UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	VT23B5.1	VT23B5.1	0	chrIV 12,665,034	contains similarity to Homo sapiens Isoform 2 of WD repeat and FYVE domain-containing protein 3; ENSEMBL:ENSP00000318466
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	F18A11.2	F18A11.2	n/a	chrII 13,034,546	contains similarity to Pfam domain PF00650 CRAL/TRIO domain contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal)
4	H22K11.2	H22K11.2	n/a	chrX 6,785,820	contains similarity to Pfam domain PF01301 Glycosyl hydrolases family 35 contains similarity to Interpro domains IPR000583 (Glutamine amidotransferase, class-II), IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR001944 (Glycoside hydrolase, family 35)
5	pmp-2	C44B7.9	n/a	chrII 6,885,843	C. elegans PMP-2 protein; contains similarity to Pfam domains PF06472 (ABC transporter transmembrane region 2) , PF00005 (ABC transporter) contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR011527 (ABC transporter, transmembrane region, type 1), IPR010509 (ABC transporter, N-terminal), IPR003593 (AAA+ ATPase, core), IPR005283 (Peroxysomal long chain fatty acyl transporter)
6	F21F8.11	F21F8.11	n/a	chrV 8,283,727	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
7	F49E11.2	F49E11.2	n/a	chrIV 13,037,470	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
8	T24D11.1	T24D11.1	n/a	chrX 16,409,674	contains similarity to Pfam domain PF00566 TBC domain contains similarity to Interpro domain IPR000195 (RabGAP/TBC)
9	pgp-4	F42E11.1	n/a	chrX 11,361,531	pgp-4 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-4 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-4 activity via deletion mutations or RNAi results in no obvious defects, the precise role of PGP-4 in C. elegans development and/or behavior is not yet known; pgp-4 promoter-gfp fusion proteins are expressed in the larval excretory cell.
10	C43G2.2	C43G2.2	n/a	chrIV 6,569,098	contains similarity to Interpro domain IPR000533 (Tropomyosin)
11	pat-4	C29F9.7	n/a	chrIII 92,134	The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes.
12	aff-1	C44B7.3	n/a	chrII 6,862,137	aff-1 encodes a cell-surface protein required in late L4 larvae for various cell fusions, of which at least one (AC-utse) does not require EFF-1; in vulval development, AFF-1 is required for fusion of the anchor cell (AC) with the utse syncytium, of A cells to one another, and of D cells to one another; AFF-1 is also required for lateral seam cell fusions; since aff-1 mutants fail to mix AC with utse cytoplasm, AFF-1 is probably required to begin cell fusion by forming intercellular pores; AFF-1 has no obvious non-nematode orthologs, but is paralogous to EFF-1 and C26D10.7; AFF-1 is predicted to be largely extracellular, with eight conserved predicted disulfide bonds in its ectodomain and a single C-terminal transmembrane domain; AFF-1 is expressed in the AC, beginning around the AC's invasion of basement membrane in mid-L3 larvae, and continuing until the AC's fusion to utse; AFF-1 is also expressed in utse, beginning in L4 larvae, after which AC-utse fusion immediately ensues; in both AC and utse, AFF-1 expression requires FOS-1, and the aff-1 promoter has predicted FOS-1 binding sites; other sites of AFF-1 expression include embryonic hyp5 cells, pharyngeal muscles (Pm3 and Pm5), head and tail neurons, sheath cells of chemosensory neurons, and male tail neurons; subcellularly, AFF-1::GFP localizes to plasma membrane and (undefined) intracellular organelles; generally, AFF-1 is expressed in cells whose fusion does not require EFF-1, which may explain why AFF-1 and EFF-1 are redundantly required for viability; heat shock-driven overexpression of AFF-1, even in an eff-1 null mutant background, can induce ectopic cell fusion, and heterologous AFF-1 can induce insect Sf9 cells to fuse in vitro.
13	prx-13	F32A5.6	n/a	chrII 7,251,051	prx-13 is orthologous to the human gene PEX13 (OMIM:601789), which when mutated leads to Zellweger syndrome or neonatal adrenoleukodystrophy.
14	C53B4.3	C53B4.3	n/a	chrIV 8,972,115	C53B4.3 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:23098) (SLC22A1L; OMIM:602631), which when mutated leads to disease.
15	sgcb-1	K01A2.1	n/a	chrII 327,229	K01A2.1 is orthologous to the human gene SARCOGLYCAN, BETA (43KD DYSTROPHIN-ASSOCIATED GLYCOPROTEIN) (SGCB; OMIM:600900), which when mutated leads to disease.
16	C18E3.3	C18E3.3	n/a	chrI 4,205,990	contains similarity to Staphylococcus saprophyticus subsp saprophyticus Uro-adherence factor A precursor.; SW:Q4A0V8
17	gex-2	F56A11.1	n/a	chrIV 578,227	The gex-2 gene encodes a homolog of p140/Sra-1, a mammalian protein ligand of the small GTPase Rac1; gex-2 is required for tissue morphogenesis and cell migrations.
18	C01F1.1	C01F1.1	n/a	chrII 4,303,435	contains similarity to Pfam domain PF05793 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) contains similarity to Interpro domains IPR011991 (Winged helix repressor DNA-binding), IPR008851 (Transcription initiation factor IIF, alpha subunit), IPR011039 (Transcription Factor IIF, Rap30/Rap74, interaction)
19	F45H7.1	F45H7.1	n/a	chrIII 3,346,522	contains similarity to Mus musculus Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).; SW:SPH2_MOUSE
20	F53B3.3	F53B3.3	n/a	chrX 2,868,560
21	W10G11.17	W10G11.17	n/a	chrII 3,564,777
22	tag-335	C42C1.5	n/a	chrIV 12,277,039	C. elegans TAG-335 protein; contains similarity to Pfam domains PF00132 (Bacterial transferase hexapeptide (three repeats)) (4), PF00483 (Nucleotidyl transferase) contains similarity to Interpro domains IPR001451 (Bacterial transferase hexapeptide repeat), IPR005835 (Nucleotidyl transferase), IPR011004 (Trimeric LpxA-like)
23	R06A4.8	R06A4.8	n/a	chrII 14,354,036	R06A4.8 is orthologous to the human gene GLYCOGEN DEBRANCHING ENZYME ISOFORM 6 (AGL; OMIM:232400), which when mutated leads to glycogen storage disease, type III.
24	F54D10.3	F54D10.3	n/a	chrII 3,812,819	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domains IPR000976 (Wilm's tumour protein), IPR005020 (Protein of unknown function DUF278)
25	glb-13	F19H6.2	n/a	chrX 12,374,995	glb-13 encodes a globin with no obvious function in mass RNAi assays.
26	C10C5.1	C10C5.1	n/a	chrIV 9,362,924	contains similarity to Drosophila melanogaster Flybase gene name is CG8486-PA;; FLYBASE:CG8486
27	jph-1	T22C1.7	n/a	chrI 7,948,882	jph-1 encodes a junctophilin, a protein that belongs to a transmembrane family of proteins implicated in the formation of the junctional membrane complex that forms between the plasma membrane and the endoplasmic reticulum in excitable cells; this complex facilitates cross-talk between the cell surface and intracellular ionic channels; RNA interference of jph-1 results in a locomotion defect suggesting impaired body-wall muscle function; a jph-1 promoter-gfp fusion reporter is expressed in all muscle cells and certain neurons of the nerve ring.
28	col-69	K01A2.7	n/a	chrII 304,726	C. elegans COL-69 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
29	F53C11.3	F53C11.3	n/a	chrV 13,783,418	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR000507 (Adrenergic receptor, beta 1), IPR002424 (Insect alcohol dehydrogenase family), IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
30	Y41E3.8	Y41E3.8	n/a	chrIV 15,028,708	contains similarity to Homo sapiens Isoform 1 of H/ACA ribonucleoprotein complex subunit 1; ENSEMBL:ENSP00000226796
31	T28F4.6	T28F4.6	n/a	chrI 7,493,740	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
32	dhs-4	T05F1.10	n/a	chrI 9,648,395	dhs-4 encodes a short-chain dehydrogenase predicted to be mitochondrial.
33	F39H12.1	F39H12.1	n/a	chrX 836,268	contains similarity to Homo sapiens nuclear pore complex-associated protein TPR; ENSEMBL:ENSP00000356448
34	xrn-2	Y48B6A.3	n/a	chrII 14,160,796	C. elegans XRN-2 protein; contains similarity to Pfam domain PF03159 XRN 5'-3' exonuclease N-terminus contains similarity to Interpro domains IPR017151 (5'-3' exoribonuclease 2), IPR004859 (Putative 5-3 exonuclease), IPR002952 (Eggshell protein), IPR001878 (Zinc finger, CCHC-type)
35	prp-8	C50C3.6	n/a	chrIII 8,168,465	prp-8 is orthologous to the human gene SIMILAR TO U5 SNRNP-SPECIFIC PROTEIN (220 KD), ORTHOLOG OF S.
36	Y54E5A.1	Y54E5A.1	n/a	chrI 14,690,180	contains similarity to Pfam domains PF00487 (Fatty acid desaturase) , PF08557 (Sphingolipid Delta4-desaturase (DES)) contains similarity to Interpro domains IPR013866 (Sphingolipid delta4-desaturase, N-terminal), IPR010257 (Fatty acid desaturase, type 1, N-terminal), IPR011388 (Sphingolipid delta4-desaturase), IPR005804 (Fatty acid desaturase, type 1)
37	gst-14	F37B1.3	n/a	chrII 13,615,382	C. elegans GST-14 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
38	F58F9.4	F58F9.4	n/a	chrIV 6,231,716	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
39	pqn-95	ZK1067.7	n/a	chrII 9,226,126	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
40	acr-23	F59B1.9	n/a	chrV 3,655,579	acr-23 encodes an alpha 7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-23 is a member of the DEG-3-like group of nAChR subunits which appears to be unique to nematodes.
41	gpb-2	F52A8.2	n/a	chrI 7,319,690	gpb-2 encodes an ortholog of Gbeta(5), that is dispensable for viability, but required for normal egg-laying, locomotion, and pharyngeal pumping; GBP-2 may regulate the interaction between the GOA-1 and EGL-30 signaling pathways based on genetic analysis; gpb-2 is expressed throughout development in the nervous system and in muscle, and expression is dependent upon expression of both EAT-16 and EGL-10.
42	R173.3	R173.3	n/a	chrX 7,033,107	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
43	F45B8.3	F45B8.3	n/a	chrX 14,960,981	contains similarity to Interpro domains IPR003267 (Small proline-rich), IPR000694 (Proline-rich region)
44	tag-241	C34E11.3	n/a	chrX 11,831,339	C. elegans TAG-241 protein; contains similarity to Interpro domains IPR010978 (tRNA-binding arm), IPR009061 (Putative DNA binding), IPR004827 (Basic-leucine zipper (bZIP) transcription factor)
45	M28.8	M28.8	n/a	chrII 10,630,658	contains similarity to Interpro domain IPR000583 (Glutamine amidotransferase, class-II)
46	C03B1.7	C03B1.7	n/a	chrX 6,343,858	contains similarity to Sulfolobus tokodaii DNA double-strand break repair rad50 ATPase.; SW:Q96YR5
47	K08D10.10	K08D10.10	n/a	chrIV 4,155,758
48	T04F8.6	T04F8.6	n/a	chrX 11,669,654	contains similarity to Interpro domain IPR011992 (EF-Hand type)
49	uig-1	F32F2.1	n/a	chrV 13,278,769	C. elegans UIG-1 protein; contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR001331 (Guanine-nucleotide dissociation stimulator, CDC24, conserved site)
50	B0238.13	B0238.13	n/a	chrV 5,245,859	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)