UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	Y11D7A.1	Y11D7A.1	4e-169	chrIV 9,229,724	contains similarity to Interpro domains IPR003702 (Acetyl-CoA hydrolase/transferase), IPR001220 (Legume lectin, beta domain)
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	F47D12.3	F47D12.3	n/a	chrIII 6,298,853	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
4	F56G4.1	F56G4.1	n/a	chrI 11,343,556	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
5	srr-9	T05B11.2	n/a	chrV 7,738,784	C. elegans SRR-9 protein; contains similarity to Pfam domain PF03268 Caenorhabditis protein of unknown function, DUF267 contains similarity to Interpro domain IPR004950 (Protein of unknown function DUF267, Caenorhabditis species)
6	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
7	K03H1.10	K03H1.10	n/a	chrIII 9,923,743	contains similarity to Pfam domains PF02172 (KIX domain) , PF02135 (TAZ zinc finger) contains similarity to Interpro domains IPR003101 (Coactivator CBP, KIX), IPR000197 (Zinc finger, TAZ-type)
8	srp-6	C03G6.19	n/a	chrV 7,385,156	srp-6 encodes a functional serpin (serine protease inhibitor)
9	R06A10.1	R06A10.1	n/a	chrI 1,087,211	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
10	grl-22	W03A5.3	n/a	chrIII 5,413,566	grl-22 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
11	F09C12.6	F09C12.6	n/a	chrII 5,117,137	contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
12	dhs-30	T25G12.7	n/a	chrX 17,233,193	dhs-30 encodes a member of the short-chain dehydrogenases/reductases family (SDR) homologous to HSD, which when mutated leads to cortisol 11-beta ketoreductase deficiency (OMIM:218030).
13	F15D3.6	F15D3.6	n/a	chrI 11,574,794	contains similarity to Pfam domain PF04707 PRELI-like family contains similarity to Interpro domain IPR006797 (MSF1)
14	Y76A2B.5	Y76A2B.5	n/a	chrIII 13,547,827	contains similarity to Danio rerio Zgc:91819 protein.; TR:Q6GMH4
15	F22B3.8	F22B3.8	n/a	chrIV 11,423,572	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000980 (SH2 motif), IPR008266 (Tyrosine protein kinase, active site)
16	lec-4	C44F1.3	n/a	chrIII 3,772,356	lec-4 encodes a predicted galectin that exhibits sugar binding properties in vitro.
17	srp-5	C03G6.18	n/a	chrV 7,382,647	srp-5 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-5 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases; however, as loss of srp-5 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-5 in C. elegans development and/or behavior is not yet known.
18	dct-11	W06B11.3	n/a	chrX 5,838,856	C. elegans DCT-11 protein ;
19	C01H6.6	C01H6.6	n/a	chrI 7,223,298	C01H6.6 encodes a predicted transmembrane protein orthologous to human ACDP1-ACDP4 and S. cerevisiae MAM3, and paralogous to C33D12.2, C52D10.12, M02F4.3, R04E5.2, and R13G10.4; by orthology with MAM3, C01H6.6 may participate in metal homoeostasis; C01H6.6, MAM3, and ACDP1-ACDP4 belong to a family of proteins (sharing an ACD domain) from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein; bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; C01H6.6 has no obvious function in RNAi assays.
20	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
21	pah-1	K08F8.4	n/a	chrII 8,763,866	pah-1 encodes a biochemically active phenylalanine-4-hydroxylase orthologous to human PAH (OMIM:261600, mutated in phenylketonuria); recombinant PAH-1 has hydroxylase activity on phenylalanine and tryptophan substrates in vitro; pah-1 is expressed in seam cells, tail hypodermal cells, and ventral hypodermis, with stronger posterior than anterior expression; PAH-1 might help provide tyrosine for cross-linking in the cuticle, and is partially required for the tyrosinemic phenotype of K10C2.4(RNAi) animals.
22	T12B3.3	T12B3.3	n/a	chrIV 7,375,883	contains similarity to Pfam domain PF03009 Glycerophosphoryl diester phosphodiesterase family contains similarity to Interpro domain IPR004129 (Glycerophosphoryl diester phosphodiesterase)
23	W09D12.1	W09D12.1	n/a	chrV 14,919,682	contains similarity to Pfam domain PF00413 Matrixin contains similarity to Interpro domains IPR000585 (Hemopexin), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR006026 (Peptidase, metallopeptidases), IPR001818 (Peptidase M10A and M12B, matrixin and adamalysin), IPR002477 (Peptidoglycan binding-like), IPR016293 (Peptidase M10A, matrix metallopeotidase)
24	col-33	F36A4.6	n/a	chrIV 4,264,264	col-33 encodes a predicted cuticular collagen; by homology, col-33 is predicted to play a role in cuticle biosynthesis and regulation of body size and morphogenesis; however, as loss of col-33 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of COL-33 in C. elegans development and/or behavior is not yet known.
25	T18D3.8	T18D3.8	n/a	chrX 12,437,812
26	F56B3.6	F56B3.6	n/a	chrIV 789,430	contains similarity to Pfam domain PF03134 TB2/DP1, HVA22 family contains similarity to Interpro domain IPR004345 (TB2/DP1 and HVA22 related protein)
27	C43D7.7	C43D7.7	n/a	chrV 19,319,210	contains similarity to Dictyostelium discoideum Filament-interacting protein.; TR:Q967Y0
28	F10C1.3	F10C1.3	n/a	chrII 5,757,653
29	F58H7.8	F58H7.8	n/a	chrIV 908,458
30	twk-1	F21C3.1	n/a	chrI 7,270,700	C. elegans TWK-1 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2)
31	C49D10.8	C49D10.8	n/a	chrII 3,859,527	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
32	C25F9.5	C25F9.5	n/a	chrV 19,409,124	contains similarity to Pfam domain PF00176 SNF2 family N-terminal domain contains similarity to Interpro domain IPR000330 (SNF2-related)
33	K02B2.3	K02B2.3	n/a	chrIV 5,938,425	contains similarity to Pfam domain PF04678 Protein of unknown function, DUF607 contains similarity to Interpro domain IPR006769 (Protein of unknown function DUF607)
34	lite-1	C14F11.3	n/a	chrX 6,228,375	C. elegans LITE-1 protein; contains similarity to Pfam domain PF08395 7tm Chemosensory receptor contains similarity to Interpro domains IPR009318 (Trehalose receptor), IPR013604 (7TM chemoreceptor)
35	F25E2.2	F25E2.2	n/a	chrX 808,888	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
36	C24A11.6	C24A11.6	n/a	chrI 5,396,389
37	pat-10	F54C1.7	n/a	chrI 5,019,533	pat-10 encodes body wall muscle troponin C, the calcium-binding component of the troponin complex of actin thin filaments; PAT-10 is essential for muscle contraction and thus for completion of embryonic morphogenesis and elongation; by homology, PAT-10 likely functions to regulate body wall muscle contraction in response to changes in intracellular calcium; PAT-10 is expressed in body wall muscle but is also detected in vulval and anal muscles; expression in body wall muscle begins during early embryonic morphogenesis, concurrent with expression of other body wall muscle structural components.
38	T20D4.12	T20D4.12	n/a	chrV 3,397,421	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)
39	F57G4.5	F57G4.5	n/a	chrV 17,642,359	contains similarity to Mus musculus Dentin sialophosphoprotein precursor (Dentin matrix protein-3) (DMP-s3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP);sDentin sialoprotein (DSP)].; SW:DSPP_MOUSE
40	C30H6.8	C30H6.8	n/a	chrIV 17,382,648	contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR013766 (Thioredoxin domain), IPR006662 (Thioredoxin-related)
41	cyp-35B3	K07C6.2	n/a	chrV 3,946,183	C. elegans CYP-35B3 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
42	ttr-46	T07C12.7	n/a	chrV 9,951,666	C. elegans TTR-46 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
43	C33H5.16	C33H5.16	n/a	chrIV 7,802,511	contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase)
44	F59A6.3	F59A6.3	n/a	chrII 5,009,745	contains similarity to Interpro domains IPR000436 (Sushi/SCR/CCP), IPR016060 (Complement control module)
45	msp-152	ZK546.6	n/a	chrII 4,933,207	msp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
46	hgo-1	W06D4.1	n/a	chrI 9,052,445	hgo-1 encodes a putative homogentisate 1,2-dioxygenase, orthologous to human HGD (OMIM:607474, mutated in alkaptonuria), that is required for normal resistance to hypertonic stress; HGO-1 is expressed in larval and adult hypodermis and intestine, and in larval pharynx; HGO-1 is required for the tyrosinemic phenotype of K10C2.4(RNAi) animals.
47	W09H1.5	W09H1.5	n/a	chrII 13,186,582	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR016040 (NAD(P)-binding)
48	mtl-2	T08G5.10	n/a	chrV 14,018,435	mtl-2 encodes one of two C. elegans metallothioneins, small, cysteine-rich, metal-binding proteins; MTL-2 functions in metal detoxification and homeostasis and stress adaptation; in addition, mtl-2 plays a role in regulating growth and fertility; mtl-2 expression is induced in larval and adult intestinal cells following exposure to cadmium or heat shock; MTL-2 intestinal expression is dependent upon ELT-2, an intestine-specific GATA-type transcription factor; mtl-2 is downregulated by DAF-16 in daf-2 mutants.
49	R02D3.8	R02D3.8	n/a	chrIV 256,589	contains similarity to Pfam domain PF00929 Exonuclease contains similarity to Interpro domains IPR013520 (Exonuclease, RNase T and DNA polymerase III), IPR006055 (Exonuclease), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
50	K07H8.9	K07H8.9	n/a	chrIV 8,285,786	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR004087 (K Homology), IPR004088 (K Homology, type 1)