UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	daf-5	W01G7.1	0	chrII 14,035,373	daf-5 encodes a proline-rich protein, conserved in C. briggsae but not observed in non-nematode genomes, that promotes dauer formation in the group II branch of the dauer pathway, may regulate chemosensation via AWC neurons, and may regulate egg laying; daf-5 mutations suppress the dauer phenotype of group II Daf-c mutants; daf-5(e1385) partially suppresses dauer formation by aex-6(sa699) mutants at 26.8 degrees C.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	R102.1	R102.1	n/a	chrIV 10,686,816	contains similarity to Oryza sativa Similar to Arabidopsis thaliana chromosome 4.; TR:Q9LWR6
4	pqn-60	R11G11.7	n/a	chrV 504,306	pqn-60 encodes a 154-residue, glutamine/asparagine (Q/N)-rich ('prion'-like) protein, predicted to have coiled-coil structure, with many paralogs in nematodes but no obvious non-nematode orthologs; PQN-60 inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51.
5	myo-5	F58G4.1	n/a	chrV 8,113,539	C. elegans MYO-5 protein; contains similarity to Pfam domains PF01576 (Myosin tail) , PF00612 (IQ calmodulin-binding motif) , PF02736 (Myosin N-terminal SH3-like domain) , PF00063 (Myosin head (motor domain)) contains similarity to Interpro domains IPR010989 (t-SNARE), IPR002957 (Keratin, type I), IPR000533 (Tropomyosin), IPR009053 (Prefoldin), IPR004009 (Myosin, N-terminal, SH3-like), IPR002928 (Myosin tail), IPR001609 (Myosin head, motor region)
6	D1005.3	D1005.3	n/a	chrX 1,453,357	contains similarity to Pfam domain PF07716 Basic region leucine zipper contains similarity to Interpro domains IPR011700 (Basic leucine zipper), IPR004827 (Basic-leucine zipper (bZIP) transcription factor)
7	ins-26	ZC334.1	n/a	chrI 14,037,463	ins-26 encodes an insulin-like peptide.
8	B0303.14	B0303.14	n/a	chrIII 8,714,993	contains similarity to Homo sapiens 33 kDa protein; VG:OTTHUMP00000025234
9	F37H8.3	F37H8.3	n/a	chrII 11,182,323	contains similarity to Pfam domain PF00702 haloacid dehalogenase-like hydrolase contains similarity to Interpro domains IPR011945 (Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal), IPR006402 (HAD-superfamily hydrolase, subfamily IA, variant 3), IPR005834 (Haloacid dehalogenase-like hydrolase)
10	unc-41	C27H6.1	n/a	chrV 9,971,233	unc-41 encodes an ortholog of Drosophila STONED A (STNA) required for normal locomotion; a beta-strand in the mu-adaptin-like domain of UNC-41 binds the C2A domain of SNT-1, and this binding is required for SNT-1 endocytosis, punctate localization of UNC-41 in neurons, and transgenic rescue of unc-41(e268) animals; UNC-41 is also required for normal secretion of EGL-17 from P6.p cells, and for embryonic viability; UNC-41 is expressed in the larval and adult nervous system; UNC-41, like other stonins, is an adaptin, and by orthology with stonins is predicted to be a protein adaptor that helps sort SNT-1 endocytotically.
11	C01B4.8	C01B4.8	n/a	chrV 2,491,606	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
12	M7.12	M7.12	n/a	chrIV 11,097,281	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
13	ceh-26	K12H4.1	n/a	chrIII 8,069,282	ceh-26 encodes a protein that contains a prospero-related homeodomain; expressed in nuclei of the adult head, tail neurons, and one cell in the postdeirids.
14	T21B6.3	T21B6.3	n/a	chrX 10,946,988	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
15	K08C7.4	K08C7.4	n/a	chrIV 10,679,875	contains similarity to Bos taurus Cylicin-2 (Cylicin II) (Multiple-band polypeptide II).; SW:Q28092
16	F28B1.1	F28B1.1	n/a	chrV 17,043,156	contains similarity to Mus musculus Hypothetical protein.; TR:Q8C3I4
17	W01A8.3	W01A8.3	n/a	chrI 7,066,580	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
18	cyp-33C8	R08F11.3	n/a	chrV 3,802,105	C. elegans CYP-33C8 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
19	mec-7	ZK154.3	n/a	chrX 7,775,712	mec-7 encodes a beta-tubulin required for touch sensitivity along the body wall, and for normal levels of locomotor activity; it is strongly expressed in six touch receptor neurons, with weak expression in FLP, PVD, and BDU cells.
20	myo-2	T18D3.4	n/a	chrX 12,471,624	myo-2 encodes a muscle-type specific myosin heavy chain isoform; myo-2 is expressed in pharyngeal muscle.
21	ben-1	C54C6.2	n/a	chrIII 3,539,934	A beta-tubulin that confers benzimidazole sensitivity.
22	gpb-1	F13D12.7	n/a	chrII 11,745,729	gpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline.
23	mec-12	C44B11.3	n/a	chrIII 3,135,388	mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons.
24	B0272.4	B0272.4	n/a	chrX 9,429,267	contains similarity to Pfam domain PF00378 Enoyl-CoA hydratase/isomerase family contains similarity to Interpro domain IPR001753 (Crotonase, core)
25	F16G10.5	F16G10.5	n/a	chrII 2,368,093
26	H11E01.3	H11E01.3	n/a	chrX 1,612,018	contains similarity to Staphylococcus saprophyticus subsp saprophyticus Uro-adherence factor A precursor.; SW:Q4A0V8
27	Y48B6A.5	Y48B6A.5	n/a	chrII 14,173,958	contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
28	lgc-25	R03E1.3	n/a	chrX 14,160,175	C. elegans LGC-25 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR003567 (Cytochrome c-type biogenesis protein), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
29	K08D9.4	K08D9.4	n/a	chrV 3,199,601	contains similarity to Pfam domain PF06342 Alpha/beta hydrolase of unknown function (DUF1057) contains similarity to Interpro domains IPR008262 (Lipase, active site), IPR010463 (Protein of unknown function DUF1057, lipase putative), IPR003089 (Alpha/beta hydrolase)
30	C39E9.10	C39E9.10	n/a	chrIV 13,088,275	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR006052 (Tumor Necrosis Factor), IPR016196 (MFS general substrate transporter)
31	Y18D10A.8	Y18D10A.8	n/a	chrI 12,848,697	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR016021 (MIF4-like, type 1/2/3), IPR004087 (K Homology), IPR000694 (Proline-rich region), IPR004088 (K Homology, type 1), IPR016024 (Armadillo-type fold)
32	ugt-43	F01D4.1	n/a	chrIV 10,466,113	C. elegans UGT-43 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
33	ugt-57	F01E11.1	n/a	chrX 6,992,905	C. elegans UGT-57 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
34	K07E3.1	K07E3.1	n/a	chrX 8,112,540	contains similarity to Trichomonas vaginalis G3 Dentin sialophosphoprotein, putative.; TR:A2DMT3
35	srz-60	C04C3.1	n/a	chrIV 3,429,627	C. elegans SRZ-60 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
36	inx-13	Y8G1A.2	n/a	chrI 3,751,248	inx-13 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; INX-13 is essential for larval development and osmoregulation, and may be a component of the gap junctions that link the excretory and hypodermal cells; INX-13 is expressed embryonically in hypodermis and post-embryonically, in hypodermal seam cells, the excretory cell, and the developing vulva and spermatheca; in hypodermal cells, INX-13 localizes to the plasma membrane at points of contact between adjacent cells.
37	F37A4.4	F37A4.4	n/a	chrIII 6,715,740	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00023 (Ankyrin repeat) , PF00533 (BRCA1 C Terminus (BRCT) domain) (2)contains similarity to Interpro domains IPR002110 (Ankyrin), IPR003125 (Protein of unknown function WSN), IPR001357 (BRCT)
38	ZC449.5	ZC449.5	n/a	chrX 5,036,581	contains similarity to Lodderomyces elongisporus Putative uncharacterized protein.; TR:A5DYU9
39	nhr-62	Y67A6A.2	n/a	chrI 9,842,194	C. elegans NHR-62 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
40	pqn-71	T23F1.6	n/a	chrV 15,466,350	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
41	ZK596.1	ZK596.1	n/a	chrIV 10,900,848	contains similarity to Pfam domain PF02520 Domain of unknown function DUF148 contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR003677 (Protein of unknown function DUF148)
42	C01G10.5	C01G10.5	n/a	chrV 15,089,276	contains similarity to Homo sapiens Glycine/tyrosine-rich protein; ENSEMBL:ENSP00000335001
43	F46F5.4	F46F5.4	n/a	chrII 805,580	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
44	ace-3	Y48B6A.8	n/a	chrII 14,207,809	ace-3 encodes one of four C. elegans acetylcholinesterases (AChE); ACE-3 represents ~5% of the total AChE activity in C. elegans and in vitro, hydrolyzes acetylthio-, butyrylthio-, and propionylthiocholine substrates with equal efficiency; although loss-of-function mutations in ace-3 result in no obvious defects, animals doubly mutant with ace-1 or ace-2 have slight defects in backward locomotion and animals triply mutant for ace-1, -2, and -3 arrest as unhatched, yet fully developed, embryos; ace-3 is the downstream gene in an operon with a fourth AChE-encoding gene, ace-4, and transcriptional reporter fusions with ace-4 upstream sequences direct expression in pharyngeal muscles pm3, 4, 5, and 7, the two CAN (canal associated neuron) cells, midbody dorsal body wall muscles in larvae, and several neurons in the head and anal ganglion
45	fbxb-36	F07E5.6	n/a	chrII 2,061,815	C. elegans FBXB-36 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
46	spc-1	K10B3.10	n/a	chrX 3,122,249	spc-1 encodes the C. elegans alpha spectrin ortholog; during development, spc-1 activity is required for body morphogenesis, formation of body wall muscles, locomotion, and larval development.
47	gst-20	Y48E1B.10	n/a	chrII 13,608,893	C. elegans GST-20 protein; contains similarity to Pfam domain PF02798 Glutathione S-transferase, N-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
48	F41C6.6	F41C6.6	n/a	chrX 6,881,383
49	E02C12.11	E02C12.11	n/a	chrV 9,379,644	contains similarity to Pfam domain PF07914 Protein of unknown function (DUF1679) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species)
50	grl-4	F42C5.7	n/a	chrIV 7,310,282	grl-4 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-4 is expressed in pharynx, reproductive system, vulva, larval neurons, and larval rectal epithelium; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.