UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	pqn-73	W01C9.3	0	chrII 8,543,297	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
2	bra-2	F23H11.1	n/a	chrIII 911,744	The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway
3	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
4	T25C8.1	T25C8.1	n/a	chrIII 13,611,268	contains similarity to Interpro domains IPR002345 (Lipocalin), IPR000577 (Carbohydrate kinase, FGGY)
5	VC27A7L.1	VC27A7L.1	n/a	chrV 12,165,914	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
6	W02B12.4	W02B12.4	n/a	chrII 11,457,473	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
7	C04E7.3	C04E7.3	n/a	chrX 345,208	contains similarity to Homo sapiens inner centromere protein antigens 135/155kDa isoform 2; ENSEMBL:ENSP00000278849
8	F47B8.6	F47B8.6	n/a	chrV 14,329,569	contains similarity to Drosophila heteroneura Aminopeptidase N (Fragment).; TR:O61534
9	mex-5	W02A2.7	n/a	chrIV 13,354,881	mex-5 encodes a novel protein that contains two CCCH zinc finger motifs; maternally provided MEX-5, which functions partly redundantly with the highly similar CCCH finger protein MEX-6, is essential for transducing polarity cues and establishing soma/germline asymmetry in the early embryo; in regulating soma/germline asymmetry, MEX-5 interacts with, and activates, the SOCS-box protein ZIF-1, which functions as part of an E3 ubiquitin ligase complex that degrades germ plasm proteins in somatic blastomeres; accordingly, ectopic expression of MEX-5 throughout the early embryo results in reduced expression of germline proteins in germline blastomeres; MEX-5 is a cytoplasmic protein expressed at uniform levels in oocytes and newly fertilized eggs; from the 1-cell to 4-cell stages of embryogenesis, MEX-5 expression is dynamic, with highest levels seen in the anterior AB blastomere and, for a time, its daughters, the anterior portion of the P1 blastomere, P1 centrosomes (both, then posterior only), and the EMS and C blastomeres; the asymmetric distribution of MEX-5 in early embryos depends upon wild-type activity of the PAR and OMA-1 proteins.
10	thoc-3	F32H2.4	n/a	chrI 8,972,046	C. elegans THOC-3 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
11	C06A5.6	C06A5.6	n/a	chrI 5,984,551
12	ugt-32	F47C10.6	n/a	chrV 3,842,918	C. elegans UGT-32 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
13	srj-25	C05E4.10	n/a	chrV 735,347	C. elegans SRJ-25 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR001991 (Sodium:dicarboxylate symporter)
14	F57C2.3	F57C2.3	n/a	chrII 14,524,512	contains similarity to Homo sapiens Hypothetical protein; ENSEMBL:ENSP00000265391
15	C04E6.11	C04E6.11	n/a	chrV 5,915,960	contains similarity to Homo sapiens Leucine-rich PPR motif-containing protein, mitochondrial precursor; ENSEMBL:ENSP00000260665
16	vps-16	C05D11.2	n/a	chrIII 6,434,734	vps-16 encodes the C. elegans homolog of the Saccharomyces cerevisiae vacuolar sorting protein Vps16p; in C. elegans, vps-16 activity is required for biogenesis of the lysosome-related gut granules and for embryonic development; in addition, vps-16 is required for normal body morphology and regulation of germline apoptosis.
17	C03G6.5	C03G6.5	n/a	chrV 7,365,571	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)
18	clec-38	T25E12.10	n/a	chrV 16,734,718	C. elegans CLEC-38 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
19	srbc-29	C02A12.2	n/a	chrV 3,470,161	C. elegans SRBC-29 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
20	let-502	C10H11.9	n/a	chrI 4,741,246	let-502 encodes a Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase); let-502 is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization.
21	F35C11.5	F35C11.5	n/a	chrII 8,254,199	contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR013090 (Phospholipase A2, active site)
22	mex-6	AH6.5	n/a	chrII 9,525,192	mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins.
23	ZK673.4	ZK673.4	n/a	chrII 10,453,965	ZK673.4 encodes a protein with a THAP or THAP-like domain; other proteins with such domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1.
24	pap-1	Y32F6A.3	n/a	chrV 10,444,197	pap-1 encodes a poly (A) polymerase; large-scale RNAi screens indicate that PAP-1 activity is essential for reproduction, embryonic and larval development, proper body morphology, normal rates of growth, and coordinated locomotion.
25	srx-56	C03G6.2	n/a	chrV 7,374,979	C. elegans SRX-56 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
26	mat-2	W10C6.1	n/a	chrII 11,116,985	mat-2 encodes a subunit of the anaphase-promoting complex or cyclosome (APCC) which is a multi-subunit E3 ubiquitin ligase that targets proteins for degradation during the metaphase-to-anaphase transition of the cell cycle; mat-2 is required for chromosome segregation during meiosis I and is involved in polarity specification of the anterior/posterior axis in the developing embryo.
27	fbxa-206	Y102A5C.1	n/a	chrV 16,917,839	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
28	F32D8.3	F32D8.3	n/a	chrV 10,887,380	F32D8.3 encodes a putative secreted TIL-domain protease inhibitor paralogous to SWM-1, ISL-1, and the products of 11 other C. elegans genes; F32D8.3 and its relatives are collectively similar to other TIL-domain protease inhibitors from nematodes, insects, and vertebrates; F32D8.3 has no obvious function in mass RNAi assays.
29	ric-3	T14A8.1	n/a	chrIV 7,819,689	The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.
30	hdl-1	ZK829.2	n/a	chrIV 11,947,905	C. elegans HDL-1 protein; contains similarity to Pfam domain PF00282 Pyridoxal-dependent decarboxylase conserved domain contains similarity to Interpro domains IPR002129 (Pyridoxal phosphate-dependent decarboxylase), IPR010977 (Aromatic-L-amino-acid decarboxylase), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
31	T06C12.8	T06C12.8	n/a	chrV 15,883,366	contains similarity to Interpro domain IPR016054 (Ly-6 antigen / uPA receptor -like)
32	twk-2	T12C9.3	n/a	chrII 4,447,199	twk-2 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; the precise role of TWK-2 in C. elegans development and/or behavior is not yet known, but TWK-2 may function redundantly with other TWK channels; TWK-2 is expressed in a subset of neurons.
33	ulp-1	T10F2.3	n/a	chrIII 5,167,689	C. elegans ULP-1 protein; contains similarity to Pfam domain PF02902 Ulp1 protease family, C-terminal catalytic domain contains similarity to Interpro domain IPR003653 (Peptidase C48, SUMO/Sentrin/Ubl1)
34	cpr-3	T10H4.12	n/a	chrV 15,297,739	C. elegans CPR-3 protein; contains similarity to Pfam domain PF00112 Papain family cysteine protease contains similarity to Interpro domains IPR013128 (Peptidase C1A, papain), IPR000169 (Peptidase, cysteine peptidase active site), IPR000668 (Peptidase C1A, papain C-terminal)
35	srp-1	C05E4.3	n/a	chrV 754,193	srp-1 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-1 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases; however, as loss of srp-1 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-1 in C. elegans development and/or behavior is not yet known.
36	F42A9.6	F42A9.6	n/a	chrIV 8,610,474
37	sru-18	T04A11.9	n/a	chrIV 12,503,147	C. elegans SRU-18 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domains IPR003839 (Protein of unknown function DUF215), IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
38	cyb-2.1	Y43E12A.1	n/a	chrIV 10,986,675	C. elegans CYB-2.1 protein; contains similarity to Pfam domains PF00134 (Cyclin, N-terminal domain) , PF02984 (Cyclin, C-terminal domain) contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal), IPR004367 (Cyclin, C-terminal), IPR014400 (Cyclin, A/B/D/E)
39	srd-26	T02B5.4	n/a	chrV 14,162,174	C. elegans SRD-26 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
40	C50H2.4	C50H2.4	n/a	chrV 9,917,432	contains similarity to Arabidopsis thaliana Putative cytochrome P450.; TR:Q9LQ26
41	K08F4.3	K08F4.3	n/a	chrIV 10,129,732	contains similarity to Pfam domain PF05753 Translocon-associated protein beta (TRAPB) contains similarity to Interpro domain IPR008856 (Translocon-associated beta)
42	F14H12.8	F14H12.8	n/a	chrX 4,363,765
43	ZC443.1	ZC443.1	n/a	chrV 12,809,256	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
44	T11F8.1	T11F8.1	n/a	chrIV 5,480,072
45	him-17	T09E8.2	n/a	chrV 13,178,423	him-17 encodes a protein with no obvious non-nematode homologs that localizes to chromatin in germline nuclei, and that is required for double-stranded break (DSB) formation, chiasmata, crossovers, and genetic recombination during meiosis, but is dispensable for homolog pairing and synapsis, spo-11 germline transcription, or the conversion of DSBs into chiasmata; HIM-17 is also required for normal organization of meiotic stages in the germline, and to promote its orderly transistion from (potentially tumorous) mitosis to meiosis; moreover, HIM-17 is required for normal dimethylation of lysine 9 residues on H3 histones in meiotic prophase chromosomes from early pachytene onward, with null him-17(ok424) mutants showing greatly reduced or delayed dimethylation in both hermaphrodite and male germlines; HIM-17 cooperates with GLP-1 to promote meiotic entry, and with EGO-1 to promote germline viability; HIM-17 has six THAP and THAP-like domains, a domain type also found in CDC-14B, CTB-1, GON-14, LIN-15A, LIN-15B, and LIN-36, along with ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1; missense or truncating mutations of HIM-17's THAP and THAP-like domains cause partial loss of function, implying that the domains collectively and partially contribute to HIM-17 activity; of the C. elegans genes encoding THAP or THAP-like domains, at least four (lin-15A, lin-15B, lin-36, and him-17) interact genetically with lin-35/Rb.
46	F33H1.4	F33H1.4	n/a	chrII 10,177,309	contains similarity to Pfam domain PF02178 (AT hook motif)
47	F20H11.5	F20H11.5	n/a	chrIII 6,588,571	F20H11.5 encodes a putative secreted D-aspartate oxidase (DASPO), paralogous to C47A10.5 and F18E3.7; recombinant F20H11.5 protein is insoluble when expressed in E. coli, and thus has not yet been tested in vitro for activity; F20H11.5 is expressed in a head mesodermal cell, hypodermis, other head cells, and vulva.
48	F31E3.6	F31E3.6	n/a	chrIII 6,982,722
49	ceh-8	ZK265.4	n/a	chrI 8,248,368	ceh-8 encodes a paired-like homeodomain protein of the Q50 class orthologous to the Rx homeobox protein of humans (RAX; OMIM:601881) and Drosophila (CG10052-PA); CEH-8 and RX belong to one of at least 18 distinct families of paired-like homeodomain proteins, including 12 families in the Q50 class.
50	C16A11.6	C16A11.6	n/a	chrII 4,237,141