UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	rec-8	W02A2.6	0	chrIV 13,351,138	rec-8 encodes a meiosis-specific cohesin complex subunit orthologous to Saccharomyces cerevisiae and Schizosaccharomyces pombe Rec8p; REC-8 is essential for pairing of homologoues and sister chromatids during meiosis and thus for proper chromosome disjunction; in the germline, REC-8 associates with chromatin of transition zone nuclei, and co-localizes with SMC-1 along the longitudinal axes of synapsed chromosomes at pachytene and in a cruciform pattern at diakinesis; REC-8 localization to chromatin is dependent upon TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS, and additionally, REC-8 and SCC-3 are mutually required for chromatin localization; REC-8 cleavage and degradation during meiosis I is dependent on the AIR-2 aurora-like kinase and during meiosis II on AIR-2 and the PLK-1 polo-like kinase.
2	hlh-15	C43H6.8	n/a	chrX 2,413,123	C. elegans HLH-15 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
3	C35D10.5	C35D10.5	n/a	chrIII 4,862,879	contains similarity to Pfam domain PF03981 Ubiquinol-cytochrome C chaperone contains similarity to Interpro domain IPR007129 (Ubiquinol-cytochrome C chaperone)
4	syp-1	F26D2.2	n/a	chrV 16,406,704	C. elegans SYP-1 protein ; contains similarity to Paramecium tetraurelia Chromosome undetermined scaffold_7, whole genome shotgun sequence.; TR:A0DYW0
5	col-175	C35B8.1	n/a	chrX 9,234,064	C. elegans COL-175 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
6	ZC317.7	ZC317.7	n/a	chrV 5,469,825	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003980 (Histamine H3 receptor)
7	C16A11.3	C16A11.3	n/a	chrII 4,231,931	contains similarity to Pfam domains PF04435 (Domain of unknown function (DUF545)) , PF00069 (Protein kinase domain) , PF00628 (PHD-finger) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR006570 (SPK), IPR002290 (Serine/threonine protein kinase), IPR001965 (Zinc finger, PHD-type), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR011011 (Zinc finger, FYVE/PHD-type)
8	bath-1	F59H6.9	n/a	chrII 2,028,219	C. elegans BATH-1 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
9	C44E4.3	C44E4.3	n/a	chrI 4,639,174	contains similarity to Pfam domain PF00155 Aminotransferase class I and II contains similarity to Interpro domains IPR004838 (Aminotransferases, class-I, pyridoxal-phosphate-binding site), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR004839 (Aminotransferase, class I and II), IPR000796 (Aspartate/other aminotransferase), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
10	grd-3	W05E7.1	n/a	chrIV 3,440,050	grd-3 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; GRD-3 is expressed in adult anterior and posterior seam cells, overlapping GRD-5 expression; GRD-3 is also strongly expressed upon infection with the gram-negative bacterium Serratia marcescens, indicating that GRD-3 may be part of C. elegans' innate immunity response; the Ground domain is predicted to form a cysteine-crosslinked protein acting as an intercellular signal, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-3 is weakly required for normal molting; GRD-3 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
11	R11A8.1	R11A8.1	n/a	chrIV 10,356,114	contains similarity to Homo sapiens Hypothetical protein; ENSEMBL:ENSP00000299601
12	cas-2	C18E3.6	n/a	chrI 4,191,639	C. elegans CAS-2 protein; contains similarity to Pfam domains PF01213 (Adenylate cyclase associated (CAP) N terminal) , PF08603 (DE Adenylate cyclase associated (CAP) C terminal) contains similarity to Interpro domains IPR001837 (Adenylate cyclase-associated CAP), IPR000694 (Proline-rich region), IPR013992 (Adenylate cyclase-associated CAP, N-terminal), IPR003073 (Orphan nuclear receptor, NURR type), IPR016098 (Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal), IPR006599 (CARP motif), IPR013912 (Adenylate cyclase-associated CAP, C-terminal)
13	W01A11.1	W01A11.1	n/a	chrV 6,500,809	contains similarity to Pfam domains PF06441 (Epoxide hydrolase N terminus) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR016292 (Epoxide hydrolase), IPR000073 (Alpha/beta hydrolase fold-1), IPR000639 (Epoxide hydrolase-like), IPR010497 (Epoxide hydrolase, N-terminal)
14	F44E7.3	F44E7.3	n/a	chrV 5,772,314
15	prg-1	D2030.6	n/a	chrI 7,586,932	C. elegans PRG-1 protein; contains similarity to Pfam domains PF02170 (PAZ domain) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
16	F54D5.2	F54D5.2	n/a	chrII 11,573,977	contains similarity to Interpro domain IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
17	C36A4.5	C36A4.5	n/a	chrIII 3,846,247	contains similarity to Interpro domains IPR003993 (Treacher Collins syndrome, treacle), IPR000694 (Proline-rich region), IPR005819 (Histone H5)
18	ZK1193.2	ZK1193.2	n/a	chrX 411,499	contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00059 (Lectin C-type domain) contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR002049 (EGF-like, laminin), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR013032 (EGF-like region, conserved site), IPR001304 (C-type lectin), IPR006582 (Region of unknown fuction MD, Caenorhabditis elegans), IPR002035 (von Willebrand factor, type A)
19	W07G4.4	W07G4.4	n/a	chrV 13,045,013	contains similarity to Pfam domain PF00883 Cytosol aminopeptidase family, catalytic domain contains similarity to Interpro domain IPR000819 (Peptidase M17, leucyl aminopeptidase, C-terminal)
20	F02D8.4	F02D8.4	n/a	chrV 14,986,177	contains similarity to Pfam domain PF00246 Zinc carboxypeptidase contains similarity to Interpro domains IPR000834 (Peptidase M14, carboxypeptidase A), IPR009020 (Proteinase inhibitor, propeptide)
21	F55G1.5	F55G1.5	n/a	chrIV 7,475,614	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
22	nlp-24	F35B12.7	n/a	chrV 11,616,534	C. elegans NLP-24 protein; contains similarity to Interpro domain IPR000817 (Prion protein)
23	F38A1.9	F38A1.9	n/a	chrIV 1,244,866
24	col-103	F56B3.1	n/a	chrIV 763,047	C. elegans COL-103 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR000817 (Prion protein), IPR008160 (Collagen triple helix repeat), IPR013286 (Annexin, type VII)
25	R07E5.13	R07E5.13	n/a	chrIII 4,414,076	This gene encodes a homolog of mammalian BRAIN PROTEIN 44-LIKE (BRP44L).
26	C45B2.1	C45B2.1	n/a	chrX 6,086,305
27	rde-1	K08H10.7	n/a	chrV 9,989,751	rde-1 encodes a novel, conserved protein that is a member of the PIWI/STING/Argonaute/Zwille/eIF2c family of proteins; rde-1 activity is required for RNA-mediated interference (RNAi), likely at a point after small interfering RNAs (siRNAs) have been produced from dsRNA triggers; RDE-1 interacts with RDE-4 in vivo and its activity is also required for accumulation of dsRNA bound to RDE-4.
28	F29C4.6	F29C4.6	n/a	chrIV 120,551	contains similarity to Pfam domain PF01171 PP-loop family contains similarity to Interpro domains IPR011063 (PP-loop), IPR012089 (PP-loop ATPase, YdaO-related), IPR000541 (Protein of unknown function UPF0021), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold)
29	C14B1.6	C14B1.6	n/a	chrIII 3,716,084	contains similarity to Interpro domain IPR008162 (Inorganic pyrophosphatase)
30	K11H3.4	K11H3.4	n/a	chrIII 9,835,521	contains similarity to Pfam domain PF02213 (GYF domain)
31	T13F3.6	T13F3.6	n/a	chrV 16,270,691	contains similarity to Paramecium tetraurelia 51B type surface protein.; TR:Q27167
32	cdd-2	F49E8.4	n/a	chrIV 7,547,502	A functional cytidine deaminase that affects morphology of embryos; it is expressed at all life cycle stages.
33	R11F4.3	R11F4.3	n/a	chrII 4,071,458	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR016054 (Ly-6 antigen / uPA receptor -like)
34	scl-27	ZK6.3	n/a	chrV 400,930	C. elegans SCL-27 protein; contains similarity to Pfam domain PF00188 SCP-like extracellular protein contains similarity to Interpro domains IPR014044 (SCP-like extracellular), IPR001283 (Allergen V5/Tpx-1 related)
35	F46B6.4	F46B6.4	n/a	chrV 9,778,673	contains similarity to Pfam domain PF01926 GTPase of unknown function contains similarity to Interpro domains IPR016496 (GTP-binding protein, HflX), IPR002917 (GTP-binding protein, HSR1-related), IPR003593 (AAA+ ATPase, core), IPR006073 (GTP1/OBG)
36	W02G9.4	W02G9.4	n/a	chrV 2,668,540	contains similarity to Pfam domain PF00431 CUB domain contains similarity to Interpro domain IPR000859 (CUB)
37	fbxa-59	T12B5.8	n/a	chrIII 942,155	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
38	C03B8.2	C03B8.2	n/a	chrIII 7,716,234
39	C47E8.4	C47E8.4	n/a	chrV 14,684,638	contains similarity to Pfam domain PF04921 XAP5 protein contains similarity to Interpro domains IPR007005 (XAP5 protein), IPR000533 (Tropomyosin)
40	xtr-2	F17A2.1	n/a	chrX 12,316,529	xtr-2 encodes a protein with similarity to TRA-2A and TRA-2B in a region known as the MX region, hypothesized to be a protein-protein interaction domain involved in negatively regulating tra-2 activity in the germ line.
41	C29H12.5	C29H12.5	n/a	chrII 6,111,947	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR000953 (Chromo domain), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR016197 (Chromo domain-like)
42	vha-7	C26H9A.1	n/a	chrIV 12,646,915	vha-7 encodes an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-7 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); vha-7 is expressed in hypodermis and uterus; VHA-7 is dispensable for viability, since vha-7(RNAi) animals develop to normal, healthy adults; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; VHA-7 is predicted to capture protons from V-ATPase transmembrane rotor components and export the protons across the membrane.
43	ugt-14	H23N18.2	n/a	chrV 4,907,256	C. elegans UGT-14 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
44	zim-1	T07G12.6	n/a	chrIV 10,551,197	zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
45	C28A5.1	C28A5.1	n/a	chrIII 4,431,952	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8IJR3
46	tyr-2	K08E3.1	n/a	chrIII 13,745,634	C. elegans TYR-2 protein; contains similarity to Pfam domains PF00264 (Common central domain of tyrosinase) , PF01549 (ShK domain-like) (2)contains similarity to Interpro domains IPR008922 (Di-copper centre-containing), IPR002227 (Tyrosinase), IPR003582 (Metridin-like ShK toxin)
47	nspb-6	H04M03.2	n/a	chrIV 5,895,659	C. elegans NSPB-6 protein; contains similarity to Pfam domain PF07312 Protein of unknown function (DUF1459) contains similarity to Interpro domain IPR009924 (Protein of unknown function DUF1459)
48	Y57G11A.5	Y57G11A.5	n/a	chrIV 14,512,160	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
49	F33H2.2	F33H2.2	n/a	chrI 15,025,433	contains similarity to Homo sapiens Protein FAM91A1; ENSEMBL:ENSP00000335082
50	mut-14	C14C11.6	n/a	chrV 5,659,724	mut-14 mutants exhibit germline transposon activation, a deficient response to RNAi, resistance to co-suppression, and transgene desilencing.