UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	W07E6.2	W07E6.2	0	chrII 482,556	W07E6.2 encodes an ortholog of S. cerevisiae RSA4 that may suppress tumorous growth in the germline; like PRO-1, -2, and -3, W07E6.2 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	Y53C12B.1	Y53C12B.1	4e-17	chrII 9,744,521	contains similarity to Pfam domains PF08625 (Utp13 specific WD40 associated domain) , PF00400 (WD domain, G-beta repeat) (8)contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR013934 (Small-subunit processome, Utp13), IPR015943 (WD40/YVTN repeat-like)
4	F14B4.3	F14B4.3	n/a	chrI 9,283,761	contains similarity to Pfam domains PF06883 (RNA polymerase I, Rpa2 specific domain) , PF04561 (RNA polymerase Rpb2, domain 2) , PF04567 (RNA polymerase Rpb2, domain 5) , PF04565 (RNA polymerase Rpb2, domain 3) , PF00562 (RNA polymerase Rpb2, domain 6) , PF04560 (RNA polymerase Rpb2, domain 7) , PF04563 (RNA polymerase beta subunit) contains similarity to Interpro domains IPR007120 (DNA-directed RNA polymerase, subunit 2, domain 6), IPR007641 (RNA polymerase Rpb2, domain 7), IPR007644 (RNA polymerase, beta subunit, protrusion), IPR009674 (RNA polymerase I, Rpa2 specific), IPR015712 (DNA-directed RNA polymerase, subunit 2), IPR007645 (RNA polymerase Rpb2, domain 3), IPR007642 (RNA polymerase Rpb2, domain 2), IPR007647 (RNA polymerase Rpb2, domain 5), IPR007121 (RNA polymerase, beta subunit, conserved site)
5	K05C4.5	K05C4.5	n/a	chrI 14,745,264	contains similarity to Interpro domains IPR015943 (WD40/YVTN repeat-like), IPR011044 (Quinoprotein amine dehydrogenase, beta chain-like)
6	cdr-4	K01D12.11	n/a	chrV 12,407,975	C. elegans CDR-4 protein; contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR010987 (Glutathione S-transferase, C-terminal-like)
7	cyp-36A1	C34B7.3	n/a	chrI 8,343,858	C. elegans CYP-36A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I)
8	vha-2	R10E11.2	n/a	chrIII 9,782,355	vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus.
9	H06H21.3	H06H21.3	n/a	chrIV 4,811,443	contains similarity to Pfam domain PF01176 Translation initiation factor 1A / IF-1 contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold), IPR006196 (S1, IF1 type), IPR001253 (Eukaryotic initiation factor 1A (eIF-1A))
10	ruvb-1	C27H6.2	n/a	chrV 9,979,753	C. elegans RUVB-1 protein; contains similarity to Pfam domain PF06068 TIP49 C-terminus contains similarity to Interpro domains IPR010339 (TIP49, C-terminal), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal)
11	cpn-4	F49D11.8	n/a	chrI 10,925,036	cpn-4 encodes a calponin homolog, most closely related to its paralog CPN-3 in C. elegans; CPN-4 is somewhat more similar to calponins per se (such as CLP1 and CLP2 in humans) than to the to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25.
12	rps-13	C16A3.9	n/a	chrIII 6,374,498	rps-13 encodes a small ribosomal subunit S13 protein; by homology, RPS-13 is predicted to function in protein biosynthesis; in C. elegans, RPS-13 activity is required for embryonic and germline development.
13	C18E9.6	C18E9.6	n/a	chrII 8,972,695	contains similarity to Pfam domain PF01459 Eukaryotic porin contains similarity to Interpro domain IPR001925 (Porin, eukaryotic type)
14	C47E12.7	C47E12.7	n/a	chrIV 9,981,472	contains similarity to Pfam domain PF05997 Nucleolar protein,Nop52 contains similarity to Interpro domain IPR010301 (Nucleolar, Nop52)
15	pfd-3	T06G6.9	n/a	chrI 12,729,010	pfd-3 encodes a putative prefoldin, orthologous to human VBP1 (OMIM:300133), that is required for normal alpha-tubulin synthesis, microtubule growth, mitotic spindle formation and positioning, early embryonic cell division, and embryonic and larval viability; PFD-3 is expressed cytoplasmically in most, if not all, tissues.
16	ZK185.3	ZK185.3	n/a	chrIV 4,529,575	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
17	K08F11.5	K08F11.5	n/a	chrIV 4,714,405	contains similarity to Pfam domains PF08356 (EF hand associated) , PF08355 (EF hand associated) , PF00071 (Ras family) , PF00036 (EF hand) (2), PF08477 (Miro-like protein) (2)contains similarity to Interpro domains IPR013566 (EF hand associated, type-1), IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras), IPR006689 (ARF/SAR superfamily), IPR013567 (EF hand associated, type-2)
18	W02B12.11	W02B12.11	n/a	chrII 11,474,835	contains similarity to Pfam domain PF02709 Galactosyltransferase contains similarity to Interpro domain IPR003859 (Metazoa galactosyltransferase)
19	T23B12.2	T23B12.2	n/a	chrV 8,468,082	contains similarity to Pfam domain PF00573 Ribosomal protein L4/L1 family contains similarity to Interpro domains IPR013005 (Ribosomal protein L4/L1e, bacterial-type), IPR002136 (Ribosomal protein L4/L1e)
20	K04A8.10	K04A8.10	n/a	chrV 6,569,901	contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
21	F20G2.1	F20G2.1	n/a	chrV 13,752,929	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
22	eif-3.D	R08D7.3	n/a	chrIII 8,970,522	eif-3.D encodes the C. elegans ortholog of the translation initiation factor 3 subunit d (eIF3d/Moe1); by homology, EIF-3.D is predicted to function as part of the eIF3 translation initiation complex but also as part of a Ras-mediated pathway that regulates mitotic spindle formation; in C. elegans, large-scale RNAi screens indicate that eif-3.D is required for embryonic and germline development, locomotion, and normal rates of post-embryonic growth; in the early embryo, eif-3.D is specifically required for the fidelity of meiotic divisions and normal pseudocleavage; eif-3.D function is likely conserved, as expression of eif-3.D in Schizosaccharomyces pombe can rescue the mitotic spindle and growth defects associated with moe1 mutant cells; to date, eif-3.D expression has been reported in anterior neurons and the pharynx, beginning at late stages of embryogenesis.
23	F36A2.3	F36A2.3	n/a	chrI 8,800,214	contains similarity to Pfam domain PF02615 Malate/L-lactate dehydrogenase contains similarity to Interpro domain IPR003767 (Malate/L-lactate dehydrogenase)
24	ers-3	T07A9.2	n/a	chrIV 389,575	ers-3 encodes a a glutamine (E)/glutaminyl (Q) tRNA synthetase.
25	srt-55	T16H12.8	n/a	chrIII 10,105,558	C. elegans SRT-55 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
26	phb-2	T24H7.1	n/a	chrII 6,252,083	phb-2 encodes one of two subunits of the mitochondrial prohibitin complex; loss of phb-2 activity via RNAi indicates that phb-2 function is required for mitochondrial biogenesis and maintenance and for embryonic, germline, and somatic gonad development.
27	C01F1.5	C01F1.5	n/a	chrII 4,280,801	contains similarity to Interpro domain IPR001506 (Peptidase M12A, astacin)
28	pbs-7	F39H11.5	n/a	chrI 8,695,820	pbs-7 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-7 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-7 activity via large-scale RNAi screens indicates that, in C. elegans, PBS-7 is required for normal movement and for embryonic, germline, and larval development.
29	rpn-3	C30C11.2	n/a	chrIII 8,448,263	C. elegans RPN-3 protein; contains similarity to Pfam domains PF01399 (PCI domain) , PF08375 (Proteasome regulatory subunit C-terminal) contains similarity to Interpro domains IPR013586 (26S proteasome regulatory subunit, C-terminal), IPR013143 (PCI/PINT associated module), IPR000717 (Proteasome component region PCI), IPR015350 (Beta-trefoil)
30	scrm-4	F11A6.2	n/a	chrI 11,681,649	scrm-4 encodes a putative phospholipid scramblase homologous to human PLSCR1-5, and paralogous to other C. elegans SCRMs (e.g., SCRM-1); in apoptotic germline cells, SCRM-4 is fully dispensable for normally rapid engulfment and largely dispensable for phosphatidylserine exposure; SCRM-4 does not bind WAH-1 in vitro, and scrm-4(tm624) mutants have no obvious phenotype.
31	ugt-33	C35A5.2	n/a	chrV 10,494,911	C. elegans UGT-33 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
32	pqn-47	F59B10.1	n/a	chrII 10,499,684	pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays; pqn-47(cxP5915) homozygotes are sluggish.
33	F57B9.3	F57B9.3	n/a	chrIII 6,940,892	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014014 (RNA helicase, DEAD-box type, Q motif), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
34	F59F5.2	F59F5.2	n/a	chrX 10,534,095	contains similarity to Cryptosporidium parvum Exonuclease ii, possible.; TR:Q7YYI5
35	cct-1	T05C12.7	n/a	chrII 8,186,346	cct-1 encodes a putative alpha subunit of the eukaryotic cytosolic ('T complex') chaperonin, orthologous to human TCP1 (OMIM:186980), and required for normal pronuclear-centrosome rotation, positioning of the mitotic spindle, meiosis, and distal tip cell migration; CCT-1 is also required to repress SKN-1-dependent transcription of gst-4, and for fertility and viability; CCT-1 is expressed in larval and adult pharynx, intestine, body wall muscle, and neurons, as well as adult rectal epithelium; cct-1 mRNA is enriched in cultured touch receptor neurons.
36	F53H8.3	F53H8.3	n/a	chrX 940,562	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005829 (Sugar transporter, conserved site), IPR005828 (General substrate transporter), IPR003663 (Sugar transporter), IPR016196 (MFS general substrate transporter)
37	K12H4.3	K12H4.3	n/a	chrIII 8,046,749	contains similarity to Pfam domain PF04427 Brix domain contains similarity to Interpro domain IPR007109 (Brix)
38	F44D12.9	F44D12.9	n/a	chrIV 10,020,215	contains similarity to Pfam domain PF01733 Nucleoside transporter contains similarity to Interpro domains IPR001991 (Sodium:dicarboxylate symporter), IPR002259 (Delayed-early response protein/equilibrative nucleoside transporter), IPR016196 (MFS general substrate transporter)
39	F46E10.11	F46E10.11	n/a	chrV 6,532,557	contains similarity to Interpro domain IPR008197 (Whey acidic protein, 4-disulphide core)
40	ugt-12	T19H12.9	n/a	chrV 4,888,389	C. elegans UGT-12 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
41	W03F9.10	W03F9.10	n/a	chrV 129,988	contains similarity to Pfam domains PF04046 (PSP) , PF04037 (Domain of unknown function (DUF382)) contains similarity to Interpro domains IPR006568 (PSP, proline-rich), IPR007180 (Protein of unknown function DUF382)
42	cah-3	K05G3.3	n/a	chrX 16,488,368	cah-3 encodes a putative carbonic anhydrase, closely similar to its paralog CAH-5; cah-3 is expressed in intestine and head (including neurons) of L3 larvae through adults, and its transcription is moderately stimulated by DBL-1 and SMA-2; CAH-3 is bound by CKU-80 in two-hybrid assays, but has no obvious function in mass RNAi assays.
43	F55B11.1	F55B11.1	n/a	chrIV 14,406,976	The F55B11.1 gene encodes an ortholog of the human gene XANTHINE DEHYDROGENASE (XDH), which when mutated leads to xanthinuria (OMIM:278300).
44	C29F7.2	C29F7.2	n/a	chrX 13,417,071	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
45	dnj-19	T05C3.5	n/a	chrV 5,504,025	This gene encodes a protein containing a DnaJ ('J') domain.
46	F23C8.5	F23C8.5	n/a	chrI 2,419,472	The F23C8.5 gene encodes an ortholog of the human gene ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT (ETFB), which when mutated leads to glutaricaciduria type IIB (OMIM:130410).
47	gas-1	K09A9.5	n/a	chrX 15,588,527	The gas-1 gene encodes a 49 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, fecundity, and normal lifespan; gas-1 is expressed in the nematode neuromuscular system; its subcellular distribution appears to be mitochondrial; drug effects on mutants versus wild-type indicate that gas-1 functions at least partially through presynaptic effects; gas-1 mutants have strongly reduced Complex I-dependent metabolism in mitochondria, while Complex II-dependent metabolism is conversely increased in mutants; gas-1 mitochondria look structurally normal.
48	B0491.7	B0491.7	n/a	chrII 11,350,625	B0491.7 encodes a putative diphthine synthase orthologous to S. cerevisiae DPH5; DPH5 is an S-adenosylmethionine:EF-2 methyltransferase required for the enzymatic conversion of 3-amino-3-carboxypropyl-histidine to diphthine; DPH5 adds at least the last two of the three methyl groups present in diphthine, and is homologous to bacterial AdoMet:uroporphyrinogen III methyltransferases.
49	clec-17	E03H4.10	n/a	chrI 12,430,738	C. elegans CLEC-17 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00059 (Lectin C-type domain) (2)contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
50	C17E4.9	C17E4.9	n/a	chrI 9,432,529	contains similarity to Pfam domain PF00287 Sodium / potassium ATPase beta chain contains similarity to Interpro domain IPR000402 (ATPase, P-type cation exchange, beta subunit)