UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	grd-3	W05E7.1	7e-89	chrIV 3,440,050	grd-3 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; GRD-3 is expressed in adult anterior and posterior seam cells, overlapping GRD-5 expression; GRD-3 is also strongly expressed upon infection with the gram-negative bacterium Serratia marcescens, indicating that GRD-3 may be part of C. elegans' innate immunity response; the Ground domain is predicted to form a cysteine-crosslinked protein acting as an intercellular signal, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-3 is weakly required for normal molting; GRD-3 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	rec-8	W02A2.6	n/a	chrIV 13,351,138	rec-8 encodes a meiosis-specific cohesin complex subunit orthologous to Saccharomyces cerevisiae and Schizosaccharomyces pombe Rec8p; REC-8 is essential for pairing of homologoues and sister chromatids during meiosis and thus for proper chromosome disjunction; in the germline, REC-8 associates with chromatin of transition zone nuclei, and co-localizes with SMC-1 along the longitudinal axes of synapsed chromosomes at pachytene and in a cruciform pattern at diakinesis; REC-8 localization to chromatin is dependent upon TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS, and additionally, REC-8 and SCC-3 are mutually required for chromatin localization; REC-8 cleavage and degradation during meiosis I is dependent on the AIR-2 aurora-like kinase and during meiosis II on AIR-2 and the PLK-1 polo-like kinase.
4	W03G9.2	W03G9.2	n/a	chrI 4,963,346	contains similarity to Interpro domains IPR000994 (Peptidase M24, catalytic core), IPR001545 (Gonadotropin, beta chain)
5	F52E10.4	F52E10.4	n/a	chrX 16,286,357	contains similarity to Homo sapiens Zinc finger protein 277; ENSEMBL:ENSP00000006035
6	vha-7	C26H9A.1	n/a	chrIV 12,646,915	vha-7 encodes an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-7 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); vha-7 is expressed in hypodermis and uterus; VHA-7 is dispensable for viability, since vha-7(RNAi) animals develop to normal, healthy adults; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; VHA-7 is predicted to capture protons from V-ATPase transmembrane rotor components and export the protons across the membrane.
7	srg-23	Y25C1A.11	n/a	chrII 3,095,026	C. elegans SRG-23 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
8	cpb-3	B0414.5	n/a	chrI 5,790,196	cpb-3 encodes a CPEB orthologous to Drosophila ORB, zebrafish ZORBA, and human CPEB1, and paralogous to FOG-1 and CPB-1/2; CPB-3 inhibits physiological apoptosis in oocytes, keeping it down to a normal level of ~50% in hermaphrodite gonads; independently of apoptosis, CPB-3 is also required for normal oogenesis, sperm/oocyte switching (upstream of FEM-3), and the transistion from mitosis to meiosis by oocytes (in parallel with GLD-3); cpb-3(RNAi) results in elevated (though not 100%) physiological germ cell apoptosis, independent of CEP-1; in cpb-3(RNAi) animals, excess physiological apoptosis actually promotes fertility, since cpb-3(RNAi) hermaphrodites have larger brood sizes than those with apoptosis suppressed by ced-3(n717), and aging ced-3(n717);cpb-3(RNAi) animals have abnormal oocytes that fail to exit pachytene and proceed through diakinesis; CPB-3 is mainly cytoplasmic, and strongly expressed in pachytene oocytes; cpb-3(bt17);daz-1(tj3) hermaphrodites have a synthetic phenotype of total sterility and masculinization; CPB-3 colocalizes with DAZ-1 in vivo, coimmunoprecipitates with DAZ-1, and binds DAZ-1 in two-hybrid assays.
9	scl-27	ZK6.3	n/a	chrV 400,930	C. elegans SCL-27 protein; contains similarity to Pfam domain PF00188 SCP-like extracellular protein contains similarity to Interpro domains IPR014044 (SCP-like extracellular), IPR001283 (Allergen V5/Tpx-1 related)
10	B0222.5	B0222.5	n/a	chrV 9,153,570	contains similarity to Pfam domains PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) , PF00086 (Thyroglobulin type-1 repeat) contains similarity to Interpro domains IPR000716 (Thyroglobulin type-1), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa)
11	Y57G11C.18	Y57G11C.18	n/a	chrIV 14,841,760	contains similarity to Interpro domain IPR000767 (Disease resistance protein)
12	T13F3.6	T13F3.6	n/a	chrV 16,270,691	contains similarity to Paramecium tetraurelia 51B type surface protein.; TR:Q27167
13	cdr-5	K01D12.14	n/a	chrV 12,409,917	C. elegans CDR-5 protein; contains similarity to Pfam domain PF00043 Glutathione S-transferase, C-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
14	K11H12.7	K11H12.7	n/a	chrIV 666,215
15	R148.4	R148.4	n/a	chrIII 3,172,188
16	Y40H7A.9	Y40H7A.9	n/a	chrIV 15,207,561	contains similarity to Pfam domains PF01461 (7TM chemoreceptor) , PF00112 (Papain family cysteine protease) contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR013128 (Peptidase C1A, papain), IPR000668 (Peptidase C1A, papain C-terminal)
17	ttr-15	T07C4.5	n/a	chrIII 10,338,481	C. elegans TTR-15 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
18	T22B7.7	T22B7.7	n/a	chrX 5,652,816	contains similarity to Homo sapiens CGI16-iso; ENSEMBL:ENSP00000368599
19	Y37D8A.21	Y37D8A.21	n/a	chrIII 12,929,839	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
20	ZK669.3	ZK669.3	n/a	chrII 7,941,811	contains similarity to Pfam domain PF03227 Gamma interferon inducible lysosomal thiol reductase (GILT) contains similarity to Interpro domain IPR004911 (Gamma interferon inducible lysosomal thiol reductase GILT)
21	F28H7.2	F28H7.2	n/a	chrV 10,748,416	contains similarity to Pfam domains PF01370 (NAD dependent epimerase/dehydratase family) , PF00106 (short chain dehydrogenase) contains similarity to Interpro domains IPR001509 (NAD-dependent epimerase/dehydratase), IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
22	B0228.6	B0228.6	n/a	chrII 7,754,791
23	Y12A6A.1	Y12A6A.1	n/a	chrX 13,620,760
24	nhr-218	T13F3.2	n/a	chrV 16,259,537	C. elegans NHR-218 protein; contains similarity to Pfam domain PF00105 Zinc finger, C4 type (two domains) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
25	btb-16	F39E9.2	n/a	chrII 3,297,442	C. elegans BTB-16 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
26	sptf-2	T22C8.5	n/a	chrII 8,626,542	C. elegans SPTF-2 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
27	T21F4.1	T21F4.1	n/a	chrX 5,631,021	T21F4.1 is orthologous to the human gene ARGINASE TYPE I ERYTHROID VARIANT (ARG1; OMIM:207800), which when mutated leads to argininemia.
28	E03H4.2	E03H4.2	n/a	chrI 12,403,805	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domain IPR002485 (Protein of unknown function DUF13)
29	ttr-30	T08A9.2	n/a	chrX 7,331,455	C. elegans TTR-30 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
30	prg-2	C01G5.2	n/a	chrIV 6,528,248	C. elegans PRG-2 protein; contains similarity to Pfam domains PF02171 (Piwi domain) , PF02170 (PAZ domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
31	ZK1193.4	ZK1193.4	n/a	chrX 424,854
32	htp-3	F57C9.5	n/a	chrI 4,828,421	C. elegans HTP-3 protein; contains similarity to Pfam domain PF02301 HORMA domain contains similarity to Interpro domain IPR003511 (DNA-binding HORMA)
33	F56B6.6	F56B6.6	n/a	chrX 3,532,316	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
34	ZC132.4	ZC132.4	n/a	chrV 4,302,829	contains similarity to Uukuniemi virus Envelope glycoprotein precursor (GP) (M polyprotein) [Contains:sGlycoprotein G1; Glycoprotein G2].; SW:P09613
35	srx-86	F38B7.7	n/a	chrV 11,563,703	C. elegans SRX-86 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
36	T10B11.6	T10B11.6	n/a	chrI 6,944,267	contains similarity to Pfam domain PF05705 Eukaryotic protein of unknown function (DUF829) contains similarity to Interpro domain IPR008547 (Protein of unknown function DUF829, eukaryotic)
37	nhr-163	C33G8.12	n/a	chrV 6,984,709	C. elegans NHR-163 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
38	R04B5.5	R04B5.5	n/a	chrV 10,088,214	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR011597 (GroES-related), IPR016040 (NAD(P)-binding), IPR002328 (Alcohol dehydrogenase, zinc-containing, conserved site)
39	D2007.1	D2007.1	n/a	chrIII 8,155,633
40	C18H9.5	C18H9.5	n/a	chrII 6,693,979	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
41	his-44	F08G2.1	n/a	chrII 13,826,823	his-44 encodes an H2B histone.
42	F46B6.4	F46B6.4	n/a	chrV 9,778,673	contains similarity to Pfam domain PF01926 GTPase of unknown function contains similarity to Interpro domains IPR016496 (GTP-binding protein, HflX), IPR002917 (GTP-binding protein, HSR1-related), IPR003593 (AAA+ ATPase, core), IPR006073 (GTP1/OBG)
43	Y57G11C.7	Y57G11C.7	n/a	chrIV 14,755,336	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
44	msp-38	K08F4.8	n/a	chrIV 10,143,514	msp-38 encodes a member of the major sperm protein family; msp-38 has a C. briggsae homolog as predicted by the Wobble Bulk Aware Bulk Aligner (WABA).
45	ZK632.9	ZK632.9	n/a	chrIII 9,825,065	contains similarity to Barley yellow dwarf virus Coat protein.; SW:COAT_BYDVN
46	F35C8.1	F35C8.1	n/a	chrX 5,378,292	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
47	srbc-68	T24A6.13	n/a	chrV 3,546,145	C. elegans SRBC-68 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
48	srp-2	C05E4.1	n/a	chrV 763,702	srp-2 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily that is orthologous to human NEUROSERPIN (OMIM:602445, mutated in familial encephalopathy with neuroserpin inclusion bodies); SRP-2 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases, and in vitro, recombinant SRP-2 is able to inhibit granzyme B activity; however, as loss of srp-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-2 in C. elegans development and/or behavior is not yet known; srp-2 expression is detected in hypodermal cells, particularly in the lateral seam cells.
49	zim-1	T07G12.6	n/a	chrIV 10,551,197	zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
50	hlh-12	C28C12.8	n/a	chrIV 8,478,993	C. elegans HLH-12 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding), IPR002418 (Transcription regulator Myc)