UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	nhr-127	T13F3.3	0	chrV 16,263,066	nhr-127 encodes a member of the nuclear hormone receptor family; expressed in hypodermal seam cells from the embryonic 1.5-fold stage until the L1 larval stage.
2	mls-2	C39E6.4	n/a	chrX 4,760,178	mls-2 encodes a homeodomain protein of the HMX family; during postembryonic development, MLS-2 is required for cell proliferation, cleavage orientation, and fate specification in the mesodermal M lineage; in regulating M lineage proliferation and fate specification, MLS-2 appears to act upstream of CYE-1/cyclin E and HLH-1/CeMyoD, respectively, the latter of which is not expressed in the M lineage in mls-2 mutant animals; MLS-2 is expressed in the nuclei of early proliferating undifferentiated M lineage cells (up to the 8-M stage), in a subset of head neurons, and in cells near the vulva during the L2 and L3 larval stages.
3	dyf-8	C43C3.3	n/a	chrX 9,700,112	dyf-8 encodes a protein predicted to form a cell-surface ligand with a zona pellucida domain; DYF-8 is required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating, and dauer formation.
4	srh-148	K08G2.5	n/a	chrV 15,857,580	C. elegans SRH-148 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
5	let-381	F26B1.7	n/a	chrI 6,322,210	let-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-318 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult.
6	fbxb-115	T26H2.2	n/a	chrV 19,239,099	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
7	F38A5.7	F38A5.7	n/a	chrIV 6,602,016
8	F28B3.4	F28B3.4	n/a	chrI 4,937,314	contains similarity to Pfam domain PF06464 DMAP1-binding Domain contains similarity to Interpro domains IPR010506 (DMAP1-binding), IPR005398 (Tubby, N-terminal)
9	tsp-17	C02F12.1	n/a	chrX 3,682,658	C. elegans TSP-17 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domains IPR000301 (CD9/CD37/CD63 antigen), IPR008952 (Tetraspanin)
10	W04H10.2	W04H10.2	n/a	chrII 606,109
11	F28H1.1	F28H1.1	n/a	chrI 3,996,331
12	fut-6	T05A7.5	n/a	chrII 4,654,556	C. elegans FUT-6 protein; contains similarity to Pfam domain PF00852 Glycosyltransferase family 10 (fucosyltransferase) contains similarity to Interpro domain IPR001503 (Glycosyl transferase, family 10)
13	R07C3.7	R07C3.7	n/a	chrII 916,765
14	lim-7	C04F1.3	n/a	chrI 5,721,019	lim-7 encodes a LIM homeodomain protein; a lim-7 mutation can result in lethality or sterility; lim-7 reporter fusion are specifically expressed in the somatic gonadal sheath cells during the L4 larval stage and continuing through adulthood.
15	sdz-19	F45E6.6	n/a	chrX 12,502,884	C. elegans SDZ-19 protein ;
16	F53B3.5	F53B3.5	n/a	chrX 2,876,207	F53B3.5 encodes a claudin homolog that may regulate ion channels; F53B3.5 is distantly similar to mammalian voltage-dependent calcium channel gamma subunits that are known or suspected to prevent epilepsy in vivo (e.g., stargazin; MGI:1316660); F53B3.5 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water.
17	unc-119	M142.1	n/a	chrIII 10,907,547	unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues.
18	C06C3.7	C06C3.7	n/a	chrII 9,385,835	contains similarity to Saccharomyces cerevisiae Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Ygl245wp), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; SGD:YGL105W
19	F34D6.1	F34D6.1	n/a	chrII 2,680,190	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
20	fbxa-137	T27B7.7	n/a	chrV 2,280,414	C. elegans FBXA-137 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
21	Y51A2B.2	Y51A2B.2	n/a	chrV 18,375,467	contains similarity to Pfam domain PF04789 Protein of unknown function (DUF621) contains similarity to Interpro domain IPR006874 (Protein of unknown function DUF621)
22	T15B7.15	T15B7.15	n/a	chrV 6,837,660	contains similarity to Interpro domain IPR000533 (Tropomyosin)
23	Y17G7B.17	Y17G7B.17	n/a	chrII 12,096,120	contains similarity to Drosophila melanogaster Flybase gene name is Mlf-PD;; FLYBASE:CG8295
24	fbxb-49	K05F6.1	n/a	chrII 1,570,989	C. elegans FBXB-49 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
25	nhr-157	C17E7.5	0.0000002	chrV 3,867,765	C. elegans NHR-157 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
26	F21H7.3	F21H7.3	n/a	chrV 16,232,966	contains similarity to Rickettsia conorii Hypothetical protein RC0540.; TR:Q92I80
27	F56C9.8	F56C9.8	n/a	chrIII 7,317,655
28	sdz-18	F45C12.11	n/a	chrII 1,705,740	C. elegans SDZ-18 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
29	ZC204.6	ZC204.6	n/a	chrII 1,644,534
30	lon-2	C39E6.1	n/a	chrX 4,743,993	lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface.
31	nhr-79	T26H2.9	0.0000000000001	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
32	C05E11.3	C05E11.3	n/a	chrX 4,580,554	contains similarity to Mus musculus Lysosomal-associated transmembrane protein 4A (Golgi 4-transmembranesspanning transporter) (Mouse transporter protein) (MTP).; SW:Q60961
33	F26D2.13	F26D2.13	n/a	chrV 16,435,139	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
34	C24A3.8	C24A3.8	n/a	chrX 9,006,620
35	F25D1.2	F25D1.2	n/a	chrV 10,531,704	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
36	T05C1.1	T05C1.1	n/a	chrII 4,479,688
37	R160.6	R160.6	n/a	chrX 4,372,098
38	col-105	F58F6.2	n/a	chrIV 1,358,519	C. elegans COL-105 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR003979 (Tropoelastin), IPR000694 (Proline-rich region), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
39	F49D11.7	F49D11.7	n/a	chrI 10,923,733
40	K12B6.7	K12B6.7	n/a	chrV 6,297,759
41	srj-37	F48G7.1	n/a	chrV 639,279	C. elegans SRJ-37 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
42	fbxb-19	F58E1.9	n/a	chrII 1,688,706	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
43	C55B6.5	C55B6.5	n/a	chrX 7,205,013	contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core)
44	srt-12	E03D2.4	n/a	chrV 4,241,727	C. elegans SRT-12 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
45	ZK218.8	ZK218.8	n/a	chrV 17,116,486	contains similarity to Pfam domain PF02171 Piwi domain contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
46	col-9	F54B11.1	n/a	chrX 13,590,542	col-9 encodes a collagen protein.
47	T23F11.4	T23F11.4	n/a	chrIII 4,664,270	contains similarity to Interpro domain IPR007087 (Zinc finger, C2H2-type)
48	H09G03.1	H09G03.1	n/a	chrIII 3,228,491
49	C05D12.5	C05D12.5	n/a	chrII 11,434,516	contains similarity to Homo sapiens Isoform 1 of Cingulin-like protein 1; ENSEMBL:ENSP00000281282
50	che-12	B0024.8	n/a	chrV 10,303,399	che-12 encodes a conserved protein that contains at least seven predicted HEAT repeats; CHE-12 activity is required continuously in sensory neurons for formation of distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis to a subset of attractants, including sodium chloride; a che-12::gfp promoter fusion is expressed in the two phasmid neurons and the subset of amphid neurons that contain relatively simple cilia; a CHE-12::GFP protein localizes to cilia in a manner suggesting that it requires intraflagellar transport for proper localization, but is unlikely to be a core IFT particle component; che-12 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor.