UCSC C. elegans Gene Sorter

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

UCSC C. elegans Gene Sorter

genome assembly search

sort by display output

#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	W09D10.3	W09D10.3	5e-80	chrIII 10,708,021	contains similarity to Pfam domain PF00542 Ribosomal protein L7/L12 C-terminal domain contains similarity to Interpro domains IPR013823 (Ribosomal protein L7/L12, C-terminal), IPR014719 (Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like), IPR008932 (Ribosomal protein L7/L12, oligomerisation)
2	dct-18	F58G1.4	n/a	chrII 12,932,607	C. elegans DCT-18 protein; contains similarity to Interpro domain IPR000886 (Endoplasmic reticulum, targeting sequence)
3	W04G3.5	W04G3.5	n/a	chrX 11,074,823	contains similarity to Pfam domain PF00156 Phosphoribosyl transferase domain contains similarity to Interpro domains IPR005946 (Phosphoribosyl pyrophosphokinase), IPR000836 (Phosphoribosyltransferase)
4	F25B4.6	F25B4.6	n/a	chrV 5,683,638	F25B4.6 is orthologous to the human gene 3-HYDROXY-3-METHYLGLUTARYL COA SYNTHASE (HMGCS2; OMIM:600234), which when mutated leads to disease.
5	H06H21.3	H06H21.3	n/a	chrIV 4,811,443	contains similarity to Pfam domain PF01176 Translation initiation factor 1A / IF-1 contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold), IPR006196 (S1, IF1 type), IPR001253 (Eukaryotic initiation factor 1A (eIF-1A))
6	C44B7.7	C44B7.7	n/a	chrII 6,879,653	contains similarity to Homo sapiens Uncharacterized protein C7orf24; ENSEMBL:ENSP00000275428
7	aqp-11	ZK525.2	n/a	chrIII 13,673,891	aqp-11 encodes a putative aquaporin with no function in mass RNAi assays, perhaps reflecting genetic redundancy with its paralogs AQP-9 and AQP-10; AQP-11 is orthologous to Drosophila CG12251 and human AQP11 (OMIM:609914), AQP12A (OMIM:609789), and AQP12B.
8	F36A2.3	F36A2.3	n/a	chrI 8,800,214	contains similarity to Pfam domain PF02615 Malate/L-lactate dehydrogenase contains similarity to Interpro domain IPR003767 (Malate/L-lactate dehydrogenase)
9	erv-46	K09E9.2	n/a	chrX 15,615,388	C. elegans ERV-46 protein; contains similarity to Pfam domain PF07970 Protein of unknown function (DUF1692) contains similarity to Interpro domain IPR012936 (Protein of unknown function DUF1692)
10	cct-1	T05C12.7	n/a	chrII 8,186,346	cct-1 encodes a putative alpha subunit of the eukaryotic cytosolic ('T complex') chaperonin, orthologous to human TCP1 (OMIM:186980), and required for normal pronuclear-centrosome rotation, positioning of the mitotic spindle, meiosis, and distal tip cell migration; CCT-1 is also required to repress SKN-1-dependent transcription of gst-4, and for fertility and viability; CCT-1 is expressed in larval and adult pharynx, intestine, body wall muscle, and neurons, as well as adult rectal epithelium; cct-1 mRNA is enriched in cultured touch receptor neurons.
11	ife-2	R04A9.4	n/a	chrX 382,059	ife-2 encodes a translation initiation factor 4F, cap-binding subunit (eIF-4E); by homology, IFE-2 is predicted to function in cap-dependent mRNA translation initiation; loss of ife-2 activity in adult animals extends lifespan.
12	lpd-6	K09H9.6	n/a	chrI 3,146,111	lpd-6 encodes a predicted rRNA-binding protein that is orthologous to Drosophila Peter Pan and the Saccharomyces cerevisiae SSF1 and SSF2 proteins that are required for ribosomal large subunit maturation; loss of lpd-6 activity via RNAi indicates that, in C. elegans, LPD-6 is required for fat storage and for larval growth and development; based upon its similarity to yeast SSF1 and SSF2, LPD-6 is predicted to be a nucleolar protein.
13	F01F1.9	F01F1.9	n/a	chrIII 5,862,653	contains similarity to Pfam domain PF02127 Aminopeptidase I zinc metalloprotease (M18) contains similarity to Interpro domain IPR001948 (Peptidase M18, aminopeptidase I)
14	phb-2	T24H7.1	n/a	chrII 6,252,083	phb-2 encodes one of two subunits of the mitochondrial prohibitin complex; loss of phb-2 activity via RNAi indicates that phb-2 function is required for mitochondrial biogenesis and maintenance and for embryonic, germline, and somatic gonad development.
15	K10C2.1	K10C2.1	n/a	chrX 6,425,780	contains similarity to Pfam domain PF00450 Serine carboxypeptidase contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001563 (Peptidase S10, serine carboxypeptidase)
16	clec-17	E03H4.10	n/a	chrI 12,430,738	C. elegans CLEC-17 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00059 (Lectin C-type domain) (2)contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
17	pfd-3	T06G6.9	n/a	chrI 12,729,010	pfd-3 encodes a putative prefoldin, orthologous to human VBP1 (OMIM:300133), that is required for normal alpha-tubulin synthesis, microtubule growth, mitotic spindle formation and positioning, early embryonic cell division, and embryonic and larval viability; PFD-3 is expressed cytoplasmically in most, if not all, tissues.
18	ZK686.3	ZK686.3	n/a	chrIII 7,768,245	ZK686.3 is orthologous to the putative tumor suppressor N33 (OMIM:601385, associated with homozygous deletion in metastatic prostate cancer and with loss of function in other tumors); ZK686.3 is also homologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3.
19	gst-13	T26C5.1	n/a	chrII 9,231,840	C. elegans GST-13 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
20	daf-36	C12D8.5	n/a	chrV 10,224,591	daf-36 encodes a protein homologous to the catalytic subunit of Rieske-like oxygenases; DAF-36 functions in a hormone biosynthetic pathway producing a ligand for the DAF-12 nuclear receptor that regulates the developmental decision between reproductive growth and dauer formation; a daf-36::gfp reporter fusion is expressed in the intestine, the head mesodermal cell, two unidentified head neurons (not XXXR/L) and, in dauers, the lateral seam cells; DAF-36 localizes to the cytoplasm in the intestine and to a cytosolic meshwork in dauer seam cells.
21	nol-5	W01B11.3	n/a	chrI 3,268,107	C. elegans NOL-5 protein; contains similarity to Pfam domains PF01798 (Putative snoRNA binding domain) , PF08060 (NOSIC (NUC001) domain) , PF08156 (NOP5NT (NUC127) domain) contains similarity to Interpro domains IPR012974 (NOP5, N-terminal), IPR005819 (Histone H5), IPR002687 (Pre-mRNA processing ribonucleoprotein, binding region), IPR012976 (NOSIC)
22	gsto-1	C29E4.7	n/a	chrIII 7,946,235	gsto-1 encodes an experimentally verified thiol oxidoreductase and dehydroascorbate reductase, required for normal stress resistance; formally, GSTO-1 is an omega-class glutathione transferase (GST; EC 2.5.1.18), but it has little activity in vitro on classic GST substrates; GSTO-1 is expressed in postembryonic intestine; gsto-1(RNAi) induces hypersensitivity to heat-, arsenite-, juglone-, paraquat-, or cumene hydroperoxide-induced stresses, whereas overexpression of GSTO-1 enhances resistance to them; gsto-1 transcription is upregulated by stress; ELT-2 may directly activate gsto-1 transcription in developing gut via a 300-nucleotide sequence upstream of gsto-1's ATG start site.
23	F23C8.5	F23C8.5	n/a	chrI 2,419,472	The F23C8.5 gene encodes an ortholog of the human gene ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT (ETFB), which when mutated leads to glutaricaciduria type IIB (OMIM:130410).
24	eft-1	ZK328.2	n/a	chrIII 6,011,147	eft-1 encodes an elongation factor 2 (EF-2)-like protein; by homology, EFT-1 is predicted to function as a GTPase required for the elongation step of protein synthesis; loss of eft-1 activity via large-scale RNAi indicates that eft-1 is an essential gene required for embryonic development, reproduction, and the overall health of the animal; eft-1 mRNA is detectable at all stages of C. elegans development.
25	K05C4.5	K05C4.5	n/a	chrI 14,745,264	contains similarity to Interpro domains IPR015943 (WD40/YVTN repeat-like), IPR011044 (Quinoprotein amine dehydrogenase, beta chain-like)
26	C29F7.3	C29F7.3	n/a	chrX 13,419,306	contains similarity to Pfam domain PF00406 Adenylate kinase contains similarity to Interpro domains IPR000764 (Uridine kinase), IPR000850 (Adenylate kinase), IPR006266 (UMP-CMP kinase), IPR011769 (Adenylate/cytidine kinase, N-terminal)
27	C18E9.6	C18E9.6	n/a	chrII 8,972,695	contains similarity to Pfam domain PF01459 Eukaryotic porin contains similarity to Interpro domain IPR001925 (Porin, eukaryotic type)
28	B0334.5	B0334.5	n/a	chrII 11,498,118	contains similarity to Interpro domain IPR008949 (Terpenoid synthase)
29	pqn-47	F59B10.1	n/a	chrII 10,499,684	pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays; pqn-47(cxP5915) homozygotes are sluggish.
30	dap-3	C14A4.2	n/a	chrII 10,581,748	dap-3 is an ortholog of mammalian death-associated protein 3 (DAP3), a mitochondrial ribosomal protein that promotes apoptosis.
31	T08B1.1	T08B1.1	n/a	chrV 1,984,861	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR000817 (Prion protein), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
32	clec-56	F08H9.7	n/a	chrV 14,475,609	C. elegans CLEC-56 protein; contains similarity to Pfam domains PF00431 (CUB domain) (2), PF00059 (Lectin C-type domain) contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
33	K04A8.10	K04A8.10	n/a	chrV 6,569,901	contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
34	F38E11.5	F38E11.5	n/a	chrIV 9,461,841	F38E11.5 encodes a beta' (beta-prime) subunit of the coatomer (COPI) complex; in mass RNAi assays, F38E11.5 is required for fertility and general health.
35	F57B9.3	F57B9.3	n/a	chrIII 6,940,892	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014014 (RNA helicase, DEAD-box type, Q motif), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
36	W07E6.2	W07E6.2	n/a	chrII 482,556	W07E6.2 encodes an ortholog of S. cerevisiae RSA4 that may suppress tumorous growth in the germline; like PRO-1, -2, and -3, W07E6.2 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline.
37	ZK1098.7	ZK1098.7	n/a	chrIII 9,523,311	contains similarity to Drosophila melanogaster Flybase gene name is mRpS23-PA;; FLYBASE:CG31842
38	R07H5.8	R07H5.8	n/a	chrIV 11,210,138	contains similarity to Pfam domain PF00294 pfkB family carbohydrate kinase contains similarity to Interpro domains IPR011611 (Carbohydrate/purine kinase), IPR002139 (Ribokinase), IPR001805 (Adenosine kinase), IPR002173 (Carbohydrate/puine kinase, PfkB, conserved site)
39	eif-3.D	R08D7.3	n/a	chrIII 8,970,522	eif-3.D encodes the C. elegans ortholog of the translation initiation factor 3 subunit d (eIF3d/Moe1); by homology, EIF-3.D is predicted to function as part of the eIF3 translation initiation complex but also as part of a Ras-mediated pathway that regulates mitotic spindle formation; in C. elegans, large-scale RNAi screens indicate that eif-3.D is required for embryonic and germline development, locomotion, and normal rates of post-embryonic growth; in the early embryo, eif-3.D is specifically required for the fidelity of meiotic divisions and normal pseudocleavage; eif-3.D function is likely conserved, as expression of eif-3.D in Schizosaccharomyces pombe can rescue the mitotic spindle and growth defects associated with moe1 mutant cells; to date, eif-3.D expression has been reported in anterior neurons and the pharynx, beginning at late stages of embryogenesis.
40	lbp-5	W02D3.7	n/a	chrI 6,731,777	lbp-5 encodes a predicted intracellular fatty acid binding protein (iFABP) that is most similar to the vertebrate muscle and heart FABPs; by homology, LBP-5 is predicted to function as an intracellular transporter for small hydrophobic molecules such as lipids and steroid hormones; loss of lbp-5 activity via large-scale RNAi screens indicates that, in C. elegans, LBP-5 is required for movement.
41	C29F7.2	C29F7.2	n/a	chrX 13,417,071	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
42	T19D12.1	T19D12.1	n/a	chrII 6,670,282	contains similarity to Drosophila melanogaster Flybase gene name is Sgs1-PA;; FLYBASE:CG3047
43	trap-4	Y56A3A.21	n/a	chrIII 11,920,954	C. elegans TRAP-4 protein; contains similarity to Pfam domain PF05404 Translocon-associated protein, delta subunit precursor (TRAP-delta) contains similarity to Interpro domain IPR008855 (Translocon-associated)
44	gas-1	K09A9.5	n/a	chrX 15,588,527	The gas-1 gene encodes a 49 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, fecundity, and normal lifespan; gas-1 is expressed in the nematode neuromuscular system; its subcellular distribution appears to be mitochondrial; drug effects on mutants versus wild-type indicate that gas-1 functions at least partially through presynaptic effects; gas-1 mutants have strongly reduced Complex I-dependent metabolism in mitochondria, while Complex II-dependent metabolism is conversely increased in mutants; gas-1 mitochondria look structurally normal.
45	F53E10.6	F53E10.6	n/a	chrV 2,602,650	contains similarity to Pfam domain PF07890 Rrp15p contains similarity to Interpro domain IPR012459 (Protein of unknown function DUF1665)
46	tbb-1	K01G5.7	n/a	chrIII 10,741,585	This gene encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-1 is redundant for embryonic viability, due to its paralog TBB-2.
47	pabp-2	C17E4.5	n/a	chrI 9,421,408	pabp-2 encodes the C. elegans PABPN1 (polyadenylate-binding protein, nuclear 1) ortholog; by homology, PABP-2 is predicted to function as a poly(A)-binding protein involved in several aspects of pre-mRNA processing; large-scale RNAi screens indicate that pabp-2 activity is essential for embryonic and larval development, as well as normal rates of growth and locomotion; in humans, expansion of a polyalanine repeat in PABPN1 is associated with oculopharyngeal muscular dystrophy (OPMD, OMIM:602279).
48	F32A5.3	F32A5.3	n/a	chrII 7,234,327	contains similarity to Pfam domain PF00450 Serine carboxypeptidase contains similarity to Interpro domain IPR001563 (Peptidase S10, serine carboxypeptidase)
49	gst-36	R07B1.4	n/a	chrX 9,862,249	C. elegans GST-36 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR003083 (S-crystallin), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
50	W03F9.10	W03F9.10	n/a	chrV 129,988	contains similarity to Pfam domains PF04046 (PSP) , PF04037 (Domain of unknown function (DUF382)) contains similarity to Interpro domains IPR006568 (PSP, proline-rich), IPR007180 (Protein of unknown function DUF382)