UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	Y47H9C.7	Y47H9C.7	0	chrI 11,892,653	Y47H9C.7 is orthologous to the human gene EUKARYOTIC TRANSLATION INITIATION FACTOR 2B, SUBUNIT 2 (BETA, 39KD) (EIF2B2; OMIM:606454), which when mutated leads to disease.
2	alr-1	R08B4.2	n/a	chrX 11,123,705	C. elegans ALR-1 protein; contains similarity to Pfam domain PF00046 Homeobox domain contains similarity to Interpro domains IPR012287 (Homeodomain-related), IPR000047 (Helix-turn-helix motif, lambda-like repressor), IPR013847 (POU), IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
3	F48A11.4	F48A11.4	n/a	chrII 214,905
4	rod-1	F55G1.4	n/a	chrIV 7,481,969	C. elegans ROD-1 protein ; contains similarity to Caenorhabditis remanei Putative RoughDeal (Fragment).; TR:Q4TTM7
5	C52E12.4	C52E12.4	n/a	chrII 7,017,594	contains similarity to Pfam domains PF01477 (PLAT/LH2 domain) , PF02141 (DENN (AEX-3) domain) , PF03456 (uDENN domain) , PF03455 (dDENN domain) , PF02759 (RUN domain) contains similarity to Interpro domains IPR005112 (dDENN), IPR001024 (Lipoxygenase, LH2), IPR008976 (Lipase/lipooxygenase, PLAT/LH2), IPR004012 (RUN), IPR005113 (uDENN), IPR001194 (DENN)
6	lin-1	C37F5.1	n/a	chrIV 2,288,106	lin-1 encodes an Ets-domain-containing transcription factor that is a member of the ETS gene family that includes human ELK1, 3, and 4 (OMIM:600247); LIN-1 functions as a general effector of MAP kinase-mediated signaling; when MAP kinase is inactive, LIN-1 forms a complex with LIN-31/WH that inhibits vulval cell fate specification; upon MAP kinase activation (vulval induction), LIN-1 is phosphorylated, dissociates from LIN-31, and becomes inactive, thus allowing for vulval development.
7	fbxb-76	H02I12.2	n/a	chrIV 11,378,732	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
8	his-12	ZK131.6	n/a	chrII 13,821,298	his-12 encodes an H2A histone; his-12 is contained within the histone gene cluster HIS3.
9	K06A4.4	K06A4.4	n/a	chrV 9,502,894	contains similarity to Pfam domain PF03083 MtN3/saliva family contains similarity to Interpro domain IPR004316 (MtN3 and saliva related transmembrane protein)
10	F53B1.2	F53B1.2	n/a	chrX 2,110,346	contains similarity to Pfam domains PF07647 (SAM domain (Sterile alpha motif)) , PF00536 (SAM domain (Sterile alpha motif)) contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR000326 (Phosphatidic acid phosphatase type 2/haloperoxidase), IPR013761 (Sterile alpha motif-type), IPR001660 (Sterile alpha motif SAM), IPR011510 (Sterile alpha motif homology 2)
11	cah-5	R173.1	n/a	chrX 7,021,932	cah-5 encodes a member of the carbonic anhydrase family.
12	cacn-1	W03H9.4	n/a	chrII 14,137,700	cacn-1 encodes an ortholog of Drosophila CACTIN and human C19orf29 that is required for normal distal tip cell migration, embryonic viability, fertility, locomotion, vulval morphogenesis, and normally rapid growth; like CACTIN, CACN-1 contains predicted coiled-coil domains, but otherwise lacks recognizable similarity to known proteins.
13	Y38H6C.14	Y38H6C.14	n/a	chrV 20,527,484	contains similarity to Leishmania major strain Friedlin Proteophosphoglycan 5.; TR:Q4FX62
14	M01B2.10	M01B2.10	n/a	chrV 15,261,657	contains similarity to Homo sapiens Phytanoyl-CoA 2-hydroxylase-interacting protein-like; ENSEMBL:ENSP00000362987
15	C53C11.1	C53C11.1	n/a	chrX 17,340,978	contains similarity to Interpro domain IPR010993 (Sterile alpha motif homology)
16	syn-13	F36F2.4	n/a	chrI 9,003,016	C. elegans SYN-13 protein; contains similarity to Pfam domain PF05739 SNARE domain contains similarity to Interpro domains IPR010989 (t-SNARE), IPR006011 (Syntaxin, N-terminal), IPR000727 (Target SNARE coiled-coil region), IPR006012 (Syntaxin/epimorphin, conserved site)
17	F45G2.10	F45G2.10	n/a	chrIII 13,438,200	contains similarity to Pfam domain PF01883 Domain of unknown function DUF59 contains similarity to Interpro domain IPR002744 (Protein of unknown function DUF59)
18	dat-1	T23G5.5	n/a	chrIII 9,244,759	dat-1 encodes a plasma membrane dopamine transporter; DAT-1 is predicted to regulate dopaminergic neurotransmission via reuptake of dopamine into presynaptic neurons; when expressed in HeLa cells, DAT-1 exhibits high affinity, saturable dopamine transport; further, in primary cultures of C. elegans dopaminergic neurons, DAT-1 also exhibits a channel mode of conduction that leads to membrane depolarization; in hermaphrodites, dat-1 is expressed in the eight dopaminergic neurons (4 CEPs, 2 ADEs, and 2 PDEs), while in males dat-1 is additionally expressed in the three pairs of tail dopaminergic neurons; dat-1 expression begins during embryogenesis with the exception of expression in the PDE neurons which are born postembryonically.
19	nhr-227	T27B7.5	n/a	chrV 2,286,399	C. elegans NHR-227 protein; contains similarity to Pfam domain PF00105 Zinc finger, C4 type (two domains) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
20	E02H9.4	E02H9.4	n/a	chrIII 2,457,255	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
21	cdc-42	R07G3.1	n/a	chrII 7,617,275	cdc-42 encodes a RHO GTPase which controls polarity of both individual cells and developing embryos by regulating the localization of PAR proteins; CDC-42 is expressed at hypodermal cell boundaries; cdc-42 expression levels are unusually stable, with relatively little variation between adults, dauers, and L3 larvae, or between wild-type and daf-2(e1370ts) or daf-16(m26) mutant adults.
22	sra-31	C56C10.5	n/a	chrII 6,577,792	C. elegans SRA-31 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domain IPR000344 (Nematode chemoreceptor, Sra)
23	F38A1.13	F38A1.13	n/a	chrIV 1,265,538
24	tgt-1	ZK829.6	n/a	chrIV 11,958,629	tgt-1 encodes a tRNA-guanine transglycosylase predicted to be mitochondrial.
25	F08D12.7	F08D12.7	n/a	chrII 2,768,193	F08D12.7 encodes a novel protein conserved amongst Caenorhaditis species; although loss of F08D12.7 activity via RNAi results in no obvious defects, F08D12.7 transcripts are enriched in L1-stage muscle and upregulated in L2 larvae in response to overexpression of hlh-2 and hlh-8; in addition, in analyses of the early embryonic transcriptome, F08D12.7 transcripts are classified as strictly maternal; an F08D12.7::gfp reporter fusion is expressed in the vm1 and vm2 vulval muscles, the intestinal and anal depressor muscles, the hypodermis, distal tip cell, ventral nerve cord, head and tail neurons, and body wall muscle.
26	C05G5.2	C05G5.2	n/a	chrX 14,748,776	contains similarity to Xenopus laevis Nucleolar phosphoprotein.; TR:Q91803
27	C25G6.4	C25G6.4	n/a	chrX 1,248,831
28	ing-3	Y51H1A.4	n/a	chrII 13,879,211	Y51H1A.4 is orthologous to the human gene P33ING1B (ING1; OMIM:601566), which when mutated leads to disease.
29	Y37E11B.6	Y37E11B.6	n/a	chrIV 3,598,943	Y37E11B.6 encodes an ortholog of Rpp21 (Rpr2), a protein subunit of the endoribonuclease RNAse P, which cleaves tRNA precursors to produce their mature 5' end.
30	T15D6.4	T15D6.4	n/a	chrI 12,375,417	contains similarity to Aedes aegypti N-acetyllactosaminide beta-1,3-n-acetylglucosaminyltransferase.; TR:Q175J5
31	F18A12.7	F18A12.7	n/a	chrII 3,412,942	contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
32	F40G9.1	F40G9.1	n/a	chrIII 196,177	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
33	str-20	C05E4.2	n/a	chrV 757,182	C. elegans STR-20 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
34	F53H1.3	F53H1.3	n/a	chrIV 1,334,268	contains similarity to Pfam domain PF07792 Protein of unknown function (DUF1630) contains similarity to Interpro domain IPR012860 (Protein of unknown function DUF1630)
35	Y116A8C.25	Y116A8C.25	n/a	chrIV 17,076,616	contains similarity to Pfam domain PF03881 Fructosamine kinase contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR005581 (Fructosamine kinase)
36	flr-1	F02D10.5	n/a	chrX 13,454,529	flr-1 encodes an ion channel that belongs to the DEG/ENaC sodium channel superfamily; flr-1 activity is essential for normal defecation rhythm, growth rates, expulsion, and dauer larvae formation; a rescuing FLR-1::GFP reporter is expressed in the intestine from embryonic to adult stages where it localizes to the membranes facing the inner lumen as well as to part of the lateral membrane between intestinal cells.
37	F53A2.3	F53A2.3	n/a	chrIII 13,338,285	contains similarity to Streptococcus agalactiae Hypothetical protein.; TR:Q8E5X9
38	tsr-1	F53G2.6	n/a	chrII 2,466,865	tsr-1 encodes a homolog of human transportin-SR, a nuclear transport receptor, and affects embryonic viability.
39	math-39	T08E11.2	n/a	chrII 1,832,929	C. elegans MATH-39 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
40	cdh-1	R10F2.1	n/a	chrIII 2,923,253	cdh-1 encodes a cadherin that is similar, in the extracellular domain, to the Drosophila cadherin Dachsous (Ds); although the precise role of cdh-1 in C. elegans development and/or behavior is not yet known, loss of cdh-1 activity via RNAi using the hypersensitive rrf-3 strain can result in locomotion and growth defects, as well as larval lethality.
41	K02E7.4	K02E7.4	n/a	chrII 1,073,572	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domain IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
42	F36D1.8	F36D1.8	n/a	chrI 11,257,879	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
43	R148.2	R148.2	n/a	chrIII 3,184,321
44	F44F1.4	F44F1.4	n/a	chrI 13,264,689	contains similarity to Sulfolobus solfataricus DNA double-strand break repair rad50 ATPase.; SW:Q97WH0
45	tra-4	F53B3.1	n/a	chrX 2,855,643	C. elegans TRA-4 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR008162 (Inorganic pyrophosphatase), IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
46	T14G10.8	T14G10.8	n/a	chrIV 10,146,609	contains similarity to Homo sapiens Splice isoform 1 of P08235 Mineralocorticoid receptor; ENSEMBL:ENSP00000281330
47	R01H2.1	R01H2.1	n/a	chrIII 7,062,968
48	F53A2.9	F53A2.9	n/a	chrIII 13,357,930	contains similarity to Pfam domain PF00646 (F-box domain)
49	W03A5.6	W03A5.6	n/a	chrIII 5,440,330
50	nhr-78	F36A4.14	n/a	chrIV 4,276,441	C. elegans NHR-78 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)