UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	smg-5	W02D3.8	0	chrI 6,735,096	smg-5 encodes a novel protein that contains two N-terminal tetratricopeptide (TPR) repeats and a C-terminal PINc domain found in nucleotide-binding proteins; SMG-5 is a component of the nonsense-mediated mRNA decay (NMD) pathway and likely functions in regulation of dephosphorylation of SMG-2, the C. elegans UPF1 ortholog, an ATPase and RNA helicase required for NMD in worms, yeast, and mammals; SMG-5 physically interacts with SMG-7, SMG-2, and the PAA-1 and LET-92 structural and catalytic subunits, respectively, of a protein phosphatase 2A (PP2A), suggesting that SMG-5 may function to direct SMG-2 to a PP2A phosphatase that regulates its activity in vivo; SMG-5 also interacts, in vivo, with components of the RNA interference (RNAi) pathway, suggesting a potential link between RNAi and NMD; SMG-5::GFP fusion proteins localize to both the nucleus and the cytoplasm.
2	sec-10	C33H5.9	n/a	chrIV 7,780,928	C. elegans SEC-10 protein; contains similarity to Pfam domain PF07393 Exocyst complex component Sec10 contains similarity to Interpro domain IPR009976 (Exocyst complex component Sec10)
3	cyp-14A2	K09A11.3	n/a	chrX 13,268,561	C. elegans CYP-14A2 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
4	T20F5.3	T20F5.3	n/a	chrI 3,910,087	contains similarity to Pfam domain PF01765 Ribosome recycling factor contains similarity to Interpro domains IPR002661 (Ribosome recycling factor), IPR001669 (Arginine repressor)
5	B0019.2	B0019.2	n/a	chrI 12,777,941	contains similarity to Pfam domains PF04435 (Domain of unknown function (DUF545)) , PF02178 (AT hook motif) contains similarity to Interpro domains IPR006570 (SPK), IPR000637 (HMG-I and HMG-Y, DNA-binding), IPR009057 (Homeodomain-like)
6	ZK1098.4	ZK1098.4	n/a	chrIII 9,543,651	contains similarity to Pfam domain PF01008 Initiation factor 2 subunit family contains similarity to Interpro domain IPR000649 (Initiation factor 2B related)
7	F13B6.2	F13B6.2	n/a	chrIV 7,459,793
8	F55C10.4	F55C10.4	n/a	chrV 11,387,665	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
9	gbh-1	D2089.5	n/a	chrII 10,692,053	gbh-1 encodes a predicted ortholog of human hBBOX1; expressed in the intestine and in head and body muscles.
10	F22G12.3	F22G12.3	n/a	chrI 13,153,129	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
11	C11D2.3	C11D2.3	n/a	chrIV 6,154,348
12	str-7	F22B8.5	n/a	chrV 16,098,738	C. elegans STR-7 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
13	C32D5.10	C32D5.10	n/a	chrII 6,350,550	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
14	C46G7.2	C46G7.2	n/a	chrIV 6,016,483	contains similarity to Anisakis simplex 29kDa protein from Anisakis simplex.; TR:Q9U5Z9
15	C27H6.3	C27H6.3	n/a	chrV 9,981,996	contains similarity to Homo sapiens Acidic (Leucine-rich) nuclear phosphoprotein 32 family, member E; ENSEMBL:ENSP00000358111
16	srt-69	B0238.8	n/a	chrV 5,264,800	C. elegans SRT-69 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
17	nfyc-1	F23F1.1	n/a	chrII 44,432	C. elegans NFYC-1 protein; contains similarity to Pfam domains PF00808 (Histone-like transcription factor (CBF/NF-Y) and archaeal histone) , PF00125 (Core histone H2A/H2B/H3/H4) contains similarity to Interpro domains IPR009072 (Histone-fold), IPR007125 (Histone core), IPR003958 (Transcription factor CBF/NF-Y/archaeal histone)
18	K09F6.3	K09F6.3	n/a	chrII 2,258,704	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00102 (Protein-tyrosine phosphatase) contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR003125 (Protein of unknown function WSN)
19	K09C4.10	K09C4.10	n/a	chrX 3,278,116	contains similarity to Staphylococcus aureus Serine-rich adhesin for platelets precursor (Staphylococcus aureusssurface protein A).; SW:Q7A362
20	pqn-38	F44B9.7	n/a	chrIII 8,026,555	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
21	F39B2.3	F39B2.3	n/a	chrI 14,788,812	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR016040 (NAD(P)-binding)
22	F41B5.6	F41B5.6	n/a	chrV 2,240,376	contains similarity to Pfam domain PF03564 Protein of unknown function (DUF1759) contains similarity to Interpro domain IPR005312 (Protein of unknown function DUF1759)
23	W03G1.3	W03G1.3	n/a	chrIV 512,107
24	D2085.6	D2085.6	n/a	chrII 8,660,679	D2085.6 is orthologous to the human gene CLASS A GLCNAC-INOSITOL PHOSPHOLIPID ASSEMBLY PROTEIN (PIGA; OMIM:311770), which when mutated leads to paroxysmal nocturnal hemoglobinuria.
25	fbxa-51	T12B5.1	n/a	chrIII 962,902	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
26	Y39A3A.2	Y39A3A.2	n/a	chrIII 2,057,188	contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold)
27	F28C1.1	F28C1.1	n/a	chrV 12,452,041	contains similarity to Drosophila melanogaster Flybase gene name is CG6695-PA;; FLYBASE:CG6695
28	T22F3.7	T22F3.7	n/a	chrV 3,599,159	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
29	R07G3.5	R07G3.5	n/a	chrII 7,598,098	contains similarity to Pfam domain PF00300 Phosphoglycerate mutase family contains similarity to Interpro domain IPR013078 (Phosphoglycerate mutase)
30	twk-26	C33D12.3	n/a	chrX 3,052,381	C. elegans TWK-26 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2), IPR003092 (Potassium channel, two pore-domain, TASK)
31	pink-1	EEED8.9	n/a	chrII 5,394,469	pink-1 encodes a predicted serine/threonine protein kinase that is most similar to the Drosophila and human PINK1 (PTEN-induced kinase) protein kinases, the latter of which has been implicated in familial forms of Parkinson's disease; although loss of C. elegans pink-1 activity via large-scale RNAi screens results in no obvious abnormalities, studies in Drosophila indicate that Drosophila PINK1 is a mitochondrial protein that genetically interacts with Drosophila parkin and is essential for maintaining mitochondrial function and integrity in several tissues, including flight muscles and dopaminergic neurons.
32	rabn-5	F01F1.4	n/a	chrIII 5,865,475	C. elegans RABN-5 protein; contains similarity to Pfam domains PF09311 (Rab5 binding) , PF01363 (FYVE zinc finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000306 (Zinc finger, FYVE-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002867 (Zinc finger, C6HC-type), IPR015390 (Rabaptin, GTPase-Rab5 binding), IPR017455 (Zinc finger, FYVE-related), IPR011011 (Zinc finger, FYVE/PHD-type)
33	F38B6.4	F38B6.4	n/a	chrX 6,677,310	contains similarity to Pfam domains PF02844 (Phosphoribosylglycinamide synthetase, N domain) , PF02769 (AIR synthase related protein, C-terminal domain) , PF02843 (Phosphoribosylglycinamide synthetase, C domain) , PF01071 (Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain) , PF00551 (Formyl transferase) , PF00586 (AIR synthase related protein, N-terminal domain) contains similarity to Interpro domains IPR016185 (PreATP-grasp-like fold), IPR011761 (ATP-grasp fold), IPR004733 (Phosphoribosylformylglycinamidine cyclo-ligase), IPR002376 (Formyl transferase, N-terminal), IPR016188 (PurM, N-terminal-like), IPR000728 (AIR synthase related protein), IPR004607 (Phosphoribosylglycinamide formyltransferase), IPR013815 (ATP-grasp fold, subdomain 1), IPR010918 (AIR synthase related protein, C-terminal), IPR013816 (ATP-grasp fold, subdomain 2), IPR013817 (Pre-ATP-grasp fold), IPR011054 (Rudiment single hybrid motif), IPR000115 (Phosphoribosylglycinamide synthetase)
34	F55G1.9	F55G1.9	n/a	chrIV 7,476,741	contains similarity to Pfam domain PF03807 NADP oxidoreductase coenzyme F420-dependent contains similarity to Interpro domains IPR004455 (NADP oxidoreductase, coenzyme F420-dependent), IPR000304 (Delta 1-pyrroline-5-carboxylate reductase), IPR016040 (NAD(P)-binding)
35	pps-1	T14G10.1	n/a	chrIV 10,163,166	pps-1 is orthologous to human PAPSS1 (OMIM:603262) and human PAPSS2 (OMIM:603005, mutated in spondyloepimetaphyseal dysplasia).
36	cul-6	K08E7.7	n/a	chrIV 12,588,438	cul-6 encodes a member of the cullin family that may physically interact with SKR-3.
37	ttll-5	C55A6.2	n/a	chrV 11,510,749	ttll-5 encodes a putative tubulin polyglutamylase orthologous to human TTLL5; TTLL-5 is required for embryonic development and fertility; by orthology, TTLL-5 is expected to initiate glutamyl chains rather than elongating them, to prefer alpha-tubulin over beta-tubulin as a substrate, and to have non-tubulin substrates.
38	T19C3.4	T19C3.4	n/a	chrIII 619,226	contains similarity to Pfam domain PF03134 TB2/DP1, HVA22 family contains similarity to Interpro domain IPR004345 (TB2/DP1 and HVA22 related protein)
39	6R55.2	6R55.2	n/a	chrX 17,713,765
40	F52C6.13	F52C6.13	n/a	chrII 1,930,469
41	moc-1	T06H11.4	n/a	chrX 10,137,338	moc-1 encodes an ortholog of human GEPHYRIN (GPHN; OMIM:603930), which when mutated leads to molybdenum cofactor (MoCo) deficiency; MOC-1 is also paralogous to LIN-46.
42	spr-1	D1014.8	n/a	chrV 8,128,020	spr-1 encodes the C. elegans ortholog of the human corepressor CoREST that functions in HDAC-containing complexes to mediate transcriptional repression; in C. elegans, spr-1 was first identified in screens for genetic suppressors of the egg-laying defective phenotype of sel-12/presenilin mutants; subsequent genetic analyses showed that spr-1 likely functions as a negative regulator of LIN-12/Notch signaling in multiple cells, including those of the somatic gonad, vulva, and early embryo; spr-1 also interacts genetically with sem-5 to regulate postembryonic growth rates and lin-35Rb to regulate vulval morphogenesis and germline proliferation; in binding assays and yeast two-hybrid experiments, SPR-1 interacts with SPR-5, the C. elegans ortholog of the LSD1 histone demethylase; an SPR-1::MYC fusion protein expressed under the control of the cog-2 promoter localizes to the nucleus and shows increased staining in nuclear speckles and what appears to be the nucleolus.
43	F32B4.6	F32B4.6	n/a	chrI 11,516,108	contains similarity to Pfam domains PF07819 (PGAP1-like protein) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR012908 (PGAP1-like)
44	T19C9.8	T19C9.8	n/a	chrV 17,239,506	contains similarity to Amsacta moorei entomopoxvirus AMV141.; TR:Q9EMQ8
45	C33G3.4	C33G3.4	n/a	chrX 14,073,660	C33G3.4 is orthologous to the human gene BETA-MANNOSIDASE (MANBA; OMIM:248510), which when mutated leads to disease.
46	W04C9.2	W04C9.2	n/a	chrI 489,263
47	Y43F8C.7	Y43F8C.7	n/a	chrV 19,642,720	contains similarity to Anopheles gambiae str PEST AGAP011346-PA.; TR:Q7PST7
48	srh-177	K02E2.3	n/a	chrV 20,363,754	C. elegans SRH-177 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
49	Y54G11A.2	Y54G11A.2	n/a	chrII 14,253,902	contains similarity to Pfam domain PF05670 Domain of unknown function (DUF814) contains similarity to Interpro domain IPR008532 (Protein of unknown function DUF814)
50	F23F12.8	F23F12.8	n/a	chrIII 6,485,986	F23F12.8 encodes a large (980-residue) protein, predicted to be secreted, with two chitin-binding peritrophin-A domains, separated by a low-complexity region; F23F12.8 is synthesized in larval and adult pharynx, a known site of chitin deposition; like CEJ-1 and CPG-2 in embryos, F23F12.8 might participate in chitin synthesis, and its peritrophin-A domains might enable mechanical cross-linking of chitin.