEC-67 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
29	R06B10.1	R06B10.1	n/a	chrIII 969,326	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00102 (Protein-tyrosine phosphatase) contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR003125 (Protein of unknown function WSN)
30	sel-1	F45D3.5	n/a	chrV 12,562,037	sel-1 encodes two isoforms of a highly conserved transmembrane protein orthologous to human SEL1 (OMIM:602329) and Saccharomyces cerevisiae HRD3, a member of the HMG-CoA Reductase Degradation (HRD) complex that degrades malfolded endoplasmic reticulum (ER)-resident proteins; SEL-1 functions as a negative regulator of the LIN-12/GLP-1 Notch-like signaling pathway in C. elegans where it appears to function cell autonomously to regulate LIN-12 turnover; along with ABU-1, an ER-associated Type I transmembrane protein, SEL-1 may be a component of a cell survival pathway induced when unfolded proteins accumulate in the ER; SEL-1 is expressed throughout larval and adult stages of development, and detected in all tissues except the pharynx; within cells, SEL-1 appears to localize to intracellular vesicles, consistent with its proposed role in protein turnover.
31	daf-6	F31F6.5	n/a	chrX 14,891,298	daf-6 is required for an unidentified function of the nonneuronal amphidial sheath cells that promotes correct morphology of both the amphid and the outer labial sensilla; daf-6 mutants disrupt the joining of the amphid sheath and socket cells to form the receptor channel, and display defects in several distinct functions including formation of dauer larvae, chemotaxis, osmotic avoidance, male mating, negative regulation of lifespan, negative regulation of ASJ's axonal growth late in development, and dye uptake by amphids and phasmids; daf-6 has recently been reported to be identical to the coding sequence ptr-7/F31F6.5, but this assertion has not yet been verified by transgenic rescue.
32	pqn-47	F59B10.1	n/a	chrII 10,499,684	pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays; pqn-47(cxP5915) homozygotes are sluggish.
33	tag-257	F46G11.3	n/a	chrX 5,784,865	C. elegans TAG-257 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
34	pmp-4	T02D1.5	n/a	chrIV 17,404,001	The pmp-4 gene encodes a homolog of human ALD, which when mutated leads to X-linked adrenoleukodystrophy (OMIM:300100).
35	ZK899.5	ZK899.5	n/a	chrX 9,460,355	contains similarity to Interpro domain IPR002048 (Calcium-binding EF-hand)
36	F44B9.2	F44B9.2	n/a	chrIII 8,023,742	contains similarity to Interpro domain IPR000694 (Proline-rich region)
37	dod-24	C32H11.12	n/a	chrIV 12,940,724	C. elegans DOD-24 protein; contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003366 (CUB-like region)
38	cogc-6	K07C11.9	n/a	chrV 8,219,777	cogc-6 encodes an ortholog of mammalian COG-6, a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); COGC-6 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, COGC-6 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast.
39	K02C4.2	K02C4.2	n/a	chrII 8,076,226	contains similarity to Brugia pahangi Alt-1 protein.; TR:O96781
40	ptr-24	F46G10.5	n/a	chrX 13,345,071	ptr-24 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-24 has no known function in vivo.
41	cyp-33A1	C12D5.7	n/a	chrV 7,680,386	C. elegans CYP-33A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV)
42	T20D4.3	T20D4.3	n/a	chrV 3,420,496	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
43	clec-186	ZK896.7	n/a	chrIV 12,867,615	C. elegans CLEC-186 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
44	dre-1	K04A8.6	n/a	chrV 6,535,821	dre-1 encodes an ortholog of human FBXO11/PRMT9 (OMIM:607871, associated with vitiligo and otitis media) that is required, in conjunction with DAF-12 and its partners, for global developmental timing of the transistion from larval to adult cell fates; DRE-1 has an N-terminal F-box domain, three central tandem C-terminal CASH domains, and a C-terminal zinc finger; hypomorphic dre-1 mutations are synthetically heterochronic with loss-of-function daf-12 alleles, inducing defective distal tip cell migration and precocious fusion of seam cells; five different hypomorphic dre-1 alleles alter conserved glycine residues in the CASH domain region, whereas the null dre-1(hd60) allele is lethal at the three-fold embryo stage; DRE-1 is expressed in many tissues, including epidermal and distal tip cells, and localizes to both nucleus and cytoplasm; strong loss-of-function of dre-1 (the dh99 mutant fed RNAi) induces defects at all four molts; dre-1 also has synthetic phenotypes with daf-9(k182), daf-36(k114), and lin-29(n546); dre-1-like enhancement of daf-12 is also seen in skr-1(RNAi), cul-1(RNAi), or rbx-1/2(RNAi) animals; DRE-1 and SKR-1 bind one another, as do their human orthologs; DRE-1 affects lin-29 expression, and is suppressed by lin-42(RNAi); DRE-1 is paralogous to C. elegans BE0003N10.3.
45	mppb-1	ZC410.2	n/a	chrIV 9,075,567	C. elegans MPPB-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
46	Y43C5B.3	Y43C5B.3	n/a	chrIV 10,354,101	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR001312 (Hexokinase), IPR001993 (Mitochondrial substrate carrier)
47	Y48A6B.10	Y48A6B.10	n/a	chrIII 11,041,221	contains similarity to Interpro domain IPR000694 (Proline-rich region)
48	cyp-37A1	F01D5.9	n/a	chrII 14,015,298	C. elegans CYP-37A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV)
49	wht-5	F19B6.4	n/a	chrIV 12,338,972	C. elegans WHT-5 protein; contains similarity to Pfam domains PF01061 (ABC-2 type transporter) , PF00005 (ABC transporter) contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR003593 (AAA+ ATPase, core), IPR013525 (ABC-2 type transporter)
50	spon-1	F10E7.4	n/a	chrII 7,118,495	C. elegans SPON-1 protein; contains similarity to Pfam domains PF06468 (Spondin_N) , PF00090 (Thrombospondin type 1 domain) (5), PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) , PF02014 (Reeler domain) contains similarity to Interpro domains IPR000884 (Thrombospondin, type I), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR003067 (Plasmodium circumsporozoite protein), IPR009465 (Spondin, N-terminal), IPR002861 (Reeler region)