UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ztf-4	T10B11.3	2e-177	chrI 6,927,973	C. elegans ZTF-4 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1), IPR007087 (Zinc finger, C2H2-type)
2	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	ceh-40	F17A2.5	n/a	chrX 12,319,393	ceh-40 encodes one of two C. elegans homeodomain proteins homologous to Extradenticle (Exd/Pbx); ceh-40 genetically interacts with ceh-20 and unc-62 during embryonic development: while loss of ceh-40 activity alone results in no significant embryonic lethality, loss of ceh-40 and ceh-20, or ceh-40, ceh-20, and unc-62, results in incompletely penetrant embryonic lethality.
4	C03E10.3	C03E10.3	n/a	chrV 11,287,593	contains similarity to Clostridium perfringens Probable cytochrome C-type biogenesis protein.; TR:Q8XME8
5	F25B4.2	F25B4.2	n/a	chrV 5,710,856	contains similarity to Pfam domain PF04710 Pellino contains similarity to Interpro domain IPR006800 (Pellino)
6	E04D5.2	E04D5.2	n/a	chrII 10,420,700	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
7	lin-59	T12F5.4	n/a	chrI 3,717,339	C. elegans LIN-59 protein; contains similarity to Pfam domains PF01426 (BAH domain) , PF00628 (PHD-finger) , PF00856 (SET domain) contains similarity to Interpro domains IPR001214 (SET), IPR001965 (Zinc finger, PHD-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR001025 (Bromo adjacent region), IPR011011 (Zinc finger, FYVE/PHD-type), IPR006560 (AWS)
8	F23F1.4	F23F1.4	n/a	chrII 26,912
9	T05H4.11	T05H4.11	n/a	chrV 6,425,085
10	F21D5.6	F21D5.6	n/a	chrIV 8,740,745	contains similarity to Xenopus laevis Ribonuclease H2 subunit B (RNase H2 subunit B) (Ribonuclease HIssubunit B).; SW:Q5HZP1
11	ZK836.3	ZK836.3	n/a	chrV 12,195,261
12	C25F6.6	C25F6.6	n/a	chrX 5,450,509
13	F22B8.6	F22B8.6	n/a	chrV 16,101,647	F22B8.6 encodes a putative cystathionine gamma-lyase; F22B8.6 is orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), extremely similar to its paralog ZK1127.10, and also paralogous to C12C8.2; either F22B8.6, or ZK1236.10, or both proteins weakly inhibit DHC-1 in vivo; otherwise, F22B8.6 has no obvious function in mass RNAi assays, perhaps because of genetic redundancy with ZK1127.10.
14	C29G2.3	C29G2.3	n/a	chrV 2,581,907
15	F01G10.10	F01G10.10	n/a	chrIV 10,247,944	contains similarity to Pfam domains PF02886 (LBP / BPI / CETP family, C-terminal domain) , PF01273 (LBP / BPI / CETP family, N-terminal domain) contains similarity to Interpro domain IPR001124 (Lipid-binding serum glycoprotein)
16	ZK418.5	ZK418.5	n/a	chrIII 7,073,217	contains similarity to Mus musculus Transmembrane protein 147.; SW:Q9CQG6
17	C05E7.4	C05E7.4	n/a	chrX 12,966,891	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
18	ZK154.4	ZK154.4	n/a	chrX 7,779,677
19	dnj-23	T24H10.3	n/a	chrII 9,107,885	This gene encodes a protein containing a DnaJ ('J') domain.
20	C25G6.5	C25G6.5	n/a	chrX 1,253,316	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002232 (5-Hydroxytryptamine 6 receptor), IPR000611 (Neuropeptide Y receptor), IPR000276 (GPCR, rhodopsin-like)
21	ZK218.1	ZK218.1	n/a	chrV 17,092,954	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
22	D1025.1	D1025.1	n/a	chrX 14,521,627	contains similarity to Homo sapiens Splice isoform 3 of Q9ULU4 Protein kinase C binding protein 1; ENSEMBL:ENSP00000262975
23	F13H6.5	F13H6.5	n/a	chrV 6,373,505	contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
24	T07F12.4	T07F12.4	n/a	chrX 4,897,382	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
25	ceh-20	F31E3.1	n/a	chrIII 6,980,772	ceh-20 encodes the C. elegans ortholog of the homeodomain co-factor Extradenticle (Exd/Pbx); together with ceh-40 and unc-62, ceh-20 activity is required for embryonic viability; ceh-20 is also required as a cofactor for LIN-39- and MAB-5- dependent postembryonic mesoderm patterning; in addition, ceh-20 is required for regulating post-embryonic migrations of the Q neuroblast descendants and for regulating vulval development; a CEH-20::GFP fusion protein is expressed in embryos and postembryonically in many cell types including the Q, P, and V cells and their descendants; CEH-20 localizes to the nucleus.
26	hda-2	C08B11.2	n/a	chrII 8,021,602	hda-2 encodes a Class I histone deacetylase; by homology, HDA-2 is predicted to function in deacetylation of histone residues and transcriptional regulation; loss of hda-2 activity via RNAi results in an increased spontaneous mutation rate, suggesting that hda-2 also plays a role in regulating genome stability.
27	his-12	ZK131.6	n/a	chrII 13,821,298	his-12 encodes an H2A histone; his-12 is contained within the histone gene cluster HIS3.
28	gstk-2	D2024.7	n/a	chrIV 7,241,341	C. elegans GSTK-2 protein; contains similarity to Pfam domain PF01323 DSBA-like thioredoxin domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR001853 (DSBA oxidoreductase), IPR014440 (HCCA isomerase/glutathione S-transferase kappa)
29	rheb-1	F54C8.5	n/a	chrIII 9,455,024	rheb-1 encodes a GTPase orthologous to the mammalian Rheb and Rheb1 GTPases; loss of rheb-1 activity via RNAi indicates that RHEB-1 is involved in the mitochondrial unfolded protein response and that its function is required for normal growth rates, body size, osmoregulation, reproduction, and locomotion.
30	emb-27	F10B5.6	n/a	chrII 8,160,979	emb-27 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of the anaphase-promoting complex (APC) subunit APC-6 (CDC16); required maternally and paternally, EMB-27 activity is essential for proper execution of the metaphase-to-anaphase transition during meiosis (both oogenesis and spermatogenesis) and mitosis (during germline proliferation); EMB-27 activity is also critical for embryonic anterior-posterior (A-P) axis formation, production of the secreted eggshell, and normal vulval development; in establishing the embryonic A-P axis, EMB-27 likely acts upstream of the separin protease to ensure proper localization of PAR-3 and PAR-2 to the anterior and posterior cortices, respectively.
31	let-60	ZK792.6	n/a	chrIV 11,689,627	let-60 encodes a member of the GTP-binding RAS protooncogene family; let-60 activity is required for viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, chemotaxis, sex myoblast migration, and muscle membrane extension; let-60 acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis; let-60 is expressed in neural, muscle, and hypodermal lineages.
32	F39H12.3	F39H12.3	n/a	chrX 839,898	contains similarity to Pfam domains PF00612 (IQ calmodulin-binding motif) (3), PF02197 (Regulatory subunit of type II PKA R-subunit) contains similarity to Interpro domains IPR003117 (cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta), IPR000048 (IQ calmodulin-binding region)
33	glt-7	W03G1.1	n/a	chrIV 533,911	C. elegans GLT-7 protein; contains similarity to Pfam domain PF00375 Sodium:dicarboxylate symporter family contains similarity to Interpro domain IPR001991 (Sodium:dicarboxylate symporter)
34	C47A4.1	C47A4.1	n/a	chrIV 13,716,255	contains similarity to Interpro domain IPR015609 (Molecular chaperone, heat shock protein, Hsp40, DnaJ)
35	F57G4.6	F57G4.6	n/a	chrV 17,643,424	contains similarity to Interpro domains IPR013048 (Meiotic recombination Spo11), IPR006578 (MADF)
36	clec-35	Y102A5B.2	n/a	chrV 16,853,143	C. elegans CLEC-35 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
37	ckb-3	B0285.10	n/a	chrIII 4,371,823	ckb-3 encodes a putative choline kinase; CKB-1 through CKB-4 comprise a related group ('B') of choline kinases.
38	R52.6	R52.6	n/a	chrII 2,112,662	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domains IPR003326 (Protein of unknown function DUF130), IPR001507 (Endoglin/CD105 antigen)
39	F48G7.7	F48G7.7	n/a	chrV 626,072	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
40	spr-5	Y40B1B.6	n/a	chrI 13,443,987	spr-5 encodes the C. elegans ortholog of the human histone demethylase LSD1 (lysine-specific demethylase 1) that functions to mediate chromatin remodeling and transcriptional regulation; loss of spr-5 activity can suppress the egg-laying defective (Egl) phenotype of mutations in sel-12/presenilin and derepresses expression of hop-1, which encodes the second C. elegans presenilin, by 20- to 30-fold; in binding assays and yeast two-hybrid experiments, SPR-5 interacts with SPR-1, the C. elegans ortholog of CoREST.
41	F09E10.5	F09E10.5	n/a	chrX 1,492,033
42	T09E11.1	T09E11.1	n/a	chrI 12,338,593	contains similarity to Pfam domain PF03360 Glycosyltransferase family 43 contains similarity to Interpro domain IPR005027 (Glycosyl transferase, family 43)
43	T03G11.4	T03G11.4	n/a	chrX 5,167,050	contains similarity to Pfam domain PF01532 Glycosyl hydrolase family 47 contains similarity to Interpro domain IPR001382 (Glycoside hydrolase, family 47)
44	bath-39	F25H9.4	n/a	chrV 13,460,604	C. elegans BATH-39 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
45	dat-1	T23G5.5	n/a	chrIII 9,244,759	dat-1 encodes a plasma membrane dopamine transporter; DAT-1 is predicted to regulate dopaminergic neurotransmission via reuptake of dopamine into presynaptic neurons; when expressed in HeLa cells, DAT-1 exhibits high affinity, saturable dopamine transport; further, in primary cultures of C. elegans dopaminergic neurons, DAT-1 also exhibits a channel mode of conduction that leads to membrane depolarization; in hermaphrodites, dat-1 is expressed in the eight dopaminergic neurons (4 CEPs, 2 ADEs, and 2 PDEs), while in males dat-1 is additionally expressed in the three pairs of tail dopaminergic neurons; dat-1 expression begins during embryogenesis with the exception of expression in the PDE neurons which are born postembryonically.
46	C26E1.1	C26E1.1	n/a	chrV 13,297,767	contains similarity to Rattus norvegicus GLUT4 vesicle protein.; TR:Q9Z1X1
47	T22F7.1	T22F7.1	n/a	chrIII 544,286	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR006655 (Molybdopterin oxidoreductase, prokaryotic, conserved site), IPR001991 (Sodium:dicarboxylate symporter), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
48	srh-239	T26H5.3	n/a	chrV 15,446,542	C. elegans SRH-239 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
49	F33D11.5	F33D11.5	n/a	chrI 5,836,021	contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR013099 (Ion transport 2), IPR003092 (Potassium channel, two pore-domain, TASK)
50	flt-1	ZK783.4	n/a	chrIII 7,653,227	flt-1 encodes a putative homolog of flectin, an extracellular matrix protein thought to provide a microenvironment of great elasticity; however, FLT-1 protein contains no similarity to other ECM components, instead mostly appearing to be made up of chromatin or DNA-binding domains; FLT-1 also contains a glutamine/asparagine-rich domain, which may mediate epigenetic regulation.