UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ssu-1	Y113G7A.11	0	chrV 20,126,167	ssu-1 encodes, by alternative splicing, two isoforms of a cytosolic alcohol sulfotransferase that interacts in the ASJ amphid neurons with the stomatins UNC-1 and UNC-24; the longer SSU-1 isoform is required for normal anesthetic sensitivity and unc-1 phenotypes; ssu-1(fc73) suppresses the anesthetic sensitivity and uncoordinated phenotypes of unc-1 and unc-24 mutants; ssu-1(fc73), along with daf-12, suppresses the synthetic constitutive dauer-formation phenotype of fc83;unc-24(e138) mutants; ssu-1 suppression is rescued by transgenic expression of SSU-1 in the ASJ neurons alone, implying that sulfation is required for an endocrine function; SSU-1 protein sulfates 4-nitrophenol and 2-naphthol substrates, and bisphenol A, but not monoamines or hydroxysteroids; SSU-1 is cytosolic, but its activity is not detectable in cytosolic extracts; ssu-1 is strongly expressed in embryos, growing larvae, and dauer larvae; ssu-1 expression is increased in daf-2; by homology with other sulfotransferases, SSU-1 may link sulfates to the alcohol group of small molecules as part of detoxification or signal transduction.
2	mif-3	F13G3.9	n/a	chrI 7,313,193	C. elegans MIF-3 protein; contains similarity to Pfam domain PF01187 Macrophage migration inhibitory factor (MIF) contains similarity to Interpro domains IPR014347 (Tautomerase), IPR001398 (Macrophage migration inhibitory factor)
3	T27D1.3	T27D1.3	n/a	chrIII 3,684,552	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR008365 (Prostanoid receptor), IPR001991 (Sodium:dicarboxylate symporter), IPR002455 (GPCR, family 3, gamma-aminobutyric acid receptor, type B), IPR000276 (GPCR, rhodopsin-like)
4	C16D6.1	C16D6.1	n/a	chrX 12,525,704	contains similarity to Interpro domain IPR000694 (Proline-rich region)
5	F33E2.6	F33E2.6	n/a	chrI 12,589,287	contains similarity to Interpro domains IPR006030 (Molluscan rhodopsin C-terminal tail), IPR000694 (Proline-rich region)
6	K03H6.5	K03H6.5	n/a	chrIV 1,531,807	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
7	C53A5.5	C53A5.5	n/a	chrV 14,541,386	contains similarity to Pfam domains PF02888 (Calmodulin binding domain) , PF03530 (Calcium-activated SK potassium channel) , PF07885 (Ion channel) contains similarity to Interpro domains IPR004178 (Calmodulin-binding), IPR015449 (Potassium channel, calcium-activated, SK), IPR011996 (Potassium channel, calcium-activated, SK, conserved region), IPR003931 (Potassium channel, calcium-activated, SK, conserved region, subgroup), IPR013099 (Ion transport 2)
8	srw-140	C03A7.3	n/a	chrV 5,166,467	C. elegans SRW-140 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
9	F07C3.2	F07C3.2	n/a	chrV 9,226,731
10	str-4	C50B6.10	n/a	chrV 13,338,836	C. elegans STR-4 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
11	F58E6.1	F58E6.1	n/a	chrV 9,742,698	n/a
12	nhr-39	F44A2.4	n/a	chrV 9,303,947	C. elegans NHR-39 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
13	F32D1.3	F32D1.3	n/a	chrV 4,355,654	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (3), PF08409 (Domain of unknown function (DUF1736)) , PF00515 (Tetratricopeptide repeat) (6)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013618 (Region of unknown function DUF1736), IPR008940 (Protein prenyltransferase), IPR001440 (Tetratricopeptide TPR-1), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region)
14	str-27	T23D5.1	n/a	chrV 15,734,895	C. elegans STR-27 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
15	egl-10	F28C1.2	n/a	chrV 12,459,067	egl-10 encodes an RGS protein, expressed in neurons, that affects egg laying and negatively regulates GOA-1 (Galpha[o]) signalling; it requires the Gbeta(5) ortholog GPB-2 for this activity, and genetically interacts with the egl-30 and goa-1 signaling pathways.
16	tkr-1	C38C10.1	n/a	chrIII 9,386,535	tkr-1 encodes a G protein-coupled receptor that is the C. elegans tachykinin-like neuropeptide receptor homolog; by homology, TKR-1 is predicted to function in modulation of excitatory neurotransmission; as loss of tkr-1 activity via RNAi results in moderate reduction of fat content, TKR-1 may play a specific role in regulating lipid metabolism; a tkr-1 reporter gene fusion is reportedly expressed in the socket cells of the deirid and post-deirid sensilla from the L2 larval stage through adulthood.
17	srh-22	C02E7.4	n/a	chrV 4,923,929	C. elegans SRH-22 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
18	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
19	CD4.5	CD4.5	n/a	chrV 5,590,729
20	dyf-5	M04C9.5	n/a	chrI 9,360,991	dyf-5 encodes a putative MAP kinase orthologous to human MAK/ICK (OMIM:154235), Chlamydomonas reinhardtii LF4, and Leishmania mexicana MPK9; DYF-5 negatively regulates cilial length, restricts KAP-1 to middle ciliary segments, is required for normal localization of six IFT components, and is required for OSM-3 to comigrate normally with IFT particles; DYF-5 is also required for dye-filling of amphid and phasmid neurons and for normal chemotaxis, dauer formation, and male mating; DYF-5 is expressed in head neurons (including amphid neurons), tail neurons (including phasmid neurons), CAN cells, excretory canal neurons, posterior lateral ganglion neurons and in many male tail cells; dyf-5 mutant cilia are abnormally elongated, either failing to enter the amphid channel or accumulating IFT proteins at their distal ends, whereas DYF-5 overexpression results in truncated cilia; the dyf-5 promoter region contains an X-box, predicted to be bound and transcriptionally activated by DAF-19, and dyf-5 is regulated by DAF-19 in vivo; dyf-5 animals are slightly shorter than normal.
21	C18G1.1	C18G1.1	n/a	chrV 4,779,553
22	F55A4.7	F55A4.7	n/a	chrX 1,037,733	contains similarity to Pfam domain PF00402 Calponin family repeat contains similarity to Interpro domain IPR000557 (Calponin repeat)
23	Y113G7B.24	Y113G7B.24	n/a	chrV 20,231,897	contains similarity to Pfam domain PF05916 Synthetic lethal mutants of dpb11-1 five contains similarity to Interpro domain IPR008591 (GINS complex, Sld5 component)
24	sre-26	Y57A10C.4	n/a	chrII 12,419,774	C. elegans SRE-26 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
25	srh-74	C45B11.4	n/a	chrV 11,047,962	C. elegans SRH-74 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
26	F42A6.2	F42A6.2	n/a	chrIV 3,341,612
27	nhr-167	C49F5.4	n/a	chrX 11,981,020	C. elegans NHR-167 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
28	sng-1	T08A9.3	n/a	chrX 7,328,590	sng-1 encodes the C. elegans synaptogyrin ortholog, a vertebrate integral membrane synaptic vesicle protein; loss-of-function mutations in sng-1 result in no obvious defects in synaptogenesis or neuronal activity, suggesting that SNG-1 is likely required for more subtle neuronal functions; SNG-1::GFP reporters are expressed throughout the nervous system in neurons in the dorsal and ventral nerve cords, as well as the anterior nerve ring; SNG-1 colocalizes with the synaptic vesicle component SNT-1.
29	clec-146	Y48E1B.9	n/a	chrII 13,592,126	C. elegans CLEC-146 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
30	Y57A10B.1	Y57A10B.1	n/a	chrII 12,362,805	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
31	F31F4.11	F31F4.11	n/a	chrV 663,441	contains similarity to Pfam domains PF00788 (Ras association (RalGDS/AF-6) domain) , PF02204 (Vacuolar sorting protein 9 (VPS9) domain) contains similarity to Interpro domains IPR013995 (Vacuolar sorting protein 9, subgroup), IPR003123 (Vacuolar sorting protein 9), IPR000159 (Ras-association)
32	C18H7.6	C18H7.6	n/a	chrIV 590,772	contains similarity to Interpro domain IPR000817 (Prion protein)
33	str-143	C09H5.4	n/a	chrV 8,068,920	C. elegans STR-143 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
34	T09E8.4	T09E8.4	n/a	chrV 13,182,889	contains similarity to Pfam domain PF02460 Patched family contains similarity to Interpro domains IPR003392 (Patched), IPR000731 (Sterol-sensing 5TM box)
35	str-250	C06B3.10	n/a	chrV 13,919,315	C. elegans STR-250 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
36	srx-21	F31F4.4	n/a	chrV 678,220	C. elegans SRX-21 protein; contains similarity to Pfam domain PF03383 Caenorhabditis serpentine receptor-like protein, class xa contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR005047 (Protein of unknown function DUF286, G protein-coupled receptor-like putative Caenorhabditis species)
37	C05E4.12	C05E4.12	n/a	chrV 759,998	contains similarity to Pfam domain PF06542 Protein of unknown function (DUF1114) contains similarity to Interpro domain IPR009497 (Protein of unknown function DUF1114)
38	T16H12.9	T16H12.9	n/a	chrIII 10,110,649	contains similarity to Saccharomyces cerevisiae RNA polymerase I subunit A34.5; SGD:YJL148W
39	R05A10.7	R05A10.7	n/a	chrIV 14,161,499	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domain IPR012444 (Protein of unknown function DUF1647)
40	gcy-18	ZK896.8	n/a	chrIV 12,863,005	gcy-18 encodes a receptor-type guanylyl cyclase that, along with gcy-8 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-18 functions redundantly with gcy-8 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; in addition, microarray experiments indicate that gcy-18 expression is induced in daf-16(RNAi); daf-2(RNAi) double mutants and repressed in daf-2(RNAi) mutants, suggesting that GCY-18 activity may contribute to a shortened lifespan; consistent with this, loss of gcy-18 activity via RNAi does result in lifespan extension; GCY-18 is expressed exclusively in the AFD thermosensory neurons, where it localizes to sensory endings.
41	gab-1	ZC482.1	n/a	chrIII 12,775,682	gab-1 encodes a gamma-aminobutyric acid (GABA) receptor beta-like subunit with both the neurotransmitter-gated ion-channel ligand binding and transmembrane domains; gab-1 can form a GABA-responsive channel when co-expressed with alpha/gamma type subunits in a heterologous expression system; experiments with gab-1 indicate that GABA receptors are involved in the mechanism of resistance to the widely used broad-spectrum anthelmintic drug Ivermectin.
42	F16G10.13	F16G10.13	n/a	chrII 2,395,441	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domain IPR003326 (Protein of unknown function DUF130)
43	C06C6.1	C06C6.1	n/a	chrV 16,011,384	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR010916 (TonB box, conserved site)
44	F53F4.2	F53F4.2	n/a	chrV 13,589,230	contains similarity to Hordeum vulgare Glycine-rich cell wall structural protein precursor.; SW:P17816
45	T18D3.5	T18D3.5	n/a	chrX 12,464,020	contains similarity to Streptococcus pneumoniae Com protein (Fragment).; TR:Q9RIM4
46	srx-74	F41F3.6	n/a	chrV 4,660,713	C. elegans SRX-74 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
47	C50D2.6	C50D2.6	n/a	chrII 86,096
48	Y47D3B.3	Y47D3B.3	n/a	chrIII 11,400,137	contains similarity to Homo sapiens Low-density lipoprotein receptor-related protein 2 precursor; ENSEMBL:ENSP00000263816
49	srz-10	ZK1037.11	n/a	chrV 15,308,296	C. elegans SRZ-10 protein ;
50	btb-15	C08E3.2	n/a	chrII 1,611,924	C. elegans BTB-15 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)