UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	Y48E1B.8	Y48E1B.8	0	chrII 13,587,287	contains similarity to Pfam domain PF03407 Protein of unknown function (DUF271) contains similarity to Interpro domain IPR005069 (Protein of unknown function DUF271)
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	nud-1	F53A2.4	n/a	chrIII 13,341,947	nud-1 encodes the C. elegans ortholog of the Aspergillus nidulans nudC, which mediates nuclear migration along Aspergillus hyphae.
4	F59E11.5	F59E11.5	n/a	chrV 8,995,696
5	frs-2	F22B5.9	n/a	chrII 8,465,894	C. elegans FRS-2 protein; contains similarity to Pfam domains PF03483 (B3/4 domain) , PF03484 (tRNA synthetase B5 domain) contains similarity to Interpro domains IPR009061 (Putative DNA binding), IPR004531 (Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic), IPR005146 (B3/B4 tRNA-binding domain), IPR005147 (tRNA synthetase, B5)
6	ugt-48	C18C4.3	n/a	chrV 5,546,863	C. elegans UGT-48 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR001412 (Aminoacyl-tRNA synthetase, class I, conserved site), IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
7	C29F7.2	C29F7.2	n/a	chrX 13,417,071	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
8	vrs-1	ZC513.4	n/a	chrV 8,033,348	vrs-1 encodes a predicted valyl-tRNA synthetase that affects embryonic viability, growth, and morphology
9	M03B6.1	M03B6.1	n/a	chrX 13,842,218
10	ugt-21	C33A12.6	n/a	chrIV 9,501,385	C. elegans UGT-21 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
11	sur-5	K03A1.5	n/a	chrX 7,303,412	sur-5 encodes a protein with high similarity to H. sapiens Acetoacetyl-coenzyme A synthetase; sur-5 negatively regulates let-60 during vulval induction, based on genetic analysis, and genetically synergises with lin-45 with respect to larval death, uncoordinated movement and egg-laying defects; sur-5 is strongly expressed in most cells of C. elegans, including the VPCs and is localized primarily to the nucleus.
12	tag-210	W08E3.3	n/a	chrI 13,342,122	C. elegans TAG-210 protein; contains similarity to Pfam domains PF01926 (GTPase of unknown function) , PF06071 (Protein of unknown function (DUF933)) contains similarity to Interpro domains IPR012675 (Beta-grasp fold, ferredoxin-type), IPR013029 (Protein of unknown function DUF933), IPR004396 (Conserved hypothetical protein CHP00092), IPR002917 (GTP-binding protein, HSR1-related), IPR012676 (TGS-like), IPR006073 (GTP1/OBG)
13	cyp-35A2	C03G6.15	n/a	chrV 7,363,242	C. elegans CYP-35A2 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV)
14	clec-57	F08H9.6	n/a	chrV 14,470,810	C. elegans CLEC-57 protein; contains similarity to Pfam domains PF00431 (CUB domain) (2), PF00059 (Lectin C-type domain) contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
15	C18A11.3	C18A11.3	n/a	chrX 8,063,304
16	nuo-1	C09H10.3	n/a	chrII 11,099,005	nuo-1 encodes a encodes a 51 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, and progression through development; nuo-1 is orthologous to human NDUFV1 (OMIM:161015, mutated in Leigh syndrome); nuo-1(ua1) induces a developmental arrest at the third larval (L3) stage that blocks reproduction, and thus is lethal to a population homozygous for nuo-1(ua1); yet arrested L3 nuo-1(ua1) animals have an individual lifespan significantly longer than normal.
17	F11C1.3	F11C1.3	n/a	chrX 12,983,754	contains similarity to Pfam domain PF01130 CD36 family contains similarity to Interpro domain IPR002159 (CD36 antigen)
18	C44B7.7	C44B7.7	n/a	chrII 6,879,653	contains similarity to Homo sapiens Uncharacterized protein C7orf24; ENSEMBL:ENSP00000275428
19	ptr-14	R09H10.4	n/a	chrIV 10,618,200	ptr-14 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-14 is weakly required for normal molting from L4 to adult stages; PTR-14 is also required for normal growth to full size and locomotion.
20	K06A5.6	K06A5.6	n/a	chrI 6,465,004	contains similarity to Pfam domains PF08028 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02770 (Acyl-CoA dehydrogenase, middle domain) , PF00441 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02771 (Acyl-CoA dehydrogenase, N-terminal domain) contains similarity to Interpro domains IPR013107 (Acyl-CoA dehydrogenase, type 2, C-terminal), IPR006090 (Acyl-CoA oxidase/dehydrogenase, type 1), IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR006089 (Acyl-CoA dehydrogenase, conserved site), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR006092 (Acyl-CoA dehydrogenase, N-terminal)
21	fbxa-64	T28A11.21	n/a	chrV 3,277,607	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
22	F44B9.2	F44B9.2	n/a	chrIII 8,023,742	contains similarity to Interpro domain IPR000694 (Proline-rich region)
23	amt-4	C05E11.5	n/a	chrX 4,567,404	amt-4 encodes a member of the ammonium transporter protein family.
24	phb-2	T24H7.1	n/a	chrII 6,252,083	phb-2 encodes one of two subunits of the mitochondrial prohibitin complex; loss of phb-2 activity via RNAi indicates that phb-2 function is required for mitochondrial biogenesis and maintenance and for embryonic, germline, and somatic gonad development.
25	gsto-1	C29E4.7	n/a	chrIII 7,946,235	gsto-1 encodes an experimentally verified thiol oxidoreductase and dehydroascorbate reductase, required for normal stress resistance; formally, GSTO-1 is an omega-class glutathione transferase (GST; EC 2.5.1.18), but it has little activity in vitro on classic GST substrates; GSTO-1 is expressed in postembryonic intestine; gsto-1(RNAi) induces hypersensitivity to heat-, arsenite-, juglone-, paraquat-, or cumene hydroperoxide-induced stresses, whereas overexpression of GSTO-1 enhances resistance to them; gsto-1 transcription is upregulated by stress; ELT-2 may directly activate gsto-1 transcription in developing gut via a 300-nucleotide sequence upstream of gsto-1's ATG start site.
26	ZK856.5	ZK856.5	n/a	chrV 10,187,411	contains similarity to Pfam domain PF00149 Calcineurin-like phosphoesterase contains similarity to Interpro domain IPR004843 (Metallophosphoesterase)
27	tufm-2	C43E11.4	n/a	chrI 4,248,543	C. elegans TUFM-2 protein; contains similarity to Pfam domains PF03143 (Elongation factor Tu C-terminal domain) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR005225 (Small GTP-binding protein), IPR004160 (Translation elongation factor EFTu/EF1A, C-terminal), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009001 (Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)
28	T25D3.2	T25D3.2	n/a	chrII 155,462	contains similarity to Mus musculus 39S ribosomal protein L28, mitochondrial precursor (L28mt) (MRP-L28).; SW:Q9D1B9
29	drs-2	F10C2.6	n/a	chrV 12,050,440	drs-2 encodes a putative aspartyl-tRNA synthetase.
30	tsfm-1	F55C5.5	n/a	chrV 12,270,895	F55C5.5 encodes a translational elongation factor Ts (EF-Ts) that binds two different EF-Tu proteins (EF-TU1/Y71H2AM.23 and EF-TU2/C43E11.4) in vitro, stimulating guanine-nucleotide exchange and mRNA translation; F55C5.5 is predicted to be mitochondrial and has a putative N-terminal transit peptide sequence; F55C5.5 is required in mass RNAi assays for normally rapid growth and for maintenance of the germline.
31	F25B4.6	F25B4.6	n/a	chrV 5,683,638	F25B4.6 is orthologous to the human gene 3-HYDROXY-3-METHYLGLUTARYL COA SYNTHASE (HMGCS2; OMIM:600234), which when mutated leads to disease.
32	nhx-2	B0495.4	n/a	chrII 7,692,262	nhx-2 encodes a sodium/proton exchanger expressed in the apical membranes of intestinal cells; NHX-2 is required for normally high growth rates, and for propagation or maintenance of the germline, NHX-2 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of extracellular sodium for an intracellular proton.
33	F59B8.2	F59B8.2	n/a	chrIV 9,439,991	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004790 (Isocitrate dehydrogenase NADP-dependent, eukaryotic), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
34	T23B12.2	T23B12.2	n/a	chrV 8,468,082	contains similarity to Pfam domain PF00573 Ribosomal protein L4/L1 family contains similarity to Interpro domains IPR013005 (Ribosomal protein L4/L1e, bacterial-type), IPR002136 (Ribosomal protein L4/L1e)
35	pfd-3	T06G6.9	n/a	chrI 12,729,010	pfd-3 encodes a putative prefoldin, orthologous to human VBP1 (OMIM:300133), that is required for normal alpha-tubulin synthesis, microtubule growth, mitotic spindle formation and positioning, early embryonic cell division, and embryonic and larval viability; PFD-3 is expressed cytoplasmically in most, if not all, tissues.
36	aqp-11	ZK525.2	n/a	chrIII 13,673,891	aqp-11 encodes a putative aquaporin with no function in mass RNAi assays, perhaps reflecting genetic redundancy with its paralogs AQP-9 and AQP-10; AQP-11 is orthologous to Drosophila CG12251 and human AQP11 (OMIM:609914), AQP12A (OMIM:609789), and AQP12B.
37	H19N07.1	H19N07.1	n/a	chrV 11,111,736	contains similarity to Pfam domains PF03143 (Elongation factor Tu C-terminal domain) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR004160 (Translation elongation factor EFTu/EF1A, C-terminal), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009001 (Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)
38	K07G5.5	K07G5.5	n/a	chrI 7,171,105	contains similarity to Pfam domain PF01545 Cation efflux family contains similarity to Interpro domain IPR002524 (Cation efflux protein)
39	T19D12.1	T19D12.1	n/a	chrII 6,670,282	contains similarity to Drosophila melanogaster Flybase gene name is Sgs1-PA;; FLYBASE:CG3047
40	M88.2	M88.2	n/a	chrIII 4,541,915	contains similarity to Aedes aegypti Mitochondrial ribosomal protein, S34, putative.; TR:Q17JQ1
41	folt-2	F37B4.7	n/a	chrV 2,874,024	folt-2 encodes a putative folate transporter; FOLT-2 is orthologous to human SLC19A1 (OMIM:600424), SLC19A2 (OMIM:603941, mutated in thiamine-responsive megaloblastic anemia syndrome), and SLC19A3 (OMIM:606152, mutated in biotin-responsive basal ganglia disease); heterologously expressed FOLT-2 does not significantly transport folate; FOLT-2 has no obvious function in mass RNAi assays, perhaps because of genetic redundancy with its paralogs FOLT-1 and FOLT-3.
42	tag-197	F08C6.3	n/a	chrX 7,566,676	C. elegans TAG-197 protein; contains similarity to Pfam domain PF04129 Vps52 / Sac2 family contains similarity to Interpro domain IPR007258 (Vps52/Sac2)
43	dap-3	C14A4.2	n/a	chrII 10,581,748	dap-3 is an ortholog of mammalian death-associated protein 3 (DAP3), a mitochondrial ribosomal protein that promotes apoptosis.
44	tag-257	F46G11.3	n/a	chrX 5,784,865	C. elegans TAG-257 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
45	F23C8.5	F23C8.5	n/a	chrI 2,419,472	The F23C8.5 gene encodes an ortholog of the human gene ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT (ETFB), which when mutated leads to glutaricaciduria type IIB (OMIM:130410).
46	H23N18.4	H23N18.4	n/a	chrV 4,902,178	contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
47	K12H4.3	K12H4.3	n/a	chrIII 8,046,749	contains similarity to Pfam domain PF04427 Brix domain contains similarity to Interpro domain IPR007109 (Brix)
48	R03D7.1	R03D7.1	n/a	chrII 10,928,740	R03D7.1 is orthologous to the human gene METHIONINE SYNTHASE (MTR; OMIM:156570), which when mutated leads to disease.
49	R74.7	R74.7	n/a	chrIII 4,205,094	contains similarity to Pfam domain PF01728 FtsJ-like methyltransferase contains similarity to Interpro domains IPR015507 (Ribosomal RNA methyltransferase J), IPR002877 (Ribosomal RNA methyltransferase RrmJ/FtsJ)
50	B0272.3	B0272.3	n/a	chrX 9,432,002	contains similarity to Pfam domains PF00725 (3-hydroxyacyl-CoA dehydrogenase, C-terminal domain) , PF02737 (3-hydroxyacyl-CoA dehydrogenase, NAD binding domain) contains similarity to Interpro domains IPR013328 (Dehydrogenase, multihelical), IPR008927 (6-phosphogluconate dehydrogenase, C-terminal-like), IPR006176 (3-hydroxyacyl-CoA dehydrogenase, NAD binding), IPR006168 (NAD-dependent glycerol-3-phosphate dehydrogenase), IPR006108 (3-hydroxyacyl-CoA dehydrogenase, C-terminal), IPR006180 (3-hydroxyacyl-CoA dehydrogenase, conserved site), IPR016040 (NAD(P)-binding), IPR006036 (Potassium uptake protein TrkA)