UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	fbxa-114	Y113G7B.7	0	chrV 20,197,592	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
2	T28A8.3	T28A8.3	n/a	chrIII 13,507,200	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
3	T10B11.8	T10B11.8	n/a	chrI 6,953,068
4	F57B10.4	F57B10.4	n/a	chrI 6,567,540	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2E8Z5
5	M02D8.2	M02D8.2	n/a	chrX 8,739,895
6	msh-2	H26D21.2	n/a	chrI 3,695,931	The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).
7	B0001.2	B0001.2	n/a	chrIV 12,148,704	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
8	R11A8.1	R11A8.1	n/a	chrIV 10,356,114	contains similarity to Homo sapiens Hypothetical protein; ENSEMBL:ENSP00000299601
9	klp-18	C06G3.2	n/a	chrIV 7,041,936	klp-18 encodes a kinesin motor protein whose motor domain is most similar to that of the Xenopus and human klp2 proteins; loss of klp-18 activity via RNAi indicates that KLP-18 is required for the assembly of a disordered array of acentrosomal (female meiotic) microtubules into an organized, functional, bipolar spindle; in addition, KLP-18 may also play a role in cortex dynamics during post-meiotic development; antibody staining indicates that during meiosis and mitosis (early embryonic) KLP-18 localizes to: 1) spindles, and especially spindle poles, during prometaphase, metaphase, and early anaphase, and 2) the interzone during late anaphase and telophase; in early embryos, KLP-18 is also seen around the nucleus and cell cortex at sites of cell-cell contact; KLP-18 expression in later embryos and larvae is confined to the germ line which, in adults, stains brightly in both distal and proximal regions.
10	D2030.8	D2030.8	n/a	chrI 7,593,243	contains similarity to Interpro domains IPR005479 (Carbamoyl phosphate synthetase, large subunit, ATP-binding), IPR013830 (Esterase, SGNH hydrolase-type)
11	T28A8.5	T28A8.5	n/a	chrIII 13,502,424	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
12	col-141	T15B7.5	n/a	chrV 6,830,181	C. elegans COL-141 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
13	ZK836.2	ZK836.2	n/a	chrV 12,199,854	contains similarity to Pfam domains PF02779 (Transketolase, pyrimidine binding domain) , PF00676 (Dehydrogenase E1 component) contains similarity to Interpro domains IPR011603 (2-oxoglutarate dehydrogenase, E1 component), IPR005475 (Transketolase, central region), IPR001017 (Dehydrogenase, E1 component)
14	F52B5.3	F52B5.3	n/a	chrI 8,321,160	The F52B5.3 gene encodes a DEAH helicase orthologous to the Drosophila SpindleE protein.
15	F25G6.9	F25G6.9	n/a	chrV 8,567,613	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
16	C03B8.2	C03B8.2	n/a	chrIII 7,716,234
17	F01G4.4	F01G4.4	n/a	chrIV 11,144,606	contains similarity to Myxococcus xanthus Pseudouridine synthase (EC 5.4.99.-).; TR:Q1D5Q2
18	bath-1	F59H6.9	n/a	chrII 2,028,219	C. elegans BATH-1 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
19	F55G1.6	F55G1.6	n/a	chrIV 7,474,219	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR011016 (Zinc finger, variant RING-type)
20	K12D12.5	K12D12.5	n/a	chrII 11,862,086	contains similarity to Interpro domains IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
21	K09F6.2	K09F6.2	n/a	chrII 2,268,709	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
22	W05F2.6	W05F2.6	n/a	chrI 3,370,130	contains similarity to Interpro domains IPR000504 (RNA recognition motif, RNP-1), IPR001620 (Dopamine D3 receptor)
23	C50F7.4	C50F7.4	n/a	chrIV 7,729,765	contains similarity to Pfam domains PF08442 (ATP-grasp domain) , PF00549 (CoA-ligase) contains similarity to Interpro domains IPR013650 (ATP-grasp fold, succinyl-CoA synthetase-type), IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR005809 (Succinyl-CoA synthetase, beta subunit), IPR013815 (ATP-grasp fold, subdomain 1), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR013816 (ATP-grasp fold, subdomain 2), IPR016102 (Succinyl-CoA synthetase-like)
24	hrd-1	F55A11.3	n/a	chrV 11,768,584	C. elegans HRD-1 protein; contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000694 (Proline-rich region), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
25	K10C8.1	K10C8.1	n/a	chrV 12,693,876	contains similarity to Pfam domain PF04857 CAF1 family ribonuclease contains similarity to Interpro domains IPR006941 (Ribonuclease CAF1), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
26	htp-1	F41H10.10	n/a	chrIV 5,390,947	C. elegans HTP-1 protein; contains similarity to Pfam domain PF02301 HORMA domain contains similarity to Interpro domain IPR003511 (DNA-binding HORMA)
27	K02B12.5	K02B12.5	n/a	chrI 8,522,044	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domains IPR002110 (Ankyrin), IPR013026 (Tetratricopeptide region)
28	apc-2	K06H7.6	n/a	chrIII 8,082,080	apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC, a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae's Apc2p have 32% identity in their cullin domains (considered crucial for function), but otherwise share no obvious similarity; inactivating apc-2 with RNAi causes embryos to arrest at the meiotic one-cell stage, implying that APC-2 is required for the metaphase-to-anaphase transition of meiosis I; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16, cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphic alleles, APC-2 is likely to be required for asymmetrical segregation of cell fate determinants in two-cell embryos.
29	T24A6.1	T24A6.1	n/a	chrV 3,559,431
30	bath-4	F52C6.8	n/a	chrII 1,917,377	C. elegans BATH-4 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
31	math-24	C46F9.3	n/a	chrII 1,901,084	The C46F9.3 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis.
32	F02D8.4	F02D8.4	n/a	chrV 14,986,177	contains similarity to Pfam domain PF00246 Zinc carboxypeptidase contains similarity to Interpro domains IPR000834 (Peptidase M14, carboxypeptidase A), IPR009020 (Proteinase inhibitor, propeptide)
33	bath-2	F52C6.11	n/a	chrII 1,922,182	C. elegans BATH-2 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
34	F13D12.5	F13D12.5	n/a	chrII 11,727,540	contains similarity to Interpro domain IPR001814 (Filamentous bacteriophage Vg4 protein)
35	pfn-2	F35C8.6	n/a	chrX 5,353,590	C. elegans PFN-2 protein; contains similarity to Pfam domain PF00235 Profilin contains similarity to Interpro domains IPR002097 (Profilin/allergen), IPR005455 (Profilin, plant)
36	K02C4.3	K02C4.3	n/a	chrII 8,083,916	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domain IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
37	cid-1	K10D2.3	n/a	chrIII 5,177,184	cid-1 (also known as pup-1) encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, orthologous to human ZCCHC6 and ZCCHC11, and paralogous to PUP-2; CID-1 prevents larvae from growing to adulthood in media containing hydroxyurea (HU, a drug that stalls replication forks) and represses HSP-4 expression; CID-1 is required for gonadogenesis, embryonic and vulval development, normally rapid growth, and normally short lifespan; CID-1, like HSP-4, is expressed in postmitotic intestinal cells; by orthology with Cid1p in fission yeast, CID-1 is predicted to act in a DNA synthesis-to-mitosis checkpoint; in cid-1(rf35::Tc4) mutants or cid-1(RNAi) animals grow from L1 larvae to adulthood despite the presence of HU, are abnormally resistant to lethal heat shock, overexpress hsp-4::GFP, have protruding vulvae, have abnormally short and thick gonads with fewer germ cells than normal, produce disorganized embryos, grow slowly, and have abnormally long lifespans; CID-1 and its eukaryotic homologs are distantly related to the GLD-2 family of poly(A) polymerases.
38	F10F2.2	F10F2.2	n/a	chrIII 4,631,042	contains similarity to Pfam domains PF02769 (AIR synthase related protein, C-terminal domain) (2), PF00586 (AIR synthase related protein, N-terminal domain) contains similarity to Interpro domains IPR016188 (PurM, N-terminal-like), IPR001220 (Legume lectin, beta domain), IPR000728 (AIR synthase related protein), IPR010073 (Phosphoribosylformylglycinamidine synthase, eukaryotes and proteobacteria), IPR010918 (AIR synthase related protein, C-terminal), IPR002016 (Haem peroxidase, plant/fungal/bacterial)
39	coh-3	F08H9.1	n/a	chrV 14,458,664	coh-3 encodes a member of the Rad21/Rec8-like family of cohesion proteins that is expressed in the germline; an effect on embryonic viability has been reported based on some RNAi screens, but has not been demonstrated in others.
40	klc-1	M7.2	n/a	chrIV 11,085,048	klc-1 encodes one of two C. elegans kinesin light chains; by homology, KLC-1 is predicted to function, along with kinesin-like heavy chains, as part of a multimeric kinesin complex involved in intracellular transport; consistent with this, KLC-1 has been shown to interact with UNC-116/kinesin, KCA-1/kinesin cargo adaptor, and the ARX-2/Arp2/3 complex component in yeast two-hybrid assays; RNAi experiments indicate that klc-1 activity is required for normal embryonic development.
41	cul-4	F45E12.3	n/a	chrII 7,303,864	cul-4 encodes one of six C. elegans cullin proteins; CUL-4 activity is essential for negative regulation of DNA-replication licensing and thus, for maintenance of genome stability; in regulating DNA replication, CUL-4 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that degrades the replication licensing factor CDT-1 and indirectly promotes nuclear export of the replication licensing factor CDC-6 by negatively regulating the levels of the CKI-1 CDK inhibitor; cul-4 mRNA is expressed throughout development with highest levels seen in embryos and lower levels seen in larvae and adults; maternal cul-4 mRNA is present in early embryos and larval and adult mRNA is most notably present in the intestine and germ line.
42	C27A12.2	C27A12.2	n/a	chrI 6,043,841	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
43	ZK1193.3	ZK1193.3	n/a	chrX 418,922	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR013032 (EGF-like region, conserved site)
44	ptr-2	C32E8.8	n/a	chrI 3,791,060	ptr-2 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-2 is required for cytokinesis in somatic cells, but not in the germline (the converse of PTC-1's function); PTR-2 is partially required for normal molting from L4 to adult stages; PTR-2 is also required for normal male tail development, growth to full size, locomotion, and viability.
45	F56D2.2	F56D2.2	n/a	chrIII 5,588,134	contains similarity to Pfam domains PF05773 (RWD domain) , PF01485 (IBR domain) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR006575 (RWD), IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR002867 (Zinc finger, C6HC-type)
46	C05D12.2	C05D12.2	n/a	chrII 11,420,763	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site), IPR006582 (Region of unknown fuction MD, Caenorhabditis elegans)
47	R52.2	R52.2	n/a	chrII 2,127,157	contains similarity to Pfam domains PF03564 (Protein of unknown function (DUF1759)) , PF05585 (Protein of unknown function (DUF1758)) contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR008737 (Protein of unknown function DUF1758), IPR005312 (Protein of unknown function DUF1759), IPR001878 (Zinc finger, CCHC-type)
48	his-66	H02I12.6	n/a	chrIV 11,400,571	his-66 encodes an H2B histone.
49	col-98	F14F7.1	n/a	chrIII 13,019,448	C. elegans COL-98 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR000596 (Cholecystokinin receptor, type A), IPR002952 (Eggshell protein), IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR009143 (Wnt-6 protein), IPR008160 (Collagen triple helix repeat), IPR013286 (Annexin, type VII)
50	B0495.2	B0495.2	n/a	chrII 7,700,550	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR008351 (JNK MAP kinase), IPR002290 (Serine/threonine protein kinase), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core)