UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	pop-1	W10C8.2	0	chrI 2,826,881	pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva.
2	srv-19	H04M03.6	n/a	chrIV 5,873,058	C. elegans SRV-19 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
3	trx-2	B0024.9	n/a	chrV 10,314,942	C. elegans TRX-2 protein; contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012335 (Thioredoxin fold), IPR015467 (Thioredoxin family), IPR001200 (Phosducin), IPR013766 (Thioredoxin domain), IPR006662 (Thioredoxin-related), IPR012336 (Thioredoxin-like fold)
4	unc-40	T19B4.7	n/a	chrI 5,685,676	The unc-40 gene encodes a netrin receptor that is required to guide dorsal-ventral cell and axon migrations, and is required for correct polarization and migration of the neuroblasts QL and QR.
5	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
6	C28A5.5	C28A5.5	n/a	chrIII 4,451,510	contains similarity to Petunia hybrida PGPS/D8.; TR:Q9ZTN1
7	F45F2.7	F45F2.7	n/a	chrV 8,523,135	contains similarity to Pfam domain PF03189 Protein of unknown function, DUF270 contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR004878 (Protein of unknown function DUF270), IPR016196 (MFS general substrate transporter)
8	F48C5.1	F48C5.1	n/a	chrX 11,445,448	contains similarity to Pfam domain PF00047 Immunoglobulin domain contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR000742 (EGF-like, type 3), IPR007110 (Immunoglobulin-like), IPR013032 (EGF-like region, conserved site), IPR013151 (Immunoglobulin)
9	F36A4.11	F36A4.11	n/a	chrIV 4,245,281
10	T10G3.4	T10G3.4	n/a	chrV 13,483,233	contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
11	srh-281	F11A5.1	n/a	chrV 16,191,496	C. elegans SRH-281 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR000175 (Sodium:neurotransmitter symporter), IPR003002 (7TM chemoreceptor, subfamily 1)
12	F29C12.6	F29C12.6	n/a	chrII 13,129,953	contains similarity to Helicobacter pylori Cytotoxicity associated immunodominant antigen (120 kDa protein)s(CAG pathogenicity island protein 26).; SW:CAGA_HELPY
13	K10D2.4	K10D2.4	n/a	chrIII 5,173,569
14	srx-133	F09F3.4	n/a	chrV 13,849,303	C. elegans SRX-133 protein ;
15	str-240	K02H11.2	n/a	chrV 1,521,205	C. elegans STR-240 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
16	glb-12	C52A11.2	n/a	chrII 10,730,655	glb-12 encodes a globin; glb-12 transcription is higher in L3 and dauers than in young adults; in mass RNAi assays, glb-12 is required for embryonic viability, larval growth, and normal body shape, locomotion, and egg laying.
17	srj-33	T07C12.1	n/a	chrV 9,936,513	C. elegans SRJ-33 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
18	F46B6.2	F46B6.2	n/a	chrV 9,773,402	contains similarity to Trypanosoma brucei Hypothetical protein.; TR:Q7YVJ9
19	C30H6.9	C30H6.9	n/a	chrIV 17,379,717	contains similarity to Bacillus anthracis Hypothetical protein.; TR:Q81PV8
20	srj-40	F38H12.2	n/a	chrV 4,102,865	C. elegans SRJ-40 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
21	K04E7.1	K04E7.1	n/a	chrX 6,462,585
22	str-84	F59E11.13	n/a	chrV 8,980,200	C. elegans STR-84 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
23	sru-47	F36D1.3	n/a	chrI 11,290,448	C. elegans SRU-47 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domains IPR015964 (Cytochrome C oxidase subunit II-like, transmembrane region), IPR003839 (Protein of unknown function DUF215)
24	srx-120	F49C5.2	n/a	chrII 12,532,032	C. elegans SRX-120 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
25	srj-7	T28A11.10	n/a	chrV 3,245,861	C. elegans SRJ-7 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
26	B0416.3	B0416.3	n/a	chrX 9,292,441
27	F54C1.1	F54C1.1	n/a	chrI 5,011,081	contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
28	ces-1	F43G9.11	n/a	chrI 8,634,989	ces-1 encodes a C2H2-type zinc finger transcription factor that is a member of the Snail family of proteins that includes Drosophila Scratch, Snail, and Slug, and human SNAIL and SLUG; although the normal function of CES-1 is not fully understood, gain-of-function mutations indicate that CES-1 can function as a transcriptional repressor that blocks programmed cell death in specific neurons by inhibiting expression of the cell-death activator EGL-1; in regulating EGL-1 expression, CES-1 appears to antagonize the transcriptional activity of the bHLH proteins, HLH-2 and HLH-3; despite its cell-type specific role in apoptosis, CES-1 expression is reportedly detected in many embryonic nuclei from the 100-cell stage of embryogenesis through the beginning of morphogenesis, with some CES-1 expression remaining at later embryonic stages; genetic studies indicate that CES-1 is negatively regulated by the bZIP transcription factor CES-2, which can bind CES-1 upstream sequences in vitro and thus may directly regulate CES-1 transcription in vivo
29	grd-11	K02E2.2	n/a	chrV 20,356,705	grd-11 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, four Ground domains, an short region of low-complexity sequence, and a Hint/Hog domain; the Hint/Hog domain is predicted to cut GRD-2 into two halves and then covalently link cholesterol to the C-terminus of the Ground domain; the four N-terminal Ground domains are predicted to form one or more cysteine-crosslinked proteins involved in intercellular signalling; Ground domains have subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; grd-11 has no obvious function in RNAi assays.
30	F37H8.2	F37H8.2	n/a	chrII 11,173,534	contains similarity to Saccharomyces cerevisiae Structural maintenance of chromosomes (SMC) protein; SGD:YOL034W
31	B0348.1	B0348.1	n/a	chrV 49,270	contains similarity to Interpro domain IPR006629 (LPS-induced tumor necrosis factor alpha factor)
32	str-246	W09D6.3	n/a	chrIII 11,078,457	C. elegans STR-246 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
33	rpb-12	F23B2.13	n/a	chrIV 9,146,652	C. elegans RPB-12 protein; contains similarity to Pfam domain PF03604 DNA directed RNA polymerase, 7 kDa subunit contains similarity to Interpro domain IPR006591 (RNA polymerase Rbp10)
34	ZK218.1	ZK218.1	n/a	chrV 17,092,954	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
35	F28A10.5	F28A10.5	n/a	chrII 850,172	contains similarity to Pfam domain PF05050 Protein of unknown function (DUF672) contains similarity to Interpro domain IPR007744 (Protein of unknown function DUF672)
36	Y6E2A.1	Y6E2A.1	n/a	chrV 15,710,013	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000832 (GPCR, family 2, secretin-like)
37	str-141	F47G9.2	n/a	chrV 11,323,048	C. elegans STR-141 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
38	K09B11.4	K09B11.4	n/a	chrIV 13,429,722	contains similarity to Patella vulgata Twist protein (Fragment).; TR:Q8WQQ8
39	C10E2.5	C10E2.5	n/a	chrX 16,752,685
40	K02A6.1	K02A6.1	n/a	chrX 8,219,837
41	B0207.6	B0207.6	n/a	chrI 5,936,242	contains similarity to Pfam domain PF03029 Conserved hypothetical ATP binding protein contains similarity to Interpro domain IPR004130 (Protein of unknown function, ATP binding)
42	T17A3.9	T17A3.9	n/a	chrIII 152,890
43	acr-9	C40C9.2	n/a	chrX 13,644,544	acr-9 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors.
44	srd-21	W06G6.3	n/a	chrV 16,630,499	C. elegans SRD-21 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
45	D1046.3	D1046.3	n/a	chrIV 8,931,564	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier)
46	srg-64	ZK678.6	n/a	chrX 15,738,657	C. elegans SRG-64 protein; contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
47	hlh-19	F57C12.3	n/a	chrX 556,516	C. elegans HLH-19 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
48	D1007.9	D1007.9	n/a	chrI 4,591,009
49	nhr-262	F09C6.8	n/a	chrV 16,906,069	C. elegans NHR-262 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
50	ceh-14	F46C8.5	n/a	chrX 7,530,621	ceh-14 encodes a LIM homeodomain protein orthologous to Drosophila Lim3 and the vertebrate Lhx3 and Lhx4 proteins; ceh-14 is required for specification of the AFD thermosensory neurons and for normal thermotactic behavior; a ceh-14::GFP reporter fusion is expressed in head and tail neurons, including the AFD thermosensory neurons, during late embryonic, larval, and adult stages. Animals triply mutant for the LIM homeobox genes ceh-14, lin-11, and ttx-3 which are required for function of the AFD, AIZ, and AIY neurons, respectively, exhibit a basic cryophilic thermotaxis response suggesting that, in C. elegans, there is more than one pathway for integration of thermosensory input.