UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	mes-4	Y2H9A.1	0	chrV 13,435,282	mes-4 encodes a SET domain-containing protein that also contains three plant homeodomain (PHD) fingers; MES-4 is required maternally for normal germline development, but in contrast to MES-2, -3, and -6, does not appear to be required for somatic anteroposterior patterning; in germline development, MES-4 activity is essential for regulating active chromatin states and for excluding the MES-2/MES-3/MES-6 chromatin repression complex from the autosomes; MES-4 is also required for germline silencing of repetitive transgene arrays; MES-4 localizes to autosomes, and is detectable in the distal, mitotic region of the germline, in meiotic germ cells during late pachytene, and in oocytes; MES-4 is detected in all somatic and germline nuclei of the early embryo, but by the 100-cell stage, its expression becomes restricted to the primordial germ cells, Z2 and Z3; exclusion of MES-4 from X chromosomes requires the activity of the MES-2, -3, -6 complex.
2	adbp-1	VW02B12L.4	n/a	chrII 11,444,624	C. elegans ADBP-1 protein ;
3	F36A2.8	F36A2.8	n/a	chrI 8,811,005	contains similarity to Pfam domain PF05005 Janus/Ocnus family (Ocnus) contains similarity to Interpro domain IPR007702 (Janus/Ocnus)
4	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
5	fbxa-139	B0391.9	n/a	chrV 15,593,604	C. elegans FBXA-139 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
6	W06A11.2	W06A11.2	n/a	chrII 4,060,321
7	F56A8.4	F56A8.4	n/a	chrIII 13,264,008	contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
8	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
9	F55C5.4	F55C5.4	n/a	chrV 12,273,750	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
10	F09E5.11	F09E5.11	n/a	chrII 5,357,780	F09E5.11 encodes a divergent ortholog of S. cerevisiae VPH2/VMA12; like VPH2, F09E5.11 may be required for vacuolar proton-translocating ATPase (V-ATPase) assembly in the endoplasmic reticulum.
11	mxl-2	F40G9.11	n/a	chrIII 187,571	C. elegans MXL-2 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
12	ZK1248.11	ZK1248.11	n/a	chrII 5,828,127	contains similarity to Xenopus laevis E3 SUMO-protein ligase NSE2 (EC 6.-.-.-) (Non-structural maintenancesof chromosomes element 2 homolog) (Non-SMC element 2 homolog).; SW:Q7ZXH2
13	mom-5	T23D8.1	n/a	chrI 9,967,489	mom-5 encodes one of four C. elegans members of the Frizzled (Fz) family of seven transmembrane receptors; during development, MOM-5 activity is required for asymmetric cell division in the early embryo as well as for asymmetric cell division during neuronal development; MOM-5::GFP is enriched at the posterior pole of cells prior to division and during later stages of embryogenesis, is found at the leading edges of epidermal cells during ventral enclosure; in neuroblasts, MOM-5 is required for proper subcellular distribution of DSH-2 to the cortex.
14	fbxb-119	B0462.3	n/a	chrV 18,319,134	C. elegans FBXB-119 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
15	C48B4.11	C48B4.11	n/a	chrIII 9,565,286	contains similarity to Interpro domain IPR006069 (ATPase, P-type cation exchange, alpha subunit)
16	T22C1.3	T22C1.3	n/a	chrI 7,939,331	contains similarity to Pfam domain PF06728 GPI transamidase subunit PIG-U contains similarity to Interpro domain IPR009600 (GPI transamidase subunit PIG-U)
17	srh-128	Y47G7B.1	n/a	chrII 2,704,344	C. elegans SRH-128 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
18	M05D6.2	M05D6.2	n/a	chrII 8,469,058	contains similarity to Pfam domain PF05794 T-complex protein 11 contains similarity to Interpro domain IPR008862 (T-complex 11)
19	Y4C6B.1	Y4C6B.1	n/a	chrIV 5,355,504	contains similarity to Interpro domain IPR000694 (Proline-rich region)
20	his-60	F55G1.11	n/a	chrIV 7,487,766	his-60 encodes an H4 histone; by homology, HIS-60 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-60 expression is detected in early embryos, beginning at the 28-cell stage and continuing through the comma stage (early morphogenesis); his-60 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV.
21	uba-2	W02A11.4	n/a	chrI 12,745,085	uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation.
22	K02E7.3	K02E7.3	n/a	chrII 1,077,813	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
23	ceh-49	F17A9.6	n/a	chrV 6,119,282	ceh-49 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; CEH-49 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, CEH-49 is (somewhat distantly) affiliated with CEH-48, Drosophila ONECUT, and mammalian HNF6 proteins; CEH-49 has no obvious function in mass RNAi assays.
24	F59E12.11	F59E12.11	n/a	chrII 5,648,707	contains similarity to Homo sapiens Isoform 1 of Loss of heterozygosity 12 chromosomal region 1 protein; ENSEMBL:ENSP00000321546
25	pqn-45	F56F3.1	n/a	chrIII 4,473,243	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
26	C55C3.5	C55C3.5	n/a	chrIV 5,699,611	contains similarity to Interpro domain IPR001124 (Lipid-binding serum glycoprotein)
27	sdz-26	R06A4.6	n/a	chrII 14,382,371	C. elegans SDZ-26 protein; contains similarity to Pfam domain PF07149 Pes-10 contains similarity to Interpro domain IPR009819 (Pes-10)
28	F31C3.3	F31C3.3	n/a	chrI 15,045,790	contains similarity to Interpro domain IPR001000 (Glycoside hydrolase, family 10)
29	set-17	T21B10.5	n/a	chrII 8,939,689	set-17 encodes a SET domain-containing protein orthologous to human PRDM11 and PRDM7 (Q9NQW5-2; OMIM:609759); SET-17 is expressed in many or all cells of embryo, and several postembryonic tissues (hypodermis, muscle, and excretory cell); neither set-17(n5017) nor set-17(RNAi) have any obvious phenotypes.
30	hcp-3	F58A4.3	n/a	chrIII 9,615,787	The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
31	C49C3.7	C49C3.7	n/a	chrIV 17,333,023	contains similarity to Homo sapiens Isoform Short of CAP-Gly domain-containing linker protein 1; ENSEMBL:ENSP00000355314
32	wdfy-2	D2013.2	n/a	chrII 9,320,794	wdfy-2 encodes a WD40- and FYVE-domain containing protein that is orthologous to mammalian WDFY2; WDFY-2 is one of twelve C. elegans FYVE-domain-containing proteins; wdfy-2 activity is essential for wild-type levels of endocytosis.
33	T11B7.1	T11B7.1	n/a	chrIV 8,841,747	contains similarity to Mus musculus Girdin (Girders of actin filament) (Coiled-coil domain-containingsprotein 88A) (Akt phosphorylation enhancer) (APE) (Hook-relatedsprotein 1) (HkRP1) (G alpha-interacting vesicle-associated protein)s(GIV).; SW:Q5SNZ0
34	K07F5.12	K07F5.12	n/a	chrIV 9,856,975	contains similarity to Pfam domain PF07857 CEO family (DUF1632) contains similarity to Interpro domain IPR012435 (Protein of unknown function DUF1632)
35	T02C12.2	T02C12.2	n/a	chrIII 4,020,894	contains similarity to Danio rerio Zgc:56295.; TR:Q7ZU76
36	M02B7.4	M02B7.4	n/a	chrIV 3,802,482	contains similarity to Pfam domain PF08660 Oligosaccharide biosynthesis protein Alg14 like contains similarity to Interpro domain IPR013969 (Oligosaccharide biosynthesis protein Alg14 like)
37	tbg-1	F58A4.8	n/a	chrIII 9,627,816	tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes.
38	rnf-5	C16C10.7	n/a	chrIII 4,165,557	This gene encodes a homolog of mammalian RNF5, a C3HC4 (RING-finger) zinc-finger protein.
39	Y106G6H.15	Y106G6H.15	n/a	chrI 10,473,965	contains similarity to Pfam domain PF07160 Protein of unknown function (DUF1395) contains similarity to Interpro domain IPR009829 (Protein of unknown function DUF1395)
40	fbxb-78	E04A4.1	n/a	chrIV 4,738,137	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
41	C14B1.8	C14B1.8	n/a	chrIII 3,719,182	C14B1.8 encodes a coiled-coil protein.
42	C33H5.6	C33H5.6	n/a	chrIV 7,776,604	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR000664 (Lethal(2) giant larvae protein), IPR015943 (WD40/YVTN repeat-like)
43	F40G9.7	F40G9.7	n/a	chrIII 165,986
44	T25B9.8	T25B9.8	n/a	chrIV 10,767,369	contains similarity to Interpro domain IPR003006 (Immunoglobulin/major histocompatibility complex, conserved site)
45	bath-3	F59H6.10	n/a	chrII 2,029,895	C. elegans BATH-3 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
46	F46F11.8	F46F11.8	n/a	chrI 5,625,448
47	pch-2	F10B5.5	n/a	chrII 8,159,065	pch-2 encodes a putative AAA+-type ATPase orthologous to budding yeast PCH2 and human TRIP13 (OMIM:604507); PCH-2 is required for the apoptosis of pachytene cells induced by unsynapsed chromosomal pairing centers, but is dispensable for meiotic apoptosis induced by DNA damage; PCH-2-mediated apoptosis is inhibited by SYP-1 and SYP-2, while it requires HIM-8 (and probably HIM-8's paralogs, ZIM-1/-3 and C02F5.12); however, PCH-2-mediated apoptosis does not require SPO-11; pch-2 transcripts are enriched during oogenesis; the excess germline apoptosis of syp-1(me17) mutants is partially suppressed by pch-2(tm1458), and fully suppressed by pch-2(tm1458);spo-11(ok79).
48	C47G2.4	C47G2.4	n/a	chrII 11,292,129	contains similarity to Pfam domain PF04791 LMBR1-like membrane protein contains similarity to Interpro domain IPR006876 (LMBR1-like conserved region)
49	T12F5.1	T12F5.1	n/a	chrI 3,742,059
50	C15C6.4	C15C6.4	n/a	chrI 12,214,144	C15C6.4 encodes an ortholog of Pop4 (Rpp29), a protein subunit of the endoribonuclease RNAse P, which cleaves tRNA precursors to produce their mature 5' end; C15C6.4 is evolutionarily ubiquitous among eukaryotes.