UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ceh-41	T26C11.5	3e-126	chrX 1,847,671	ceh-41 encodes a a ONECUT class CUT homeobox protein with a single N-terminal OCAM domain; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-41 is one of three nematode-specific ONECUT genes in a cluster with ceh-21 and ceh-39; ceh-41 has no obvious function in mass RNAi assays.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	die-1	C18D1.1	n/a	chrII 10,064,931	die-1 encodes a C2H2 zinc finger protein containing four fingers, homologous to CG18265-PA in Drosophila; DIE-1 is autonomously required in the posterior dorsal hypodermis for intercalation, for morphogenesis in other embryonic tissues, and for normal postembryonic growth and vulval development.
4	amx-1	R13G10.2	n/a	chrIII 3,824,311	C. elegans AMX-1 protein; contains similarity to Pfam domains PF01593 (Flavin containing amine oxidoreductase) , PF01266 (FAD dependent oxidoreductase) contains similarity to Interpro domains IPR006076 (FAD dependent oxidoreductase), IPR001613 (Flavin-containing amine oxidase), IPR000960 (Flavin-containing monooxygenase FMO), IPR002937 (Amine oxidase), IPR016040 (NAD(P)-binding), IPR007526 (SWIRM)
5	pro-1	R166.4	n/a	chrII 10,540,649	pro-1 encodes a WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae IPI3; pro-1 activity is required for ribosome biogenesis and specifically, for efficient processing of intervening sequence 2 (ITS2) from rRNA intermediates during 26S rRNA maturation; during development, pro-1 is essential for larval growth, fertility, and normal cell division patterns; in addition, pro-1 is required cell autonomously in the somatic gonad for proper spatial and temporal regulation of germline development and proliferation; a pro-1 promoter::gfp fusion construct reveals that pro-1 is widely expressed in the embryo as well as in every major post-embryonic lineage including the somatic gonad.
6	M02D8.3	M02D8.3	n/a	chrX 8,734,954	contains similarity to Dictyostelium discoideum PHD Zn finger-containing protein.; TR:Q1ZXQ2
7	ugt-11	T19H12.10	n/a	chrV 4,893,822	C. elegans UGT-11 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
8	T05G5.1	T05G5.1	n/a	chrIII 9,741,123	contains similarity to Pfam domain PF00008 EGF-like domain contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006209 (EGF-like)
9	K01A2.3	K01A2.3	n/a	chrII 315,416
10	M04C9.3	M04C9.3	n/a	chrI 9,353,710	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like), IPR000816 (Peptidase C15, pyroglutamyl peptidase I)
11	dpm-3	F28D1.11	n/a	chrIV 12,391,825	dpm-3 encodes a putative regulatory subunit of dolichol phosphate mannosyltransferase, orthologous to human DPM3 (OMIM:605951); in mass RNAi assays, DPM-3 is required for normal body size, fertility, and health.
12	F54F2.7	F54F2.7	n/a	chrIII 8,806,716	contains similarity to Interpro domain IPR011053 (Single hybrid motif)
13	nas-12	C24F3.3	n/a	chrIV 10,225,155	nas-12 encodes an astacin-like metalloprotease; large-scale expression studies reveal that a nas-12::GFP promoter fusion is expressed in the intestine and in the pharyngeal and rectal gland cells.
14	F49E7.2	F49E7.2	n/a	chrX 1,096,278
15	T08B2.8	T08B2.8	n/a	chrI 6,211,579	contains similarity to Interpro domain IPR012678 (Ribosomal protein L23/L15e, core)
16	fbxb-31	M151.5	n/a	chrII 3,638,541	C. elegans FBXB-31 protein; contains similarity to Pfam domains PF07735 (F-box associated) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR012885 (F-box associated type 2)
17	glit-1	F55D10.3	n/a	chrX 4,713,649	C. elegans GLIT-1 protein; contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
18	srbc-63	T06E6.11	n/a	chrV 15,412,055	C. elegans SRBC-63 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
19	T25E12.6	T25E12.6	n/a	chrV 16,743,622	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
20	F07E5.5	F07E5.5	n/a	chrII 2,056,499	contains similarity to Pfam domain PF00098 Zinc knuckle contains similarity to Interpro domains IPR013084 (Zinc finger, CCHC retroviral-type), IPR001878 (Zinc finger, CCHC-type)
21	hint-1	F21C3.3	n/a	chrI 7,280,150	C. elegans HINT-1 protein; contains similarity to Pfam domain PF01230 HIT domain contains similarity to Interpro domains IPR001310 (Histidine triad (HIT) protein), IPR011151 (Histidine triad motif), IPR011146 (Histidine triad-like motif)
22	rha-1	T07D4.3	n/a	chrII 8,880,999	rha-1 encodes an ATP-dependent DEAD/H box RNA helicase orthologous to human RNA helicase A and Drosophila Maleless, an essential component of the dosage compensation machinery required for increased X-linked transcription in males; by homology, RHA-1 is predicted to function in regulation of transcription, translation, RNA processing, and/or RNA replication; in C. elegans, RHA-1 is required for germ cell proliferation, normal germ cell nuclear morphology, RNA-mediated interference (RNAi) of germline-expressed genes, and silencing of germline-expressed transgenes; RHA-1 is reported to localize to the nucleus and the cytoplasm.
23	egl-26	C23H3.1	n/a	chrII 70,469	egl-26 encodes a protein that contains an H-box and an NC domain that is a member of the LRAT (lecithin retinol acyltransferase) subfamily of the NlpC/P60 superfamily of enzymes; egl-26 activity is required for fertility, egg laying, and vulval development, specifically the connection of the uterus to the vulva mediated by proper morphogenesis of vulF, the most dorsal vulval cell; EGL-26 is an apical membrane protein that is expressed in many cells, including vulF, and appears to be expressed near the vulva and uterus only during the L4 larval stage; EGL-26 membrane localization is necessary for its function.
24	W06A11.4	W06A11.4	n/a	chrII 4,056,790
25	F16B12.5	F16B12.5	n/a	chrX 14,100,488	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR017442 (Serine/threonine protein kinase-related)
26	srd-53	F13G3.2	n/a	chrI 7,294,860	C. elegans SRD-53 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
27	T07A9.1	T07A9.1	n/a	chrIV 384,318	contains similarity to Homo sapiens Protein; VG:OTTHUMP00000025811
28	B0454.9	B0454.9	n/a	chrII 3,053,483	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
29	ZC196.5	ZC196.5	n/a	chrV 8,731,102	contains similarity to Pfam domain PF05218 Protein of unknown function (DUF713) contains similarity to Interpro domain IPR007883 (Protein of unknown function DUF713)
30	sru-9	Y45F10B.11	n/a	chrIV 13,589,633	C. elegans SRU-9 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
31	F13E6.2	F13E6.2	n/a	chrX 10,671,215	contains similarity to Pfam domain PF05186 Dpy-30 motif contains similarity to Interpro domains IPR000850 (Adenylate kinase), IPR007858 (Dpy-30), IPR011769 (Adenylate/cytidine kinase, N-terminal)
32	ZK418.5	ZK418.5	n/a	chrIII 7,073,217	contains similarity to Mus musculus Transmembrane protein 147.; SW:Q9CQG6
33	F26D11.1	F26D11.1	n/a	chrV 7,982,245	contains similarity to Pfam domain PF01202 Shikimate kinase contains similarity to Interpro domains IPR000623 (Shikimate kinase), IPR006001 (Carbohydrate kinase, thermoresistant glucokinase)
34	F37F2.2	F37F2.2	n/a	chrI 1,442,805	contains similarity to Pfam domain PF01922 SRP19 protein contains similarity to Interpro domain IPR002778 (Signal recognition particle, SRP19 subunit)
35	dnj-14	K02G10.8	n/a	chrX 4,710,717	This gene encodes a protein containing a DnaJ ('J') domain.
36	F40G9.9	F40G9.9	n/a	chrIII 169,417	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
37	tag-289	F14F3.3	n/a	chrX 10,523,120	C. elegans TAG-289 protein; contains similarity to Pfam domain PF03062 MBOAT family contains similarity to Interpro domain IPR004299 (Membrane bound O-acyl transferase, MBOAT)
38	R12C12.5	R12C12.5	n/a	chrII 6,044,615	contains similarity to Pfam domain PF03357 Snf7 contains similarity to Interpro domain IPR005024 (Snf7)
39	F52C12.2	F52C12.2	n/a	chrIV 1,956,651	contains similarity to Pfam domains PF04068 (Possible metal-binding domain in RNase L inhibitor, RLI) , PF04034 (Domain of unknown function (DUF367)) contains similarity to Interpro domains IPR007209 (Possible metal-binding region in RNase L inhibitor, RLI), IPR007177 (Protein of unknown function DUF367)
40	F59D12.5	F59D12.5	n/a	chrX 15,646,886
41	pix-1	K11E4.4	n/a	chrX 13,730,745	C. elegans PIX-1 protein ;
42	B0285.3	B0285.3	n/a	chrIII 4,342,632	contains similarity to Interpro domain IPR002952 (Eggshell protein)
43	gpc-2	F08B6.2	n/a	chrI 6,757,967	gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles).
44	R10E4.11	R10E4.11	n/a	chrIII 4,299,234	contains similarity to Pfam domain PF00096 (Zinc finger, C2H2 type)
45	tag-131	H38K22.3	n/a	chrIII 4,318,987	C. elegans TAG-131 protein; contains similarity to Pfam domain PF00173 Cytochrome b5-like Heme/Steroid binding domain contains similarity to Interpro domain IPR001199 (Cytochrome b5)
46	F22B5.10	F22B5.10	n/a	chrII 8,467,514	contains similarity to Pfam domain PF05809 Eukaryotic protein of unknown function (DUF841) contains similarity to Interpro domain IPR008559 (Protein of unknown function DUF841, eukaryotic)
47	C05G5.2	C05G5.2	n/a	chrX 14,748,776	contains similarity to Xenopus laevis Nucleolar phosphoprotein.; TR:Q91803
48	ddr-1	C25F6.4	n/a	chrX 5,463,626	The C25F6.4 gene encodes a protein tyrosine kinase homolog that is also homologous to human RS1.
49	dep-1	F44G4.8	n/a	chrII 9,012,700	dep-1 encodes a class III receptor protein tyrosine phosphatase (R-PTP) orthologous to human R-PTPs such as PTPRJ/Dep-1 (mutated in epithelial cancers; OMIM:600925); DEP-1 is required, redundantly with LIP-1 and LET-60, and downstream of LIN-12, to promote secondary over primary vulval fate in the P5.p and P7.p lineages; DEP-1 is expressed in P5.p and P7.p lineages, and dep-1 acts cell-autonomously in these lineages; DEP-1 colocalizes with LET-23 in punctae, and binds LET-23 in vitro; DEP-1, with LIP-1, is also required for normal duct cell and excretory pore development; dep-1 mutations are wild-type in isolation, but have vulval phenotypes with added mutations in lin-15, lip-1, or let-60; DEP-1 laterally inhibits secondary vulval fates in parallel with LIN-12/Notch signalling; in primary (P5.p) vulval cells, LET-60/RAS-activated SUR-2 inhibits dep-1 and lin-12 expression; since RNAi of 125 out of 165 predicted C. elegans protein phosphatase genes fails to enhance lip-1 mutations, the LIP-1/DEP-1 interaction is likely to be highly specific.
50	twk-28	C52B9.6	n/a	chrX 4,276,975	C. elegans TWK-28 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2), IPR003092 (Potassium channel, two pore-domain, TASK)