UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lgc-50	T20B12.9	0	chrIII 7,393,409	C. elegans LGC-50 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002289 (Gamma-aminobutyric-acid A receptor, beta subunit), IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	F55E10.6	F55E10.6	n/a	chrX 8,345,470	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
4	ZK370.8	ZK370.8	n/a	chrIII 8,753,333	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013026 (Tetratricopeptide region)
5	W02B12.11	W02B12.11	n/a	chrII 11,474,835	contains similarity to Pfam domain PF02709 Galactosyltransferase contains similarity to Interpro domain IPR003859 (Metazoa galactosyltransferase)
6	H34C03.2	H34C03.2	n/a	chrIV 6,759,933	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domains IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR006615 (Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)
7	tag-257	F46G11.3	n/a	chrX 5,784,865	C. elegans TAG-257 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
8	pcp-2	F23B2.12	n/a	chrIV 9,162,862	C. elegans PCP-2 protein; contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domains IPR008758 (Peptidase S28), IPR000258 (Bacterial ice-nucleation proteins octamer repeat)
9	H03A11.1	H03A11.1	n/a	chrX 15,211,201	H03A11.1 encodes an FAM20 ortholog; murine FAM20A is a secreted protein expressed in hematopoietic cells.
10	K10D11.6	K10D11.6	n/a	chrIV 12,988,061	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
11	Y56A3A.19	Y56A3A.19	n/a	chrIII 11,915,313	contains similarity to Pfam domain PF00550 Phosphopantetheine attachment site contains similarity to Interpro domains IPR006163 (Phosphopantetheine-binding), IPR009081 (Acyl carrier protein-like), IPR003231 (Acyl carrier protein (ACP))
12	ppk-1	F55A12.3	n/a	chrI 5,361,848	ppk-1 encodes a putative phosphatidylinositol-4-phosphate 5' kinase that is essential for ovulation, intense gonad sheath contraction and dilation of the spermathecal valve during oocyte maturation, and UNC-54 filament organization; more generally, PPK-1 is required for fertility, progression through larval development, normal locomotion and defecation, and overall health; defects of ppk-1(RNAi) animals in sterility, ovulation, and UNC-54 filaments are suppressed by the gain-of-function itr-1(sy290) allele, presumably through increased IP(3) signalling; PPK-1 is expressed in gonad sheath, spermatheca, uterine and vulva muscles, distal tip cells, intestine, head mesodermal cell, and many neurons (e.g., in the ventral nerve cord, near the nerve ring, and in tail); PPK-1 may be activated by VAV-1; PPK-1 is orthologous to five human proteins (e.g., PIP5K1B, OMIM:602745), and distantly paralogous to PPK-2.
13	F48C1.6	F48C1.6	n/a	chrI 5,318,763
14	mrp-3	E03G2.2	n/a	chrX 15,934,560	C. elegans MRP-3 protein; contains similarity to Pfam domains PF00664 (ABC transporter transmembrane region) (2), PF00005 (ABC transporter) (2)contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR011527 (ABC transporter, transmembrane region, type 1), IPR001140 (ABC transporter, transmembrane region), IPR003593 (AAA+ ATPase, core)
15	K03C7.3	K03C7.3	n/a	chrX 3,828,246
16	ZK328.6	ZK328.6	n/a	chrIII 6,029,645	contains similarity to Pfam domains PF02818 (PPAK motif) , PF00646 (F-box domain) contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
17	F43G9.1	F43G9.1	n/a	chrI 8,607,769	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004434 (Isocitrate dehydrogenase NAD-dependent, mitochondrial), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
18	gly-13	B0416.6	n/a	chrX 9,295,081	gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates; gly-13 is expressed throughout development in many cell types; gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14.
19	maoc-1	E04F6.3	n/a	chrII 7,196,834	maoc-1 encodes an ortholog of human HSD17B4 (OMIM:601860, mutated in D-bifunctional protein deficiency); MAOC-1 contains a MaoC-like domain found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit) and by homology, is predicted to function in peroxisomal fatty acid beta-oxidation; loss of maoc-1 activity via RNAi results in lifespan extension, increased fat content, and an increased susceptibility to pathogens.
20	F25E5.1	F25E5.1	n/a	chrV 7,468,526	contains similarity to Interpro domain IPR009091 (Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)
21	prx-19	F54F2.8	n/a	chrIII 8,808,467	prx-19 is orthologous to the human gene PEROXISOMAL FARNESYLATED PROTEIN (PXF; OMIM:600279), which when mutated leads to peroxisome biogenesis (Zellweger) syndrome of complementation group J.
22	lst-2	R160.7	n/a	chrX 4,380,673	C. elegans LST-2 protein; contains similarity to Pfam domain PF01363 FYVE zinc finger contains similarity to Interpro domains IPR000306 (Zinc finger, FYVE-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR017455 (Zinc finger, FYVE-related), IPR011011 (Zinc finger, FYVE/PHD-type)
23	K08E4.6	K08E4.6	n/a	chrIV 12,077,637	contains similarity to Pfam domain PF01105 emp24/gp25L/p24 family/GOLD contains similarity to Interpro domains IPR009038 (GOLD), IPR000348 (emp24/gp25L/p24)
24	vha-2	R10E11.2	n/a	chrIII 9,782,355	vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus.
25	nlt-1	ZK892.2	n/a	chrII 10,000,661	nlt-1 encodes a member of the SCP-2 sterol transfer family.
26	abcf-1	F18E2.2	n/a	chrV 12,762,189	C. elegans ABCF-1 protein; contains similarity to Pfam domain PF00005 ABC transporter contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR003593 (AAA+ ATPase, core)
27	cpn-4	F49D11.8	n/a	chrI 10,925,036	cpn-4 encodes a calponin homolog, most closely related to its paralog CPN-3 in C. elegans; CPN-4 is somewhat more similar to calponins per se (such as CLP1 and CLP2 in humans) than to the to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25.
28	asg-2	C53B7.4	n/a	chrX 6,841,624	asg-2 encodes a homolog of subunit G of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); asg-2 activity is required for growth at a normally high rate and for normal osmoregulation; in addition, asg-2 activity is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; an ASG-2::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons.
29	K02B12.7	K02B12.7	n/a	chrI 8,528,009	contains similarity to Pfam domain PF01412 Putative GTPase activating protein for Arf contains similarity to Interpro domain IPR001164 (Arf GTPase activating protein)
30	ptr-14	R09H10.4	n/a	chrIV 10,618,200	ptr-14 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-14 is weakly required for normal molting from L4 to adult stages; PTR-14 is also required for normal growth to full size and locomotion.
31	F43E2.9	F43E2.9	n/a	chrII 7,359,080
32	F35C11.4	F35C11.4	n/a	chrII 8,250,751	contains similarity to Homo sapiens Uncharacterized protein C9orf125; ENSEMBL:ENSP00000363980
33	F08A8.3	F08A8.3	n/a	chrI 12,948,957	contains similarity to Pfam domains PF01756 (Acyl-CoA oxidase) , PF02770 (Acyl-CoA dehydrogenase, middle domain) contains similarity to Interpro domains IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR012258 (Acyl-CoA oxidase), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR002655 (Acyl-CoA oxidase, C-terminal), IPR009075 (Acyl-CoA dehydrogenase/oxidase C-terminal)
34	fshr-1	C50H2.1	n/a	chrV 9,892,316	fshr-1 encodes a putative neuropeptide receptor required for normal acetylcholine secretion by synapses; FSHR-1 is orthologous to human follicle-stimulating hormone receptor (OMIM:136435; mutated in ovarian dysgenesis), thyrotropin receptor (OMIM:603372; mutated in hyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutated in precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1 puncta at synapses, suggesting exocytotic defects; the requirement for FSHR-1 and ten other predicted neuropeptide signalling proteins in cholinergic neurotransmission indicates that such signalling is important for regulating acetylcholine release at neuromuscular junctions; possible ligands of FSHR-1 are FLP-1 and NLP-12.
35	ubh-4	C08B11.7	n/a	chrII 8,038,864	C. elegans UBH-4 protein; contains similarity to Pfam domain PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 contains similarity to Interpro domains IPR001578 (Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1), IPR017390 (Ubiquitinyl hydrolase, UCH37 type)
36	ugt-16	ZC443.6	n/a	chrV 12,826,207	C. elegans UGT-16 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
37	tag-314	F15H10.4	n/a	chrV 10,427,635	C. elegans TAG-314 protein; contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002867 (Zinc finger, C6HC-type)
38	nuo-1	C09H10.3	n/a	chrII 11,099,005	nuo-1 encodes a encodes a 51 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, and progression through development; nuo-1 is orthologous to human NDUFV1 (OMIM:161015, mutated in Leigh syndrome); nuo-1(ua1) induces a developmental arrest at the third larval (L3) stage that blocks reproduction, and thus is lethal to a population homozygous for nuo-1(ua1); yet arrested L3 nuo-1(ua1) animals have an individual lifespan significantly longer than normal.
39	F59F5.2	F59F5.2	n/a	chrX 10,534,095	contains similarity to Cryptosporidium parvum Exonuclease ii, possible.; TR:Q7YYI5
40	R09F10.1	R09F10.1	n/a	chrX 8,324,257	contains similarity to Pfam domains PF08246 (Cathepsin propeptide inhibitor domain (I29)) , PF00112 (Papain family cysteine protease) contains similarity to Interpro domains IPR013128 (Peptidase C1A, papain), IPR000169 (Peptidase, cysteine peptidase active site), IPR013201 (Proteinase inhibitor I29, cathepsin propeptide), IPR000668 (Peptidase C1A, papain C-terminal)
41	Y43F8C.4	Y43F8C.4	n/a	chrV 19,627,836	contains similarity to Homo sapiens 90 kDa protein; VG:OTTHUMP00000182483
42	cyp-25A1	C36A4.1	n/a	chrIII 3,833,539	C. elegans CYP-25A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
43	F01D5.3	F01D5.3	n/a	chrII 13,999,536	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR001368 (TNFR/CD27/30/40/95 cysteine-rich region), IPR003582 (Metridin-like ShK toxin)
44	tufm-2	C43E11.4	n/a	chrI 4,248,543	C. elegans TUFM-2 protein; contains similarity to Pfam domains PF03143 (Elongation factor Tu C-terminal domain) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR005225 (Small GTP-binding protein), IPR004160 (Translation elongation factor EFTu/EF1A, C-terminal), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009001 (Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)
45	F42A10.5	F42A10.5	n/a	chrIII 6,172,231	contains similarity to Interpro domain IPR003072 (Orphan nuclear receptor, NOR1 type)
46	eft-2	F25H5.4	n/a	chrI 9,165,168	eft-2 encodes a homolog of translation elongation factor 2 (EF-2), a GTP-binding protein essential for the elongation phase of protein synthesis; eft-2 is required for embryogenesis and vulval morphogenesis, and is expressed during all stages of development, including the dauer larval stage.
47	B0286.3	B0286.3	n/a	chrII 4,371,091	contains similarity to Pfam domains PF01259 (SAICAR synthetase) , PF00731 (AIR carboxylase) contains similarity to Interpro domains IPR001636 (SAICAR synthetase), IPR000031 (1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase), IPR013816 (ATP-grasp fold, subdomain 2)
48	K08C7.1	K08C7.1	n/a	chrIV 10,658,786	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
49	F52G2.3	F52G2.3	n/a	chrIV 13,545,784	contains similarity to Pfam domain PF07547 RSD-2 N-terminal domain contains similarity to Interpro domain IPR011508 (RSD-2, N-terminal)
50	F53C11.1	F53C11.1	n/a	chrV 13,776,738	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)