UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	rab-11.2	W04G5.2	3e-112	chrI 11,633,357	C. elegans RAB-11.2 protein; contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR006688 (ADP-ribosylation factor), IPR013753 (Ras), IPR006689 (ARF/SAR superfamily)
2	twk-25	M04B2.5	n/a	chrIV 11,507,989	C. elegans TWK-25 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2), IPR003092 (Potassium channel, two pore-domain, TASK)
3	C34F6.10	C34F6.10	n/a	chrX 11,233,244	contains similarity to Pfam domain PF00041 Fibronectin type III domain contains similarity to Interpro domains IPR008957 (Fibronectin, type III-like fold), IPR003961 (Fibronectin, type III), IPR000694 (Proline-rich region)
4	nhr-143	F59E11.11	n/a	chrV 8,974,032	C. elegans NHR-143 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
5	unc-7	R07D5.1	n/a	chrX 15,134,407	unc-7 encodes an innexin required for gap junction formation in invertebrates; UNC-7 is also required for normal locomotion, egg-laying, inhibition of feeding by tapping, avermectin sensitivity, and ivermectin sensitivity, as well as for the antagonism of UNC-79 and UNC-80 activity by volatile anesthetics; unc-7 is genetically required, and transcribed in, neurons rather than muscle cells, from larval stages L1 through L4; homologs of UNC-7 include Drosophila OGRE and SHAKING-B, as well as 24 C. elegans paralogs (including EAT-5, UNC-9, and INX-1 through INX-20); UNC-7 genetically interacts with UNC-124, and unc-7 mutants are phenotypically similar to unc-9 and unc-124 mutants; UNC-7 genetically interacts with AVR-14 and GLC-1 in the response to ivermectin.
6	F54E2.4	F54E2.4	n/a	chrV 2,806,913	contains similarity to Pfam domains PF00047 (Immunoglobulin domain) , PF07679 (Immunoglobulin I-set domain) (3)contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR013098 (Immunoglobulin I-set), IPR009134 (Vascular endothelial growth factor receptor, VEGFR, N-terminal), IPR013783 (Immunoglobulin-like fold), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype), IPR013151 (Immunoglobulin)
7	zag-1	F28F9.1	n/a	chrIV 3,858,673	zag-1 encodes a homeodomain protein of the ZFH class which consists of a homeodomain flanked by two clusters of C2H2-type zinc fingers and is related to transcriptional repressors encoded by Drosophila zfh-1 and the vertebrate ZEB genes; ZAG-1 is required for locomotion, for neuronal differentiation, and for proper axonal branching and fasciculation; from late embryogenesis through adult stages of development, ZAG-1 is expressed dynamically in head and tail neurons and in the intestinal and anal depressor muscles.
8	lin-48	F34D10.5	n/a	chrIII 3,746,355	lin-48 encodes a C2H2-type zinc-finger transcription factor that is orthologous to Drosophila OVO and mouse OVO1; LIN-48 is required for development of the hindgut, the male tail, and the excretory duct cell; in hindgut and male tail development, LIN-48 activity is essential for proper fate specification of the U, F, and K' blast cells and B blast cell descendants, and in excretory duct cell development, for normal duct cell morphogenesis; a LIN-48 translational reporter is expressed in the nuclei of the U, F, K, and K' blast cells, the excretory duct cell, and up to 10 cells in the head region beginning in late embryogenesis and continuing through adulthood; in addition, expression is detected in the neuronal support cells of the phasmid and labial sensory structures beginning at the late L1 larval stage; in hindgut cell specification, LIN-48 functions with EGL-38/Pax, which appears to be a direct transcriptional regulator of LIN-48 expression, and in excretory duct cell development, LIN-48 is likely under the control of the CES-2 bZip transcription factor
9	gpa-5	F53B1.7	n/a	chrX 2,119,972	gpa-5 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in AWA, with faint expression in ASI.
10	F40A3.2	F40A3.2	n/a	chrV 7,880,134	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR013032 (EGF-like region, conserved site)
11	R10D12.8	R10D12.8	n/a	chrV 13,951,956	contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
12	srh-27	W05H5.4	n/a	chrII 12,449,129	C. elegans SRH-27 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
13	cyp-34A10	B0213.16	n/a	chrV 3,971,866	C. elegans CYP-34A10 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV)
14	abch-1	C56E6.5	n/a	chrII 6,530,223	C. elegans ABCH-1 protein; contains similarity to Interpro domain IPR003439 (ABC transporter-like)
15	srd-59	E04F6.1	n/a	chrII 7,206,230	C. elegans SRD-59 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
16	ugt-61	F39G3.1	n/a	chrV 4,743,888	C. elegans UGT-61 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
17	F45D3.2	F45D3.2	n/a	chrV 12,541,972	contains similarity to Dictyocaulus viviparus Putative uncharacterized protein.; TR:Q6E6T3
18	T09E11.3	T09E11.3	n/a	chrI 12,369,888	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
19	mom-1	T07H6.2	n/a	chrX 6,295,619	mom-1 encodes a predicted O-acyltransferase that is orthologous to Porcupine proteins conserved across a wide range of species; MOM-1 functions as part of a Wnt/MAPK signaling pathway that is required maternally for endoderm induction in the early embryo; by homology, MOM-1 is predicted to be a membrane-spanning endoplasmic reticulum protein that stimulates post-translational processing of Wnt signaling molecules such as MOM-2; embryonic mosaic analysis indicates that MOM-1 activity is required in the signaling cell, P2, for proper specification of endoderm, consistent with its predicted role in processing MOM-2/Wnt.
20	tpi-1	Y17G7B.7	n/a	chrII 12,038,108	tpi-1 encodes a putative triosephosphate isomerase orthologous to human TPI1 (OMIM:190450, mutated in TPI deficiency) and Drosophila WASTED AWAY; despite the severity of TPI mutant phenotypes in humans and Drosophila, TPI-1 has no obvious function in mass RNAi assays.
21	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
22	K01C8.2	K01C8.2	n/a	chrII 8,268,517	contains similarity to Interpro domain IPR006150 (Cysteine-rich repeat)
23	nhr-96	F44C8.11	n/a	chrV 2,234,310	nhr-96 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain.
24	srh-105	T27A1.7	n/a	chrII 508,784	C. elegans SRH-105 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
25	F21D9.1	F21D9.1	n/a	chrV 19,267,093	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
26	F14B8.6	F14B8.6	n/a	chrX 6,930,764
27	F02C9.2	F02C9.2	n/a	chrV 3,135,542	contains similarity to Pfam domain PF03385 Protein of unknown function, DUF288 contains similarity to Interpro domains IPR005049 (Protein of unknown function DUF288), IPR002972 (Prostaglandin D synthase)
28	K06A1.3	K06A1.3	n/a	chrII 6,442,625	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
29	gtl-2	F54D1.5	n/a	chrIV 11,277,712	gtl-2 encodes a predicted receptor-activated calcium channel and represents a family of calcium channels, the other two family members being gtl-1 and gon-2.
30	F39D8.3	F39D8.3	n/a	chrX 15,423,577	contains similarity to Homo sapiens Sperm-specific thioredoxin; ENSEMBL:ENSP00000304908
31	fbxa-111	Y102A5C.14	n/a	chrV 16,949,135	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
32	ltd-1	K02C4.4	n/a	chrII 8,090,520	ltd-1 encodes a protein with LIM and transglutaminase domains; LTD-1 is homologous to the mouse KY protein (MGI:96709, mutated in kyphoscoliosis), and to the HILLARIN protein of Hirudo medicinalis, found at axon hillocks; ltd-1 is expressed in hypodermal cells from the twofold stage embryo to adulthood, but has no obvious function in mass RNAi assays.
33	gcy-3	R134.1	n/a	chrII 9,504,941	gcy-3 is predicted to encode a guanylate cyclase.
34	srx-67	K07C6.10	n/a	chrV 3,917,627	C. elegans SRX-67 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
35	str-111	F10A3.15	n/a	chrV 16,168,531	C. elegans STR-111 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
36	ZC132.5	ZC132.5	n/a	chrV 4,306,648	contains similarity to Pfam domain PF05380 Pao retrotransposon peptidase contains similarity to Interpro domains IPR008042 (Retrotransposon, Pao), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
37	F18F11.4	F18F11.4	n/a	chrIV 332,622	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
38	R08B4.3	R08B4.3	n/a	chrX 11,119,911	contains similarity to Homo sapiens 23 kDa protein; VG:OTTHUMP00000170038
39	T27C4.2	T27C4.2	n/a	chrV 3,729,612
40	frm-9	F31B12.3	n/a	chrX 10,817,663	frm-9 encodes a B41/ERM (ezrin/radixin/moesin) domain containing protein.
41	ocam-1	T02B5.2	n/a	chrV 14,167,452	T02B5.2 encodes a protein with an OCAM domain, a nematode-specific motif conserved between T02B5.2 and two other nematode ONECUT homeobox proteins (CEH-21 and CEH-41); this gene is probably derived from a ONECUT gene that lost both tit cut domain and its homeodomain; T02B5.2 has no obvious function in mass RNAi assays.
42	T10D4.1	T10D4.1	n/a	chrII 3,151,352	contains similarity to Pfam domains PF01579 (Domain of unknown function DUF19) , PF02343 (Domain of unknown function DUF130) contains similarity to Interpro domains IPR003326 (Protein of unknown function DUF130), IPR002542 (Protein of unknown function DUF19)
43	ZK896.4	ZK896.4	n/a	chrIV 12,881,875	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003366 (CUB-like region)
44	T19B4.1	T19B4.1	n/a	chrI 5,703,857	contains similarity to Pfam domains PF03712 (Copper type II ascorbate-dependent monooxygenase, C-terminal domain) , PF01436 (NHL repeat) (4), PF01082 (Copper type II ascorbate-dependent monooxygenase, N-terminal domain) contains similarity to Interpro domains IPR008977 (PHM/PNGase F-fold), IPR000323 (Copper type II, ascorbate-dependent monooxygenase, N-terminal), IPR000720 (Peptidyl-glycine alpha-amidating monooxygenase), IPR014783 (Copper type II, ascorbate-dependent monooxygenase, C-terminal), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR013017 (NHL repeat, subgroup), IPR014784 (Copper type II, ascorbate-dependent monooxygenase-like, C-terminal), IPR015943 (WD40/YVTN repeat-like), IPR001258 (NHL repeat)
45	C12D5.10	C12D5.10	n/a	chrV 7,692,770	contains similarity to Pfam domain PF03236 Domain of unknown function DUF263 contains similarity to Interpro domain IPR004920 (Protein of unknown function DUF263)
46	R06F6.6	R06F6.6	n/a	chrII 10,807,531	contains similarity to Pfam domain PF00046 Homeobox domain contains similarity to Interpro domains IPR012287 (Homeodomain-related), IPR013847 (POU), IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
47	H05C05.3	H05C05.3	n/a	chrIII 2,967,980
48	T07G12.4	T07G12.4	n/a	chrIV 10,537,682	contains similarity to Pfam domain PF00860 Permease family contains similarity to Interpro domain IPR006043 (Xanthine/uracil/vitamin C permease)
49	fbxa-183	F44E7.6	n/a	chrV 5,781,921	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
50	ire-1	C41C4.4	n/a	chrII 8,118,482	ire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis.