UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	Y113G7A.12	Y113G7A.12	2.9999999999999997e-44	chrV 20,140,914
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	ndx-2	W02G9.1	n/a	chrV 2,664,041	ndx-2 encodes a NUDIX hydrolase; by sequence comparison, NDX-2 is predicted to be orthologous to human NUDT5 which, in vitro, possesses ADP-sugar diphosphatase activity; in C. elegans, loss of ndx-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways.
4	F37C4.1	F37C4.1	n/a	chrIV 3,890,907	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
5	K08D10.9	K08D10.9	n/a	chrIV 4,159,983
6	T02G6.2	T02G6.2	n/a	chrI 11,801,906	contains similarity to Arabidopsis thaliana Hypothetical protein.; TR:Q9C9Y9
7	W02D7.3	W02D7.3	n/a	chrV 8,294,341
8	ceh-12	F33D11.4	n/a	chrI 5,841,090	ceh-12 encodes a homeobox protein orthologous to human HLXB9 (OMIM:142994, mutated in Currarino syndrome) that is required for normal synaptic inputs to motor neurons VA2-VA10 (sisters to VB3-VB11); ceh-12 is expressed in VB motor neurons, but repressed in their VA siblings by UNC-4 and UNC-37; unc-4 or unc-37 mutants show ectopic CEH-12 expression in VA neurons, which is both necessary and sufficient to induce VA neurons to form gap junctions with normally VB-specific interneurons; ceh-12 mutations have no grossly obvious phenotype, and have no effect on del-1 or acr-5 repression in VB neurons, but do suppress the backward movement defect of unc-4 mutants, and do derepress vab-7 (normally restricted to DB and VC motor neurons); CEH-12, like other HLXB9 orthologs, has an N-terminal eh1 domain that may interact with UNC-37/Groucho, and that may indicate CEH-12 to be a transcriptional repressor.
9	srbc-56	F54B8.12	n/a	chrV 15,831,110	C. elegans SRBC-56 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
10	Y106G6G.2	Y106G6G.2	n/a	chrI 10,325,764	contains similarity to Interpro domain IPR000904 (SEC7-like)
11	F36D1.6	F36D1.6	n/a	chrI 11,270,696	contains similarity to Pfam domain PF03761 Domain of unknown function (DUF316) contains similarity to Interpro domains IPR005514 (Protein of unknown function DUF316), IPR009003 (Peptidase, trypsin-like serine and cysteine)
12	col-132	C39E9.9	n/a	chrIV 13,090,324	C. elegans COL-132 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
13	F31B9.2	F31B9.2	n/a	chrX 15,919,200	contains similarity to Mus musculus Radixin (ESP10).; SW:RADI_MOUSE
14	W06B11.1	W06B11.1	n/a	chrX 5,850,462	contains similarity to Pfam domain PF05301 Protein of unknown function (DUF738) contains similarity to Interpro domain IPR007965 (Protein of unknown function DUF738)
15	K03A11.4	K03A11.4	n/a	chrX 13,080,030	contains similarity to Pfam domain PF02995 Protein of unknown function (DUF229) contains similarity to Interpro domains IPR004245 (Protein of unknown function DUF229), IPR017850 (Alkaline-phosphatase-like, core domain)
16	fbxa-110	Y102A5C.8	n/a	chrV 16,937,848	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
17	ceh-6	K02B12.1	n/a	chrI 8,500,257	ceh-6 encodes a POU family homeodomain protein, homologous to human POU3F4 (OMIM:304400, mutated in conductive deafness 3) that affects embryonic viability, locomotion, and molting, and that regulates ectodermal and excretory function; CEH-6 is expressed dynamically during development and expression includes neurons, the excretory cell, and ectodermal cells.
18	K08C9.6	K08C9.6	n/a	chrI 11,499,274	contains similarity to Archaeoglobus fulgidus Hypothetical protein AF0327.; TR:O29920
19	F47G6.2	F47G6.2	n/a	chrI 1,475,611	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
20	T05A1.3	T05A1.3	n/a	chrIV 9,563,673	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype)
21	nhr-216	T09D3.4	n/a	chrV 5,356,451	C. elegans NHR-216 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
22	srd-31	F07C4.8	n/a	chrV 7,634,059	C. elegans SRD-31 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
23	C34G6.3	C34G6.3	n/a	chrI 5,897,020	contains similarity to Interpro domain IPR005819 (Histone H5)
24	srd-71	C13B7.4	n/a	chrV 2,424,746	C. elegans SRD-71 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR001614 (Myelin proteolipid protein PLP), IPR003002 (7TM chemoreceptor, subfamily 1), IPR002016 (Haem peroxidase, plant/fungal/bacterial)
25	spe-19	Y113G7A.10	n/a	chrV 20,039,581	C. elegans SPE-19 protein ;
26	B0207.11	B0207.11	n/a	chrI 5,963,581	B0207.11 encodes a nematode-specific protein probably required for a normally high ovulation rate; B0207.11 has no obvious non-nematode homologs, but does have a putative N-terminal coiled-coil domain and an SH2 motif, and is is paralogous to four other C. elegans proteins (F42G4.6, F44F4.10, T08G11.2, and Y81G3A.1); B0207.11(tm322) hermaphrodites show abnormal egg-laying, retaining significantly fewer eggs than wild-type (perhaps due to a lowered ovulation rate) while retaining late-stage embryos; B0207.11 has no obvious phenotype in mass RNAi experiments, possibly because of genetic redundancy with its paralogs.
27	H40L08.3	H40L08.3	n/a	chrX 15,073,031	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2EJ43
28	C54E4.4	C54E4.4	n/a	chrIV 2,163,172
29	F49B2.6	F49B2.6	n/a	chrI 14,335,445	contains similarity to Pfam domain PF01433 Peptidase family M1 contains similarity to Interpro domains IPR014782 (Peptidase M1, membrane alanine aminopeptidase, N-terminal), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR001930 (Peptidase M1, membrane alanine aminopeptidase)
30	ZC404.7	ZC404.7	n/a	chrV 6,779,108
31	F47B7.1	F47B7.1	n/a	chrX 3,788,259	contains similarity to Pfam domain PF01679 Uncharacterized protein family UPF0057 contains similarity to Interpro domain IPR000612 (Protein of unknown function UPF0057)
32	Y49A3A.4	Y49A3A.4	n/a	chrV 14,357,603	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
33	ZK418.6	ZK418.6	n/a	chrIII 7,076,490	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000694 (Proline-rich region), IPR000276 (GPCR, rhodopsin-like)
34	srz-1	F14F8.3	n/a	chrV 16,676,674	srz-1 encodes a predicted seven-pass G protein-coupled receptor; as loss of srz-1 activity via large-scale RNAi screens results in no obvious abnormalities, the precise role of SRZ-1 in C. elegans development and/or behavior is not yet known.
35	srd-8	B0547.4	n/a	chrIV 5,644,418	C. elegans SRD-8 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
36	try-6	F48A9.3	n/a	chrI 6,586,594	C. elegans TRY-6 protein; contains similarity to Pfam domains PF00089 (Trypsin) , PF03761 (Domain of unknown function (DUF316)) contains similarity to Interpro domains IPR001314 (Peptidase S1A, chymotrypsin), IPR001254 (Peptidase S1 and S6, chymotrypsin/Hap), IPR005514 (Protein of unknown function DUF316), IPR009003 (Peptidase, trypsin-like serine and cysteine)
37	C26H9A.2	C26H9A.2	n/a	chrIV 12,657,776	contains similarity to Interpro domains IPR016024 (Armadillo-type fold), IPR008985 (Concanavalin A-like lectin/glucanase)
38	K02D10.3	K02D10.3	n/a	chrIII 8,771,549
39	T04C9.3	T04C9.3	n/a	chrIII 5,985,695
40	stdh-1	C06B3.4	n/a	chrV 13,907,215	stdh-1 encodes a putative steroid dehydrogenase required for normally short lifespan; STDH-1 is orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1, and paralogous to LET-767 and STDH-2/-4; STDH-1 is expressed in larval intestine, and in both larval and adult body wall muscle and neurons.
41	F27C8.5	F27C8.5	n/a	chrIV 9,591,134	contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
42	H12D21.5	H12D21.5	n/a	chrV 14,894,419	contains similarity to Interpro domains IPR001307 (Thiosulfate sulfurtransferase), IPR000463 (Cytosolic fatty-acid binding protein), IPR001763 (Rhodanese-like)
43	Y113G7B.15	Y113G7B.15	n/a	chrV 20,226,741	contains similarity to Pfam domains PF08246 (Cathepsin propeptide inhibitor domain (I29)) , PF00112 (Papain family cysteine protease) contains similarity to Interpro domains IPR013128 (Peptidase C1A, papain), IPR000169 (Peptidase, cysteine peptidase active site), IPR013201 (Proteinase inhibitor I29, cathepsin propeptide), IPR000668 (Peptidase C1A, papain C-terminal)
44	F26A1.3	F26A1.3	n/a	chrIII 4,827,878	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR017442 (Serine/threonine protein kinase-related)
45	K02H8.1	K02H8.1	n/a	chrX 17,004,963	K02H8.1 encodes, by alternative splicing, two isoforms of a putative MUSCLEBLIND-type mRNA splicing regulator required in adults for normal muscle dense body organization, locomotion, and vulval morphogenesis; K02H8.1 is orthologous to Drosophila MBL and human MBNL1 (OMIM:606516), MBNL2 (OMIM:607327), and MBNL3 (OMIM:300413); K02H8.1 is transcribed in larvae and adults; K02H8.1(RNAi) animals show protruding vulvae, progressive uncoordination, and disordered dense bodies; while K02H8.1 is required in adults, it is dispensable in larvae, perhaps reflecting a progressive muscle dystrophy in K02H8.1(RNAi) animals.
46	ZK1290.10	ZK1290.10	n/a	chrII 7,552,859	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003582 (Metridin-like ShK toxin)
47	bath-25	T27C10.4	n/a	chrI 10,877,883	C. elegans BATH-25 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00036 (EF hand) (2), PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR003299 (Flagellar calcium-binding protein (calflagin)), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
48	gcy-11	C30G4.3	n/a	chrX 17,049,964	C. elegans GCY-11 protein; contains similarity to Pfam domains PF00069 (Protein kinase domain) , PF00211 (Adenylate and Guanylate cyclase catalytic domain) contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001054 (Adenylyl cyclase class-3/4/guanylyl cyclase), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
49	lge-1	K09C8.4	n/a	chrX 10,968,138	C. elegans LGE-1 protein; contains similarity to Pfam domain PF01501 Glycosyl transferase family 8 contains similarity to Interpro domain IPR002495 (Glycosyl transferase, family 8)
50	F49F1.6	F49F1.6	n/a	chrIV 4,122,198	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)