UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	T27F6.7	T27F6.7	7.999999999999999e-138	chrI 12,496,077	contains similarity to Timmia bavarica NADH dehydrogenase subunit 4 (Fragment).; TR:Q94YV9
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	R06B9.4	R06B9.4	n/a	chrII 13,754,197	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR011021 (Arrestin-like, N-terminal)
4	mcd-1	Y51H1A.6	n/a	chrII 13,891,577	mcd-1 encodes a highly acidic C2H2-type zinc-finger protein that, in conjunction with LIN-35/Rb, DPL-1/DP, EFL-1/E2F, LIN-37/Mip40, and LIN-52, promotes the developmentally programmed progression of cells through full apoptosis; MCD-1 can promote ectopic apoptosis in cells normally fated to live, and is thus active in such cells; MCD-1 is not required for CED-3-independent cell death, does not regulate CED-9, and probably does not transcriptionally regulate egl-1; MCD-1 and its partners do not act together with CED-1 or CED-8, and their function in cell death is distinct from the LET-60/RAS or SynMuv pathways; however, MCD-1 is redundantly required with some class B/C synMuv proteins for viability (LIN-9, LIN-35/Rb, or LIN-37/Mip40) and normally rapid growth (DPL-1/DP, LIN-13, LIN-53, LIN-54, or MYS-1); in mcd-1(n4005) animals, cells that would normally undergo apoptosis can instead pass through an episode of pre-apoptotic condensation, after which they sometimes revert to normal shape, survive, and differentiate; MCD-1 contains an N-terminal low-complexity region and a single central zinc-finger, but no other recognizable protein domains; MCD-1 is paralogous to Y48E1B.7, but has no obvious non-nematode orthologs.
5	lin-11	ZC247.3	n/a	chrI 10,251,797	lin-11 encodes a predicted LIM homeodomain transcription factor that affects vulval development, neuronal development and fate specification, utse cell differentiation, and fertility; it is expressed in some neurons, the vulva, pi cells and their progeny, and the spermatheca.
6	nlp-13	E03D2.1	n/a	chrV 4,237,211	nlp-13 encodes a predicted neuropeptide of the MSFamide family; expressed primarily in neurons or in the endocrine/secretory cells, and expression includes pharyngeal neurons that modulate pharyngeal pumping of food.
7	stdh-4	F25G6.5	n/a	chrV 8,550,589	stdh-4 encodes a putative steroid dehydrogenase expressed in larval and adult pharynx; STDH-4 is orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1, and paralogous to LET-767 and STDH-1/-3; STDH-4 has no obvious function in mass RNAi assays.
8	srw-139	C44C3.7	n/a	chrV 2,984,742	C. elegans SRW-139 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
9	B0041.3	B0041.3	n/a	chrI 4,645,153	contains similarity to Pfam domain PF01476 LysM domain contains similarity to Interpro domain IPR002482 (Peptidoglycan-binding LysM)
10	Y79H2A.4	Y79H2A.4	n/a	chrIII 12,041,576	contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
11	F26F2.7	F26F2.7	n/a	chrV 20,581,046	contains similarity to Pfam domain PF05346 Eukaryotic membrane protein family contains similarity to Interpro domain IPR008010 (Protein of unknown function DUF747, CMV receptor)
12	srw-12	C41G6.2	n/a	chrV 15,237,968	C. elegans SRW-12 protein ;
13	Y53C10A.3	Y53C10A.3	n/a	chrI 11,969,389	Y53C10A.3 encodes a paralog of HSF-1 that might regulate ubq-1, since ubq-1 has 5'-flanking sequences resembling heat shock regulatory elements, yet is uninduced by heat shock.
14	F55G1.12	F55G1.12	n/a	chrIV 7,494,554	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
15	lrp-2	T21E3.3	n/a	chrI 3,939,445	C. elegans LRP-2 protein; contains similarity to Pfam domains PF00008 (EGF-like domain) (6), PF07974 (EGF-like domain) , PF00057 (Low-density lipoprotein receptor domain class A) (14), PF00058 (Low-density lipoprotein receptor repeat class B) (7)contains similarity to Interpro domains IPR000033 (), IPR000742 (EGF-like, type 3), IPR006209 (EGF-like), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich), IPR001881 (EGF-like calcium-binding), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR013032 (EGF-like region, conserved site), IPR013111 (EGF, extracellular), IPR015943 (WD40/YVTN repeat-like)
16	C09B7.2	C09B7.2	n/a	chrX 2,669,882
17	trxr-2	ZK637.10	n/a	chrIII 8,915,015	C. elegans TRXR-2 protein; contains similarity to Pfam domains PF02852 (Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain) , PF07992 (Pyridine nucleotide-disulphide oxidoreductase) , PF00070 (Pyridine nucleotide-disulphide oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR000447 (FAD-dependent glycerol-3-phosphate dehydrogenase), IPR000103 (Pyridine nucleotide-disulphide oxidoreductase, class-II), IPR012999 (Pyridine nucleotide-disulphide oxidoreductase, class I, active site), IPR004099 (Pyridine nucleotide-disulphide oxidoreductase, dimerisation), IPR006338 (Thioredoxin and glutathione reductase selenoprotein), IPR016156 (FAD/NAD-linked reductase, dimerisation), IPR001327 (Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region), IPR000815 (Mercuric reductase), IPR016040 (NAD(P)-binding), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
18	nspb-11	F35C5.10	n/a	chrII 12,907,461	C. elegans NSPB-11 protein ;
19	Y116A8C.15	Y116A8C.15	n/a	chrIV 16,996,337	contains similarity to Homo sapiens similar to KIAA1357 protein; ENSEMBL:ENSP00000258005
20	srsx-1	F40D4.5	n/a	chrV 17,177,360	C. elegans SRSX-1 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
21	F56H6.11	F56H6.11	n/a	chrI 12,309,058	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
22	C53D6.4	C53D6.4	n/a	chrIV 9,020,038	contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR013766 (Thioredoxin domain)
23	ZK430.5	ZK430.5	n/a	chrII 4,411,199	contains similarity to Pfam domain PF03568 Peptidase family C50 contains similarity to Interpro domain IPR005314 (Peptidase C50, separase)
24	F29D10.2	F29D10.2	n/a	chrI 8,842,038	contains similarity to Interpro domains IPR000853 (Nematoda metallothionein, family 6), IPR000006 (Metallothionein, vertebrate), IPR002952 (Eggshell protein), IPR004035 (Endonuclease III, iron-sulphur binding, conserved site-1), IPR001396 (Echinodermata metallothionein, family 4), IPR001008 (Mollusc metallothionein, family 2)
25	viln-1	C10H11.1	n/a	chrI 4,753,615	C. elegans VILN-1 protein; contains similarity to Pfam domain PF02209 Villin headpiece domain contains similarity to Interpro domains IPR007122 (Gelsolin), IPR003128 (Villin headpiece)
26	F22H10.5	F22H10.5	n/a	chrX 16,687,280	contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core)
27	C09G9.3	C09G9.3	n/a	chrIV 8,871,534	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
28	W02B8.1	W02B8.1	n/a	chrII 13,900,226
29	rog-1	F54D12.6	n/a	chrII 1,374,343	rog-1 encodes a protein with an insulin receptor substrate-1 (IRS-type) phosphotyrosine-binding (PTB) domain that is required for the progression from pachytene to diakinesis in meiosis; rog-1 is primarily transcribed in germ cells, and this expression is required for oocyte development; ROG-1 is orthologous to human FRS2 (OMIM:607743) and FRS3 (OMIM:607744); rog-1(tm1031) mutant oocytes fail to progress from pachytene to diakinesis, a phenotype reminiscent of let-60 or mpk-1 mutant oocytes, and rog-1(tm1031) gonads lack phosphorylated MPK-1; rog-1(tm1031) and rog-1(RNAi) hermaphrodites show reduced brood sizes and increased embryonic lethality, with rog-1(tm1031) being more phenotypically severe than rog-1(RNAi); rog-1(tm1031) germ cell, brood size, and MPK-1 phosphorylation phenotypes are suppressed by the gain-of-function mutations let-60(n1046) or let-60(ga89ts); during meiosis, ROG-1 may function as an adaptor downstream of LET-23 and upstream of LET-60.
30	K05F6.8	K05F6.8	n/a	chrII 1,567,541	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
31	Y40B1A.2	Y40B1A.2	n/a	chrI 13,348,157	contains similarity to Pfam domain PF00397 WW domain contains similarity to Interpro domains IPR002349 (WW), IPR001202 (WW/Rsp5/WWP)
32	C06E1.11	C06E1.11	n/a	chrIII 8,615,394
33	cpn-1	F43G9.9	n/a	chrI 8,636,741	cpn-1 encodes a calponin homolog, more closely related to calponin per se than to its paralogs transgelin (SM22 alpha) or neuronal protein NP25, that is is dispensable for viability and gross morphology in mass RNAi screens, and that has no obvious mutant phenotype in a rearrangement that probably disrupts cpn-1.
34	C23F12.3	C23F12.3	n/a	chrX 9,393,106
35	W02B3.3	W02B3.3	n/a	chrIII 668,260
36	mab-7	ZC13.4	n/a	chrX 895,155	mab-7 encodes a protein with a hydrophobic type II transmembrane region at the N-terminus, an EGF-like motif, a ShKT motif and a long C-terminus; mab-7 is involved in morphogenesis of the male tail, specifically affecting the structural cells, neuronal processes and the hypodermal sheath of the sensory rays, as such, it affects mating in males; a mab-7 promoter-gfp construct is expressed in hypodermis, body seam, ray structural cells, and several neurons in the head and tail region.
37	C44B12.6	C44B12.6	n/a	chrIV 1,131,250	contains similarity to Interpro domain IPR010345 (Interleukin-17)
38	F53A3.1	F53A3.1	n/a	chrIII 1,941,574
39	C04E12.10	C04E12.10	n/a	chrV 3,379,728	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
40	acbp-4	F56C9.5	n/a	chrIII 7,308,549	acbp-4 encodes an Acyl-CoA-binding protein.
41	C04G6.6	C04G6.6	n/a	chrII 5,099,576
42	sru-19	T04A11.8	n/a	chrIV 12,499,445	C. elegans SRU-19 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
43	EEED8.12	EEED8.12	n/a	chrII 5,408,624	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
44	T02H6.3	T02H6.3	n/a	chrII 692,115
45	immp-1	C24H11.6	n/a	chrIII 11,775,731	C. elegans IMMP-1 protein; contains similarity to Pfam domain PF00717 Peptidase S24-like contains similarity to Interpro domains IPR001733 (Peptidase S26B, eukaryotic signal peptidase), IPR015927 (Peptidase S24, S26A, S26B and S26C), IPR014037 (Peptidase S26A), IPR011056 (Peptidase S24, S26A and S26B, C-terminal), IPR000223 (Peptidase S26A, signal peptidase I)
46	str-154	Y45G12C.12	n/a	chrV 2,559,268	C. elegans STR-154 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR001046 (Natural resistance-associated macrophage protein), IPR000276 (GPCR, rhodopsin-like)
47	C27B7.7	C27B7.7	n/a	chrIV 8,911,257	contains similarity to Pfam domains PF00047 (Immunoglobulin domain) , PF00041 (Fibronectin type III domain) (6)contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR008957 (Fibronectin, type III-like fold), IPR003961 (Fibronectin, type III), IPR013783 (Immunoglobulin-like fold), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype), IPR003962 (Fibronectin, type III subdomain), IPR013151 (Immunoglobulin)
48	his-1	T10C6.14	n/a	chrV 16,042,648	his-1 encodes an H4 histone; his-1 is contained within the histone gene cluster HIS1; transcript analysis suggests that it encodes the major class of H4 transcripts.
49	F35F10.14	F35F10.14	n/a	chrV 3,319,580
50	D1086.1	D1086.1	n/a	chrV 14,099,606	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)