UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	osm-1	T27B1.1	0	chrX 16,546,188	osm-1 encodes a WD- and WAA-repeat containing protein that is the C. elegans ortholog of intraflagellar transport (IFT) complex B component IFT172; OSM-1 is a presumptive cargo molecule for kinesin-II, and OSM-1 is required, along with OSM-6, for the proper assembly of the middle segments of sensory cilia; osm-1 may act in a pathway with avr-14 to affect resistance to ivermectin-induced cessation of pumping, and mutants are defective in avoidance of solutions of high osmotic strength; an OSM-1::GFP fusion protein is expressed in amphid and phasmid chemosensory neurons where it undergoes both anterograde and retrograde intraflagellar transport.
2	T21B10.3	T21B10.3	n/a	chrII 8,936,627	contains similarity to Homo sapiens Conserved hypothetical protein; VG:OTTHUMP00000076919
3	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
4	T24H10.4	T24H10.4	n/a	chrII 9,110,325	contains similarity to Pfam domain PF05705 Eukaryotic protein of unknown function (DUF829) contains similarity to Interpro domain IPR008547 (Protein of unknown function DUF829, eukaryotic)
5	F45F2.6	F45F2.6	n/a	chrV 8,527,305	contains similarity to Pfam domain PF03189 Protein of unknown function, DUF270 contains similarity to Interpro domain IPR004878 (Protein of unknown function DUF270)
6	F59E10.3	F59E10.3	n/a	chrII 10,873,252	F59E10.3 encodes a zeta subunit of the coatomer (COPI) complex; in mass RNAi assays, F59E10.3 is required for embryonic, larval, and adult viability, for fertility, and for normal osmoregulation.
7	K11E4.3	K11E4.3	n/a	chrX 13,721,488	The K11E4.3 gene encodes one of five paraoxonase-like proteins; it is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease.
8	ceh-13	R13A5.5	n/a	chrIII 7,556,858	a homolog of Hox genes of labial/Hox1 type; affects viability, body shape and anterior patterning during embryogenesis, interacts genetically with hox genes; and is expressed in A, D, E and MS lineages in the early embryo, and in the anterior dorsal hypodermal cells, anterior body wall muscle cells, and in the cells of the prospective ventral nerve cord at the comma stage; and in the ventral nerve cord and and ventral and dorsal hypodermal cells in L1 larvae.
9	hhat-2	Y57G11C.17	n/a	chrIV 14,827,743	C. elegans HHAT-2 protein; contains similarity to Pfam domain PF03062 MBOAT family contains similarity to Interpro domain IPR004299 (Membrane bound O-acyl transferase, MBOAT)
10	M01H9.2	M01H9.2	n/a	chrIV 4,461,106	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR002350 (Proteinase inhibitor I1, Kazal), IPR001368 (TNFR/CD27/30/40/95 cysteine-rich region), IPR003582 (Metridin-like ShK toxin)
11	F21D5.4	F21D5.4	n/a	chrIV 8,738,506	contains similarity to Pfam domain PF09091 Centromere binding protein B, DNA binding contains similarity to Interpro domains IPR006600 (Centromere protein B, helix-turn-helix), IPR012287 (Homeodomain-related), IPR009057 (Homeodomain-like), IPR015175 (Centromere protein B, DNA-binding region sub-type)
12	F08B4.4	F08B4.4	n/a	chrIV 8,679,036
13	fbxa-153	B0391.5	n/a	chrV 15,608,029	fbxa-153 encodes a protein with an N-terminal F-box domain and a C-terminal FTH domain; FBXA-153 has no obvious non-nematode orthologs; FBXA-153 shares N-terminal UNC-13 binding, and thus may share at least some functions, with ERI-1, W04D2.6, and Y55F3AM.13; FBXA-153 has no obvious function in mass RNAi assays.
14	srh-154	F20E11.12	n/a	chrV 17,441,133	C. elegans SRH-154 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR006069 (ATPase, P-type cation exchange, alpha subunit)
15	R05G6.5	R05G6.5	n/a	chrIV 7,509,013	contains similarity to Pfam domain PF05186 Dpy-30 motif contains similarity to Interpro domains IPR001564 (Nucleoside diphosphate kinase, core), IPR007858 (Dpy-30)
16	F56F11.5	F56F11.5	n/a	chrIII 2,853,197
17	W02C12.1	W02C12.1	n/a	chrIV 4,011,101	contains similarity to Pfam domains PF00008 (EGF-like domain) (10), PF07699 (GCC2 and GCC3) (4), PF07974 (EGF-like domain) (5), PF02494 (HYR domain) contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR013320 (Concanavalin A-like lectin/glucanase, subgroup), IPR003410 (Hyalin), IPR001791 (Laminin G), IPR001759 (Pentaxin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR011641 (GCC2 and GCC3), IPR006150 (Cysteine-rich repeat), IPR001881 (EGF-like calcium-binding), IPR013032 (EGF-like region, conserved site), IPR013111 (EGF, extracellular), IPR008985 (Concanavalin A-like lectin/glucanase), IPR003645 (Follistatin-like, N-terminal)
18	gpa-9	F56H9.4	n/a	chrV 12,648,055	gpa-9 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ASJ, PHB, PVQ, pharyngeal muscle, and the spermatheca.
19	lin-32	T14F9.5	n/a	chrX 2,229,639	lin-32 encodes a basic helix-loop-helix transcription factor that is required for development of several types of neurons, including the touch receptor neurons and the male sensory ray neurons.
20	C04A11.2	C04A11.2	n/a	chrX 13,667,311	contains similarity to Homo sapiens Putative protein TPRXL; ENSEMBL:ENSP00000322097
21	cnd-1	C34E10.7	n/a	chrIII 5,241,308	cnd-1 encodes a basic helix-loop-helix protein that is most closely related to the vertebrate NeuroD transcription factors; during development, CND-1 is predicted to function as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding; CND-1::GFP expression begins in early embryogenesis (<20 cells) in four AB descendants and then continues in mitotically active AB-derived neuronal precursors, unidentified nuclei during gastrulation and enclosure, and postmitotic neurons in the head and ventral cord; at hatching CND-1::GFP expression is visible in ventral cord neurons, but this expression disappears completely by the end of the first larval stage; CND-1::GFP does not appear to be expressed in any non-neuronal ectodermal cells, as its expression does not overlap with that of LIN-26.
22	R03A10.1	R03A10.1	n/a	chrX 15,430,484	contains similarity to Saccharomyces cerevisiae Protein involved in transcription-coupled repair nucleotide exicision repair of UV-induced DNA lesions; homolog of human CSB protein; SGD:YJR035W
23	F41C3.6	F41C3.6	n/a	chrII 4,735,969
24	ttx-3	C40H5.5	n/a	chrX 11,766,841	ttx-3 encodes a LIM homeodomain protein required for functions of the interneuron AIY, including thermosensory behavior and olfactory learning.
25	F45E6.3	F45E6.3	n/a	chrX 12,488,021	contains similarity to Pfam domain PF00566 TBC domain contains similarity to Interpro domain IPR000195 (RabGAP/TBC)
26	F21D12.2	F21D12.2	n/a	chrII 7,318,858
27	hlh-27	C17C3.10	n/a	chrII 5,540,531	C. elegans HLH-27 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
28	R08C7.1	R08C7.1	n/a	chrIV 4,451,940
29	cyld-1	F40F12.5	n/a	chrIII 9,904,526	F40F12.5 encodes an ortholog of human CYLD1 (OMIM:605018, mutated in cylindromatosis); CYLD1 binds several members of the NF-kappaB signalling pathway, and can deubiquitinate target proteins.
30	str-131	C09H5.6	n/a	chrV 8,081,002	C. elegans STR-131 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
31	Y62H9A.14	Y62H9A.14	n/a	chrX 11,922,107	contains similarity to Interpro domain IPR009010 (Aspartate decarboxylase-like fold)
32	sir-2.3	F46G10.3	n/a	chrX 13,332,774	C. elegans SIR-2.3 protein; contains similarity to Pfam domain PF02146 Sir2 family contains similarity to Interpro domain IPR003000 (NAD-dependent histone deacetylase, silent information regulator Sir2)
33	Y44A6B.3	Y44A6B.3	n/a	chrV 20,633,182	contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domain IPR006583 (CW)
34	T08G5.8	T08G5.8	n/a	chrV 14,048,191	contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
35	ceh-30	C33D12.7	n/a	chrX 3,064,554	ceh-30 encodes a homeodomain protein most similar to Drosophila and mammalian BarH1 (OMIM:605211) which function in neuronal cell fate determination; the precise biological role of CEH-30 in C. elegans development and/or behavior is not yet known.
36	inx-6	C36H8.2	n/a	chrIV 12,748,113	inx-6 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; INX-6 is required for formation of pharyngeal gap junctions and thus for the electrical coupling and synchronous muscle contractions necessary for normal feeding behavior and postembryonic development; INX-6 may function redundantly with EAT-5, another C. elegans innexin; INX-6 expression is first detected in embryonic pharyngeal precursors and during later larval and adult stages, in pharyngeal corpus muscles and isthmus marginal cells, where INX-6 localizes to plaque-like structures in the plasma membrane.
37	Y38H6C.9	Y38H6C.9	n/a	chrV 20,516,299	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
38	C05G5.5	C05G5.5	n/a	chrX 14,758,374	contains similarity to Homo sapiens hypothetical protein; ENSEMBL:ENSP00000360931
39	B0563.1	B0563.1	n/a	chrX 9,171,819
40	srw-57	F36G9.1	n/a	chrV 15,954,286	C. elegans SRW-57 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR000276 (GPCR, rhodopsin-like)
41	srx-98	F19B10.8	n/a	chrII 3,670,182	C. elegans SRX-98 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
42	F47G4.6	F47G4.6	n/a	chrI 14,060,105	contains similarity to Pfam domain PF00505 HMG (high mobility group) box contains similarity to Interpro domains IPR000910 (High mobility group box, HMG1/HMG2), IPR009071 (High mobility group box, HMG)
43	unc-75	C17D12.2	n/a	chrI 11,596,943	unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM; UNC-75 is orthologous to mammalian CELF/BrunoL proteins that control pre-mRNA splicing; unc-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission.
44	C15B12.3	C15B12.3	n/a	chrX 6,467,380
45	srz-48	F20E11.1	n/a	chrV 17,459,315	C. elegans SRZ-48 protein ;
46	R160.6	R160.6	n/a	chrX 4,372,098
47	T24D8.6	T24D8.6	n/a	chrX 2,365,815
48	C46A5.4	C46A5.4	n/a	chrIV 7,752,034	contains similarity to Pfam domain PF03098 Animal haem peroxidase contains similarity to Interpro domains IPR010255 (Haem peroxidase), IPR002007 (Haem peroxidase, animal)
49	F41H8.2	F41H8.2	n/a	chrV 827,588	contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
50	srg-41	T19C4.3	n/a	chrV 11,161,148	C. elegans SRG-41 protein; contains similarity to Interpro domains IPR000500 (Connexins), IPR000609 (Serpentine gamma receptor, Caenorhabditis species)