UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	fcd-2	Y41E3.9	0	chrIV 15,031,338	fcd-2 encodes an ortholog of the human gene FANCD2 (mutated in Fanconi anemia, OMIM:227646) that is strongly required for resistance to DNA interstrand crosslinking (ICL) agents, but not to ionizing radiation (IR); fcd-2 mutants are viable and dispensable for resistance to IR, meiotic recombination, and S-phase checkpoint activation, but are hypersensitive to ICL agents; like its human ortholog, FCD-2 is monoubiquitylated and recruited to chromosomal foci after ICL but not IR; transgenic expresssion of the FANCD2 gene in mutant FA-D2 cells rescues their abnormal sensitivity to mitomycin C, an agent that cross-links strands of DNA.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	K09H9.7	K09H9.7	n/a	chrI 3,151,195	contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
4	R05D3.8	R05D3.8	n/a	chrIII 8,357,800	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
5	F48E8.6	F48E8.6	n/a	chrIII 5,444,858	contains similarity to Pfam domain PF00773 RNB domain contains similarity to Interpro domain IPR001900 (Ribonuclease II and R)
6	djr-1.1	B0432.2	n/a	chrII 291,212	djr-1.1 encodes an ortholog of DJ-1 (OMIM:602533, mutated in early-onset Parkinson disease); DJR-1.1 is required for resistance to rotenone, a mitochondrial complex I inhibitors that mimics Parkinson disease (PD); djr-1.1(RNAi) animals are partly rescued from PD-like sensitivity by D-beta-hydroxybutyrate or tauroursodeoxycholic acid, and fully rescued by both; by orthology with DJ-1, DJR-1.1 may promote stability of the transcription factors SKN-1 or SKNR-1 (homologs of mammalian NFE2L2).
7	ani-3	Y43F8C.14	n/a	chrV 19,696,771	ani-3 encodes one of three C. elegans anillins.
8	K02B7.2	K02B7.2	n/a	chrII 14,692,031	contains similarity to Pfam domains PF07735 (F-box associated) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR012885 (F-box associated type 2)
9	hsf-1	Y53C10A.12	n/a	chrI 11,957,869	hsf-1 encodes the C. elegans heat-shock transcription factor ortholog; HSF-1 functions as a transcriptional regulator of stress-induced gene expression whose activity is required for heat-shock and proteotoxicity response, larval development, innate immunity, and regulation of adult lifespan.
10	R05F9.11	R05F9.11	n/a	chrII 4,913,028
11	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
12	C47D12.2	C47D12.2	n/a	chrII 11,677,666	C47D12.2 encodes an ortholog of human FLJ20071/FLJ90130 (dymeclin, OMIM:607461, mutated in Dyggve-Melchior-Clausen dysplasia and Smith-McCort dysplasia), which has no obvious function in mass RNAi assays
13	math-37	R52.9	n/a	chrII 2,121,460	C. elegans MATH-37 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
14	hpr-17	F32A11.2	n/a	chrII 13,155,162	C. elegans HPR-17 protein; contains similarity to Pfam domain PF03215 Rad17 cell cycle checkpoint protein contains similarity to Interpro domains IPR004582 (Checkpoint protein Rad24), IPR003593 (AAA+ ATPase, core)
15	H25P19.1	H25P19.1	n/a	chrV 688,859
16	C16C2.4	C16C2.4	n/a	chrI 9,714,017	contains similarity to Pfam domain PF03909 BSD domain contains similarity to Interpro domain IPR005607 (BSD)
17	C04F5.8	C04F5.8	n/a	chrV 5,112,623	contains similarity to Bos taurus Similar to C04F5.8.; TR:Q0IIF4
18	col-70	H17B01.2	n/a	chrII 1,471,156	C. elegans COL-70 protein; contains similarity to Interpro domain IPR000694 (Proline-rich region)
19	C45G9.2	C45G9.2	n/a	chrIII 5,069,704	contains similarity to Pfam domain PF01207 Dihydrouridine synthase (Dus) contains similarity to Interpro domains IPR013785 (Aldolase-type TIM barrel), IPR003733 (Thiamine monophosphate synthase), IPR001269 (Dihydrouridine synthase, DuS)
20	R10E8.2	R10E8.2	n/a	chrV 18,254,063	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
21	ZK402.1	ZK402.1	n/a	chrX 1,405,182
22	C14C11.7	C14C11.7	n/a	chrV 5,665,729
23	ced-6	F56D2.7	n/a	chrIII 5,596,872	ced-6 encodes an Src homology (SH) 3 and phosphotyrosine-binding (PTB) domain-containing adaptor protein, orthologous to human CED-6/GULP, that is required for cell corpse engulfment during apoptosis; CED-6 is bound by the phosphotyrosine binding motif in the cytoplasmic tail of the transmembrane protein CED-1, and and within phagocytic cells this interaction may be part of a signal transduction pathway that promotes apoptotic cell engulfment.
24	srw-127	C33G8.1	n/a	chrV 7,013,646	C. elegans SRW-127 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
25	ttr-53	T14G10.3	n/a	chrIV 10,158,369	C. elegans TTR-53 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
26	T27E9.6	T27E9.6	n/a	chrIII 13,475,636	contains similarity to Bradyrhizobium japonicum Bsl1006 protein.; TR:Q89VN9
27	F37D6.3	F37D6.3	n/a	chrI 10,487,009	contains similarity to Interpro domain IPR002004 (Polyadenylate-binding protein/Hyperplastic disc protein)
28	C10A4.2	C10A4.2	n/a	chrX 7,412,571
29	fbxa-193	F59A1.9	n/a	chrV 17,654,348	C. elegans FBXA-193 protein; contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domains IPR001000 (Glycoside hydrolase, family 10), IPR001810 (Cyclin-like F-box)
30	ndx-9	F13H10.2	n/a	chrIV 11,010,995	The ndx-9 gene encodes a member of the NADH pyrophosphatase subfamily of the NUDIX hydrolases.
31	R11.1	R11.1	n/a	chrX 16,192,348	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
32	dos-1	ZK507.4	n/a	chrIII 9,105,304	C. elegans DOS-1 protein ;
33	C41A3.1	C41A3.1	n/a	chrX 5,427,831	contains similarity to Pfam domains PF02801 (Beta-ketoacyl synthase, C-terminal domain) (5), PF01370 (NAD dependent epimerase/dehydratase family) , PF08659 (KR domain) (2), PF00501 (AMP-binding enzyme) , PF00668 (Condensation domain) , PF00106 (short chain dehydrogenase) , PF00109 (Beta-ketoacyl synthase, N-terminal domain) (5), PF00550 (Phosphopantetheine attachment site) (8), PF00698 (Acyl transferase domain) (2)contains similarity to Interpro domains IPR016035 (Acyl transferase/acyl hydrolase/lysophospholipase), IPR006163 (Phosphopantetheine-binding), IPR001242 (Condensation domain), IPR016038 (Thiolase-like, subgroup), IPR013968 (Polyketide synthase, KR), IPR000794 (Beta-ketoacyl synthase), IPR001509 (NAD-dependent epimerase/dehydratase), IPR014031 (Beta-ketoacyl synthase, C-terminal), IPR014043 (Acyl transferase), IPR014030 (Beta-ketoacyl synthase, N-terminal), IPR008262 (Lipase, active site), IPR006162 (Phosphopantetheine attachment site), IPR000873 (AMP-dependent synthetase and ligase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016039 (Thiolase-like), IPR016040 (NAD(P)-binding), IPR009081 (Acyl carrier protein-like), IPR001227 (Acyl transferase region)
34	F20D12.2	F20D12.2	n/a	chrIV 7,951,094	contains similarity to Pfam domain PF03399 SAC3/GANP/Nin1/mts3/eIF-3 p25 family contains similarity to Interpro domain IPR005062 (SAC3/GANP/Nin1/mts3/eIF-3 p25)
35	uev-1	F39B2.2	n/a	chrI 14,790,521	uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-1 in C. elegans development and/or behavior is not yet known; UEV-1 does, however, interact with a number of proteins, such as UBC-13, that are likely involved in the response to DNA damage; thus, UEV-1 may play a role in ubiquitination and protein turnover in conjunction with DNA repair or the DNA damage checkpoint pathway.
36	C01H6.9	C01H6.9	n/a	chrI 7,231,276	C01H6.9 encodes a homolog of haploid germ cell-specific nuclear protein kinase (haspin) that specifically binds GOA-1 in yeast two-hybrid assays; C01H6.9 is expressed in PHB sensory neurons and PVT interneurons in the tail, several unidentified neurons in the head (with projections to the nose and nerve ring), and intestinal cells, with mainly nuclear localization; C01H6.9 has no obvious function or phenotype in RNAi assays, either alone or with inactivation of a close paralog (F22H10.5).
37	clec-144	T27D12.3	n/a	chrII 11,831,976	C. elegans CLEC-144 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
38	srw-134	T05B4.7	n/a	chrV 4,111,591	C. elegans SRW-134 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
39	B0261.7	B0261.7	n/a	chrI 5,270,246
40	M18.6	M18.6	n/a	chrIV 12,122,042	contains similarity to Interpro domain IPR003111 (Peptidase S16, lon N-terminal)
41	sra-9	AH6.14	n/a	chrII 9,533,057	C. elegans SRA-9 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domain IPR000344 (Nematode chemoreceptor, Sra)
42	E03H12.9	E03H12.9	n/a	chrIV 4,990,834	contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domain IPR006583 (CW)
43	btb-19	F57C2.2	n/a	chrII 14,521,504	C. elegans BTB-19 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
44	F26F4.6	F26F4.6	n/a	chrIII 4,892,477	contains similarity to Homo sapiens Similar to Suppressor protein SRP40; VG:OTTHUMP00000170311
45	wht-4	F02E11.1	n/a	chrII 3,280,577	C. elegans WHT-4 protein; contains similarity to Pfam domains PF01061 (ABC-2 type transporter) , PF00005 (ABC transporter) contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR003593 (AAA+ ATPase, core), IPR005284 (Pigment precursor permease), IPR013525 (ABC-2 type transporter)
46	tag-296	F49D11.9	n/a	chrI 10,934,755	C. elegans TAG-296 protein; contains similarity to Pfam domain PF08718 Glycolipid transfer protein (GLTP) contains similarity to Interpro domain IPR014830 (Glycolipid transfer protein, GLTP)
47	T24B8.2	T24B8.2	n/a	chrII 9,055,661	contains similarity to Pfam domain PF03357 Snf7 contains similarity to Interpro domain IPR005024 (Snf7)
48	C06A5.4	C06A5.4	n/a	chrI 5,981,191	contains similarity to Interpro domain IPR006578 (MADF)
49	lips-17	R07G3.2	n/a	chrII 7,609,466	C. elegans LIPS-17 protein; contains similarity to Pfam domain PF01674 Lipase (class 2) contains similarity to Interpro domains IPR002918 (Lipase, class 2), IPR008262 (Lipase, active site)
50	K11G9.3	K11G9.3	n/a	chrV 6,670,893	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)