UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	pat-6	T21D12.4	0	chrIV 263,062	pat-6 encodes the worm ortholog of alpha-parvin; it is required for muscle assembly and function, with mutations leading to embryonic lethality.
2	ZK682.5	ZK682.5	n/a	chrV 9,285,827	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype), IPR000480 (Glutelin)
3	T03G6.1	T03G6.1	n/a	chrX 2,609,102
4	uaf-2	Y116A8C.35	n/a	chrIV 17,117,717	uaf-2 encodes an essential U2AF35 homolog clustered in an operon with cyp-13 (RRM/cyclophilin); UAF-2's sequence is somewhat atypical for U2AF proteins (it lacks an identifiable N-terminal RNA-binding RS domain, while having an glycine-rich C-terminal region).
5	gana-1	R07B7.11	n/a	chrV 12,088,053	gana-1 encodes a protein with homology to both human alpha-galactosidase (alpha-GAL) and alpha-N-acetylgalactosaminidase (alpha-NAGA) enzymes; these dual enzymatic activities were detected in mixed culture homogenates; immunofluorescence studies show cytoplasmic expression of GANA-1 in body wall muscle and intestinal cells and in coelomocytes; the human gene alpha-galactosidase B (GALB; OMIM:104170), when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency.
6	pqn-95	ZK1067.7	n/a	chrII 9,226,126	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
7	erv-46	K09E9.2	n/a	chrX 15,615,388	C. elegans ERV-46 protein; contains similarity to Pfam domain PF07970 Protein of unknown function (DUF1692) contains similarity to Interpro domain IPR012936 (Protein of unknown function DUF1692)
8	ost-1	C44B12.2	n/a	chrIV 1,109,128	ost-1 encodes the C. elegans ortholog of the conserved basement membrane glycoprotein component osteonectin/SPARC/BM-40; loss of ost-1 function via RNAi indicates that ost-1 activity is required for embryonic and larval development, as well as for normal gut development, body size, and fecundity; an OST-1::GFP reporter fusion protein localizes to the basement membranes along body wall and sex muscles, as well as around the pharynx and gonad, with particular concentration at the spermatheca and distal tip cells.
9	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
10	sto-3	F52D10.5	n/a	chrX 11,620,945	C. elegans STO-3 protein; contains similarity to Pfam domain PF01145 SPFH domain / Band 7 family contains similarity to Interpro domains IPR001107 (Band 7 protein), IPR001972 (Stomatin)
11	dre-1	K04A8.6	n/a	chrV 6,535,821	dre-1 encodes an ortholog of human FBXO11/PRMT9 (OMIM:607871, associated with vitiligo and otitis media) that is required, in conjunction with DAF-12 and its partners, for global developmental timing of the transistion from larval to adult cell fates; DRE-1 has an N-terminal F-box domain, three central tandem C-terminal CASH domains, and a C-terminal zinc finger; hypomorphic dre-1 mutations are synthetically heterochronic with loss-of-function daf-12 alleles, inducing defective distal tip cell migration and precocious fusion of seam cells; five different hypomorphic dre-1 alleles alter conserved glycine residues in the CASH domain region, whereas the null dre-1(hd60) allele is lethal at the three-fold embryo stage; DRE-1 is expressed in many tissues, including epidermal and distal tip cells, and localizes to both nucleus and cytoplasm; strong loss-of-function of dre-1 (the dh99 mutant fed RNAi) induces defects at all four molts; dre-1 also has synthetic phenotypes with daf-9(k182), daf-36(k114), and lin-29(n546); dre-1-like enhancement of daf-12 is also seen in skr-1(RNAi), cul-1(RNAi), or rbx-1/2(RNAi) animals; DRE-1 and SKR-1 bind one another, as do their human orthologs; DRE-1 affects lin-29 expression, and is suppressed by lin-42(RNAi); DRE-1 is paralogous to C. elegans BE0003N10.3.
12	inx-5	R09F10.4	n/a	chrX 8,301,164	inx-5 encodes a predicted member of the innexin family; expressed in the embryonic hypodermis, developing vulva, seam cells, and spermatheca.
13	his-41	C50F4.5	n/a	chrV 9,546,148	his-41 encodes an H2B histone.
14	F55B11.1	F55B11.1	n/a	chrIV 14,406,976	The F55B11.1 gene encodes an ortholog of the human gene XANTHINE DEHYDROGENASE (XDH), which when mutated leads to xanthinuria (OMIM:278300).
15	alg-1	F48F7.1	n/a	chrX 13,953,681	A homolog of rde-1 that is involved in RNA interference and affects developmental timing along with alg-2 and dcr-1 by regulating expression of the lin-4 and let-7 small temporal RNAs.
16	pfn-3	K03E6.6	n/a	chrX 1,080,056	C. elegans PFN-3 protein; contains similarity to Pfam domain PF00235 Profilin contains similarity to Interpro domains IPR002097 (Profilin/allergen), IPR005455 (Profilin, plant)
17	F29C12.4	F29C12.4	n/a	chrII 13,119,692	contains similarity to Pfam domains PF03764 (Elongation factor G, domain IV) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) , PF00679 (Elongation factor G C-terminus) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR005517 (Translation elongation factor EFG/EF2, domain IV), IPR005225 (Small GTP-binding protein), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009000 (Translation elongation and initiation factors/Ribosomal, beta-barrel), IPR000640 (Translation elongation factor EFG/EF2, C-terminal), IPR004540 (Translation elongation factor EFG/EF2), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR009022 (Elongation factor G, III and V)
18	gei-18	Y37A1B.15	n/a	chrIV 13,981,773	C. elegans GEI-18 protein ;
19	C46H11.7	C46H11.7	n/a	chrI 5,042,625	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR003582 (Metridin-like ShK toxin)
20	gex-2	F56A11.1	n/a	chrIV 578,227	The gex-2 gene encodes a homolog of p140/Sra-1, a mammalian protein ligand of the small GTPase Rac1; gex-2 is required for tissue morphogenesis and cell migrations.
21	B0303.2	B0303.2	n/a	chrIII 8,685,551	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)
22	ark-1	C01C7.1	n/a	chrIV 12,626,527	ark-1 encodes a homolog of the nonreceptor tyrosine kinase ACK which inhibits signalling through the EGF receptor homolog LET-23, both in (RAS-dependent) vulval development and in (RAS-independent) ovulation.
23	atf-5	T04C10.4	n/a	chrX 14,809,925	atf-5 encodes a homolog of the mammalian bZIP transcription factors ATF4 and ATF5, analogous to GCN4 in S. cerevisiae; like like ATF4 and GCN4, atf-5 has an extensive 5' UTR with one 37-residue uORF; ATF4 is poorly translated in unstressed cells but well-translated during ER stress, amino acid starvation, or arsenite treatment; possibly atf-5 is also translationally regulated in a way similar to ATF4.
24	F08G2.7	F08G2.7	n/a	chrII 13,838,597	contains similarity to Saccharomyces cerevisiae Suppresor of mar1-1 (sir2) mutation; SGD:YDR310C
25	F53F1.5	F53F1.5	n/a	chrV 13,415,573	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001859 (Ribosomal protein P2), IPR013286 (Annexin, type VII)
26	grd-12	F02D8.2	n/a	chrV 14,979,221	grd-12 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity proline-rich domain, and a C-terminal Ground domain; GRD-12 is expressed in intestine, rectal epithelium, undefined head and tail cells, vulva, and hypodermis; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-12 is required for normal growth to full size, locomotion, and vulval morphogenesis; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
27	cls-2	R107.6	n/a	chrIII 9,056,749	cls-2 encodes one of three predicted orthologs of mammalian CLASPs and of Drosophila ORBIT/MAST, microtubule-binding proteins required for fibroblast polarization and mitosis; cls-2 is required in mass RNAi assays for embryonic development and normal mitotic spindles; it has been claimed that, in an RNAi screen of potential microtubule tip-binding proteins, only cls-2(RNAi) yielded embryonic lethality and meiotic defects.
28	pqn-47	F59B10.1	n/a	chrII 10,499,684	pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays; pqn-47(cxP5915) homozygotes are sluggish.
29	gosr-2.1	B0272.2	n/a	chrX 9,440,914	C. elegans GOSR-2.1 protein; contains similarity to Pfam domain PF05008 Vesicle transport v-SNARE protein contains similarity to Interpro domain IPR007705 (Vesicle transport v-SNARE)
30	C26B9.3	C26B9.3	n/a	chrX 5,339,194
31	gpa-12	F18G5.3	n/a	chrX 9,247,895	gpa-12 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in the pharynx and in the hypodermis.
32	Y113G7B.16	Y113G7B.16	n/a	chrV 20,268,307	contains similarity to Pfam domain PF05600 Protein of unknown function (DUF773) contains similarity to Interpro domain IPR008491 (Protein of unknown function DUF773)
33	R04B3.3	R04B3.3	n/a	chrX 2,474,889
34	gei-15	M03A8.4	n/a	chrX 6,821,678	C. elegans GEI-15 protein ;
35	Y45G12C.3	Y45G12C.3	n/a	chrV 2,556,848	contains similarity to Pfam domain PF02798 Glutathione S-transferase, N-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
36	K02B12.7	K02B12.7	n/a	chrI 8,528,009	contains similarity to Pfam domain PF01412 Putative GTPase activating protein for Arf contains similarity to Interpro domain IPR001164 (Arf GTPase activating protein)
37	prx-12	F08B12.2	n/a	chrX 11,393,885	C. elegans PRX-12 protein; contains similarity to Pfam domain PF04757 Pex2 / Pex12 amino terminal region contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR017375 (Peroxisome assembly, p12), IPR006845 (Pex, N-terminal)
38	F19B2.5	F19B2.5	n/a	chrV 20,158,395	contains similarity to Mus musculus Helicase-like transcription factor (EC 3.6.1.-) (SWI/SNF-relatedsmatrix-associated actin-dependent regulator of chromatin subfamily Asmember 3) (Sucrose nonfermenting protein 2-like 3) (TNF-responseselement-binding protein) (P113).; SW:Q6PCN7
39	set-15	R11E3.4	n/a	chrIV 4,777,653	set-15 encodes a SET domain-containing protein required for normally short lifespan; SET-15 has no non-nematode orthologs, but several paralogs (SET-6, SET-13, SET-19, SET-20, SET-21, and SET-32); other than extending lifespan, set-15(RNAi) has no obvious phenotype.
40	vha-19	Y55H10A.1	n/a	chrIV 3,371,328	vha-19 encodes an ortholog of subunit Ac45 of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-19 is a predicted V-ATPase transmembrane rotor component; Ac45 is a nonhomologous replacement for subunit c', which is found in fungi but not in animals; conversely, orthologs of Ac45 are only found in animals; VHA-19 is predicted to help carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export.
41	ldh-1	F13D12.2	n/a	chrII 11,725,839	ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency.
42	Y54E5A.1	Y54E5A.1	n/a	chrI 14,690,180	contains similarity to Pfam domains PF00487 (Fatty acid desaturase) , PF08557 (Sphingolipid Delta4-desaturase (DES)) contains similarity to Interpro domains IPR013866 (Sphingolipid delta4-desaturase, N-terminal), IPR010257 (Fatty acid desaturase, type 1, N-terminal), IPR011388 (Sphingolipid delta4-desaturase), IPR005804 (Fatty acid desaturase, type 1)
43	sft-4	C54H2.5	n/a	chrX 5,779,970	sft-4 encodes a member of the SURF family highly conserved with the mouse Surf-4 gene, and conservation includes an encoded dilysine motif that is implicated in endoplasmic reticulum localization of the mouse protein.
44	B0416.1	B0416.1	n/a	chrX 9,307,010	contains similarity to Pfam domain PF07810 TMC domain contains similarity to Interpro domain IPR012496 (TMC)
45	ZC513.7	ZC513.7	n/a	chrV 8,039,921	C. elegans probable non-coding RNA
46	nhr-45	F16H11.5	n/a	chrX 4,658,348	C. elegans NHR-45 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
47	gst-21	ZK697.6	n/a	chrV 1,731,381	C. elegans GST-21 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
48	M03A8.3	M03A8.3	n/a	chrX 6,802,151	n/a
49	ccb-1	T28F2.5	n/a	chrI 3,644,343	ccb-1 encodes a homolog of the beta subunits of dihydropyridine sensitive L-type calcium channels that, in RNAi screens, is dispensable for viability or grossly normal morphology; a mutant allele of ccb-1 exists, but its phenotype has not yet been described.
50	uig-1	F32F2.1	n/a	chrV 13,278,769	C. elegans UIG-1 protein; contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR001331 (Guanine-nucleotide dissociation stimulator, CDC24, conserved site)