UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	T24C4.5	T24C4.5	0	chrIII 878,584	contains similarity to Pfam domain PF01896 Eukaryotic and archaeal DNA primase small subunit contains similarity to Interpro domains IPR014052 (DNA primase, small subunit, eukaryotic and archaeal), IPR002755 (DNA primase, small subunit)
2	pri-1	F58A4.4	6e-163	chrIII 9,613,184	pri-1 encodes a homolog of the DNA polymerase alpha-primase subunit D that is required in embryos for the normal timing of embryonic cell divisions, much as DIV-1 is.
3	W04A8.6	W04A8.6	n/a	chrI 13,856,302	contains similarity to Interpro domain IPR011598 (Helix-loop-helix DNA-binding)
4	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
5	fsn-1	C26E6.5	n/a	chrIII 4,938,358	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins
6	polh-1	F53A3.2	n/a	chrIII 1,947,677	polh-1 encodes a putative DNA polymerase eta orthologous to human POLH (OMIM:603968, mutated in xeroderma pigmentosum); POLH-1 promotes lagging-strand synthesis through G/C rich sequences, is required for normal resistance to UV-induced mutagenesis in early embryos, and suppresses the damage-induced DNA replication checkpoint in embryos; polh-1(RNAi) enhances the mutator phenotype of dog-1(gk10) 2.3-fold.
7	C50B6.3	C50B6.3	n/a	chrV 13,314,685	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
8	R10D12.12	R10D12.12	n/a	chrV 13,961,624	contains similarity to Pfam domain PF04101 Glycosyltransferase family 28 C-terminal domain contains similarity to Interpro domain IPR007235 (Glycosyl transferase, family 28, C-terminal)
9	C17F4.5	C17F4.5	n/a	chrII 3,247,215	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
10	W01A8.5	W01A8.5	n/a	chrI 7,070,051	contains similarity to Interpro domain IPR009057 (Homeodomain-like)
11	B0511.7	B0511.7	n/a	chrI 10,632,437	contains similarity to Pfam domain PF00498 FHA domain contains similarity to Interpro domains IPR008984 (SMAD/FHA domain), IPR000253 (Forkhead-associated)
12	R11H6.5	R11H6.5	n/a	chrV 14,611,457	contains similarity to Pfam domain PF07528 DZF contains similarity to Interpro domains IPR006561 (DZF), IPR006116 (2-5-oligoadenylate synthetase, ubiquitin-like region)
13	C25A1.1	C25A1.1	n/a	chrI 10,162,948	contains similarity to Danio rerio Novel protein (Zgc:65774).; TR:Q1LX81
14	C08F8.3	C08F8.3	n/a	chrIV 11,155,803	contains similarity to Gallus gallus Dosal neuron-tube nuclear protein.; TR:Q8QHJ7
15	C29A12.1	C29A12.1	n/a	chrV 10,812,876	contains similarity to Mesocricetus auratus Synaptonemal complex protein 1 (SCP-1 protein) (Meiotic chromosomessynaptic protein) (Fragment).; SW:SCP1_MESAU
16	W04D2.4	W04D2.4	n/a	chrV 12,496,219	contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
17	C41D11.5	C41D11.5	n/a	chrI 4,450,433
18	F43D2.1	F43D2.1	n/a	chrV 14,613,051	contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal), IPR015429 (Transcription regulator cyclin)
19	C35D10.10	C35D10.10	n/a	chrIII 4,861,200	contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR013766 (Thioredoxin domain)
20	C05C8.6	C05C8.6	n/a	chrV 7,236,014	contains similarity to Pfam domains PF07707 (BTB And C-terminal Kelch) , PF00651 (BTB/POZ domain) contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR008979 (Galactose-binding like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ), IPR011705 (BTB/Kelch-associated), IPR013089 (Kelch related)
21	C17H11.4	C17H11.4	n/a	chrX 8,181,277	contains similarity to Drosophila melanogaster Flybase gene name is ari-1-PC;; FLYBASE:CG5659
22	spe-42	B0240.2	n/a	chrV 11,735,328	C. elegans SPE-42 protein; contains similarity to Pfam domain PF07782 DC-STAMP-like protein contains similarity to Interpro domain IPR012858 (DC-STAMP-like)
23	met-2	R05D3.11	n/a	chrIII 8,377,993	C. elegans MET-2 protein; contains similarity to Pfam domains PF05033 (Pre-SET motif) , PF00856 (SET domain) , PF01429 (Methyl-CpG binding domain) contains similarity to Interpro domains IPR001214 (SET), IPR003616 (Post-SET zinc-binding region), IPR003606 (Pre-SET zinc-binding sub-group), IPR001739 (Methyl-CpG DNA binding), IPR007728 (Pre-SET zinc-binding region)
24	F41G3.6	F41G3.6	n/a	chrII 6,743,499
25	pie-1	Y49E10.14	n/a	chrIII 12,427,870	pie-1 encodes a C-x8-C-x5-C-x3-H-type zinc-finger protein; maternally provided PIE-1 is essential for germline cell fate determination, as it functions as a repressor of RNA polymerase II-dependent gene expression in the developing germ line; PIE-1 localization, initially uniform and then concentrated in the posterior germ cell lineages, is regulated by other maternally supplied gene products including PAR-1, MEX-5, and MEX-6.
26	hcp-3	F58A4.3	n/a	chrIII 9,615,787	The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
27	H21P03.2	H21P03.2	n/a	chrIV 11,481,604	contains similarity to Pfam domain PF08743 Nse4 contains similarity to Interpro domain IPR014854 (Nse4)
28	F17C11.10	F17C11.10	n/a	chrV 10,963,667	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR009071 (High mobility group box, HMG), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
29	rpb-3	C36B1.3	n/a	chrI 8,729,359	C. elegans RPB-3 protein; contains similarity to Pfam domains PF01000 (RNA polymerase Rpb3/RpoA insert domain) , PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) contains similarity to Interpro domains IPR011263 (DNA-directed RNA polymerase, RpoA/D/Rpb3-type), IPR011262 (DNA-directed RNA polymerase, insert), IPR011261 (DNA-directed RNA polymerase, dimerisation)
30	F44B9.8	F44B9.8	n/a	chrIII 8,028,820	contains similarity to Pfam domains PF00004 (ATPase family associated with various cellular activities (AAA)) , PF08542 (Replication factor C) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR008921 (DNA polymerase III clamp loader subunit, C-terminal), IPR000767 (Disease resistance protein), IPR001270 (Chaperonin clpA/B), IPR013748 (Replication factor C), IPR003593 (AAA+ ATPase, core)
31	brc-1	C36A4.8	n/a	chrIII 3,858,030	brc-1 encodes an ortholog of human BRCA1 (OMIM:113705, mutated in early onset breast and ovarian cancer) required for double-strand break repair via inter-sister recombination during meiosis; BRC-1 forms a heterodimer with BRD-1, which constitutes an E3 ubiquitin ligase; after irradiation, the DNA checkpoint proteins ATL-1 and MRE-11 are required for BRC-1/BRD-1 heterodimers to associate with RAD-51 and LET-70/Ubc5, and to ubiquitylate damaged chromatin; brc-1(RNAi) animals have excess chromosomal nondisjunction, abnormally high levels of CEP-1-dependent germ cell apoptosis (both with and without gamma-irradiation) and hypersensitivity to gamma-irradiation (e.g., abnormal sterility after irradiation); BRC-1 and BRD-1 bind one another, probably through their N-terminal RING domains, in yeast two-hybrid experiments and pull-down assays; BRC-1/BRD-1 heterodimers may interact with RAD-51 and other proteins via mutual binding to UBC-9; brc-1 is genetically dispensable for the induction of nuclear ATL-1 foci by gamma-irradiation or hydroxyurea.
32	T03F6.3	T03F6.3	n/a	chrIII 13,390,012	contains similarity to Pfam domain PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase contains similarity to Interpro domains IPR006148 (Glucosamine/galactosamine-6-phosphate isomerase), IPR004547 (Glucosamine-6-phosphate isomerase)
33	set-17	T21B10.5	n/a	chrII 8,939,689	set-17 encodes a SET domain-containing protein orthologous to human PRDM11 and PRDM7 (Q9NQW5-2; OMIM:609759); SET-17 is expressed in many or all cells of embryo, and several postembryonic tissues (hypodermis, muscle, and excretory cell); neither set-17(n5017) nor set-17(RNAi) have any obvious phenotypes.
34	F32E10.5	F32E10.5	n/a	chrIV 7,576,352	contains similarity to Pfam domain PF00567 Tudor domain contains similarity to Interpro domains IPR008191 (Maternal tudor protein), IPR002011 (Receptor tyrosine kinase, class II, conserved site), IPR002999 (Tudor)
35	rfc-3	C39E9.13	n/a	chrIV 13,096,350	C. elegans RFC-3 protein; contains similarity to Interpro domains IPR008921 (DNA polymerase III clamp loader subunit, C-terminal), IPR003593 (AAA+ ATPase, core)
36	F29G9.7	F29G9.7	n/a	chrV 6,036,359	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
37	F11C1.2	F11C1.2	n/a	chrX 12,986,446	contains similarity to Lactococcus lactis Rgg protein, putative.; TR:O87251
38	W03C9.2	W03C9.2	n/a	chrII 11,963,758	contains similarity to Schizosaccharomyces pombe Transcription elongation factor S-II (TFIIS).; SW:TFS2_SCHPO
39	bath-7	F52C6.10	n/a	chrII 1,920,562	C. elegans BATH-7 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
40	F59A6.5	F59A6.5	n/a	chrII 5,001,644	contains similarity to Pfam domains PF00169 (PH domain) , PF00780 (CNH domain) , PF00130 (Phorbol esters/diacylglycerol binding domain (C1 domain)) contains similarity to Interpro domains IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR000533 (Tropomyosin), IPR001180 (Citron-like), IPR002219 (Protein kinase C, phorbol ester/diacylglycerol binding)
41	C06G3.8	C06G3.8	n/a	chrIV 7,032,043	contains similarity to Pfam domain PF01336 OB-fold nucleic acid binding domain contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold)
42	cup-2	F25D7.1	n/a	chrI 10,399,657	The primary phenotype of cup-2 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes.
43	dod-18	C54G4.6	n/a	chrI 8,020,275	dod-18 encodes a Maf-like protein required for normally short lifespan; dod-18 is repressed in daf-2 mutants and induced in daf-16 mutants, and dod-18(RNAi) lengthens lifespan by 30%; MAF-like proteins are ubiquitous among eukarya, bacteria, and archaea; DOD-18 is orthologous to the N-terminal ~200 residues of human ASMTL (OMIM:300162), and to Bacillus subtilis Maf (Multicopy Associated Filamentation) protein, which inhibits septum formation; while the specific biochemical function of Maf-like proteins is unknown, the tertiary structure of B. subtilis Maf is consistent with its binding nucleic acid.
44	pfd-4	B0035.4	n/a	chrIV 11,315,430	pfd-4 encodes a putative prefoldin subunit 4, orthologous to human PFDN4 (OMIM:604898), that is dispensable for viability; PFD-4 is redundant for prefoldin function in C. elegans; pfd-4(gk403) mutants and pfd-4(RNAi) animals, unlike animals undergoing RNAi against most prefoldin subunits, have no obvious phenotypes.
45	lin-35	C32F10.2	n/a	chrI 5,811,676	lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, lin-35 activity is required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells.
46	pch-2	F10B5.5	n/a	chrII 8,159,065	pch-2 encodes a putative AAA+-type ATPase orthologous to budding yeast PCH2 and human TRIP13 (OMIM:604507); PCH-2 is required for the apoptosis of pachytene cells induced by unsynapsed chromosomal pairing centers, but is dispensable for meiotic apoptosis induced by DNA damage; PCH-2-mediated apoptosis is inhibited by SYP-1 and SYP-2, while it requires HIM-8 (and probably HIM-8's paralogs, ZIM-1/-3 and C02F5.12); however, PCH-2-mediated apoptosis does not require SPO-11; pch-2 transcripts are enriched during oogenesis; the excess germline apoptosis of syp-1(me17) mutants is partially suppressed by pch-2(tm1458), and fully suppressed by pch-2(tm1458);spo-11(ok79).
47	C16C8.13	C16C8.13	n/a	chrII 3,451,870	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
48	him-10	R12B2.4	n/a	chrIII 5,804,132	him-10 encodes a coiled coil protein that is structurally related to the Nuf2 kinetochore proteins of Schizosaccharaomyces pombe, Saccharomyces cerevisiae, and humans; in C. elegans, him-10 activity is essential for the proper structure and function of mitotic and meiotic kinetochores and thus, for proper attachment and segregation of chromosomes during mitosis and meiosis; during mitosis, HIM-10 localizes to the kinetochore region of the kinetochore-centromere complex from prophase to anaphase; during oocytes meiosis, HIM-10 surrounds chromosomes in diakinesis and prometaphase of meiosis I and meiosis II, while during male meiosis, HIM-10 surrounds spermatocyte chromosomes during metaphase I, anaphase I, and metaphase II.
49	let-99	K08E7.3	n/a	chrIV 12,569,200	let-99 encodes a protein with a DEP domain (Domain found in Dishevelled, Egl-10, and Pleckstrin); LET-99 has no obvious homologs in non-nematodes, but has a truncated paralog (LRG-1) in C. elegans; LET-99 is required for the mitotic spindle to be properly oriented with respect to the axis of cellular polarity, both during anterior migration and rotation of the nuclear-centrosome complex and during anaphase; let-99 mutants exhibit hyperactive nuclear movement and abnormal anaphase spindle pole behavior; LET-99 is mislocalized in par-2 and par-3 mutants; like other proteins containing DEP domains, LET-99 may act as part of a G protein signalling pathway (e.g., the one controlling spindle position).
50	lrr-1	F33G12.4	n/a	chrII 5,035,345	F33G12.4 encodes a leucine rich repeat-containing protein; loss of F33G12.4 activity via large-scale RNAi indicates that F33G12.4 is essential for embryonic and larval development.